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Outcomes of long-acting injectable antipsychotics use in pregnancy:A literature review

World Journal of Psychiatry 2024年第4期14卷 582-599页

作者： Ana V Pejčić Srdjan M Stefanović MilošN Milosavljević Vladimir S Janjić Marko M folić nevena d folić Jovana Z Milosavljević department of Pharmacology and Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia department of Clinical Pharmacology University Clinical Center KragujevacKragujevac 34000Serbia department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Clinic for Psychiatry University Clinical Center KragujevacKragujevac 34000Serbia Center for Pharmaceutical and Pharmacological Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia department of Pediatrics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pediatric Clinic University Clinical Center KragujevacKragujevac 34000Serbia department of Anatomy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUNd Women with a history of serious psychotic disorders are at increased risk of disease relapse during ***-acting injectable(LAI)antipsychotics have been widely used to improve adherence and prevent relapse in patients with various severe psychotic disorders,but there is a lack of high-quality data from previous research on the safety of LAI antipsychotics during *** To summarize relevant data on maternal,pregnancy,neonatal,and developmental outcomes from published cases of LAI antipsychotic use in *** A literature search was performed through November 11,2023,using three online databases:PubMed/MEdLINE,Scopus,and Web of *** reports or case series that reported information about the outcomes of pregnancy in women who used LAI antipsychotics at any point in pregnancy,with available full texts,were *** statistics,narrative summation,and tabulation of the extracted data were *** A total of 19 publications satisfied the inclusion criteria:3 case series,15 case reports,and 1 conference *** reported the outcomes of LAI antipsychotic use in 74 women and 77 *** use of secondgeneration LAI antipsychotics was reported in the majority(n=47;61.0%)of ***-generation LAI antipsychotics were administered during 30 pregnancies(39.0%).Most of the women(approximately 64%)had either satisfactory control of symptoms or no information about relapse,while approximately 12%of them had developed gestational diabetes mellitus.A minority of cases reported adverse outcomes such as stillbirth,spontaneous abortion,preterm birth,low birth weight,congenital anomalies,and neurological manifestations in ***,there were no reports of negative long-term developmental *** Currently available data seem reassuring,but further well-designed studies are required to properly evaluate the risks and benefits of LAI antipsychotic use during pregnancy.

关键词： Antipsychotic agents Long-acting injectable Pregnancy Outcome Review

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A non-isothermal Couette slip gas flow

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Science China(Physics,Mechanics & Astronomy) 2013年第9期56卷 1782-1797页

作者： MILICEV Snezana S. STEVANOVIC nevena d. University of Belgrade Faculty of Mechanical Engineering

A steady plane subsonic compressible non-isothermal Couette gas flow is analyzed for moderately high and low Reynolds *** flow channel is formed by two plates in relative *** cases are considered:(a) isothermal walls where the temperatures of the plates are equal and constant and(b) with constant but different plate *** Knudsen number is Kn 0.1,which corresponds to the slip and continuum *** flow is defined by continuity,Navier-Stokes and energy continuum equations,along with the velocity slip and the temperature jump first order boundary *** analytical solution for velocity and temperature is obtained by developing a perturbation *** first approximation corresponds to the continuum flow conditions,while the others represent the contribution of the rarefaction *** addition,a numerical solution of the problems is given to confirm the accuracy of the analytical *** exact analytical solution,for constant viscosity and conductivity is found for the isothermal walls case as *** is shown that it is entirely a substitution to the exact numerical solution for the isothermal walls case.

关键词：非等温 Navier-Stokes 气体 Knudsen数温度跳跃速度滑移流动条件流量分析

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Tough PEG-only hydrogels with complex 3d structure enabled by digital light processing of“all-PEG”resins

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Aggregate 2023年第6期4卷 57-70页

作者： Safira Noor Anindita Riccardo Conti doris Zauchner nevena Paunovi´c Wanwan Qiu Marina Green Buzhor Adva Krivitsky Zhi Luo Ralph Müller Hansjörg Grützmacher Xiao-Hua Qin Jean-Christophe Leroux Yinyin Bao department of Chemistry and Applied Biosciences Institute of Pharmaceutical SciencesETH ZurichZunichSwitzerland Laboratory of Inorganic Chemitry Department of Chemistry and Applied BiosciencesETH ZurichZurichSwitzerland department of Health Sciences and Technology Institute for BiomechanicsETH ZurichZurichSwitzerland

digital light processing(dLP)of structurally complex poly(ethylene glycol)(PEG)hydrogels with high mechanical toughness represents a long-standing challenge in theﬁeld of 3d ***,we report a 3d printing approach for the high-resolution manufacturing of structurally complex and mechanically strong PEG hydrogels via heat-assisted *** of using aqueous solutions of photo-crosslinkable monomers,PEG macromonomer melts wereﬁrst printed in the absence of water,resulting in bulk PEG ***,post-printing swelling of the printed networks was achieved in water,producing high-ﬁdelity 3d hydrogels with complex *** employing a dual-macromonomer resin containing a PEG-based four-arm macrophotoinitiator,“all-PEG”hydrogel constructs were pro-duced with compressive toughness up to 1.3 MJ m^(-3).By this approach,porous 3d hydrogel scaffolds with trabecular-like architecture were fabricated,and the scaf-fold surface supported cell attachment and the formation of a monolayer mimicking bone-lining *** study highlights the promises of heat-assisted dLP of PEG photopolymers for hydrogel fabrication,which may accelerate the development of 3d tissue-like constructs for regenerative medicine.

关键词： 3d printing digital light processing PEG hydrogels

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