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“WE DID IT OURSELVES”INDEPENDENT LEARNING IN MIDDLE SCHOOLS

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Chinese Journal of Applied Linguistics 1999年第4期22卷 2-10页

作者： neville Grant Educational writer and specialist in English language education

Recently,I was standing in the corridor of a middle school,and I heard the following ex-change between a student and a teacher who,like so many teachers these days,was hurrying,ina harassed sort of way,from one classroom to another,her arms filled with exercise books andother educational paraphernalia."Excuse me,Miss!"said the student."I don’t quite understand the third conditional!""Good question!"replied the teacher."Why don’t you look it up in the grammar notes at theback of the book?"Saying which,she swept off to her next *** question arises:was this teacher a good teacher,or a bad teacher?I hope that we shall inthe course of the next hour or so seek to establish an answer to this question!

关键词： WE DID IT OURSELVES INDEPENDENT LEARNING IN MIDDLE SCHOOLS

Realizing optimal hydrogen evolution reaction properties via tuning phosphorous and transition metal interactions

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Green Energy & Environment 2020年第4期5卷 506-512页

作者： Haishun Jiang Siyu Zhao Wenyao Li Tobias P.neville Isil Akpinar Paul R.Shearing Dan J.L.Brett Guanjie He School of Materials Engineering Shanghai University of Engineering ScienceShanghai201620China Electrochemical Innovation Lab Department of Chemical EngineeringUniversity College LondonLondonWC1E 7JEUnited Kingdom School of Chemistry University of LincolnJoseph Banks LaboratoriesGreen LaneLincolnLN67DLUnited Kingdom Faculty of Engineering Environmental EngineeringAksaray UniversityAksaray68100Turkey

Hydrogen is one of the most attractive renewables for future energy application,therefore it is vital to develop cost-effective and highlyefficient electrocatalysts for the hydrogen evolution reaction(HER)to promote the generation of hydrogen from mild *** this work,Co–Mo phosphide nanosheets with the adjustable ratio of Co and Mo were fabricated on carbon cloth by a facile hydrothermal-annealing *** to the unique nanostructures,abundant active surfaces and small resistance were *** electrocatalytic performances are obtained,such as the small overpotential of^67.3 mV to realize a current density of 10 mA cm^(-2) and a Tafel slope of 69.9 mV dec^(-1).Rapid recovery of the current response under multistep chronoamperometry is realized and excellent stability retained after the CV test for 2000 *** change of electronic states of different elements was carefully studied which suggested the optimal electrochemical performance can be realized by tuning phosphorous and metal interactions.

关键词： Co-Mo Phosphide Nanosheets Hydrogen evolution reaction Metal-phosphorous interactions

The Road to a British University

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英语学习 1996年第8期 33-36页

作者： Philip neville 李鸥

昔日要想踏进英国大学的校门,必须拿到会考A级的成绩;但是今天,无论是英国本国学生还是外国学生都可以选择其它的途径攻读学士或硕士学位,升学不再是陡径一条,你亦可通过其它的道路通往"罗马"。

关键词： EAP The Road to a British University

Evaluation of the Pathogen Detect<sup>®</sup>System and Anthracene-Based Enzyme Substrates for the Detection and Differentiation of <i>E. coli</i>and Total Coliforms in Water Samples

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Journal of Water Resource and Protection 2015年第9期7卷 689-701页

作者： neville Hewage Mazen Saleh Department of Biology Laurentian University Sudbury Canada

Indirect detection of Escherichia coli and total coliforms can be based on the enzymatic activities of β-glucuronidase (β-glu) and β-galactosidase (β-gal). These enzymes utilize the substrates anthracene-β-d-glucuronide and pyrene d-galactopyranoside, respectively. Substrate cleavage by the enzyme releases the soluble fluorescent molecules 2-hydroxyanthracene and 1-hydroxypyrene, which can then be detected by a fluorometer. The Pathogen Detect? system is an automated portable unit that can measure fluorescent enzyme products. In this report, we investigated the utility of the Pathogen Detect? system for potential automation of water quality monitoring. The PDS unit has the ability to detect E. coli, mean 14.7 h at a standard deviation of 1.5, when the sample mean is 9.1 cells in 100 mL with a standard deviation of 12.6. Similarly, total coliforms may be detected at mean 14.7 h with a standard deviation of 1.4 when the sample mean is 59.6 cells in 100 mL, with a standard deviation of 144.5. The PDS unit has the ability to detect single cells of either total coliforms or E. coli in 100 mL water sample within 18 hours. Turbidity and color of water samples have no impact on the detection of E. coli and total coliforms.

关键词： Escherichia coli Total Coliforms Enzyme Substrate Water Quality

Dental anomalies in first-degree relatives of transposed canine probands

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International Journal of Oral Science 2015年第3期7卷 169-173页

作者： Adriana Bartolo neville Calleja Fraser McDonald Simon Camilleri Broadstreet Dental Centre Department of Public Health Medical School University of Malta Dental Institute Department of Orthodontics Kings College London

The aim of this study was to investigate and compare the inheritance pattern and prevalence of inheritable dental anomalies in a sample of patients with maxillary canine—first premolar transposition and their first-degree relatives with a sample of palatally displaced canine families. Thirty-five consecutive maxillary canine—first premolar transposition probands and 111 first-degree relatives were matched to 35 consecutive palatally displaced canine probands and 115 first-degree relatives. These were assessed for palatally displaced canines and incisor-premolar hypodontia. Parental age at birth of the proband was also noted. The results revealed that（i） there is no difference in the overall prevalence of palatally displaced canine or incisor-premolar hypodontia between the groups of relatives;（ii） first-degree relatives of bilateral palatally displaced canine probands have a higher prevalence of palatally displaced canine and incisor-premolar hypodontia than those with unilateral palatally displaced canine; and（iii） maternal age at birth of the maxillary canine—first premolar transposition probands was significantly higher than that of the palatally displaced canine *** results suggest that maxillary canine—first premolar transposition and palatally displaced canine are unlikely to be different genetic entities and also indicate environmental or epigenetic influences on dental development.

关键词： ectopic epigenomics genetics hypodontia orthodontics tooth eruption

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深圳中信金融中心项目结构体系优化设计

建筑结构学报 2016年第S1期37卷 158-164页

作者： BEGHINI Alessandro MATHIAS neville SARKISIAN Mark 潘斌李盛勇程华群 Skidmore Owings&MerrillLLP旧金山94111 广州容柏生建筑结构设计事务所广东广州510170 华阳国际设计集团深圳公司广东深圳518038

介绍了基于数值有限元分析、图形静力学和Maxwell荷载路径等经典理论的结构优化工具,及其在深圳中信金融中心项目中的应用。结合使用了商用结构优化软件和自开发程序,以期得到深圳中信金融中心项目结构最佳几何形式。在结构优化过程中... 详细信息

介绍了基于数值有限元分析、图形静力学和Maxwell荷载路径等经典理论的结构优化工具,及其在深圳中信金融中心项目中的应用。结合使用了商用结构优化软件和自开发程序,以期得到深圳中信金融中心项目结构最佳几何形式。在结构优化过程中考虑结构性能标准,如整体刚度最大化、给定点变形最小化、目标周期、屈曲因子最大化、应力分布均匀等。最佳几何形式在最小化结构材料的前提下实现结构刚度最大化,整个优化过程是基于材料线弹性假定,为保证结构体系在地震作用下的延性,塔楼角部设置延性框架梁耗能。优化后的斜交网格结构体系效率高,相比核心筒提供更大的抗侧力刚度,但也使得节点层楼板拉应力增大,并且优化使得体系冗余度下降,因此需要注重楼板拉应力控制和抗连续倒塌设计。

关键词：高层结构结构优化拓扑优化可持续性设计概念设计

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以模块为基础的薄带材和箔材平直度控制

钢铁 2003年第6期38卷 36-40页

作者： R.Burnham I.Cole A.Gentile P.neville 达涅利集团自动化公司

薄带材和箔材的平直度或板形控制必然要求一定程度的模型化。这是由于轧钢工艺本身的复杂性所要求的。描述在轧制带卷前到形成良好初始平直度的最佳轧制程序表及在高平直度控制情况下生产带卷的过程中使用的模块。集中讨论在普通 4辊铝... 详细信息

薄带材和箔材的平直度或板形控制必然要求一定程度的模型化。这是由于轧钢工艺本身的复杂性所要求的。描述在轧制带卷前到形成良好初始平直度的最佳轧制程序表及在高平直度控制情况下生产带卷的过程中使用的模块。集中讨论在普通 4辊铝薄带和箔材轧机上所用的平直度模块。

关键词：薄带材箔材平直度板形控制最小均方板形模型模块轧制

Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation

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Journal of Animal Science and Biotechnology 2013年第4期4卷 287-293页

作者： Tammi L neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme Center for Nutrition and Pregnancy Department of Animal Sciences North Dakota State University

Background： Objectives were to examine the effects of selenium （Se） supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes （n = 84） were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se （adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BVV]） and nutritional plane （60% IRES], 100% [CON], or 140% [EXC]）. At parturition, lambs were removed and 42 ewes （7/treatment） were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present （P 〈 0.05）, least squares means from the highest-order interaction are presented. Results： Final body weight of ewes was least （P 〈 0.002） in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy （parturition or d 20 of lactation）. In ewes necropsied at parturition, mammary glands were heavier （P = 0.02） in EXC compared to RES, with CON intermediate. Concentration of RNA （rag/g） was decreased （P= 0.01） in EXC compared to CON at parturition. There was a tendency （P= 0.07） for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater （P_〈 0.02） number of proliferating cells then all other treatments. Mammary vascular area tended （P = 0.08） to be affected by a Se by nutrition interaction where ASe-CON had less （P= 0.007） vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased （P 〈- 0.05） in RES compared to CON and EXC-fed ewes. Conclusions： Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland develo

关键词： Mammary gland Nutrition Proliferation Selenium Vascularity

Molecular Docking of Selective Binding Affinity of Sulfonamide Derivatives as Potential Antimalarial Agents Targeting the Glycolytic Enzymes: GAPDH, Aldolase and TPI

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Open Journal of Biophysics 2017年第1期7卷 41-57页

作者： neville Forlemu Porshaye Watkins Joseph Sloop School of Science & Technology (Chemistry) Georgia Gwinnett College 1000 University Center Lane Lawrenceville GA USA

The parasite Plasmodium falciparum is responsible for the major world scourge malaria, a disease that affects 3.3 billion people worldwide. The development of new drugs is critical because of the diminished effectiveness of current antimalarial agents mainly due to parasitic resistance, side effects and cost. Molecular docking was used to explore structural motifs responsible for the interactions between triose phosphate isomerase (TPI), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and aldolase (ALD) from human and Plasmodium cells with 8 novel sufonylamide derivatives. All the ligands modeled, interact with all three enzymes in the micromolar range. The top ligand (sulfaE) shows a 70-fold increase in selective binding to pfTPI compared to hTPI (dissociation constant-KI of 7.83 μM and 0.177 μM for hTPI and pfTPI respectively), on par with antimalarial drug *** and GAPDH form complexes with similar binding sites, comprising amino acids of similar chemical properties and polarities. Human TPI and pfTPI bind sulfonamide derivatives using two distinct binding sites and residues. Key residues at the dimer interface of pfTPI (VAL44, SER45, TYR48, GLN64, ASN65, VAL78) form a tight pocket with favorable polar contacts. The affinity with TPI is the most specific, stable, and selective suggesting pfTPI is a candidate for development of antimalarial drugs.

关键词： Malaria Glycolytic Enzymes AutoDock4.2 Dissociation Constant Triosephosphate Isomerase Binding Affinity