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transit Network Design:a Hybrid Enhanced Artificial Bee Colony Approach and a Case Study

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International Journal of transportation Science and technology 2013年第3期2卷 243-260页

作者： Y.Jiang W.Y.Szeto t.M.ng Department of Civil Engineering The University of Hong KongHong KongP.R.China

A bus network design problem in a suburban area of Hong Kong is *** objective is to minimize the weighted sum of the number of transfers and the total travel time of passengers by restructuring bus routes and determining new frequencies.A mixed integer optimization model is developed and was solved by a Hybrid Enhanced Artificial Bee Colony algorithm(HEABC).A case study was conducted to investigate the effects of different design parameters,including the total number of bus routes available,the maximum route duration within the study area and the maximum allowable number of bus routes that originated from each *** model and results are useful for improving bus service policies.

关键词： transit network design Artificial bee colony algorithm Heuristic

Second fundamental forms of holomorphic isometries of the Poincar disk into bounded symmetric domains and their boundary behavior along the unit circle

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Science China Mathematics 2009年第12期52卷 2628-2646页

作者： MOK ngaiming ng Sui Chung Department of Mathematics The University of Hong Kong

Motivated by problems arising from Arithmetic Geometry,in an earlier article one of the authors studied germs of holomorphic isometries between bounded domains with respect to the Bergman *** the case of a germ of holomorphic isometry f:(Δ,λ ds 2Δ ;0) → (Ω,ds 2Ω ;0) of the Poincar disk Δ into a bounded symmetric domain Ω C N in its Harish-Chandra realization and equipped with the Bergman metric,f extends to a proper holomorphic isometric embedding F:(Δ,λ ds 2Δ) → (Ω,ds 2Ω) and Graph(f) extends to an affine-algebraic variety V  C × C *** of F which are not totally geodesic have been *** arise primarily from the p-th root map ρ p:H → H p and a non-standard holomorphic embedding G from the upper half-plane to the Siegel upper half-plane H 3 of genus *** the current article on the one hand we examine second fundamental forms σ of these known examples,by computing explicitly σ *** the other hand we study on the theoretical side asymptotic properties of σ for arbitrary holomorphic isometries of the Poincar disk into *** such mappings expressing via the inverse Cayley transform in terms of the Euclidean coordinate τ=s + it on the upper half-plane H,we have φ(τ)=t 2 u(τ),where u t=0 ≡ *** show that u must satisfy the first order differential equation u t | t=0 ≡ 0 on the real axis outside a finite number of points at which u is *** a by-product of our method of proof we show that any non-standard holomorphic isometric embedding of the Poincar disk into the polydisk must develop singularities along the boundary *** equation φuφt | t=0 ≡ 0 along the real axis for holomorphic isometries into polydisks distinguishes the latter maps from holomorphic isometries into Siegel upper half-planes arising from *** the end of the article we formulate characterization problems for holomorphic isometries suggested both by the theoretical and the computational results of the article.

关键词： holomorphic isometry Poincar disk Siegel upper half-plane second fundamental form asymptotics

Critical analysis of feeding jejunostomy following resection of upper gastrointestinal malignancies

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World Journal of Gastrointestinal Surgery 2017年第2期9卷 53-60页

作者： Andrew M Blakely Saad Ajmal Rachel E Sargent thomas t ng thomas J Miner Department of Surgery Rhode Island HospitalProvidence Warren Alpert Medical School of Brown University Providence

AIM to assess nutritional recovery,particularly regarding feeding jejunostomy tube(FJt)utilization,following upper gastrointestinal resection for malignancy. MEtHODS A retrospective review was performed of a prospectively-maintained database of adult patients who underwent esophagectomy or gastrectomy(subtotal or total)for cancer with curative intent,from January 2001 to June 2014. Patient demographics,the approach to esophagectomy,the extent of gastrectomy,FJt placement and utilization at discharge,administration of parenteral nutrition(PN),and complications were evaluated. All patients were followed for at least ninety days or until *** the 287 patients underwent upper GI resection,comprised of 182 esophagectomy(n=107 transhiatal,58.7%; n=56 Ivor-Lewis,30.7%)and 105 gastrectomy [n=63 subtotal(SG),60.0%; n=42 total(tG),40.0%]. 181 of 182 esophagectomy patients underwent FJt,compared with 47 of 105 gastrectomy patients(99.5% vs 44.8%,P t had undergone tG(n=39,92.9% vs n=8 SG,12.9%,P ngth of stay was similar between esophagectomy and gastrectomy groups(14.7 d vs 17.1 d,P=0.076). Upon discharge,87 esophagectomy patients(48.1%)were taking enteral feeds,with 53(29.3%)fully and 34(18.8%)partially dependent. Meanwhile,20 of 39 tG patients(51.3%)were either fully(n=3,7.7%)or partially(n=17,43.6%)dependent on tube feeds,compared with 5 of 8 SG patients(10.6%),all of whom were partially dependent. Gastrectomy patients were significantly less likely to be fully dependent on tube feeds at discharge compared to esophagectomy patients(6.4% vs 29.3%,P=0.0006). PN was administered despite FJt placement more often following gastrectomy than esophagectomy(n=11,23.4% vs n=7,3.9%,P=0.0001). FJt-specific complications requiring reoperation within 30 d of resection occurred more commonly in the gastrectomy group(n=6),all after tG,compared to 1 esophagectomy patient(12.8% vs 0.6%,P=0.0003). Six of 7 patients(85.7%)who experienced tube-re

关键词： Feeding jejunostomy Esophagectomy Gastrectomy Nutritional recovery Outcomes

Reverse Genetic Analysis of Adaptive Mutations within the Capsid Proteins of Enterovirus 71(EV-A71) Strains Necessary for Infection of CHO-K1 Cells

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Virologica Sinica 2020年第1期35卷 110-114页

作者： Carla Bianca Luena Victorio Yishi Xu Qimei ng Vincent t.K.Chow Kaw Bing Chua temasek Lifesciences Laboratory 1 Research LinkNational University of SingaporeSingapore 117604Singapore Host and Pathogen Interactivity Laboratory Department of MicrobiologyYong Loo Lin School of MedicineNational University Health SystemNational University of SingaporeSingapore 117545Singapore Present Address:Laboratory for translational and Molecular Imaging Cancer and Stem Cell Biology ProgrammeDuke-NUS Medical SchoolSingapore 169857Singapore

Dear Editor,Previous studies had described the adaptation of enterovirus 71(EV-A71)strains that enabled entry and viral replication in Chinese Hamster Ovary(CHO)cell line(Zaini and McMinn 2012;Zaini et al.2012).these adapted strains derived from serial passage of a clinical isolate in CHO cells exhibited an amino acid substitution at VP2149,which enhanced viral replication by 100*1000-fold compared to the clinical *** VP2149 mutation was claimed responsible for adaptation to CHO-K1 cells without performing detailed molecular analyses to support these *** this study,we evaluate various VP1 and VP2 mutations in two CHO-adapted EV-A71 strains derived in our lab to assess their contribution to the phenotype of CHO cell adaptation.

关键词： adapted passage claimed

High spectro-temporal compression on a nonlinear CMOS-chip

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Light(Science & Applications) 2021年第7期10卷 1347-1361页

作者： Ju Won Choi Ezgi Sahin Byoung-Uk Sohn George F.R.Chen Doris K.t.ng Anuradha M.Agarwal Lionel C.Kimerling Dawn t.H.tan Photonics Devices and System Group SUTD-MIT International Design CenterSingapore University of Technology and DesignSingapore 487372Singapore Institute of Microelectronics A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis Way#08-02Innovis TowerSingapore 138634Singapore Microphotonics Center Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Materials Research Laboratory Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA Department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA

Optical pulses are fundamentally defined by their temporal and spectral *** ability to control pulse properties allows practitioners to efficiently leverage them for advanced metrology,high speed optical communications and attosecond ***,we report 11×temporal compression of 5.8 ps pulses to 0.55 ps using a low power of 13.3 *** result is accompanied by a significant increase in the pulse peak power by 9.4×.these results represent the strongest temporal compression demonstrated to date on a complementary metal–oxide–semiconductor(CMOS)*** addition,we report the first demonstration of on-chip spectral compression,3.0×spectral compression of 480 fs pulses,importantly while preserving the pulse *** strong compression achieved at low powers harnesses advanced on-chip device design,and the strong nonlinear properties of backend-CMOS compatible ultra-silicon-rich nitride,which possesses absence of two-photon absorption and 500×larger nonlinear parameter than in stoichiometric silicon nitride *** demonstrated work introduces an important new paradigm for spectro-temporal compression of optical pulses toward turn-key,on-chip integrated systems for all-optical pulse control.

关键词： pulse optical nonlinear

Impact of the biological definition of Alzheimer’s disease using amyloid, tau and neurodegeneration (AtN):what about the role of vascular changes,inflammation,Lewy body pathology?

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translational Neurodegeneration 2018年第1期7卷 111-117页

作者： S.Gauthier H.Zhang K.P.ng t.A.Pascoal P.Rosa-Neto McGill Center for Studies in Aging Douglas Mental Health Research InstituteMontrealCanada Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology National Neuroscience InstituteSingaporeSingapore

Background:the NIA-AA research framework proposes a biological definition of Alzheimer’s disease,where asymptomatic persons with amyloid deposition would be considered as having this disease prior to ***:Notwithstanding the fact that amyloid deposition in isolation is not associated with dementia,even the combined association of amyloid and tau pathology does not inevitably need to dementia over age *** pathological factors may play a leading or an accelerating role in age-associated cognitive decline,including vascular small vessel disease,neuroinflammation and Lewy Body ***:Research should aim at understanding the interaction between all these factors,rather than focusing on them *** this will lead to a personalized approach to the prevention of brain aging,based on individual biological,genetic and cognitive profiles.

关键词： Alzheimer’s disease Diagnosis treatment Biomarkers Precision medicine translational research Brain imaging Database analysis Human volunteer cohorts

Ground state energy of He isoelectronic sequence treated variationally via Hylleraas-like wavefunction

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Chinese Physics B 2009年第6期18卷 2238-2243页

作者： Serpil Sakiroglu Kadir Akgngr Ismail Skmen Physics Department Dokuz Eyll University

In this study, the energy for the ground state of helium and a few helium-like ions （Z=1-6） is computed variationally by using a Hylleraas-like wavefunction. A four-parameters wavefunction, satisfying boundary conditions for coalescence points, is combined with a Hylleraas-like basis set which explicitly incorporates r12 interelectronic distance. the main contribution of this work is the introduction of modified correlation terms leading to the definition of integral transforms which provide the calculation of expectation value of energy to be done analytically over single-particle coordinates instead of Hylleraas coordinates.

关键词： He isoelectronic sequence Hylleraas basis set electronic correlation variational method

Episodic dolomitization of Paleozoic limestones in the Kinta Valley,Malaysia:Implications on porosity evolution and reservoir properties

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Energy Geoscience 2021年第4期2卷 298-307页

作者： Poon Xin Hui Mu.Ramkumar R.Nagarajan Manoj J.Mathew t.F.ng South East Asia Carbonate Research Laboratory(SEACaRL) Universiti Teknologi PETRONASBandar Seri Iskandar31750TronohPerakMalaysia Department of Geology Periyar University636011SalemIndia Department of Applied Geology Curtin UniversityMalaysia98009MiriSarawakMalaysia Shale Gas Research Group Institute of Hydrocarbon RecoveryUniversiti Teknologi PETRONAS31750TronohPerakMalaysia Department of Geology University of MalayaKuala LumpurMalaysia

Carbonates undergo a variety of physical,mineralogical,chemical changes during depositional and postdepositional stages that are of interest to exploration geologists and *** over,about 60%of hydrocarbon reserves occur in carbonates with the dominant proportion associated with dolomitic reservoirs,in particular fault-associated dolomites which appear to be proven hydrocarbon *** as the critical diagenetic process thus plays an important role in determining reservoir characteristics and in designing exploration *** buried Paleozoic dolomites exhibit relatively higher porosity than their counterparts,Paleozoic ***-associated dolomites are usually targets of hydrocarbon exploration due to their good reservoir *** heterogeneity in carbonate reservoirs due to varied porosity types and distribution makes reservoir characterization a daunting ***,the key elements that control porosity development and evolution in these dolomites remain *** the influence of multiphase dolomitization,associated diagenetic events,hydrothermal alteration and their causative thermo-tectonic events on porosity evolution and reservoir quality is essential to understanding the critical processes and controlling factors that result in diverse impacts on reservoir *** this paper,an attempt is made to characterize dolomitization in homogeneous carbonate mud and its relationship with porosity evolution and reservoir *** the field,six facies types excluding host limestone are recognized,which are in turn characterized into seven petrographically recognizable phases,namely the host limestone,early replacement dolomite,sucrosic dolomite,metamorphosed dolomite,late replacement dolomite,brecciated limestone and dolomite and late stage *** analyses reveal the dominance of stoichiometric dolomites,followed by calcareous dolomites and magnesium *** all the field-based f

关键词： Dolomitization Porosity evolution Paleozoic Kinta Valley Malaysia

A Nonlocal total Variation Model for Image Decomposition: Illumination and Reflectance

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Numerical Mathematics(theory,Methods and Applications) 2014年第3期7卷 334-355页

作者： Wei Wang Michael K.ng Department of Mathematics Tongji UniversityShanghaiChina Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong Kong

In this paper,we study to use nonlocal bounded variation(NLBV)techniques to decompose an image intensity into the illumination and reflectance *** considering spatial smoothness of the illumination component and nonlocal total variation(NLtV)of the reflectance component in the decomposition framework,an energy functional is *** establish the theoretical results of the space of NLBV functions such as lower semicontinuity,approximation and *** essential properties of NLBV functions are important tools to show the existence of solution of the proposed energy *** results on both grey-level and color images are shown to illustrate the usefulness of the nonlocal total variation image decomposition model,and demonstrate the performance of the proposed method is better than the other testing methods.

关键词： Image decomposition illumination reflectance nonlocal total variation iterative method