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Association of serum lipid levels with diabetic retinopathy

International Journal of Ophthalmology(English edition) 2013年第3期6卷 346-349页

作者： Ebru nevin Cetin Yunus Bulgu Seyfullah Ozdemir Senay Topsakal Fulya Akln Hulya Aybek Cem Ylldlrlm Department of Ophthalmology Faculty of Medicine Pamukkale University Department of Endocrinology Faculty of Medicine Pamukkale University Department of Biochemistry Faculty of Medicine Pamukkale University

AIM: To assess the association between serum lipids and diabetic retinopathy (DR). · METHODS: Sixty -one diabetic patients without retinopathy (NDR), 55 diabetic patients with non - proliferative retinopathy (NPDR) and 75 diabetic patients with proliferative retinopathy (PDR) according to ETDRS grading scale were enrolled in this study. Total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and triglyceride values were compared between the groups. ·RESULTS: The groups were well-balanced in terms of age and gender (P =0.071, P =0.265 respectively). The mean HbA1c values were significantly lower in NDR group than the NPDR and PDR groups(P =0.004, P =0.009 respectively). Mean total cholesterol, triglyceride, LDL, HDL and VLDL levels were not significantly different between the groups (P =0.693, P =0.774, P =0.644, P = 0.910 and P =0.967 respectively, one way ANOVA). Mean total cholesterol, triglyceride, LDL, HDL and VLDL levels were not significantly different between the patients with ME and patients without ME(P =0.622, P =0.113, P =0.955, P =0.735 and P =0.490 respectively, t -test). The mean blood glucose significantly correlated with total cholesterol (r =0.173, P =0.017) and LDL (r =0.190, P = 0.008). The mean HbA1c significantly correlated with total cholesterol (r =0.158, P =0.030) and triglyceride (r =0.148, P =0.042). ·CONCLUSION: Serum lipid levels were not significantly associated with the severity of DR or existence of ME despite the significant correlation between the mean blood glucose, HbA1c and total cholesterol.

关键词： cholesterol diabetes mellitus diabetic retinopathy high density lipoprotein low density lipoprotein macular edema triglyceride

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The 60-year Job:The Queen

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考试(双语读写) 2012年第3期 26-28页

作者： Charles nevin

Since the age of 25,hers has been a life of meeting,greeting,touring and red boxes. Six decades on,the Queen is busier than *** Charles nevin explains,you can put it down to her sense of duty…We cannot,by convention,ask the Queen directly for her thoughts on 60 years of hard reigning,but she is unlikely to be either impressed or dismayed to find herself still working at the

关键词：上议院 The 60-year Job:The Queen

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Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration in a Turkish population

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 773-777页

作者： Yunus Bulgu Gokhan Ozan Cetin Vildan Caner Ebru nevin Cetin Volkan Yaylali Cem Yildirim Department of Ophthalmology School of MedicinePamukkale University Department of Medical Genetics School of MedicinePamukkale University Department of Medical Biology School of MedicinePamukkale University

AIM:To assess the association between age-related macular degeneration(AMD) and three single nucleotide polymorphisms(SNPS) related to the vascular endothelial growth factor(VEGF) ***:The patients who were diagnosed with AMD were included in this prospective study. Three SNPs(rs1413711, rs2146323, and rs3025033) of the VEGF gene were genotyped by real-time polymerase chain reaction in the genomic DNA isolated from peripheral blood samples of the 82 patients and 80 ***:The genotype frequencies of rs1413711 and rs2146323 were not significantly different between the study group and the control group(P =0.072 and P =0.058).However, there was a significant difference in the genotype frequencies of these SNPs between the wet type AMD and dry type AMD(P =0.005 and P =0.010,respectively). One of the SNPs(rs1413711) was also found to be associated with the severity of AMD(P =0.001)with significant genotype distribution between early,intermediate, and advanced stages of the disease. The ancestral alleles were protective for both SNPs while the polymorphic alleles increased the risk for dry ***:VEGF SNPs rs1413711 and rs2146323 polymorphisms are significantly associated with AMD subtypes in our population.

关键词： age-related macular degeneration vascular endothelial growth factor single nucleotide polymorphism

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A data-driven method for syndrome type identification and classification in traditional Chinese medicine

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Journal of Integrative Medicine 2017年第2期15卷 110-123页

作者： nevin Lianwen Zhang Chen Fu Teng Fei Liu Bao-xin Chen Kin Man Poon Pei Xian Chen Yun-ling Zhang Department of Computer Science and Engineering the Hong Kong University of Science and Technology Department of Neurology Dongfang HospitalBeijing University of Chinese Medicine Department of Mathematics and Information Technology the Education University of Hong Kong

The efficacy of traditional Chinese medicine （TCM） treatments for Western medicine （WM） diseases relies heavily on the proper classification of patients into TCM syndrome types. The authors developed a data-driven method for solving the classification problem, where syndrome types were identified and quantified based on statistical patterns detected in unlabeled symptom survey data. The new method is a generalization of latent class analysis （LCA）, which has been widely applied in WM research to solve a similar problem, i.e., to identify subtypes of a patient population in the absence of a gold standard. A well-known weakness of LCA is that it makes an unrealistically strong independence assumption. The authors relaxed the assumption by first detecting symptom co-occurrence patterns from survey data and used those statistical patterns instead of the symptoms as features for LCA. This new method consists of six steps： data collection, symptom co-occurrence pattern discovery, statistical pattern interpretation, syndrome identification, syndrome type identification and syndrome type classification. A software package called Lantern has been developed to support the application of the method. The method was illustrated using a data set on vascular mild cognitive impairment.

关键词： medicine, Chinese traditional syndrome syndrome classification latent tree analysis symptomco-occurrence patterns patient clustering stand syndrome differentiation

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Identification and classification of traditional Chinese medicine syndrome types among senior patients with vascular mild cognitive impairment using latent tree analysis

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Journal of Integrative Medicine 2017年第3期15卷 186-200页

作者： Chen Fu nevin Lianwen Zhang Bao-xin Chen Zhou Rong Chen Xiang Lan Jin Rong-juan Guo Zhi-gang Chen Yun-ling Zhang Department of Neurology Dongfang HospitalBeijing University of Chinese Medicine Department of Computer Science and Engineering The Hong Kong University of Science and Technology

OBJECTIVE： To treat patients with vascular mild cognitive impairment （VMCI） using traditional Chinese medicine （TCM）, it is necessary to classify the patients into TCM syndrome types and to apply different treatments to different types. In this paper, we investigate how to properly carry out the classification for patients with VMCI aged 50 or above using a novel data-driven method known as latent tree analysis （LTA）. METHOD： A cross-sectional survey on VMCI was carried out in several regions in Northern China between February 2008 and February 2012 which resulted in a data set that involves 803 patients and 93 symptoms. LTA was performed on the data to reveal symptom co-occurrence patterns, and the patients were partitioned into clusters in multiple ways based on the patterns. The patient clusters were matched up with syndrome types, and population statistics of the clusters are used to quantify the syndrome types and to establish classification rules. RESULTS： Eight syndrome types are identified： Qi deficiency, Qi stagnation, Blood deficiency, Blood stasis, Phlegm-dampness, Fire-heat, Yang deficiency, and Yin deficiency. The prevalence and symptom occurrence characteristics of each syndrome type are determined. Quantitative classification rules are established for determining whether a patient belongs to each of the syndrome types. CONCLUSION： A solution for the TCM syndrome classification problem for patients with VMCI and aged 50 or above is established based on the LTA of unlabeled symptom survey data. The results can be used as a reference in clinic practice to improve the quality of syndrome differentiation and to reduce diagnosis variances across physicians. They can also be used for patient selection in research projects aimed at finding biomarkers for the syndrome types and in randomized control trials aimed at determining the efficacy of TCM treatments of VMCI.

关键词： vascular mild cognitive impairment medicine, Chinese traditional syndrome latent tree analysis

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Significance of IL-1Ra and IL-6 gene variants in Turkish patients with Crimean-Congo hemorrhagic fever

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Asian Pacific Journal of Tropical Biomedicine 2019年第2期9卷 85-90页

作者： Umut Safiye Say Coskun Ayse Feyda Nursal Ferdi Gunes Aydin Rustemoglu Abdullah Yayli nevin Karakus Huseyin Sener Barut Serbulent Yigit Tokat Gaziosmanpasa University Medicine FacultyDepartment of Medical Microbiology Hitit University Medicine FacultyDepartment of Medical Genetics Obstetrics and Pediatrics Hospital Clinic of Infectious Disease Tokat Gaziosmanpasa University Medicine FacultyDepartment of Medical Biology Tokat Gaziosmanpasa University Medicine FacultyMicrobiology Laboratory Tokat Gaziosmanpasa University Medicine FacultyDepartment of Infectious Disease

Objective: To investigate the association between IL-1 Ra variable number of tandem repeat(rs2234663), IL-6-597 GA(rs1800797), IL-6-572 GC(rs1800796) and the risk of CrimeanCongo hemorrhagic fever(CCHF) in the Turkish patients. Methods: This study included 50 patients infected with CCHF and 50 healthy controls. These variants were genotyped using polymerase chain reaction and/or restriction fragment length polymorphism method. Results: The distribution of the IL-6-572 GC genotypes and alleles varied significantly between the patients and the controls. The subjects carrying IL-6-572 GC GG genotype and G allele had increased risk of developing CCHF compared to the control group(P=0.006, P=0.014, respectively). IL-6-572 GC GC genotype was higher in the controls than the patients(P=0.006). For the triple genotype combinations, the 1/2-GC-GG genotype combination was detected more frequently in the control group than CCHF patients(P=0.016). IL-6(-572/-597) GG-GG genotype was significantly higher in the patient group(P=0.015), while the GC-GG genotype was significantly lower in the patient group(P=0.005). Additionally, the G-G haplotype was significantly higher in the patient group(P=0.042), whereas C-G was found to be significantly lower in the patients than the control group(P=0.037). Conclusions: The results of this study suggest the IL-6-572 GC variant might be genetic markers of sensitivity to CCHF in the Turkish population and may facilitate greater protection against the disease.

关键词： Crimean-Congo hemorrhagic fever IL-1Ra IL-6 Variable number of tandem repeat -572GC -597GA

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Synthesis of the dl-ξ-Thiotocopherol： Newest Derivative of the dl-a-Tocopherol

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Journal of Chemistry and Chemical Engineering 2012年第1期6卷 90-95页

作者： Tuncer Mutlu Ibrahim Erol nevin Mutlu Levent Ozcan Department of Chemical Engineering Engineering Faculty University of Kocatepe ANS Campus Afyonkarahisar 03030 Turkey Department of Organic Chemistry Science and Art Faculty University of Kocatepe ANS Campus Afyonkarahisar 03030 Turkey Department of Chest and Tuberculosis City Government Hospital Gemlik 16600 Turkey Department of Analytical Chemistry Science and Art Faculty University of Kocatepe ANS Campus Afyonkarahisar 03030Turkey

Tocopherol is the most active vitamin and natural antioxidant existing in the nature known as vitamin E. Lacking of this vitamin makes drastic exchanges on the health of the living organisms. Their active chemical form is l-α-tocopherol substance. In this article, α-thiotocopherol a tocopherol derivative was synthesized via a precursor like dl-α-tocopherol, which has better antioxidant than natural α-tocopherol. And the last compound after separation and purification via TLC and PC procedures was analyzed by FTIR, GC-MS and elemental analysis, oxidative stability is tested with TGA method in air showing roughly antioxidant effect. Another approach is measurment of redox potential against a reference electrode under inert nitrogen atmosphere.

关键词： Tocopherol phenols substitute phenols thiotocopherol redox potential thermal and oxidative stability.

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Screening for hepatocellular carcinoma: summary of current guidelines up to 2018

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Hepatoma Research 2018年第8期4卷 64-73页

作者： nevin Yilmaz Ugur Eser Yilmaz Kaya Suer Vedat Goral Nedim Cakir Gastroenterology Section Research and Trainee HospitalMugla Sitki Kocman UniversityMugla48000Turkey Gastroenterology/Hepatology Department Near East University School of MedicineNicosiaMerssin 10Northern Cyprus Koc University School of Medicine Istanbul34010Turkey Department of Infectious Diseases and Clinical Microbiology Near East University School of MedicineNicosiaMerssin 10Northern Cyprus Department of Gastroenterology Medipol University School of MedicineIstanbul 34214Turkey

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related to worldwide death with a great geographical variation. To be eligible for curative therapy at the time of diagnosis is important. However, the majority of cases are diagnosed at late stages. This can be achieved with applicable screening modalities. Until now, many organizations around the world have developed guidelines according to their own evidence-based data for screening of HCC. The purpose of this article is to review the screening modalities of HCC to assist gastroenterologists and providers involved in the management of HCC.

关键词： Hepatocellular carcinoma screening guidelines surveillance

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