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Acta Pharmaceutica Sinica B 2024年第1期14卷 273-291页

作者： duc-Vinh Pham Thi-Kem nguyen Bao-Loc nguyen Jong-Oh Kim Jee-Heon Jeong Inho Choi Pil-Hoon Park Department of Pharmacology Hanoi University of PharmacyHanoi 100000Viet Nam College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Medical Biotechnology Yeungnam UniversityGyeongsan 38541Republic of Korea Research Institute of Cell Culture Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Precision Medicine School of MedicineSungkyunkwan UniversitySuwon 16419Republic of Korea

Obesity has been known to negatively modulate the life-span and immunosuppressive potential of mesenchymal stromal cells(MSC).However,it remains unclear what drives the compromised potency of obese *** this study,we examined the involvement of adiponectin,an adipose tissuederived hormone,in obesity-induced impaired therapeutic function of ***-induced obesity leads to a decrease in serum adiponectin,accompanied by impairment of survival and immunomodulatory effects of adipose-derived MSC(ADSC).Interestingly,priming with globular adiponectin(gAcrp)improved the immunomodulatory potential of obese *** effects were also observed in lean *** addition,gAcrp potentiated the therapeutic effectiveness of ADSC in a mouse model of DSS-induced ***,while obesity inhibited the glycolytic capacity of MSC,gAcrp treatment induced a metabolic shift toward glycolysis through activation of adiponectin receptor type 1/p38 MAPK/hypoxia inducible factor-1a *** findings suggest that activation of adiponectin signaling is a promising strategy for enhancing the therapeutic efficacy of MSC against immune-mediated disorders.

关键词： Adiponectin Adipose-derived stromal cells Colitis Glycolytic induction HIF1a Immunomodulation Mesenchymal stromal cells Obesity

Prediction of falling weight deflectometer parameters using hybrid model of genetic algorithm and adaptive neuro-fuzzy inference system

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Frontiers of Structural and Civil Engineering 2023年第5期17卷 812-826页

作者： Long Hoang nguyen Dung Quang VU duc Dam nguyen Fazal E.JALAL Mudassir IQBAL Vinh The DANG Hiep Van LE Indra PRAKASH Binh Thai PHAM Faculty of Civil Engineering University of Transport TechnologyHanoi 10000Vietnam Department of Civil Engineering State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200025China Department of Civil Engineering University of Engineering and TechnologyPeshawar 25120Pakistan DDG(R)Geological Survey of India Gandhinagar 382010India

A falling weight deflectometer is a testing device used in civil engineering to measure and evaluate the physical properties of pavements,such as the modulus of the subgrade reaction(Y1)and the elastic modulus of the slab(Y2),which are crucial for assessing the structural strength of *** this study,we developed a novel hybrid artificial intelligence model,i.e.,a genetic algorithm(GA)-optimized adaptive neuro-fuzzy inference system(ANFIS-GA),to predict Y1 and Y2 based on easily determined 13 parameters of rigid *** performance of the novel ANFIS-GA model was compared to that of other benchmark models,namely logistic regression(LR)and radial basis function regression(RBFR)*** models were validated using standard statistical measures,namely,the coefficient of correlation(R),mean absolute error(MAE),and root mean square error(RMSE).The results indicated that the ANFIS-GA model was the best at predicting Y1(R=0.945)and Y2(R=0.887)compared to the LR and RBFR ***,the ANFIS-GA model can be used to accurately predict Y1 and Y2 based on easily measured parameters for the appropriate and rapid assessment of the quality and strength of pavements.

关键词： falling weight deflectometer modulus of subgrade reaction elastic modulus metaheuristic algorithms

Applying Wide & Deep Learning Model for Android Malware Classification

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Computer Systems Science & Engineering 2023年第6期45卷 2741-2759页

作者： Le duc Thuan Pham Van Huong Hoang Van Hiep nguyen Kim Khanh Ha Noi University of Science and Technology Ha Noi100000Viet Nam Academy of Cryptography Techniques Ha Noi100000Viet Nam

Android malware has exploded in popularity in recent years,due to the platform’s dominance of the mobile *** the advancement of deep learning technology,numerous deep learning-based works have been proposed for the classification of Android *** learning technology is designed to handle a large amount of raw and continuous data,such as image content ***,it is incompatible with discrete features,i.e.,features gathered from multiple ***,if the feature set is already well-extracted and sparsely distributed,this technology is less effective than traditional machine *** the other hand,a wide learning model can expand the feature set to enhance the classification *** maximize the benefits of both methods,this study proposes combining the components of deep learning based on multi-branch CNNs(Convolutional Network Neural)with wide learning *** feature set is evaluated and dynamically partitioned according to its meaning and generalizability to subsets when used as input to the model’s wide or deep *** proposed model,partition,and feature set quality are all evaluated using the K-fold cross validation method on a composite dataset with three types of features:API,permission,and raw *** accuracy with Wide and Deep CNN(WDCNN)model is 98.64%,improved by 1.38%compared to RNN(Recurrent Neural Network)model.

关键词： Wide and deep(W&D)learning convolutional neural network image feature raw features generalized features

采石场粉尘和海砂混合物力学性能试验和数值研究

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岩土力学 2024年第9期45卷 2728-2740页

作者： TIEP Pham duc TU nguyen Van PHONG Pham duc CHINH Mai Viet PHONG nguyen Viet 越南勒奎东技术大学特殊工程技术研究所河内越南

越南等发展中国家的道路基础设施建设需要大量天然砂。河砂日益紧缺,其供应量将持续下降。因此,建筑行业必须实施可持续发展战略,将废弃材料与各种可利用资源相结合,以有效应对这一严峻形势。本研究的目的是测试采石场粉尘和海砂混合物... 详细信息

越南等发展中国家的道路基础设施建设需要大量天然砂。河砂日益紧缺,其供应量将持续下降。因此,建筑行业必须实施可持续发展战略,将废弃材料与各种可利用资源相结合,以有效应对这一严峻形势。本研究的目的是测试采石场粉尘和海砂混合物的力学性能,并评估其在高速公路路基层中的潜在应用。进行了一系列试验,包括材料的含水率、相对密度、休止角测试和三轴试验,以研究不同配比下混合物的组成。结合Plaxis土工试验中的校准进行了广泛的参数研究,得出了割线模量E_(50)和围压曲线。根据加州承载比CBR对公路路基层所用材料的评估结果,证明海砂和采石场粉尘混合物具有适当性能,可用于公路路基的建设。

关键词：采石场粉尘海砂土工试验模块固结试验三轴试验路基层公路加州承载比

Morphological Change in the Northern Red River Delta,Vietnam

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Journal of Ocean University of China 2018年第6期17卷 1272-1280页

作者： BUI Vuong Van FAN Daidu nguyen Dac Ve TRAN Dinh Lan TRAN duc Thanh HOANG Van Long nguyen Thi Hong Hanh Institute of Marine Environment and Resources Vietnam Academy of Science and TechnologyHaiphong 18000Vietnam State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China Hanoi University of Mining and Geology Hanoi 10000Vietnam Graduate University of Science and Technology Vietnam Academy of Science and TechnologyHanoi 10000Vietnam

Coastal erosion has become a worldwide concern, typically in the densely populated Asian mega-river deltas. Severe coastal erosion in the southern Red River Delta(RRD) has been intensively studied. Coastal morphological change in the northern RRD was examined in detail through DEM(Digital Elevation Model) analysis based on time series of bathymetrical maps(1965–2004) and Landsat images(1975–2015) in this study. The results show that the northern RRD is featured by rapid coastal accretion in the past few decades, although suspended sediment flux has dropped by roughly 60% after the completeness of Hoa Binh Dam(HBD) in 1988 and relative sea level rose at 1.9 mm yr^(-1). However, accretion at the outer part of subtidal shoals and platforms was observed to slow down quickly or even turned into erosion in the last two decades. The resuspended sediments from the erosion zone can be transported landward to replenish the inner coastal zone, keeping the latter accretion in the near future to compensate for the sediment discharge decrease from the river. However, this lag effect should be terminated soon if other adverse effects go worse, e.g., damming rivers, sea-level rising, strengthening storms, land reclamation and other poor-designed coastal engineering. Coastal planners and managers should pay full attention to these changes.

关键词： Morphological change DEM coastal erosion coastal engineering coastal management tide-dominated Red River Delta

Polygonatum kingianum rhizome extract alleviates collagen antibody-induced arthritis by modulating proinflammatory cytokine production in mice

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Asian Pacific Journal of Tropical Biomedicine 2020年第11期10卷 490-495页

作者： Huyen Do Thi Thanh Phuong Ngo Thi hien nguyen Thi Thu Nga nguyen Thi Hung Le Ngoc Thao DoThi Ha Le Minh Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Institute of Natural Products Chemistry Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Hanoi Open University101 nguyen hien str Hai Ba Trung Dist.HanoiVietnam Laboratory of Bioassay Institute of BiotechnologyVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Chemistry Lab Project Center for Research and Technology transferVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam

Objective: To evaluate the anti-arthritic effects of Polygonatum kingianum rhizome extract using both in vitro and in vivo ***: Lipopolysaccharide-induced RAW 264.7 macrophages were treated with an ethanol extract of Polygonatum kingianum rhizomes at different concentrations to determine nitric oxide and prostaglandin E2(PGE2) production. For in vivo study, Polygonatum kingianum ethanol extract was further investigated for its antiinflammatory effect in a mouse model with collagen antibodyinduced arthritis. Phytochemical study of Polygonatum kingianum ethanol extract was also ***: Saponins(142 mg/g total yield) was the main component in the Polygonatum kingianum ethanol extract. 5α,8α-ergosterol peroxide,(E,E)-9-oxooctadeca-10,12-dienoic acid and 3-(2?-hydroxy-4?-methoxy-benzyl)-5,7-dihydroxy-8-methyl-chroman-4-one were isolated from the extract. Polygonatum kingianum ethanol extract exhibited potential anti-inflammatory effects by inhibiting nitric oxide and PGE2 production in RAW 264.7 cells in a dosedependent manner. The level of arthritis in mice with collagen antibody-induced arthritis was significantly reduced(Pduced arthritis. The phytochemical screening reveals that the saponin, as the main component, and sterols(daucosterol and 5α,8α-ergosterol peroxide) from Polygonatum kingianum ethanol extract may contribute to its promising in vitro and in vivo anti-inflammatory activities.

关键词： inflammatory cytokine PGE2

A novel approach for synthesis of hierarchical mesoporous Nd2O3 nanomaterials

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Journal of Rare Earths 2017年第7期35卷 677-682页

作者： Le Huu Trinh Dinh Quang Khieu Hoang Thai Long Tran Thai Hoa Duong Tuan Quang nguyen duc Cuong College of Sciences Hue University 77 Nguyen Hue Hue City Viet Nam Faculty of Hospitality and Tourism Hue University 22 Lam Hoang Hue CityViet Nam College of Education Hue University 34 Le LoL Hue City Viet Nam

A novel route to the fabrication of hierarchical mesoporous Nd_2O_3 nanostructures including nanospheres and nanoporous network was described. Their structure and morphology evolution of the as-synthesized materials were determined by various techniques such as scanning electron microscopy, transmission electron microscopy, high-resolution transmission electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, Fourier transforminfrared spectra, nitrogen adsorption/desorption isotherm, and a formation mechanism was proposed. The results revealed that the Nd_2O_3 nanospheres had the diameter of 300 nm, which were composed of small primary nanoparticles（NPs） with the size of 10 nm. The nanoporous structure also formed the NPs of ca. 10 nm which were connected with each other to form a three-dimensional（3D） texture. This simple and mild approach to fabricate hierarchical mesoporous Nd_2O_3 nanostructures could be easily scaled up and potentially extended to synthesize other oxide hierarchical structures.

关键词： Nd2O3 hierarchical nanostructures nanospheres nanoporous network rare earths

Novel hybrid models of ANFIS and metaheuristic optimizations (SCE and ABC) for prediction of compressive strength of concrete using rebound hammer field test

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Frontiers of Structural and Civil Engineering 2022年第8期16卷 1003-1016页

作者： Dung Quang VU Fazal EJALAL Mudassir IQBAL Dam duc nguyen Duong Kien TRONG Indra PRAKASH Binh Thai PHAM University of Transport Technology Hanoi 100000Vietnam Department of Civil Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Civil Engineering University of Engineering and TechnologyPeshawar 25120Pakistan DDG(R)Geological Survey of India Gandhinagar 382010India

In this study,we developed novel hybrid models namely Adaptive Neuro Fuzzy Inference System(ANFIS)optimized by Shuffled Complex Evolution(SCE)on the one hand and ANFIS with Artificial Bee Colony(ABC)on the other *** were used to predict compressive strength(Cs)of concrete relating to thirteen concrete-strength affecting parameters which are easy to determine in the *** and laboratory tests data of 108 structural elements of 18 concrete bridges of the Ha Long-Van Don Expressway,Vietnam were *** dataset was randomly divided into a 70:30 ratio,for training(70%)and testing(30%)of the hybrid *** of the developed fuzzy metaheuristic models was evaluated using standard statistical metrics:Correlation Coefficient(R),Root Mean Square Error(RMSE)and Mean Absolute Error(MAE).The results showed that both of the novel models depict close agreement between experimental and predicted ***,the ANFIS-ABC model reflected better convergence of the results and better performance compared to that of ANFIS-SCE in the prediction of the concrete ***,the ANFIS-ABC model can be used for the quick and accurate estimation of compressive strength of concrete based on easily determined parameters for the design of civil engineering structures including bridges.

关键词： shuffled complex evolution artificial bee colony ANFIS concrete compressive strength Vietnam

Concentrations of Heavy Metals in Muscle with Relation to the Growth of Two Marine Fish Species

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生态毒理学报 2015年第3期10卷 304-310页

作者： Le Quang Dung nguyen Viet Linh nguyen Xuan Thanh nguyen duc Cu Vu Van Tu3 Takaomi Arai Institute of Marine Environment and Resources Vietnam Academic of Science and Technology Haiphong Vietnam Institute of Oceanography and Environment Universiti Malaysia Terengganu Kuala Terengganu Malaysia Institute of Environmental Technology Vietnam Academic of Science and Technology Hanoi Vietnam

Heavy metal concentrations in muscle and their relation to thegrowth of two marine fish species,including tonguefish( Cynoglossus arel) and mullet( Mugil cephalus),were studied. The samples were collected in Bach Dang estuary andconcentrations of heavy metals( As,Cd,Co,Mn,Cu,Zn,Pb,and V) in muscle of the fisheswere determined. The result showed that the accumulated trend of heavy metal is different between fish species. The concentration of As,Zn,Mn,V,Cu,Pb,Co and Cd in tonguefish were 73. 7 ± 30. 6,22. 82 ± 4.87,3. 44 ± 2. 13,1. 61 ± 0. 15,0. 71 ± 0. 13,0. 45 ± 0. 24,0. 03 ± 0. 02 and 0. 02 ± 0. 02 mg·g-1,respectively. Meanwhile the concentration of Zn,As,V,Mn,Cu,Pb,Co and Cd in mullet were 83. 41 ±19. 68,9. 78 ± 1. 92,1. 36 ± 0. 54,1. 29 ± 0. 51,0. 65 ± 0. 12,0. 42 ± 0. 20,0. 06 ± 0. 03 and0. 03 ± 0. 01mg·g-1,respectively. Comparison of metal levels among thesespecies indicated that the concentrations of As and Mn in tonguefish were significantly higher than those in mullet,whereas Zn levels in mullet were found to be higher than that in tonguefish. There is no significant differences of Cd,Co,Cu,Pb and V levels in muscle between two species. Significant inversed relationshipsbetween concentration levels of metals and lengths of tonguefish were found for Mn,Cu and Zn,butnot for As,Cd,Pb,and V. There were no significant relationships between the heavy metal concentrations and the length of mullet. In general,decreasesof the heavy metal concentrations corresponded to the increases of fish body lengths,particularly for As,Co,Cu,Mn and V and the exception for Cd. Terefore reduced risks were associated with consuming biggermullet fish,and increased risks of As and Cd were associated with consuming bigger tonguefish in Bach Dang river mouth.

关键词： heavy metals concentration levels marine fish health risk Vietnam

Detection and localization of the hemoglobin and collagen distribution of the uterine cervix

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Journal of Innovative Optical Health Sciences 2019年第4期12卷 116-126页

作者： Tran Van Tien nguyen Ngoc Quynh Le Huynh duc Phan Ngoc Khuong Cat Huynh Quang Linh Department of Applied Physics Faculty of Applied Science Ho Chi Minh City University of Technology700000 Vietnam DCSELAB—National key Laboratory of Digital Control and System Engineering 700000 Vietnam Department of Biomedical Engineering Faculty of Medicine Nguyen Tat Thanh University700000 Vietnam Department of Engineering Physics Faculty of Applied Science Ho Chi Minh City University of Technology700000 Vietnam

Changes of the blood vessels and collagen are associated with the development of abnormal cervical ***,optical coberence tomography and Mueller polarization images were 1used to provide information regarding the presence of collagen fibers in the cervical ***,most of these methods need a lot of time for image recording and are *** addition,the general survey on the absorption and distribution characteristics of collagen and blood in the cervical is still *** this study,we developed a colposcopy combining cross-polarized inage and image procssing algorithm with an fficient analytical model to map the distribution of blood and collagen in the *** this system's proof of concept,we captured and processed the case of cervical ectopy and Nabothian *** results show that the distribution of blood and collagen maps matched with anatomical and physiological when compared with Lugol's iodline *** technology has some advantages,such as low cost,real time,and can replace the 11se of acetic acid or Lugol's iodine in the future.

关键词： Hemoglobin collagen cross polarized image uterine cervix