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Myo-inositol versus metformin effects on clinical features, endocrine and metabolic profiles in infertile women with polycystic ovary syndrome: A randomized controlled trial

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Asian pacific Journal of Reproduction 2023年第6期12卷 256-265页

作者： nguyen Sa Viet Le Minh Tam Le Thanh ngoc Cao Center for OBGYN Hue Central Hospital16 Le Loi StreetHueVietnam Center for Reproductive Endocrinology and Infertility Hue University of Medicine and PharmacyHue University06 Ngo Quyen StreetHueVietnam

Objective:To compare the effectiveness of inositol and metformin on the clinical characteristics,and endocrine and metabolic profiles of infertile polycystic ovarian syndrome(PCOS)women from ***:From June 2018 to August 2022,a randomized trial was undertaken at the Hue Center for Endocrinology and Reproduction on infertile women aged 18 to 40 years with polycystic ovarian *** clinical,endocrine,and metabolic features of these individuals were assessed before and after 3 months of treatment with 2 g of inositol or 1700 mg of metformin per *** pregnancy rates,adverse effects,and tolerance of inositol were ***:The study included 171 infertile PCOS women who were eligible to participate and took part in the baseline assessment,of whom 132 women participated in data analysis after 3 *** metformin treatment,42.1%of women with oligomenorrhea experienced regular *** significantly lowered body mass index(BMI),waist circumference and testosterone levels,but had no effect on other clinical characteristics,endocrine profiles,or metabolic profiles.29.2%Of women reported experiencing side effects.21%Of them attained pregnancy,which resulted in 17.1%of live *** the inositol group,the rate of regular cycle increased by 18.2%and the total testosterone concentration significantly *** overweight/obese women with PCOS,inositol significantly decreased weight,BMI,waist and hip circumferences(P<0.05).100%Of women tolerated inositol and continued treatment.18.9%Of them became pregnant,leading to 17%of live ***:Metformin and inositol can improve weight and waist circumference in overweight/obese infertile women with *** is associated with a higher rate of regular menstruation,whereas inositol is associated with a lower rate of adverse *** spontaneous conception,clinical pregnancy,and live birth rates between two groups are comparable.

关键词： Polycystic ovarian syndrome Inositol Metformin Endocrine Metabolic Menstrual cycle Pregnancy

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Hepatitis B vaccination status and associated factors among health science students

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Asian Pacific Journal of Tropical Medicine 2023年第5期16卷 213-219页

作者： Binh Thanh nguyen Lan Y Vo Tap Van nguyen Minh Cong Vo Tinh Dang Pham Han Thi ngoc nguyen Lynda Boyer-Chu Giao Huynh Faculty of Medicine Tra Vinh UniversityTra Vinh CityTra Vinh ProvinceVietnam Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Faculty of Medical Management Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam Department of Ear Nose Throat-Head and Neck Surgery FV hospitalHo Chi Minh CityVietnam Department of Anaesthesia and Intensive Care FV hospitalHo Chi Minh CityVietnam Infection Control Department University Medical Center Ho Chi Minh CityHo Chi Minh CityVietnam San Francisco Unified School District San FranciscoCaliforniaUSA

Objective:To evaluate hepatitis B virus(HBV)vaccine coverage and its associated factors among health science students in ***:This cross-sectional study involving 459 health science students at Tra Vinh University was conducted between April and June *** were collected using a structured questionnaire with items on sociodemographic characteristics,knowledge and attitude about HBV,and vaccination status.A multivariable logistic regression model was used to explore the factors associated with vaccination ***:The majority of participants were female(65.8%)and enrolled at the medical school(56.2%).A total of 30.3%participants received the full dose of the HBV *** percentages of participants with sufficient knowledge and positive attitudes toward HBV infection were 75.2%and 43.4%,*** was 11.8 times higher in sixth-year medical students than any healthcare student in their first-year[adjusted odds ratio(aOR)11.8,95%CI 3.1-45.1,P<0.001],and the coverage was also significant higher in those who had sufficient knowledge(aOR 2.0,95%CI 1.1-3.9,P<0.05)and positive attitudes(aOR 3.0,95%CI 1.9-4.8,P<0.05)than in their ***:The majority of students were not fully vaccinated against HBV,indicating they were vulnerable to the *** and authorities should reinforce health education messages aimed at encouraging all students to get vaccinated with the HBV vaccine,enhance their awareness and knowledge of HBV,and improve attitudes toward HBV infection prevention.

关键词： Hepatitis B Knowledge Attitude Practice Vaccination Students

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Contour blasting parameters by using a tunnel blast design mode

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Journal of Central South University 2021年第1期28卷 100-111页

作者： nguyen ngoc MINH CAO Ping LIU Zhi-zhen School of Resources and Safety Engineering Central South UniversityChangsha 410083China Quang Ninh University of Industry Quang Ninh 208650Vietnam

The quality of contour blasting depends on many initial blasting *** parameters including blasthole diameter,rock Protodyakonov coefficient,tunnel area and distance between cracks on the tunnel face are more *** this study,an algorithm linking between Delphi programming language and AutoCAD was created to develop a tunnel blasting *** this model,tunnel contour blasting passport in AutoCAD can be obtained *** effects of rock Protodyakonov coefficient and cracks’distance on blastholes number and specific charge with the variation of blasthole diameter and the semi-circular tunnel face area were investigated to yield a set of equations with the highest *** results show that specific charge increases as rock Protodyakonov coefficient,cracks’distance and drillhole diameter increase,but decreases when tunnel face area *** addition,the number of drillholes increases linearly as tunnel face area increases but decreases when drillhole diameter increases.

关键词： contour blasting blasting model blasting passport tunnel blasting

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Revision of Outcomes and Complications Following Open Reduction, and Zigzag Osteotomy Combined with Fibular Allograft for Developmental Dysplasia of the Hip in Children

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Open Journal of Orthopedics 2016年第7期6卷 184-200页

作者： nguyen ngoc Hung Vietnam National Hospital for Pediatrics Hanoi Vietnam

Background: Reports of the efficacy of open reduction and Zigzag Osteotomy combined Fibular Allograft (ZOFA) for developmental dysplasia of the hip. The purposes of this study were to evaluate the long-term outcomes and complications after surgery. Methods: We performed a retrospective match-controlled study in which 158 patients had 181 hips with developmental dysplasia of the hip. Radiographs were found of acetabular index, height of dislocation, Tönnis grade, abduction angle in the spica cast, and Severin grade. At final follow-up, deformity of femoral head or neck or acetabulum was evaluated according to the Severin. Avascular necrosis was rated according to Kalamchi. Clinical evaluation was made according to modified McKay criteria. Results: Between 2009 and 2012, 133 girls (84.2%) and 25 boys (15.8%) with developmental dysplasia of the hip underwent open reduction and ZOFA;135 (85.4%) were unilateral, and 23 (14.6%) were bilateral. Patients were divided into 2 groups: group 1 included 54 patients (62 hips) aged 12 months - ≤18 months and group 2 included 84 patients (119 hips), aged >18 months - ≤36 months. According to Tönnis system: type 3 appeared in 127 hips (70.2%), and Type 4 in 54 hip (29.8%). The anterior approach was used to expose inner table of the ilium and ZOFA in all cases. Acetabular index was improved;preoperation was 42.95°, and latest follow-up 17.26°. The Kirschner Wires (KW) were not used to fix the fibular allograft at the pelvic osteotomy site. All of the fibular allografts were completely incorporated in mean time of 14 weeks (range, 12 weeks - 17 weeks) post-surgery. Clinical evaluation according to modified McKay criteria: satisfactory result (excellent and good) was achieved in 141 hips (77.9%). Avascular Necrosis (AVN) happened in 61 hips (33.7%), redislocation in 18 hips (9.9%), coxa vara in 4 hips (2.2%), trendelenburg gait in 4 hips (2.2%), and supracondylar femoral fractures in 2 hips (1.1%). Conclusions: On the basis o

关键词： DDH Redislocation Revision Surgery Hip Dysplasia Bone Allograft Salter’s Osteotomy Avascular Necrosis

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Redislocation Following Zigzag Osteotomy Combined with Fibular Allograt for Dislocation of the Hip in Children

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Open Journal of Orthopedics 2016年第4期6卷 86-97页

作者： nguyen ngoc Hung National Hospital for Pediatrics Ha Noi Viet Nam

We have reviewed 17 patients (18 hips) who required repeated open reduction for recurrent or persistent dislocation after a previous attempt at zigzag osteotomy combined with fibular allowgraft for developmental dysplasia of the hip (DDH). The purposes of this study were to examine predictors of redislocation and to evaluate the long-term outcomes after revision surgery. The mean age at primary open reduction was 24 months (13 to 36). The median time to the recognition of failure was 4.6 months. The second reduction was performed at a mean age of 26.3 months (17 to 42) and the mean age at final follow-up was 79.7 months (58 to 105) and the mean time follow-up was 42.4 months (37 to 76). We treated the hips with a new open reduction through an anteromedial approach. A constricted anteromedial capsule was always found as the main factor;all had an intact anteromedial capsule, and there was an inverted transverse ligament in five cases and a very tight psoas tendon in another four cases, eversion of the limbus in six cases, densing anterior capsule in five cases. We perform with the condition that all hips were cleared of scar tissue;five hips had adductor tenotomy;four hips required release of the psoas tendon, five eversion of the limbus. Release of the transverse ligament was required in five cases each. All hips with Kirschner wire through the femoral head into the acetabulum. Three hips required femoral shortening (average of 1.5 cm);a derotation varus osteotomy was performed in two hips from ten and twelve weeks after repeated open reduction. Postoperative results according to modified McKay criteria for clinical: excellent: 3 of 18 hips (16.7%);good: 8 of 18 hips (44.4%);fair: 6 of 18 hips (33.3%);and poor: 1 of 18 hips (5.6%). We suggest that technical failure is usually the cause for redislocation with all that has an intact anteromedial capsule. There was an inverted transverse ligament, tight psoas tendon, eversion of the limbus, and densing anterior capsule

关键词： DDH Redislocation Anteromedial Approach Salter Innominate Osteotomy Femoral Shortening

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Polygonatum kingianum rhizome extract alleviates collagen antibody-induced arthritis by modulating proinflammatory cytokine production in mice

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Asian Pacific Journal of Tropical Biomedicine 2020年第11期10卷 490-495页

作者： Huyen Do Thi Thanh Phuong Ngo Thi Hien nguyen Thi Thu Nga nguyen Thi Hung Le ngoc Thao DoThi Ha Le Minh Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Institute of Natural Products Chemistry Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Hanoi Open University101 nguyen Hien str Hai Ba Trung Dist.HanoiVietnam Laboratory of Bioassay Institute of BiotechnologyVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Chemistry Lab Project Center for Research and Technology transferVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam

Objective: To evaluate the anti-arthritic effects of Polygonatum kingianum rhizome extract using both in vitro and in vivo ***: Lipopolysaccharide-induced RAW 264.7 macrophages were treated with an ethanol extract of Polygonatum kingianum rhizomes at different concentrations to determine nitric oxide and prostaglandin E2(PGE2) production. For in vivo study, Polygonatum kingianum ethanol extract was further investigated for its antiinflammatory effect in a mouse model with collagen antibodyinduced arthritis. Phytochemical study of Polygonatum kingianum ethanol extract was also ***: Saponins(142 mg/g total yield) was the main component in the Polygonatum kingianum ethanol extract. 5α,8α-ergosterol peroxide,(E,E)-9-oxooctadeca-10,12-dienoic acid and 3-(2?-hydroxy-4?-methoxy-benzyl)-5,7-dihydroxy-8-methyl-chroman-4-one were isolated from the extract. Polygonatum kingianum ethanol extract exhibited potential anti-inflammatory effects by inhibiting nitric oxide and PGE2 production in RAW 264.7 cells in a dosedependent manner. The level of arthritis in mice with collagen antibody-induced arthritis was significantly reduced(P<0.01) after treatment with Polygonatum kingianum ethanol extract, particularly at a dose of 1 000 mg/kg body weight. Besides, the extract demonstrated the regulatory effects on serum tumor necrosis factoralpha, interleukin-6, and interleukin-10 in treated ***: Polygonatum kingianum ethanol extract has beneficial effects on inflammatory cytokine regulation and PGE2 inhibition in an experimental mouse model with collagen antibody-induced arthritis. The phytochemical screening reveals that the saponin, as the main component, and sterols(daucosterol and 5α,8α-ergosterol peroxide) from Polygonatum kingianum ethanol extract may contribute to its promising in vitro and in vivo anti-inflammatory activities.

关键词： inflammatory cytokine PGE2

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Agrobacterium-Mediated Transformation of Cry8db Gene in Vietnam Sweet Potato Cultivar

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Journal of Life Sciences 2015年第6期9卷 262-271页

作者： Pham bich ngoc Vu Thi Lan Tran Thu Trang nguyen Hoai Thuong Le Thu ngoc Chu Hoang Ha Le Tran Binh Institute of Biotechnology Vietnam Academy of Science and Technology 18-Hoang Quoc Viet Cau Giay Ha Noi 10000 Vietnam College of Science Thai Nguyen University Tan Thinh Thai Nguyen 23000 Vietnam University of Science and Technology of Ha Noi 18-Hoang Quoc Viet Cau Giay Ha Noi 10000 Vietnam

Sweet potato [Ipomoea batatas （L.） Lam.] is an important food crop in the world as well as in Vietnam. It is well known as a recalcitrant crop for gene transformation and tissue culture because of its genotype dependent in vitro responses. In present study, Agrobacterium-mediated transformation of cry8Db from Bacillus thuringiensis into KB 1 sweet potato variety has been studied. The C58cv strain carrying a pBl 121 backbone which contained cry8Db delta-endotoxin gene regulated under 35 S CaMV prom oter, and the selection marker gene, neomycin phosphotransferase （npt11） gene, was subjected for plant transformation. Callus induced from shoot tips and leaf explants were inoculated and cocultured with A. tumefaciens. The selection occurred during callus producing and plant regenerating steps. A total of 201 transgenic putative plant lines were produced, and 21 transgenic lines were positively confirmed by PCR and finalized by Southern blot. Four putative transgenic lines confirming a single copy of the crySEIb gene were transferred into soil pots in greenhouse. Biological activity evaluation for the insecticidal capacity of these transgenic lines under controlled conditions showed that the level of infestation by sweet potato weevils （Cylasformicarius） in untransformed plants was higher than that of transgenic lines.

关键词： Sweet potato Agrobacterium tumefaciens plant transformation cry8Db sweet potato weevil resistance cylas formicarius.

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Revealing efficient catalytic performance of N-CuO_(x) for aerobic oxidative coupling of aliphatic alkynes:A Langmuir-Hinshelwood reaction mechanism

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Nano Research 2022年第7期15卷 6076-6083页

作者： Jun Tang Bowen Jiao Wei Chen Fei Ruan Fengfeng Li Peixin Cui Chao Wan Minh ngoc Ha Van Noi nguyen Qingping Ke College of Chemistry and Chemical Engineering Anhui University of TechnologyMaanshan 243002China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil Sciencethe Chinese Academy of SciencesNanjing 210008China VNU Key Laboratory of Advanced Material for Green Growth VNU University of ScienceVietnam National UniversityHanoi 100000Vietnam

O_(x)idative couplings of aliphatic alkynes are crucial for the production of naturally occurring 1,*** we report the novel approach for effective synthesis of unsaturated coordinated N doped copper oxides(N-CuO_(x))catalyst,and uncover that N-CuO_(x) catalyst as an additive-free and cost-effective heterogeneous catalyst has highly catalytic performance for directly oxidative coupling of aliphatic *** key to achieve efficient oxidative coupling of aliphatic alkynes is the synergistic effect of N species and uncoordinated O/Cu species caused by N dopants,which undergoes the Langmuir–Hinshelwood reaction *** N-CuO_(x) catalyst displays~89.1%yield for hexadeca-7,9-diyne under mild conditions and stable reusability(5 cycles),showing significant advances compared with the traditionally copper *** findings highlight the heteroatom dopants that provide a new methodology for designing efficient copper catalysts in synthesis of naturally occurring 1,3-diynes.

关键词： N doped copper oxides(N-CuO_(x)) straight chain alkynes homo-coupling additive-free 1,3-diynes

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Congenital Club Foot in Children Younger than 24 Months: Decancelous Cuboid Combined with Selective Soft Tissue Release

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Open Journal of Orthopedics 2012年第3期2卷 94-110页

作者： nguyen ngoc Hung Vietnam National Hospital for Pediatrics Hanoi Vietnam

Purpose: To evaluate 2 surgical prosedures in treatment of congenital clubfeet in children younger than 24 months. Materials and methods: Data were analyzed on 319 patients (448 feet) from July 1990 to December 2005. Clinical and classification for all patients according to Diméglio. Operated patients were devided into two group: Group1, selective soft tissue release;and Group 2, selective soft tissue release combined with cuboid decancelation. Surgical result were classified according to McKay’s system. Results: There were 103 females (32.3%) and 216 males (67.7%) in this study. There were 192 patients (268 feet) in group 1, 127 patients (180 feet) in group 2. Bilateral involvement was found in 129 patients (40.4%), only the left foot affected in 65 patients (20.4%), and only the right in 125 patients (39.2%). According to the classification of Diméglio Grade II was seen in 32.4%, Grade III in 53,1%, and Grade IV in 14.5%. Postoperatively, in group 1, we got excellent result in 29.1%, good result in 49.2%, fair result in 18.3%, and poor result in 3.4%. In group 2, we attained excellent result in 50.6%, good result in 42.2%, fair result in 6.1% and poor result in 1.1%. The good to excellent result in group 2 was significantly higher in group 1 with p = 0.000042. There was no failure in both groups. Residual adduction of forefoot in frontal plane was seen in 78.0% of group 1, and 10.6% of group 2, which was also statistically significant with p ~ 0. Conclusion: Generally speaking, the procedure of selective soft tissue releases combined with cuboid decancelation showed an outstanding result with good to excellent result of 92.8%. Surgical procedure is simple, safe, and applicable for all patients with clubfeet’s deformyties.

关键词： Congenital Clubfoot Forefoot Adduction Position of Navicular Posteromedial Release Cuneiform Bones Osteotomy

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Congenital Dislocation of the Hip in Children between the Ages of One and Three: Open Reduction and Modified Salter Innominate Osteotomy Combined with Fibular Allograft

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Open Journal of Orthopedics 2013年第2期3卷 137-152页

作者： nguyen ngoc Hung National Hospital of Pediatrics of Vietnam Hanoi Vietnam.

Background: Innominate osteotomy procedures have been widely used as an integral component of combined surgery to treat developmental dysplasia of the hip in children. Autograft concern is further supported by authors who suggest the routine use of internal fixation. Problems such as graft extrusion, rotation and absorption, leading to loss of acetabular correction, were often noted in cases previously treated at our National Hospital for Pediatrics. This retrospective study reviewed the radiographic results of this treatment protocol in 106 hips developmental dislocated hips which met our inclusion criteria. The efficacy of this method to achieve and maintain a well covered and stable hip was the main objective of the study. Methods: This retrospective study reviewed the radiographs of 106 hips presenting with developmental dislocation which were treated by modified Salter’s innomiate osteotomy and using a fibular allograft as the interposition material. Dislocations of the hip were graded using the T?nnis system. Measurement of the acetabular index (AI) was the main variable. The minimum follow up period was 2 years. Possible complications such as loss of acetabular correction, hip redislocation, graft extrusion or resorption, the need for osteotomy internal fixation, delayed or non union, infection or avascular necrosis (AVN) were documented in this series. Results: Between January 2004 and December 2008, 106 surgeries were performed in 95 patients. Sixty-three (86.3%) of the patients were girls and ten (13.7%) were boys, thirteen patients (13.7%) were between twelve and eighteen months old at the time of the operation, the remaining eighty-two (86.3%) patients being between eighteen and thirty-six months old, with the mean age of 22.6 months at the time of surgery. There were eleven (11.6%) patients who had bilateral dislocation. Eighty-four (88.4%) patients were affected unilaterally. The right hip was involved in seventeen (17.9%) and the left hip in sixty-sev

关键词： Hip Dysplasia Innominate Osteotomy Congenital Dislocation of the Hip Development Dysplasia of the Hip Allograft

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