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Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： baolong Liu Phuong Linh nguyen Han Yu Xingzhi Li Huiren Wang Tram Gia bao nguyen Prakash Kumar Sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.Kachman Bara Altartouri Guoqing Lu Sathish Kumar Natarajan Mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kB ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

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Sorting by Restricted-Length-Weighted Reversals

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Genomics, Proteomics & Bioinformatics 2005年第2期3卷 120-127页

作者： Thach Cam nguyen Hieu Trung Ngo nguyen bao nguyen Department of Mathematics Singapore 117543. School of Computing National University of Singapore Singapore 117543.

Classical sorting by reversals uses the unit-cost model, that is, each reversal consumes an equal cost. This model limits the biological meaning of sorting by reversal. Bender and his colleagues extended it by assigning a cost function f（1） = l^a for all a≥ 0, where l is the length of the reversed subsequence. In this paper, we extend their results by considering a model in which long reversals are prohibited. Using the same cost function above for permitted reversals, we present tight or nearly tight bounds for the worst-case cost of sorting by reversals. Then we develop algorithms to approximate the optimal cost to sort a given 0/1 sequence as well as a given permutation. Our proposed problems are more biologically meaningful and more algorithmically general and challenging than the problem considered by Bender et al. Furthermore, our bounds are tight and nearly tight, whereas our algorithms provide good approximation ratios compared to the optimal cost to sort 0/1 sequences or permutations by reversals.

关键词： reversal sorting length-weighted permutation

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Isolation and characterization of five novel mini-M conotoxins from the venom of mollusk-hunter snail Conus bandanus

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Asian Pacific Journal of Tropical Biomedicine 2020年第8期10卷 343-352页

作者： nguyen bao Jean-Pière LE CAER Phan Thi Khanh Vinh Faculty of Food Technology Nha Trang University02 Nguyen Dinh ChieuNha TrangKhanh HoaVietnam Institut de Chimie des Substances Naturelles Centre de Recherche de Gif-FRC3115-UPR 2301F-91198 Gif-sur-YvetteFrance

Objective:To determine the new M-superfamily conotoxins from molluscivorous snail Conus bandanus in ***:Conus bandanus venom was fractionated and purified on HPLC system with an analytical reversed-phase C18 column in order to screen small *** primary structure of peptide was analyzed by matrix-assisted laser desorption/ionization time of flight tandem mass spectrometry using collision-induced dissociation and confirmed by Edman’s degradation ***:Five new conotoxins were biochemically characterized from the crude venom of the mollusk-hunting cone snail Conus bandanus,which were collected at Ke Ga reef of the Nha Trang Bay(Vietnam).Each conotoxin had 15 or 16 amino acid residues and shared the same characteristic cysteine framework V as–CC–C–C–CC–.They were termed as Bn3 b,Bn3 c,Bn3 d,Bn3 e and Bn3 f following the conotoxins ***:The conotoxins Bn3 b,Bn3 e,and Bn3 f are categorized in the mini-M conotoxins of the M1 branch,while conotoxins Bn3 c and Bn3 d are categorized in the mini-M conotoxins of the M2 *** homological analysis reveals that these conotoxins could serve as promising probe compounds for voltage-gated sodium channels.

关键词： Mini-M conotoxin Conus bandanus Cone snail venom

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Comparative Study on Sino-Vietnam Cybersecurity Legislation and Regional Cooperation

Comparative Study on Sino-Vietnam Cybersecurity Legislation ...

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作者： nguyen Phuoc bao Tri 西南政法大学

学位级别：硕士

如今,公共生活的各个领域,包括文化,娱乐,商业和学术研究在内的各个不同的行业,都因为新技术的出现而产生了彻底的变革。信息科技的发展更是成为了全球共同关注的论题。信息与数据时代的到来,显著促进了商业,教育,医疗,政治等社会方面... 详细信息

如今,公共生活的各个领域,包括文化,娱乐,商业和学术研究在内的各个不同的行业,都因为新技术的出现而产生了彻底的变革。信息科技的发展更是成为了全球共同关注的论题。信息与数据时代的到来,显著促进了商业,教育,医疗,政治等社会方面的改善与进步。然而,伴随着信息化社会的急速发展以及网络空间的迅速膨胀,新的问题也随之涌现。尽管数字化时代所具有的优势无可非议,其派生的问题同时也不容忽视,其中的网络安全问题便正为立法者及专家密切关注。同时,网络安全问题的频繁发生、复杂性和影响也使问题本身更加严峻,尤其是在诸如越南这样的发展中国家之中。同其他国家相似,越南的网络发展也极为迅速。因此,越南政府正着手探索法律手段以保护网络安全。本文包括四个主要部分论文的第一部分简要介绍了网络空间的本质,同时论述了网络安全的必要性,以便了解网络空间中的潜在危险。此外,网络犯罪中的犯罪分子构成的危险与传统犯罪所能带来的危害极为不同。因此,第二部分旨在介绍网络犯罪的法律问题。根据犯罪目的的不同将各种网络犯罪分成易于管理的类别促进了国内法和国际法的发展,使得其可以通过判断犯罪行为归属的类别,行使统一化的法律手段来规定个人或者国家的权利义务。当前网络犯罪已然成为任何发展中国家的频发问题,而此项措施可以有效裨补在当前的国内法和国际法框架中存在的缺漏。第三,越南的信息通信技术行业(ICT)已于2000年走上加速发展和相对全面发展的道路,此项行业主要由政府政策进行支持和推动。越南致力于信息社会发展,并争取在2020年前使信息成就高于东南亚平均水平。虽然越南在信息通信技术和数字领域展现出巨大潜力,但若通过充分利用资源以期实现上述宏伟目标,越南仍然面临着诸多困难和挑战。管理网络安全的问题是越南面临的主要挑战之一。在意识到网络空间的脆弱性同时,越南政府已着手制定并实施新的网络安全政策。因此,作为本文的第三部分,笔者将通过论述网络发展历程,机构监管机制和政府的法律措施三个方面来评估并分析越南的网络安全现状。在第四部分,笔者以中国作为比较研究的对象,这是因为中国将网络安全政策视为一项优先政策。此外,笔者参加了中国-东盟法律研究中心的项目,而此项目正是于中国开展。参与此项目的各国家研究人员在研究的基础上构筑合作平台,其中网络安全相关法律问题便是其中一重要论题。近年来,中国与东盟之间的合作发展迅速,但是在贸易依赖网络的今天,网络安全机制的缺乏可能导致巨大的经济损失。越南和中国互为邻国,有着相同的政治体系和法律体系,双方自国家独立之日起便建立了友好关系。因此,探索中国和越南之间的网络安全合作的可能性,将为双方在网络安全领域寻求与发展跨境合作提供有效途径。

关键词：网络安全网络信息安全国家安全互联网跨境服务中越网络安全合

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One-step hydrothermal synthesis of Sn-doped α-Fe_(2)O_(3) nanoparticles for enhanced photocatalytic degradation of Congo red

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Journal of Semiconductors 2022年第12期43卷 22-31页

作者： Van Nang Lam Thi Bich Vu Quang Dat Do Thi Thanh Xuan Le Tien Dai nguyen T-Thanh-bao nguyen Hoang Tung Do Thi Tu Oanh nguyen Department of Natural Sciences Hoa Lu UniversityNinh NhatNinh Binh CityViet Nam Institute of Theoretical and Applied Research Duy Tan UniversityHanoi 100000Viet Nam Faculty of Natural Sciences Duy Tan UniversityDa Nang 550000Vietnam Institute of Physics Vietnam Academy of Science and Technology10 Dao TanBa DinhHanoiVietnam Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCaugiayHanoiVietnam

We report on the synthesis of Sn-doped hematite nanoparticles(Sn-α-Fe_(2)O_(3) NPs)by the hydrothermal *** prepared Sn-α-Fe_(2)O_(3) NPs had a highly pure and well crystalline rhombohedral phase with an average particle size of 41.4 *** optical properties of as-synthesizedα-Fe_(2)O_(3) NPs show a higher bandgap energy(2.40-2.57 eV)than that of pure bulkα-Fe_(2)O_(3)(2.1 eV).By doping Sn intoα-Fe_(2)O_(3) NPs,the Sn-doped hematite was observed a redshift toward a long wavelength with in-creasing Sn concentration from 0%to 4.0%.The photocatalytic activity of Sn-dopedα-Fe_(2)O_(3) NPs was evaluated by Congo red(CR)dye *** degradation efficiency of CR dye using Sn-α-Fe_(2)O_(3) NPs catalyst is higher than that of pureα-Fe_(2)O_(3) *** highest degradation efficiency of CR dye was 97.8%using 2.5%Sn-dopedα-Fe_(2)O_(3) NPs catalyst under visible-light *** results suggest that the synthesized Sn-dopedα-Fe_(2)O_(3) nanoparticles might be a suitable approach to develop a photocatalytic degradation of toxic inorganic dye in wastewater.

关键词： α-Fe_(2)O_(3)nanoparticles Sn Congo red photocatalytic properties photodegradation

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FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1884-1894页

作者： Ruiqi Zhu Li Li bao nguyen Jaesung Seo Min Wu Tessa Seale Mark Levis Amy Duffield Yu Hu Donald Small Department of Oncology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Pathology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Pediatrics Johns Hopkins University School of MedicineBaltimoreMDUSA

Tyrosine kinase inhibitors(TKIs)targeting FLT3 have shown activity but when used alone have achieved limited success in clinical trials,suggesting the need for combination with other *** investigated the combination of FLT3 TKIs(Gilteritinib or Sorafenib),with Venetodax,a BCL-2 selective inhibitor(BCL-2i),on FLT3/ITD leukemia *** combination of a FLT3 TKI and a BCL-2i synergistically reduced cell proliferation and enhanced apoptosis/cell death in FLT3/ITD cell lines and primary AML *** also re-sensitized FLT3 TKI-resistant cells to Gilteritinib or Sorafenib treatment,mediated through MAPK pathway *** treatment alone dissociated BIM from MCL-1 but increased the binding of BIM to *** treatment enhanced the binding of BIM to MCL-1 but dissociated BIM from *** with the drugs together resulted in dissociation of BIM from both BCL-2 and MCL-1,with an increased binding of BIM to the cell death mediator BAX,leading to increased *** findings suggest that Venetoclax mitigates the unintended pro-survival effects of FLT3 TKI mainly through the dissociation of BIM and BCL-2 and also decreased BIM *** study provides evidence that the addition of BCL-2i enhances the effect of FLT3 TKI therapy in FLT3/ITD AML treatment.

关键词： FLT3 drugs alone treatment BIM

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Thornthwaite moisture index and depth of suction change under current and future climate‒An Australian study

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1761-1775页

作者： Md Rajibul Karim Bikash Devkota Md Mizanur Rahman Hoang bao Khoi nguyen UniSA STEM University of South AustraliaMawson Lakes CampusMawson LakesSouth Australia5095Australia

Climate change is one of the major global challenges and it can have a significant influence on the behaviour and resilience of geotechnical *** changes in moisture content in soil lead to effective stress changes and can be accompanied by significant volume changes in reactive/expansive *** volume change leads to ground movement and can exert additional stresses on structures founded on or within a shallow depth of such *** change is likely to amplify the ground movement potential and the associated problems are likely to *** effect of atmospheric boundary interaction on soil behaviour has often been correlated to Thornthwaite moisture index(TMI).In this study,the long-term weather data and anticipated future projections for various emission scenarios were used to generate a series of TMI maps for *** changes in TMI were then correlated to the depth of suction change(H s),an important input in ground movement *** all climate scenarios considered,reductions in TMI and increases in H s values were observed.A hypothetical design scenario of a footing on expansive soil under current and future climate is *** is observed that a design that might be considered adequate under the current climate scenario,may fail under future scenarios and accommodations should be made in the design for such events.

关键词： Climate change Future prediction Thornthwaite moisture index(TMI) Characteristic surface movement Infrastructure resilience

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Adiponectin restores the obesity-induced impaired immunomodulatory function of mesenchymal stromal cells via glycolytic reprogramming

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Acta Pharmaceutica Sinica B 2024年第1期14卷 273-291页

作者： Duc-Vinh Pham Thi-Kem nguyen bao-Loc nguyen Jong-Oh Kim Jee-Heon Jeong Inho Choi Pil-Hoon Park Department of Pharmacology Hanoi University of PharmacyHanoi 100000Viet Nam College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Medical Biotechnology Yeungnam UniversityGyeongsan 38541Republic of Korea Research Institute of Cell Culture Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Precision Medicine School of MedicineSungkyunkwan UniversitySuwon 16419Republic of Korea

Obesity has been known to negatively modulate the life-span and immunosuppressive potential of mesenchymal stromal cells(MSC).However,it remains unclear what drives the compromised potency of obese *** this study,we examined the involvement of adiponectin,an adipose tissuederived hormone,in obesity-induced impaired therapeutic function of ***-induced obesity leads to a decrease in serum adiponectin,accompanied by impairment of survival and immunomodulatory effects of adipose-derived MSC(ADSC).Interestingly,priming with globular adiponectin(gAcrp)improved the immunomodulatory potential of obese *** effects were also observed in lean *** addition,gAcrp potentiated the therapeutic effectiveness of ADSC in a mouse model of DSS-induced ***,while obesity inhibited the glycolytic capacity of MSC,gAcrp treatment induced a metabolic shift toward glycolysis through activation of adiponectin receptor type 1/p38 MAPK/hypoxia inducible factor-1a *** findings suggest that activation of adiponectin signaling is a promising strategy for enhancing the therapeutic efficacy of MSC against immune-mediated disorders.

关键词： Adiponectin Adipose-derived stromal cells Colitis Glycolytic induction HIF1a Immunomodulation Mesenchymal stromal cells Obesity

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Does Customer Experience Management Impact Customer Loyalty Shopping at Supermarket？ The Case in the Mekong Delta, Vietnam

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Economics World 2018年第1期6卷 13-21页

作者： Luu Tien Thuan nguyen Huynh bao Ngoc nguyen Thu Nha Trang Can Tho University Can Tho Vietnam

This research analyzes and answers the question ＂Does customer experience management impact to customer loyalty shopping at supermarket, in the case of Mekong Delta, Vietnam？＂, 321 customers of supermarkets in the Mekong Delta were interviewed by questionnaire. The descriptive statistics, factor analysis, Cronbach＇s alpha, structural equation modeling, and multi-group structural analysis methods were used in this study. The results confirm that customer experience management impacts to customer loyalty shopping at supermarkets. There are six components of customer experience management including brand name, space, commodity, staff, parking lot, and the presence of other stores in supermarkets. In particular, the commodity composition has the strongest impact on customer experience management and satisfaction and directly influences on customer loyalty. In addition, elements of customer experience management affect customer loyalty indirectly through sensory experience, social experience, and satisfaction. The results of multivariate analysis show that age group, spending per shopping at supermarkets, and marital status of the client do not change the relationships in the research model. Meanwhile, the relationship of the different models of the client group income, gender, education, occupation and customers is different. This study adds value to consumer behavior and customer experience management literature.

关键词： customer experience management customer loyalty satisfaction supermarket

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A Comparison of Control Methods for Z-Source Inverter

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Energy and Power Engineering 2012年第4期4卷 187-195页

作者： Cong-Thanh Pham Anwen Shen Phan Quoc Dzung nguyen bao Anh nguyen Xuan Phu Dept of Control Science and Engineering Huazhong University of Science and Technology Wuhan China HCMC University of Technology Ho Chi Minh City Vietnam

In recent years, Z-source inverters (ZSI) have been proposed as an replacement power conversion concept which it has both voltage buck and boost abilities. In addition, ZSI doesn’t require dead-time to protection short circuit at two switches any of the same phase leg in the inverter bridge and to achieve optimal harmonic of current, voltage. This paper presents two different control methods (CM) for ZSI. The aim of this study to compare between two modulation methods, there are modi?ed space vector pulse width modulation method (MSVM) and the simple boost control (SBC) about the unique harmonic performance features, the total average and peak switching device power of the inverter system. In addition, this paper also analyzes about the ability exceed modulation index in linear region of two CM using MATLAB/Simulink.

关键词： Buck-Boost Current Source Inverters (CSIs) Pulse-Width Modulation (PWM) Voltage Source Inverters (VSIs) Z-Source Inverters (ZSI)

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