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Anticancer effects of saponin and saponin–phospholipid complex of Panax notoginseng grown in Vietnam

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Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 795-800页

作者： Thu Dang Kim Hai nguyen Thanh Duong nguyen thuy Loi Vu Duc Thu Vu thi Hung Vu Manh Patcharee Boonsiri Tung Bui Thanh Department of Pharmacology and Clinical Pharmacy School of Medicine and PharmacyVietnam National University Department of Pharmaceutics and Pharmaceutical Technology School of Medicine and PharmacyVietnam National University Department of Pharmacology Hanoi University of Pharmacy Department of Pharmacognosy and Traditional Pharmacy School of Medicine and PharmacyVietnam National University Faculty of Biology VNU University of Science Key Laboratory of Enzyme and Protein Technology VNU University of Science Department of Pharmacology School of PharmacyLac Hong University Department of Biochemistry Faculty of MedicineKhon Kaen University

Objective:To evaluate the antitumor activity both in vitro and in vivo of saponin–phospholipid complex of Panax ***:The in vitro cytotoxic effect of saponins extract and saponin–phospholipid complex against human lung cancer NCI-H460 and breast cancer cell lines BT474 was examined using MTS *** in vivo evaluation of antitumor potential,saponin and saponin–phospholipid complex were administered orally in rats induced mammary carcinogenesis by 7,12-dimethylbenz(a)anthracene,for 30 ***:Our data showed that saponin–phospholipid complex had stronger anticancer effect compared to saponin *** IC50 values of saponin–phospholipid complex and saponin extract for NCI-H460 cell lines were 28.47 mg/m L and 47.97 mg/mL,respectively and these values for BT474 cells were 53.18 mg/mL and 86.24 mg/mL,*** vivo experiments,administration of saponin,saponin–phospholipid complex and paclitaxel(positive control) effectively suppressed 7,12-dimethylbenz(a) anthracene-induced breast cancer evidenced by a decrease in tumor volume,the reduction of lipid peroxidation level and increase in the body weight,and elevated the enzymatic antioxidant activities of superoxide dismutase,catalase,glutathione peroxidase in rat breast ***:Our study suggests that saponin extract from Panax notoginseng and saponin–phospholipid complex have potential to prevent cancer,especially breast cancer.

关键词： Panax notoginseng Saponin Saponin–phospholipid complex Breast cancer Antitumor

Flood susceptibility modelling using advanced ensemble machine learning models

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Geoscience Frontiers 2021年第3期12卷 60-77页

作者： Abu Reza Md Towfiqul Islam Swapan Talukdar Susanta Mahato Sonali Kundu Kutub Uddin Eibek Quoc Bao Pham Alban Kuriqi nguyen thi thuy Linh Department of Disaster Management Begum Rokeya UniversityRangpurBangladesh Department of Geography University of Gour BangaMaldaWest BengalIndia Environmental Quality Atmospheric Science and Climate Change Research GroupTon Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Environment and Labour Safety Ton Duc Thang UniversityHo Chi Minh CityVietnam CERIS Instituto Superior TécnicoUniversidade de LisboaLisbonPortugal Institute of Research and Development Duy Tan UniversityDanang 550000Vietnam Faculty of Environmental and Chemical Engineering Duy Tan UniversityDanang 550000Vietnam

Floods are one of nature's most destructive disasters because of the immense damage to land,buildings,and human *** is difficult to forecast the areas that are vulnerable to flash flooding due to the dynamic and complex nature of the flash ***,earlier identification of flash flood susceptible sites can be performed using advanced machine learning models for managing flood *** this study,we applied and assessed two new hybrid ensemble models,namely Dagging and Random Subspace(RS)coupled with Artificial Neural Network(ANN),Random Forest(RF),and Support Vector Machine(SVM)which are the other three state-of-the-art machine learning models for modelling flood susceptibility maps at the Teesta River basin,the northern region of *** application of these models includes twelve flood influencing factors with 413 current and former flooding points,which were transferred in a GIS *** information gain ratio,the multicollinearity diagnostics tests were employed to determine the association between the occurrences and flood influential *** the validation and the comparison of these models,for the ability to predict the statistical appraisal measures such as Freidman,Wilcoxon signed-rank,and t-paired tests and Receiver Operating Characteristic Curve(ROC)were *** value of the Area Under the Curve(AUC)of ROC was above 0.80 for all *** flood susceptibility modelling,the Dagging model performs superior,followed by RF,the ANN,the SVM,and the RS,then the several benchmark *** approach and solution-oriented outcomes outlined in this paper will assist state and local authorities as well as policy makers in reducing flood-related threats and will also assist in the implementation of effective mitigation strategies to mitigate future damage.

关键词： Flood hazard Flood vulnerability Flash floods Debris flow Teesta River basin Bangladesh

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Engine performance and combustion characteristics of a direct injection compression ignition engine fueled waste cooking oil synthetic diesel

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International Journal of Coal Science & Technology 2020年第3期7卷 560-570页

作者： Thanh Viet nguyen Khanh Duc nguyen Nang Xuan Ho vinh Duy nguyen Department of Internal Combustion Engine School of Transportation EngineeringHanoi University of Science and TechnologyHanoiViet Nam Faculty of Vehicle and Energy Engineering Phenikaa UniversityYen NghiaHa-Dong DistrictHanoiViet Nam

Biodiesels produced from various feedstocks have been considered as alternative fuels used in internal combustion engines without major *** research focuses on producing biodiesel from waste cooking oil(WCOSD)by the catalytic cracking method using MgO as the catalyst and comparing the engine operating characteristics of the test engine when using WCOSD and traditional diesel(CD)as test *** a result,the brake power of the test engine fueled WCOSD,and traditional diesel is ***,the engine fuel consumption in the case of using WCOSD is slight increases in some operating ***,the nitrogen oxides emissions of the test engine fueled WCOSD are higher than those of CD at all tested *** trend is opposite for hydrocarbon emission as the HC emission of the engine fueled by WCOSD reduces 26.3%on *** smoke emission of the test engine in case of using WCOSD is lower 17%on average than that of ***,the carbon monoxide emissions are lower at the low and medium loads and higher at the full *** results show that the new biodiesel has the same characteristics as those of commercial biodiesel and can be used as fuel for diesel engines.

关键词： Feedstock Waste cooking oil Engine characteristics Exhaust missions Ignition timing Fuel consumption

Examining data visualization pitfalls in scientific publications

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Visual Computing for Industry,Biomedicine,and Art 2021年第1期4卷 268-282页

作者： vinh T nguyen Kwanghee Jung Vibhuti Gupta Department of Information Technology TNU–University of Information and Communication TechnologyThai NguyenVietnam Department of Educational Psychology Leadershipand CounselingTexas Tech UniversityLubbockTX 79409United States Department of Computer Science and Data Science Meharry Medical CollegeNashvilleTN 37208USA

Data visualization blends art and science to convey stories from data via graphical *** different problems,applications,requirements,and design goals,it is challenging to combine these two components at their full *** the art component involves creating visually appealing and easily interpreted graphics for users,the science component requires accurate representations of a large amount of input *** a lack of the science component,visualization cannot serve its role of creating correct representations of the actual data,thus leading to wrong perception,interpretation,and *** might be even worse if incorrect visual representations were intentionally produced to deceive the *** address common pitfalls in graphical representations,this paper focuses on identifying and understanding the root causes of misinformation in graphical *** reviewed the misleading data visualization examples in the scientific publications collected from indexing databases and then projected them onto the fundamental units of visual communication such as color,shape,size,and spatial ***,a text mining technique was applied to extract practical insights from common visualization ***’s Q test and McNemar’s test were conducted to examine if there is any difference in the proportions of common errors among color,shape,size,and spatial *** findings showed that the pie chart is the most misused graphical representation,and size is the most critical *** was also observed that there were statistically significant differences in the proportion of errors among color,shape,size,and spatial orientation.

关键词： Data visualization Graphical representations Misinformation Visual encodings Association rule mining Word cloud Cochran’s Q test McNemar’s test

TabuVis:A tool for visual analytics multidimensional datasets

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Science China(Information Sciences) 2013年第5期56卷 64-75页

作者： nguyen Quang vinh QIAN Yu HUANG MaoLin ZHANG JiaWan School of Computing Engineering and Mathematics and MARCS InstituteUniversity of Western SydneyPenrith South DCNSWAustralia

this paper describes TabuVis,a light weight visual analytics system that provides a flexible,customizable and effective visualization for multidimensional *** aspects for visually analyzing data with multiple attributes are quality and appropriateness of the analytical platform whose presentation can be adjusted via domain *** commercial-free and comprehensive prototype utilizes scatter-plot approach to support the visual analytics *** system consists of multiple components enabling the complete analysis process,including data processing,automatic marks,customizable interactive visualization and *** demonstrate the effectiveness of TabuVis on various case studies using medical and Oscars datasets.

关键词： visual analytics information visualization multidimensional data analysis clinical trial data biomedical data Oscars data

Predicting soil erosion hazard in Lattakia Governorate(W Syria)

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International Journal of Sediment Research 2021年第2期36卷 207-220页

作者： Mohammed Safwan Khallouf Alaa Alshiehabi Omran Bao Pham Quoc thi thuy Linh nguyen Nam Thai Van Tran Anh Duong Harsányi Endre Institution of Land Utilization Technology and Regional Planning Faculty of Agricultural and Food Sciences and Environmental Management University of Debrecen Administration of Natural Resources Management General Commission for Scientific Agricultural Research (GCSAR) 3. Department of Soil Sciences and Land Reclamation Faculty of Agriculture Al-Baath University Department of Soil and Environment Swedish University of Agricultural Sciences (SLU) Institute of Research and Development Duy Tan University Faculty of Environmental and Chemical Engineering Duy Tan University Faculty of Water Resource Engineering Thuyloi University Ho Chi Minh City University of Technology (HUTECH) Sustainable Management of Natural Resources and Environment Research Group Faculty of Environment and Labour Safety Ton Duc Thang University

The main objective of this study is to predict soil erosion in the Lattakia Governorate(W Syria) using the Water Erosion Prediction Project model(WEPP) and to compare the result with that of the RUSLE. Field survey and data collection were carried out, and 44 soil samples were analyzed. In addition, all the necessary input files were prepared for use in the WEPP model and RUSLE. Results show that more than of 80% of the locations studied experience slight to moderate erosion(less than 5 t/ha/y), whereas the rest of the locations experience severe soil erosion hazard. Moreover, the volume of runoff estimated by the WEPP model is in the range of 51 e321 mm, and the R~2 between the simulated soil erosion and the predicted runoff reached 0.68. Interestingly, the R~2 between the WEPP model and RUSLE is 0.56, which indicates a good correlation between the two models.

关键词： Soil erosion Run-off WEPP RUSLE Syria

A study implementing real-time PCR to identify Strongyloides species of third-stage larvae in human stool samples from Southern Vietnam

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Infectious Medicine

Infectious Medicine 2023年第3期2卷 229-236页

作者： Le Duc vinh nguyen Kim Thach Huynh Hong Quang Do Nhu Binh Tran thi Duc Hanh nguyen Minh Toàn nguyen Trung Tuyen nguyen Thu Huong Department of Medical Parasitology Pham Ngoc Thach University of MedicineHo Chi Minh City 700000Vietnam Department of Fundamental Chemistry-Biochemistry Pham Ngoc Thach University of MedicineHo Chi Minh City 700000Vietnam Clinical Epidemiology Research Unit Institute of MalariologyParasitologyand Entomology Quy NhonBinh Dinh 55000Vietnam Department of Infectious Disease Military Hospital 103Hanoi 100000Vietnam Department of Epidemiology Hanoi University of Public HealthHanoi 100000Vietnam Department of Microbiology-Parasitology Hanoi University of Public HealthHanoi 100000Vietnam Department of Medicine University of Medicine and PharmacyVietnam National UniversityHanoi100000 Vietnam

Background:Strongyloidiasis,a neglected disease caused by intestinal nematodes of the genus,is endemic to tropical and subtropical areas such as *** methods only identify the genus,while DNA-molecular techniques are susceptible in Strongyloides *** study aims to determine the prevalence of dominant Strongyloides species among the population in Duc Hoa district,Long An,***:A cross-sectional study used 1190 stool specimens collected from July 2017 to November *** samples were transported within 2 h,stored at 2-8℃,and processed within 48 h for microscopy smear and culture at the Laboratory of Medical Parasitology,Pham Ngoc Thach University of Medicine(PNT).Then all positive samples with the above 2 methods were verified by real-time PCR ***-time PCR amplification was conducted at the Laboratory of Molecular Biology,***:Direct microscopy and modified Harada-Mori culture detected Strongyloides *** in 79/1190 sam-ples(6.6%).About 94.2%of the DNA samples were Strongyloides stercoralis,2.9%were co-infections with Strongy-loides ratti and ***,and 2.9%were patients with *** identity of 12/14 sequences was confirmed as *** with a high level of similarity(91.3%-100%)and over 98%for ***:DNA-molecular techniques and sequence analysis are highly suitable for identifying Strongyloides species isolated from stool *** is remarkable evidence of the presence of zoonosis *** disease in human,not just the known *** is likely to result in a certain proportion of people being infected by this animal-borne infectious pathogen.

关键词： Strongyloidiasis Strongyloides stercoralis Strongyloides ratti DNA-molecular techniques

GIS-based landslide susceptibility modeling:A comparison between fuzzy multi-criteria and machine learning algorithms

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Geoscience Frontiers 2021年第2期12卷 857-876页

作者： Sk Ajim Ali Farhana Parvin Jana Vojteková Romulus Costache nguyen thi thuy Linh Quoc Bao Pham Matej Vojtek Ljubomir Gigović Ateeque Ahmad Mohammad Ali Ghorbani Department of Geography Faculty of ScienceAligarh Muslim University(AMU)AligarhUP 202002India Department of Geography and Regional Development Faculty of Natural SciencesConstantine the Philosopher University in NitraTrieda A.Hlinku 194901 NitraSlovakia Research Institute of the University of Bucharest 90-92 Sos.Panduri5th DistrictBucharest 050663Romania National Institute of Hydrology and Water Management București-Ploiești Road97E1st DistrictBucharest 013686Romania thuyloi University 175 Tay SonDong DaHanoiViet Nam Institute of Research and Development Duy Tan UniversityDanang 550000Viet Nam Faculty of Environmental and Chemical Engineering Duy Tan UniversityDanang 550000Viet Nam Department of Geography University of Defence11000 BelgradeSerbia Sustainable Management of Natural Resources and Environment Research Group Faculty of Environment and Labour SafetyTon Duc Thang UniversityHo Chi Minh CityViet Nam

Hazards and disasters have always negative impacts on the way of *** is an overwhelming natural as well as man-made disaster that causes loss of natural resources and human properties throughout *** present study aimed to assess and compare the prediction efficiency of different models in landslide susceptibility in the Kysuca river basin,*** this regard,the fuzzy decision-making trial and evaluation laboratory combining with the analytic network process(FDEMATEL-ANP),Naïve Bayes(NB)classifier,and random forest(RF)classifier were ***,a landslide inventory map was produced with 2000 landslide and nonlandslide points by randomly dividedwith a ratio of 70%:30%for training and testing,*** geospatial database for assessing the landslide susceptibility was generated with the help of 16 landslide conditioning factors by allowing for topographical,hydrological,lithological,and land cover *** ReliefF methodwas considered for determining the significance of selected conditioning factors and inclusion in the model ***,the landslide susceptibility maps(LSMs)were generated using the FDEMATEL-ANP,Naïve Bayes(NB)classifier,and random forest(RF)classifier ***,the area under curve(AUC)and different arithmetic evaluation were used for validating and comparing the results and *** results revealed that random forest(RF)classifier is a promising and optimum model for landslide susceptibility in the study area with a very high value of area under curve(AUC=0.954),lower value of mean absolute error(MAE=0.1238)and root mean square error(RMSE=0.2555),and higher value of Kappa index(K=0.8435)and overall accuracy(OAC=92.2%).

关键词： Landslide susceptibility modeling Geographic information system Fuzzy DEMATEL Analytic network process Naïve Bayes classifier Random forest classifier

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Jaundice in Adult in-Patients at a Tertiary General Hospital

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Journal of Biosciences and Medicines 2015年第2期3卷 1-11页

作者： Le Ngoc Hung nguyen thi Le Huong nguyen thi thuy An Biochemistry Department Cho Ray Hospital Ho Chi Minh City Vietnam

Objective: The aim of the study is to investigate the “new-onset jaundice” incidence, map of causes, approaching method, and risk factors for treatment failure in adult in-patients at a tertiary general hospital as Cho Ray Hospital, Ho Chi Minh City, Viet Nam. Method: Retrospective study was done on 416 jaundice patients administered over 38 continuous days. Laboratory tests investigated were total bilirubin, direct bilirubin, AST, ALT, AST/ALT ratio, GGT, AP, bilirubin and urobilinogen in urine. Jaundice was defined as total bilirubin ≥ 2.5 mg/dL, direct bilirubin jaundice defined as direct bilirubin > 2 mg/dL and D/T percentage > 60%, the severity of AST, ALT evaluated according to Common Terminology Criteria for Adverse Events, AST/ALT ratio, and bilirubin, urobilinogen in urine. Outcome of treatment were classified in two groups: failure (dead or discharge due to worse status) and success. Descriptive statistics and analytic statistics were applied, mono-variable analysis and multinomial logistic regression to find out the independent risk factors for treatment failure. Results: The incidence of “new-onset” jaundice in adult patients was 11 ± 5 person/day. The map of jaundice included 3 phases as pre-heaptic 13.7%, in-hepatic 58.2%, and post-hepatic 22.8%. Pancreatic and biliary tract diseases accounted 17.1%, then cirrhosis 16.3%, liver tumor 14.7%, hepatitis 8.9%, sepsis 8.9%, hematology diseases 7.9%, and cardiac diseases 7.5%. A guide for approaching causes of jaundice basing on 7 parameters as total bilirubin, D/T percentage, severity of ALT, AST/ALT ratio, severity of GGT, and bilirubin and urobilinogen in urine was established. The overall mortality was 7.5% (31/416), sepsis had highest death rate of 37.8% (14/37). Sepsis and AST/ALT ratio > 2 were the two independent risk factors of mortality. Conclusion: At tertiary hospital, jaundice is common sign in adult patient, diverse enormously in many clinical wards. The map of causes of jaundice completed all

关键词： Jaundice Adults Incidence Sepsis AST/ALT Ratio New-Onset Tertiary Hospital