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达格列净对不伴糖尿病心力衰竭患者治疗过程中RAAS系统的影响研究

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达格列净对不伴糖尿病心力衰竭患者治疗过程中RAAS系统的影响研究

作者： nguyen thi thanh huyen 大理大学

学位级别：硕士

目的:研究非糖尿病心力衰竭(Heart Failure,HF)患者应用达格列净治疗后血浆中血浆肾素浓度(Plasma renin concentration,PRC)、血浆血管紧张素Ⅱ(angiotensinⅡ,ANG-II)、血浆醛固酮(Aldosterone,ALD)的浓度水平变化情况,探讨达格列净... 详细信息

目的:研究非糖尿病心力衰竭(Heart Failure,HF)患者应用达格列净治疗后血浆中血浆肾素浓度(Plasma renin concentration,PRC)、血浆血管紧张素Ⅱ(angiotensinⅡ,ANG-II)、血浆醛固酮(Aldosterone,ALD)的浓度水平变化情况,探讨达格列净对不伴糖尿病心力衰竭患者RAAS系统影响。方法:选取2021年7月至2022年10月于大理大学第一附属医院心内科收治102例非糖尿病心力衰竭患者为研究对象,44名常规治疗的患者纳入对照组,58名在常规治疗基础上口服达格列净的患者纳入实验组。记录患者一般情况,并分别在服药前及服药后第7天测定患者一般实验室指标(血尿酸、血糖、肌酐、总胆固醇、甘油三酯、血钾、血钠、低密度脂蛋白胆固醇)、BNP值、RAAS系统(PRC、ANG-II、ALD)、左室射血分数(LVEF)、心功能等级。记录两组患者基础资料以及治疗期间心衰症状、心肾功能及RAAS系统相关指标的变化情况并进行对比。结果:1.实验组患者NYHA心功能分级I级从1例(1.72%)经治疗后升到12例(20.68%);心功能II级从5例(8.62%)上升至45例(77.59%);心功能III级从40例(68.89%)降低0例(0.00%),心功能IV级从12例(20.68%)降到1例(1.72%),治疗前后心功能分级分布差异有统计学差异(P0.05)。治疗前后实验组患者均进行生命体征、Glu、TC、TG、Cr、UA,K、Na复查未出现明显异常,未发生不良反应事件,说明达格列净治疗于心衰是安全的。3.治疗后实验组BNP值为(434.55±418.40)pg/ml,对照组为(619.33±453.37)pg/ml,实验组低于对照组,组间差异具有统计学意义(P0.05);经治疗,实验组患者的PRC值显著下降至(11.58±4.77)pg/ml,差异具有统计学意义(P0.05);经治疗,实验组患者的ALD值显著下降至(65.47±12.01)pg/ml,差异具有统计学意义(P0.05)。比较两组患者治疗前后差值,实验组ALD(pg/ml)(19.05±20.16),与对照组(2.29±16.07)结果显示,实验组显著高于对照组具有统计学意义(P0.05);经治疗,实验组与对照组均显著下降,治疗前后差异均具有统计学意义(P0.05)。结论:1.达格列净可显著降低不伴糖尿病心力衰竭患者心功能分级和BNP值,且安全性佳。2.达格列净可显著降PRC、Ang-II、ALD浓度水平,且治疗效果不受性别和其他药物的影响。提示达格列净可能具有抑制RASS系统的作用。

关键词：达格列净心力衰竭 RAAS系统 SGLT2

Some Mean Convergence Theorems for the Maximum of Normed Double Sums of Banach Space Valued Random Elements

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1727-1740页

作者： Andrew ROSALSKY Le Van thanh nguyen thi THUY Department of Statistics University of FloridaGainesvilleFL 32611-8545USA Department of Mathematics Vinh UniversityVinhNghe AnViet Nam High School for Gifted Students Vinh UniversityVinhNghe AnViet Nam

In this correspondence,we establish mean convergence theorems for the maximum of normed double sums of Banach space valued random *** of the results pertain to random elements which are *** expand and improve a number of particular cases in the literature on mean convergence of random elements in Banach *** of the main contributions of the paper is to simplify and improve a recent result of Li,Presnell,and Rosalsky[Journal of Mathematical Inequalities,16,117–126(2022)].A new maximal inequality for double sums of M-dependent random elements is proved which may be of independent *** sharpness of the results is illustrated by four examples.

关键词： Double sum mean convergence Rademacher type p Banach space Banach space valued random element M-dependent random elements

Prevalence and risk factors associated with long COVID symptoms in children and adolescents in a southern province of Vietnam

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 119-128,I0001,I0002页

作者： Huynh Ngoc Linh nguyen The Tan Le thi Minh Thu nguyen Tu Loan nguyen thi To Uyen Le thanh Thao Trang Truong thanh Nam Doan Hoang Phu Faculty of Medicine Ca Mau Medical CollegeCa Mau 98000Vietnam Ca Mau Obstetrics and Pediatrics Hospital Ca Mau 98000Vietnam Faculty of Basic Science and Public Health Dong Thap Medical CollegeDong Thap 81000Vietnam Graduate University of Sciences and Technology Vietnam Academy of Science and TechnologyHa Noi 10000Vietnam Community Public Health Research Program School of Public HealthWalailak UniversityNakhon Si Thammarat 80160Thailand Faculty Public Health Can Tho University of Medicine and PharmacyCan Tho City 94000Vietnam Doctoral Program in Health Sciences College of Graduate StudiesWalailak UniversityNakhon Si Thammarat 80160Thailand

Objective:To investigate the prevalence and risk factors associated with long COVID symptoms among children and adolescents who have recovered from ***:this study applied a cross-sectional approach within community settings in a southern province of Vietnam.A structured questionnaire featuring socio-demographic information and common long COVID symptoms was *** correlation coefficients assessed associations among pairs of long COVID ***,multivariable logistic regression models were performed to investigate the risk factors of long COVID in recovered COVID-19 children and ***:Among 422 participants,39.3%reported long COVID symptoms,with a prevalence of 45.2%(SD=0.5)in children and 22.2%(SD=0.4)in *** symptoms reported were cough 34.6%(SD=0.5),fatigue 20.6%(SD=0.4),shortness of breath 10.9%(SD=0.3),and lack of appetite 6.6%(SD=0.3).Concerning risk factors of long COVID,a higher risk was observed among demographic groups,including girls(OR 1.25,95%CI 1.15-1.37;Pthis study provide crucial guidance for predicting the factors associated with the occurrence of long COVID in pediatric patients,contributing to strategic interventions aimed at mitigating the long COVID risks among children and adolescents in Vietnam.

关键词： Long COVID Prevalence Risk factors Children Adolescent Vietnam

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共享单车现阶段的问题研究

经贸实践 2017年第11X期 40-41页

作者： nguyen thi thanh huyen 南京理工大学江苏南京210000

共享单车作为一种与时俱进的新鲜产物,不仅让都市生活者出行变得更加方便,更减少了城市交通和环保压力,符合人们所倡导的绿色出行的生活理念。随着去年9月份之后,摩拜单车和ofo等共享类型产品的访问用户量以及页面浏览量的突飞猛进,市... 详细信息

共享单车作为一种与时俱进的新鲜产物,不仅让都市生活者出行变得更加方便,更减少了城市交通和环保压力,符合人们所倡导的绿色出行的生活理念。随着去年9月份之后,摩拜单车和ofo等共享类型产品的访问用户量以及页面浏览量的突飞猛进,市场占有量的呈现指数急速攀升,直接说明了共享单车用户数量和使用数量的大面积提升。随之也带来了共享单车发展过程的诸多问题。本次研究将以上海市各区的共享单车两大供应商ofo与摩拜为研究对象,采用大量的统计数据、采访、问卷调查的形式,总结出共享单车发展过程当中的瓶颈,并分析出深层次的原因以及提出相关意见,帮助企业和政府部门制定相关规范,以期达到规范共享单车运营的目的,使共享单车的服务更加文明、有序。

关键词：共享单车现阶段问题解决方法

Comparative Chemical Research in Essential Oils from Six Apiaceae Species Growing in the Northern Region of Vietnam

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1677-1687页

作者： nguyen Quang Hung nguyen thanh Tung nguyen Phuong Hanh Chu thi Thu Ha nguyen thi Nhung nguyen Thai An Vu Xuan Giang Luong Van Hao Oleh Koshovyi Ain Raal Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam Graduate University of Science and Technology Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam Department of Pharmacognosy Faculty of Pharmacognosy and Traditional MedicineHanoi University of PharmacyHoan KiemHa Noi100000Viet Nam Sa Pa Research Center of Medicinal Materials National Institute of Medicinal MaterialsDien Bien PhuSa PaLao Cai330000Viet Nam Institute of Pharmacy Faculty of MedicineUniversity of TartuTartu50411Estonia

Our study aimed to compare the essential oil(EO)concentration and composition of several Apiaceae species growing in the Northern region of *** yields of EOs from materials ranged from 0.03%(root EO of Angelica acutiloba and aerial parts EO of Heracleum bivittatum)-0.27%(leaf EO of Xyloselinum vietnamense).Gas chromatography-mass spectrometry(GC-MS)allowed the identiﬁcation of 74 components in the EOs of six Apiaceae species,making up 94.4%–100.0%of the *** EO from Angelica acutiloba,(Z)-ligustilide accounted for an extremely large proportion(94.9%).EO of Angelica pubescens was dominated by six character-istic components includingα-pinene(21.5%),β-phellandrene(18.1%),p-cymene(12.2%),3-methylnonane(8.7%),o-cymene(8.1%),and D-sylvestrene(6.2%).The EO from Cryptotaenia japonica was characterized by high amounts ofα-selinene(48.7%),β-selinene(23.7%),and trans-β-farnesene(5.4%).The EOs from leaves and stems of Xyloselinum vietnamense were characterized by high concentrations of sabinene(69.8%and 33.8%),4-terpineol(8.7%and 7.4%)andβ-pinene(4.0%and 6.5%)while EOs from aerial parts and root of Xylo-selinum leonidii comprise four characteristic monoterpenes includingα-pinene(28.2%and 52.8%),β-pinene(7.9%and 10.3%),β-phellandrene(7.6%and 15.3%),and sabinene(3.0%and 4.1%).Additionally,cryptone is also one of the major components in the EO of Xyloselinum leonidii(13.2%in the aerial parts oil and 2.8%in the root oil).In the EOs isolated from the aerial parts and root of Heracleum bivittatum,α-pinene(22.5%and 70.2%)andβ-pinene(43.2%and 20.0%)were the predominant *** appeared in the EO from aerial parts of Heracleum bivittatum with a relatively high concentration(13.5%)while bornyl acetate(5.1%)was also one of the main components in the EO from its aerial parts but was not detected in other Apiaceae species in the present *** databases help identify and control the quality of plant material studied from the family Apiaceae growing in Vietnam.

关键词： Apiaceae essential oil terpenoids gaschromatography-mass spectrometry

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中国游客对越南下龙湾旅游品牌形象认知研究

中国游客对越南下龙湾旅游品牌形象认知研究

作者：阮氏清玄（nguyen thi thanh huyen）南京理工大学

学位级别：硕士

旅游品牌形象认知是游客对品牌的了解、记忆和识别,并形成一种比较稳定的评价的心理活动过程。随着旅游业的发展和旅游市场竞争的日趋激烈,旅游市场的竞争越来越表现为旅游品牌的竞争,旅游品牌是旅游目的地的核心竞争力。游客认知对于... 详细信息

旅游品牌形象认知是游客对品牌的了解、记忆和识别,并形成一种比较稳定的评价的心理活动过程。随着旅游业的发展和旅游市场竞争的日趋激烈,旅游市场的竞争越来越表现为旅游品牌的竞争,旅游品牌是旅游目的地的核心竞争力。游客认知对于旅游目的地的品牌塑造具有重要的作用。本文通过对越南下龙湾旅游品牌形象认知进行研究,首先对国内外研究旅游品牌形象认知的研究现状及理论进行了分析和归纳。并对旅游品牌相关概念逐个进行探讨,包括对品牌、旅游品牌、品牌认知、旅游品牌定位等方面的理论进行了梳理。其次,是对越南旅游业总体的概况进行阐述,越南旅游业的基本情况和特点进行分析。选取越南下龙湾作为研究的对象,对下龙湾旅游业的发展概况,下龙湾旅游品牌的演变,并对中国游客入境旅游进行研究。重点提出研究模式和假设。主要是依照研究的需要,设计相对的选项和测量方式并且提出假设。结合调研地点和调研时间设置变量。最后,该部分内容在调研结果分析的基础上,总结出中国游客对下龙湾旅游品牌形象认知的种种结果,通过加强政府和协会的引导作用、因地制宜发展越南旅游商品、注重旅游品牌营销和对旅游产品进行市场细分四个方面来探讨提升下龙湾旅游品牌化的建议。

关键词：旅游品牌形象认知下龙湾

Influence of different land-use types on selected soil properties related to soil fertility in A Luoi District,Thua thien Hue,Vietnam

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Soil Ecology Letters 2024年第1期6卷 131-140页

作者： Khoa Phuc nguyen Tan Trong Tran Huy Dinh Le Phuong Thuy nguyen Hien Thao thi Pham Dien thanh nguyen Ngu Huu nguyen University of Agriculture and Forestry Hue UniversityHue CityThua Thien Hue 52000Vietnam School of Biotechnology Tan Tao UniversityTan Duc ECityDuc HoaLong An850000Vietnam

Land use type affects the physicochemical properties of *** value of OM and TN is high in acacia *** acidity of soil is considered a serious constraint for *** cash crops are acacia,cassava,banana,rice and *** fertility is affected by land-use types and land management,which exacerbates soil erosion and various other forms of soil degradation in the mountainous regions of *** study was conducted in A Luoi District,Thua thien Hue,Vietnam to identify the effects of land-use types on specific soil physicochemical characteristics related to soil *** physicochemical properties,such as organic matter(OM),total nitrogen(TN),total phosphorous(TP),and K+were significantly affected by land-use *** results showed that the soils were sandy in rice but clay loam for acacia and *** mean bulk density value of acacia soil was significantly greater than that of other *** were higher in the acacia soils than those in the rice,maize,and banana *** OM content was significantly higher in the acacia,cassava,and banana soils than those in the rice and maize *** mean of exchangeable K+in the rice soil was higher compared to those in other soils and was affected by land-use *** high exchangeable acidity content in the soils was probably due to intensive ***,both land use type and management did not affect the CEC ***,the inappropriate land use caused the disturbance of soil physicochemical properties,indicating that the conditions of rice and maize soils are becoming worse than acacia ***,lowering the intensity of cultivation,adopting incorporated soil fertility management,and applying organic fertilizer should preserve the existing conditions and enhance soil properties.

关键词： Land-use types soil characteristics soil frility suitable crop Vietnam

High-temperature corrosion of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho)environmental barrier coating materials by volcanic ash

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1628-1638页

作者： Ayahisa Okawa Son thanh nguyen Tadachika Nakayama thi-Mai-Dung Do Hisayuki Suematsu Shu Yin Takuya Hasegawa Tsuneo Suzuki Takashi Goto Koichi Niihara Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan Department of Creative Engineering National Institute of TechnologyKushiro 084-0916Japan Extreme Energy-Density Research Institute Nagaoka University of TechnologyNagaoka 940-2188Japan Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai 980-8577Japan

Rare-earth silicates are promising environmental barrier coatings(EBCs)that can protect SiC_(f)/Si C_(m)substrates in next-genera tion gas turbine ***,RE_(2)Si_(2)O_(7)(RE=Yb and Ho)shows potential as an EBC due to its coefficient of thermal expansion(CTE)compatible with substrates and high resistance to water vapor *** target operating temperature for next-generation tur bine blades is 1400°*** is inevitable during adhesion to molten volcanic ash,and thus,understanding the corrosion behavior o the material is crucial to its *** study investigates the high-temperature corrosion behavior of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho).Samples were prepared using a solid-state reaction and hot-press *** were then exposed to volcanic ash at 1400°C for 224,and 48 *** 48 h of exposure,volcanic ash did not react with Yb_(2)Si_(2)O_(7)but penetrated its interior,causing *** Ho_(2)Si_(2)O_(7)was partially dissolved in the molten volcanic ash,forming a reaction zone that prevented volcanic ash melts from penetrating the *** increasing heat treatment time,the reaction zone expanded,and the thickness of the acicular apatite grains increased The Ca:Si ratios in the residual volcanic ash were mostly unchanged for Yb_(2)Si_(2)O_(7)but decreased considerably over time for Ho_(2)Si_(2)O_(7).Th Ca in volcanic ash was consumed and formed apatite,indicating that RE^(3+)ions with large ionic radii(Ho>Yb)easily precipitated apatit from the volcanic ash.

关键词： environmental barrier coating volcanic ash rare-earth disilicate corrosion

Unknown DDoS Attack Detection with Fuzzy C-Means Clustering and Spatial Location Constraint Prototype Loss

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Computers, Materials & Continua 2024年第2期78卷 2181-2205页

作者： thanh-Lam nguyen HaoKao thanh-Tuan nguyen Mong-Fong Horng Chin-Shiuh Shieh Department of Electronic Engineering National Kaohsiung University of Science and TechnologyKaohsiung807618Taiwan Department of Electronic and Automation Engineering Nha Trang UniversityNha Trang650000Vietnam

Since its inception,the Internet has been rapidly *** the advancement of science and technology and the explosive growth of the population,the demand for the Internet has been on the *** applications in education,healthcare,entertainment,science,and more are being increasingly deployed based on the ***,malicious threats on the internet are on the rise as *** Denial of Service(DDoS)attacks are among the most common and dangerous threats on the internet *** scale and complexity of DDoS attacks are constantly *** Detection Systems(IDS)have been deployed and have demonstrated their effectiveness in defense against those *** addition,the research of Machine Learning(ML)and Deep Learning(DL)in IDS has gained effective results and significant ***,one of the challenges when applying ML and DL techniques in intrusion detection is the identification of unknown *** attacks,which are not encountered during the system’s training,can lead to misclassification with significant *** this research,we focused on addressing the issue of Unknown Attack Detection,combining two methods:Spatial Location Constraint Prototype Loss(SLCPL)and Fuzzy C-Means(FCM).With the proposed method,we achieved promising results compared to traditional *** proposed method demonstrates a very high accuracy of up to 99.8%with a low false positive rate for known attacks on the Intrusion Detection Evaluation Dataset(CICIDS2017)***,the accuracy is also very high,reaching 99.7%,and the precision goes up to 99.9%for unknown DDoS attacks on the DDoS Evaluation Dataset(CICDDoS2019)*** success of the proposed method is due to the combination of SLCPL,an advanced Open-Set Recognition(OSR)technique,and FCM,a traditional yet highly applicable clustering *** has yielded a novel method in the field of unknown attack *** further expands the trend of applying DL and M

关键词： Cybersecurity DDoS unknown attack detection machine learning deep learning incremental learning convolutional neural networks(CNN) open-set recognition(OSR) spatial location constraint prototype loss fuzzy c-means CICIDS2017 CICDDoS2019