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Clinical Trial of Measles and Rubella Combined Vaccine Produced by POLYVAC in Vietnam

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Open Journal of Pediatrics 2018年第2期8卷 178-188页

作者： nguyen dang hien nguyen Thuy Huong Ngo Thu Huong Pham Thi Phuong Thao Dinh Hong Duong nguyen Xuan Dong Tomio Lee Takashi Ito Tetsuo Nakayama Center for Research and Production of Vaccines and Biologicals (POLYVAC) Hanoi Vietnam Military Academy of Medicine Hanoi Vietnam Kitasato Vaccine Plant Kitasato Daiichi Sankyo Vaccine Saitama Japan Laboratory of Viral Infection I Kitasato Institute for Life Sciences Tokyo Japan

A clinical trial of measles and rubella combined vaccine (MR: MRVAC) produced by POLYVAC was conducted in Vietnam in 2016. A total of 756 subjects were enrolled, and 504 were allocated to MRVAC and 252 to control MR vaccine groups. Paired sera were obtained in 733, and the number of subjects was 403 aged 1 - 2 years, 164 aged 2 - 18 years, and 166 aged 18 - 45 years. Antibodies against measles and rubella viruses were evaluated by EIA. Most subjects had been immunized with a single dose of Expanded Programme on Immunization (EPI) measles vaccine at 9 months of age. Only 41 of 403 subjects aged 1 - 2 years were negative for measles antibody before vaccination, and all became seroconverted. A serological response of more than a 2-fold increase against measles was noted in 214 (47%, 95% CI;42.4% - 51.6%) of 458 initially seropositive individuals immunized with MRVAC and 65 (28%, 95% CI;22.3% - 33.8%) of 234 in the control group, and geometric mean titer (GMT) after vaccination was 25.49-5.60 in MRVAC and 25.03-5.24 in control group. Seroconversion against rubella virus after immunization with MRVAC was noted in 267 (98.5%, 95% CI;97.1% - 100%) of 271 initially seronegative subjects, similar to that after immunization with control group. GMT after immunization with MRVAC was 24.88-5.11 significantly lower than that after immunization with control vaccine (25.59-5.80). Most subject ≥ 2 years of age had rubella antibody because of MR vaccination campaign and no significant serological response was observed in initially seronegatives. MRVAC was highly immunogenic and safe vaccine and the domestic production of MR vaccine would contribute to realizing the goal of eliminating measles and rubella.

关键词： Measles Vaccine Rubella Vaccine MR Combined Vaccine Elimination of Measles and Rubella

Influence of different land-use types on selected soil properties related to soil fertility in A Luoi District,Thua Thien Hue,Vietnam

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Soil Ecology Letters 2024年第1期6卷 131-140页

作者： Khoa Phuc nguyen Tan Trong Tran Huy Dinh Le Phuong Thuy nguyen hien Thao Thi Pham Dien Thanh nguyen Ngu Huu nguyen University of Agriculture and Forestry Hue UniversityHue CityThua Thien Hue 52000Vietnam School of Biotechnology Tan Tao UniversityTan Duc ECityDuc HoaLong An850000Vietnam

Land use type affects the physicochemical properties of *** value of OM and TN is high in acacia *** acidity of soil is considered a serious constraint for *** cash crops are acacia,cassava,banana,rice and *** fertility is affected by land-use types and land management,which exacerbates soil erosion and various other forms of soil degradation in the mountainous regions of *** study was conducted in A Luoi District,Thua Thien Hue,Vietnam to identify the effects of land-use types on specific soil physicochemical characteristics related to soil *** physicochemical properties,such as organic matter(OM),total nitrogen(TN),total phosphorous(TP),and K+were significantly affected by land-use *** results showed that the soils were sandy in rice but clay loam for acacia and *** mean bulk density value of acacia soil was significantly greater than that of other *** were higher in the acacia soils than those in the rice,maize,and banana *** OM content was significantly higher in the acacia,cassava,and banana soils than those in the rice and maize *** mean of exchangeable K+in the rice soil was higher compared to those in other soils and was affected by land-use *** high exchangeable acidity content in the soils was probably due to intensive ***,both land use type and management did not affect the CEC ***,the inappropriate land use caused the disturbance of soil physicochemical properties,indicating that the conditions of rice and maize soils are becoming worse than acacia ***,lowering the intensity of cultivation,adopting incorporated soil fertility management,and applying organic fertilizer should preserve the existing conditions and enhance soil properties.

关键词： Land-use types soil characteristics soil frility suitable crop Vietnam

Clinical Case Report of Acute Heart Injury and Acute Rhabdomyolysis Due to Cyanide Poisoning

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Open Journal of Emergency Medicine 2024年第2期12卷 29-32页

作者： nguyen dang Duc nguyen Phuong Sinh Lam nguyen Hong Anh Poison Control Center of Bach Mai Hospital Hanoi Vietnam Thai nguyen Medicine and Pharmacy University Thai Nguyen Vietnam

Cyanide poisoning is one of the most dangerous poisonings, and it can be absorbed into the body through the mouth, inhalation and through the skin. A 32-year-old female patient was admitted to our poison control center because of high fever, severe vomiting, and seizures. Physical examination found that the patient was drowsy, had a high fever of 40 degrees Celsius, pulse of 140 beats/minute, and increased tendon and bone reflexes. Exploiting the patient’s information, it was discovered that the patient bought Cyanide to drink with the intention of committing suicide. The patient was quickly treated with gastric lavage and activated charcoal. Echocardiography recorded EF: 35%, reduced movement of the entire myocardium. CK blood test: 4562 U/L. The patient’s condition rapidly deteriorated and the patient was made ECMO, IHD and CVVHDF. After 3 days of treatment, the patient’s condition did not improve, so the family asked for the patient to go home. This article aims to describe the rapidly progressing and severe damage to the heart and muscles of patients with cyanide poisoning.

关键词： Cyanide Poisoning Acute Heart Injury Acute Rhabdomyolysis

Exponentially Bounded C-semigroup and the Cauchy Initial Value Problems in Complete Random Normed Modules

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2195-2212页

作者： Son TA CONG Thang dang HUNG Oanh Le THI Department of Mathematics University of ScienceVietnam National University 334 Nguyen TraiThanh XuanHanoiVietnam Faculty of Natural Sciences Hong Duc University565 Quang TrungDong VeThanh HoaVietnam

In this paper,the notion of C-semigroup of continuous module homomorphisms on a complete random normal(RN)module is introduced and *** existence and uniqueness of solution to the Cauchy problem with respect to exponen... 详细信息

关键词： C-semigroup Cauchy problem random normed modules L^(0)-Lipschitz

Tuberculosis Diagnosis and Visualization with a Large Vietnamese X-Ray Image Dataset

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Intelligent Automation & Soft Computing 2024年第2期39卷 281-299页

作者： nguyen Trong Vinh Lam Thanh hien Ha Manh Toan Ngo Duc Vinh Do Nang Toan Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Hanoi University of IndustryHanoi11915Vietnam

Tuberculosis is a dangerous disease to human life,and we need a lot of attempts to stop and reverse ***,in theCOVID-19 pandemic,access to medical services for tuberculosis has become very *** late detection of tuberculosis could lead to danger to patient health,even *** one of the countries heavily affected by the COVID-19 pandemic,andmany residential areas as well as hospitals have to be isolated for a long *** demands a fast and effective tuberculosis diagnosis solution to deal with the difficulty of accessingmedical services,such as an automatic tuberculosis diagnosis *** our study,aiming to build that system,we were interested in the tuberculosis diagnosis problem from the chest X-ray images of Vietnamese *** chest X-ray image is an important data type to diagnose tuberculosis,and it has also received a lot of attention from deep learning *** paper proposed a novel method for tuberculosis diagnosis and visualization using the deeplearning approach with a large Vietnamese X-ray image *** detail,we designed our custom convolutional neural network for the X-ray image classification task and then analyzed the predicted result to provide visualization as a *** prove the performance of our network model,we conducted several experiments to compare it to another study and also to evaluate it with the dataset of this *** support the implementation,we built a specific annotation system for tuberculosis under the requirements of radiologists in the Vietnam National Lung Hospital.A large experiment dataset was also from this hospital,and most of this data was for training the convolutional neural network *** experiment results were evaluated regarding sensitivity,specificity,and *** achieved high scores with a training accuracy score of 0.99,and the testing specificity and sensitivity scores were over *** on the X-ray image classification result,we visualize pr

关键词： Tuberculosis classification Vietnamese chest X-ray deep learning

Predicting 3D Radiotherapy Dose-Volume Based on Deep Learning

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Intelligent Automation & Soft Computing 2024年第2期39卷 319-335页

作者： Do Nang Toan Lam Thanh hien Ha Manh Toan nguyen Trong Vinh Pham Trung Hieu Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam

Cancer is one of the most dangerous diseaseswith *** of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and *** our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer *** image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction *** proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and *** strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the *** output of the network is added with a rectified linear unit(Re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation *** experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation *** results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the Dose-score and the Dose-volume histogram score(DVH-score).In the best training cases,the Dose-score is 3.08 and the DVH-score is *** addition,we also conducted a comparison with the results of another study in the same context of using the loss function.

关键词： CT image 3D dose prediction data preprocessing augmentation

Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 17-28页

作者： nguyen Hoa Binh Quang Vo Luan nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba Dong Thuy Thi Thu Phan Yen Thi Hoang Creswell Jacob dang Thi Minh Ha nguyen Lan Huu Shedrawy Jad L?nnroth Knut nguyen Tuan Dinh Van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;P<0.001). This resulted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

Effect of Freeze-Thaw and Urea in Solubility of GPC3-Csub Protein Expressed in Escherichia coli

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Journal of Biosciences and Medicines 2024年第4期12卷 288-297页

作者： Xuan-Truc Chu-Dao Kim-Tuyen Huynh-Dam dang-Thuc Ngo-Luong Quang-Luan Le Thanh-Thao Vo-nguyen Department of Medical Biotechnology Biotechnology Center of Ho Chi Minh City Ho Chi Minh City Vietnam

Glypican-3 is a protein encoded by the Glypican-3 gene located on human X chromosome (Xq26), composed of two subunits, a 40 kDa N-terminal subunit, and a 30 kDa C-terminal subunit. Glypican-3 is a currently potential target molecule for liver cancer treatments because of its over-expression and growth effects on hepatocellular carcinoma (HCC). This study examined the expression and purification of a C-terminal subunit of Glypican-3 protein (GPC3-Csub) due to its application in both diagnosis and therapy for hepatocellular carcinoma. The gene encoding for GPC3-Csub was successfully cloned into plasmid pET28a fused with an affinity tag composed of six consecutive histidine residues (His-tag). Recombinant protein GPC3-Csub was expressed in Escherichia coli BL21 (DE3) in the condition of adding 3% ethanol with IPTG induction. GPC3-Csub was extracted using repeated freeze-thaw cycles with lysozyme, and inclusion bodies were solubilized by 8M Urea, SDS 10% in pH 12. His-tag fused GPC3-Csub proteins allowed it to be purified by affinity chromatography method using the Nickel-nitrilotriacetic acid (Ni-NTA) column. High expression of GPC3-Csub was confirmed by Coomassie staining and western-blot. GPC3-Csub could be isolated with a Ni-NTA column and have a purity of about 90%.

关键词： Glypican-3 Affinity Chromatography Inclusion Body Liver Cancer

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糯玉米品种斯达糯46在越南的试种表现

现代农业科技 2024年第11期 19-23,27页

作者：章忠贵朱守晶 nguyen Pham Hung dang Cao Cuong 江明山李新燕华中农业大学湖北武汉430070 安徽科技学院农学院安徽凤阳233100 越南太平种子股份公司越南太平33000 北京中农斯达农业科技开发有限公司北京101500

为明确糯玉米优质品种斯达糯46在越南种植的适应性,将该品种种植于越南红河三角洲地区,以越南主栽品种HN88为对照,对其生育期、农艺性状、抗性、食味品质等进行鉴定和评价。结果表明,斯达糯46生育进程与对照HN88相似;农艺性状方面,斯达... 详细信息

为明确糯玉米优质品种斯达糯46在越南种植的适应性,将该品种种植于越南红河三角洲地区,以越南主栽品种HN88为对照,对其生育期、农艺性状、抗性、食味品质等进行鉴定和评价。结果表明,斯达糯46生育进程与对照HN88相似;农艺性状方面,斯达糯46穗位株高比优于对照HN88,抗倒伏能力强;抗病虫害方面,斯达糯46对螟虫、大斑病、小斑病、茎腐病、矮花叶病、穗腐病有良好的抗性;果穗性状方面,斯达糯46的双穗率、穗长、穗粗、穗行数、穗粒数均高于对照HN88,千粒重较对照HN88高13.3%;产量表现方面,斯达糯46的鲜穗产量较对照HN88显著增加20.9%,籽粒产量较对照HN88增加17.8%;品质评分与对照HN88接近。综合以上结果,种植于越南的斯达糯46表现了良好的气候适应性,在产量、抗性、品质、植株性状等方面表现突出,有良好的推广价值。

关键词：糯玉米斯达糯46 产量适应性越南