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Sources of transcription variation in Plasmodium falciparum

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Journal of Genetics and Genomics 2022年第10期49卷 965-974页

作者： Lindsey B.Turnbull Katrina A.Button-Simons nestor Agbayani Michael T.Ferdig Department of Pediatrics Indiana University School of MedicineIndianapolisIN 46202USA Department of Biological Sciences Eck Institute for Global HealthUniversity of Notre DameNotre DameIN 46556USA Rush School of Medicine ChicagoIL 60612USA

Variation in transcript abundance can contribute to both short-term environmental response and long-term evolutionary *** studies are designed to assess differences in mean transcription levels and do not consider other potentially important and confounding sources of transcriptional *** quantification of variation sources will improve our ability to detect and identify the mechanisms that contribute to genome-wide transcription changes that underpin adaptive *** quantify innate levels of expression variation,we measured m RnA levels for more than 5000 genes in the malaria parasite,Plasmodium falciparum,among clones derived from two parasite strains across biologically and experimentally replicated *** a mixed effects model,we partitioned the total variation among four sources—between strain,within strain,environmental batch effects,and stochastic *** found 646 genes with significant variation attributable to at least one of these *** genes were categorized by their predominant variation source and further examined using gene ontology enrichment analysis to associate function with each source of *** with environmental batch effect and within strain transcript variation may contribute to phenotypic plasticity,while genes with between strain variation may contribute to adaptive responses and processes that lead to parasite strain-specific survival under varied conditions.

关键词： Expression variation Malaria Transcription Cloning Microarray

Approximate Expressions to Evaluate the Performance in Butene-1 Purification Units

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Chinese Journal of Chemical Engineering 1998年第3期6卷 87-92页

作者： Sergio P.Bressa nestor O.Ardiaca Osvaldo M.Martinez Guillermo F.Barreto Depto.de Ing.Qca. Fac.de Ing.U.N.L.P.l esq.47(1900)La PlataDepto.de Ing.Qca.Fac.de Ing.U.N.L.P.l esq.47(1900)La PlataDepto.de Ing.Qca.Fac.de Ing.U.N.L.P.l esq.47(1900)La PlataDepto.de Ing.Qca.Fac.de Ing.U.N.L.P.l esq.47(1900)La Plata

1 InTRODUCTIOnSelective hydrogenatioll of small amounts of butynes and butadiene is industrially employedfor obtaining high purity butene-l used as co-monomer in the production of linear *** this purpose,the content o... 详细信息

关键词： selective hydrogenation butene-1 1 3-butadiene trickle bed reactor

A review of feed efficiency in swine:biology and application

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Journal of Animal Science and Biotechnology 2015年第4期6卷 369-377页

作者： John F.Patience Mariana C.Rossoni-Seräo nestor A.Gutiérrez Department of Animal Science Iowa State University

Feed efficiency represents the cumulative efficiency with which the pig utilizes dietary nutrients for maintenance, lean gain and lipid accretion. It is closely linked with energy metabolism, as the oxidation of carbon-containing components in the feed drive all metabolic processes. While much is known about nutrient utilization and tissue metabolism, blending these subjects into a discussion on feed efficiency has proven to be difficult. For example, while increasing dietary energy concentration will almost certainly increase feed efficiency, the correlation between dietary energy concentration and feed efficiency is surprisingly low. This is likely due to the plethora of non-dietary factors that impact feed efficiency, such as the environment and health as well as individual variation in maintenance requirements, body composition and body weight. nonetheless, a deeper understanding of feed efficiency is critical at many levels. To individual farms, it impacts profitability. To the pork industry, it represents its competitive position against other protein sources. To food economists, it means less demand on global feed resources. There are environmental and other societal implications as well. Interestingly, feed efficiency is not always reported simply as a ratio of body weight gain to feed consumed. This review will explain why this arithmetic calculation, as simple as it initially seems, and as universally applied as it is in science and commerce, can often be misleading due to errors inherent in recording of both weight gain and feed intake. This review discusses the importance of feed efficiency, the manner in which it can be measured and reported, its basis in biology and approaches to its improvement. It concludes with a summary of findings and recommendations for future efforts.

关键词： Caloric efficiency Energy Feed efficiency Residual feed intake Swine

生物医用Ti6Al4V合金上电弧沉积TiAln陶瓷涂层的表面、力学和体外腐蚀性能

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Transactions of nonferrous Metals Society of China 2023年第2期33卷 494-506页

作者： Mohamed HUSSEIn Madhan KUMAR nestor AnKAH Ahmed ABDELAAL Interdisciplinary Research Center for Advanced Materials King Fahd University of Petroleum&MineralsDhahran 31261Saudi Arabia Department of Mechanical Engineering King Fahd University of Petroleum&MineralsDhahran 31261Saudi Arabia

研究在医用Ti6Al4V合金上采用阴极电弧蒸发沉积制备的纳米晶TiAln涂层的表面特性和体外腐蚀性能。采用XRD和FE-SEM对其结构和表面形貌进行分析,采用显微压痕法表征其表面的显微硬度,在模拟体液和人工唾液中进行体外腐蚀实验。结果表明:... 详细信息

研究在医用Ti6Al4V合金上采用阴极电弧蒸发沉积制备的纳米晶TiAln涂层的表面特性和体外腐蚀性能。采用XRD和FE-SEM对其结构和表面形貌进行分析,采用显微压痕法表征其表面的显微硬度,在模拟体液和人工唾液中进行体外腐蚀实验。结果表明:与无涂层合金相比,沉积TiAln涂层后合金的表面硬度提高,为44.4 GPa,弹性模量为419.9 GPa,塑性变形能力增强,润湿角由(70.61±1.25)°增大到(86.27±2.2)°。生物腐蚀实验表明,沉积TiAln涂层后,Ti6Al4V合金的腐蚀电位显著正移约150 m V,腐蚀电流密度显著降低约一个数量级,电荷转移电阻提高,证明合金的耐腐蚀性提高。与无涂层的合金相比,沉积TiAln涂层后合金的表面性能、力学性能和耐腐蚀性能均有所提高。

关键词： CA-PVD TiAln 涂层腐蚀生物医用合金钛

Autolytic and Proteolytic Properties of Strains of<i>Lactococcus lactis</i>Isolated from Different Vegetables, Raw-Milk Cheeses and Commercial Starter Cultures

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Food and nutrition Sciences 2013年第11期4卷 21-26页

作者： Carolina nájera-Domínguez nestor Gutiérrez-Méndez Chemistry Faculty University Autonomous of Chihuahua Chihuahua Mexico.

The autolysis and proteolysis are important features in the strains of L. lactis used in the manufacture of cheese. The autolytic and proteolytic activity of L. lactis has been linked with the development of flavor and texture in the cheese. On the other hand, there is a growing interest in new strains isolated from raw-milk cheeses and vegetables. These wild-strains have showed different features of industrial importance in comparison with those observed in commercial cultures. However, it still not clear if the autolytic and proteolytic properties of these wild-strains differ from the industrial strains. The objective of this work was to assess the autolytic and proteolytic activities of 21 strains of L. lactis isolated from diverse sources. The rates of autolysis and proteolysis observed in vitro were highly strain-dependent. The pH and the naCl concentration in the media affected significantly the autolysis of L. lactis. The strains isolated from vegetable showed in general low and medium autolytic activity, whereas the strains isolated from raw-milk cheeses had medium to high autolytic activity. The strain with highest proteolytic activity was a strain isolated from corn leaves. Although still not clear how this strain acquired this pronounced characteristic.

关键词： Com Autolysis Proteolysis L. lactis Wild-Strains

Small-signal Model for Dual-active-bridge Converter Considering Total Elimination of Reactive Current

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Journal of Modern Power Systems and Clean Energy 2021年第2期9卷 450-458页

作者： Juan Ramon Rodriguez-Rodriguez nadia Maria Salgado-Herrera Jacinto Torres-Jimenez nestor gonzalez-Cabrera David Granados-Lieberman Martin Valtierra-Rodriguez the Universidad nacional Autonoma de Mexico Facultad de IngenieriaDepto.Energia Electri-ca.Av.Universidad 3000Col.UNAM CUCoyoacanCDMXMexico the Instituto de Energias Renovables Universidad Nacional Autonoma de MexicoPriv.Xochicalco s/nCol.Centro.TemixcoMorelosMexico the Instituto Tec-nologico Superior de Irapuato Carretera Irapuato-Silao km 12.5.IrapuatoGuanajuatoMexico the Universidad Autonoma de Queretaro Campus San Juan del RioRio Moctezuma 249San Juan del RioQueretaroMexico

Emerging technologies such as electric vehicles,solid-state transformers,and DC transformers are implemented using the closed-loop bi-directional dual-active-bridge(DAB)*** this context,it is necessary to have average models that provide an efficient way of tuning the proportional integral(PI)compensator parameters for large-and small-signal *** present a novel small-signal model(SSM)for DAB converter with a single closed-loop PI controller and the total elimination of reactive current(IQ=0).The method applies a modulation technique for IQ=0 and introduces a composite function in the controller while reducing the original nonlinear switching model,which allows to decrease the order of the transfer function and analyze the closed-loop *** proposed SSM is analyzed using different response time,load,and DC voltage *** simulation and experimental results demonstrate the ease of implementation and effectiveness of the proposed model with respect to other SSM techniques.

关键词： Small-signal model(SSM) dual-active-bridge(DAB)converter reactive current elimination proportional integral(PI)control

Inflammation-induced PInCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons

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Translational neurodegeneration 2020年第3期9卷 393-408页

作者： Kalimuthusamy natarajaseenivasan Santhanam Shanmughapriya Prema Velusamy Matthew Sayre Alvaro Garcia nestor Mas Gomez Dianne Langford Department of neurosciences and Center for neurovirology Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPA 19140USA Department of Microbiology Bharathidasan UniversityTiruchirappalli 620024India Heart and Vascular Institute Department of MedicineDepartment of Cellular and Molecular PhysiologyPenn State College of MedicineHersheyPA 17033USA

Background:Diseases and disorders with a chronic neuroinflammatory component are often linked with changes in brain *** neurodegenerative disorders,people living with human immunodeficiency virus(HIM)and Alzheimer's disease(AD)are particularly vulnerable to metabolic disturbances,but the mechanistic connections of inflammation,neurodegeneration and bioenergetic deficits in the central nervous system(CnS)are poorly *** particularly interesting new cysteine histidine-rich-protein(PInCH)is nearly undetectable in healthy mature neurons,but is robustly expressed in tauopathy-associated neurodegenerative diseases including HIV infection and *** robust PInCH expression has been reported in neurons in the brains of patients with HIV and AD,the molecular mechanisms and cellular consequences of increased PInCH expression in CnS disease remain largely ***:We investigated the regulatory mechanisms responsible for PInCH protein-mediated changes in bioenergetics,mitochondrial subcellular localization and bioenergetic deficits in neurons exposed to physialogical levels of TnFa or the HIV protein *** in the PInCH-ILK-Parvin(PIP)complex association with cofilin and TESK1 were assessed to identify factors responsible for actin depolymerization and mitochondrial *** and pharmacological inhibition experiments were conducted to confirm PInCH specificity and to reinstate proper protein-protein complex ***:We identified MEF2A as the PInCH transcription factor in neuroinflammation and determined the biological consequences of increased PInCH in ***-mediated activation of MEF2A via increased cellular calcium induced PInCH,leading to disruption of the PIP ternary complex,cofilin activation by TESK1 inactivation,and actin *** disruption of actin led to perinuclear mislocalization of mitochondria by destabilizing the kinesin-dependent mitochondrial transport machinery,resulting i

关键词： neuron Mitochondria Actin PInCH neuroinflammation

Influence of Post-Harvest Storage Technologies on Weight and Rate Losses and Sensory Profile of Cola nuts (<i>Cola nitida</i>) Produced in Côte d’Ivoire

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Open Journal of Applied Sciences 2018年第9期8卷 371-380页

作者： Jean-Marc n’Guessan Elisée Yapi Kouakoua nestor Kouakou Kouassi Georges n’Guessan Amani Department of Food Sciences and Technologies Nangui Abrogoua University Abidjan C&ocirc te d’Ivoire

The conservation of cola nuts (Cola nitida) poses a real problem in Côte d’Ivoire because of the post-harvest losses. The objective of this study was to evaluate the impact of post-harvest technologies on organoleptic and physical properties of cola nut during storage. A biopesticide, glucose syrup and biopesticide + glucose syrup were applied to fresh cola nuts before conditioning and kept at 28°C for 6 weeks. Physicochemical and sensory analyses were performed to check the quality of the nuts during storage. The results showed that the biopesticide keep cola nuts better than the others methods with only 11.66% ± 3.04% and 13.66% ± 3.95% of loss rates for white and red cola nuts respectively. Cola nuts treated with bio-pesticide retain significantly their freshness with 62.00% ± 1.15% of moisture for white nuts and 64.00% ± 2.00% of moisture for red nuts compared to those treated with glucose syrup and bio-pesticide + glucose syrup (56.66% ± 1.15%). Cola nuts treated with biopesticide have a better acceptability compared to those subjected to others treatments. The use of biopesticide for the storage of cola nuts minimizes the losses and maintains the quality whatever the type of cola.

关键词： Cola nitida Storage Post-Harvest Losses Biopesticide Glucose Syrup Quality

Impacts of Field Harvesting and Conservation Practices on the Physical Quality of Yam “Kponan” (Dioscorea cayenensis-rotundata) of Côte D’Ivoire

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Open Journal of Applied Sciences 2022年第12期12卷 1979-1994页

作者： Yapo Hypolithe Kouadio Kouakou nestor Kouassi Daouda nimaga Yao Denis n’dri n’Guessan Georges Amani Laboratory of Food Biochemistry and Technology of Tropical Products Department of Food Science and Technology NANGUI ABROGOUA University Abidjan C&ocirc te D’Ivoire Swiss Center for Scientific Research in Cô te d’Ivoire (CSRS-CI) Abidjan C&ocirc te D’Ivoire Agronomic Forestry and Environmental Engineering Department University of Man Man C&ocirc te D’Ivoire

Yam “Kponan” (Dioscorea cayenensis-rotundata) is a popular staple food in Côte d’Ivoire. However, its rapid decay during conservation prevents regular supply of markets. The objective of this study was therefore to assess the impact of field cultivation and conservation practices on some physical quality parameters of “Kponan”. To this end, “Kponan” yam from three production areas (Bondoukou, Bouna, Kouassi-Kouassikro) was cultivated in each area. At maturity, physical parameters of yams at harvest and after 3 months of storage in field were analyzed. The results showed that injury was the most significant deterioration in yam harvest. The rate of injured yams was highest for hoe-harvested in Kouassi-Kouassikro area (16.67% - 22.22%) regardless of the origin of the cuttings. The main damage observed after the 3 months of storage was rots (22.86% - 60.00%) and weight loss (8.57% - 42.86%). However, yams stored in pits in Bouna zone had less damage (40% - 48.87%) than those stored under straw huts in Bondoukou locality (100%) and at shade under a tree in Kouassi-Kouassikro area (100%). In conclusion, the physical quality of “Kponan” in field is most affected by abusive use of herbicides during weeding and clearing, hoe harvesting and storage in the shade under a tree.

关键词： “Kponan” Yam Post-Harvest Loss Cultivation Practices Conservation Practices Physical Quality