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Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery

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World Journal of Gastroenterology 2005年第47期11卷 7473-7479页

作者： nestor gonzález-roldán Eduardo Ferat-Osorio Rosalía Aduna-Vicente Isabel Wong-Baeza noemí Esquivel-Callejas Horacio Astudillo-de la Vega Patricio Sánchez-Fernández Lourdes Arriaga-Pizano Miguel Angel Villasís-Keever Constantino López-Macías Armando Isibasi Unidad de Investigación Médica en Inmunoquímica Hospital de EspecialidadesCentro Médico Nacional Siglo ⅩⅪInstituto Mexicano del Seguro Social (IMSS)México Laboratorio de Oncología Molecular Unidad de Investigación Médica en Enfermedades OncológicasHospital de OncologíaCentro Médico Nacional Siglo ⅩⅪIMSSMéxico Servicio de Gastrocirugía Hospital de EspecialidadesCentro Médico Nacional Siglo ⅩⅪIMSSMéxico Unidad de Investigación en Epidemiología Clínica Hospital de PediatríaCentro Médico Nacional Siglo ⅩⅪIMSSMéxico

AIM： To evaluate the surface expression of triggering receptor on myeloid cell 1 （TREM-1）, class Ⅱ major histocompatibility complex molecules （HLA-DR）, and the expression of the splicing variant （svTREH-1） of TREM-1 in septic patients and those subjected to major abdominal surgery. METHODS： Using flow cytometry, we examined the surface expression of TREM-1 and HLA-DR in peripheral blood monocytes from 11 septic patients, 7 elective gastrointestinal surgical patients, and 10 healthy volunteers, svTREM-1 levels were analyzed by RT-PCR. RESULTS： Basal expression of TREM-1 and HLA- DR in healthy volunteers was 35.91±14.75 MFI and 75.8±18.3%, respectively. In septic patients, TREM-1 expression was 59.9±23.9 MFI and HLA-DR expression was 44.39±20.25%, with a significant difference between healthy and septic groups （P〈0.05） for both molecules. In the surgical patients, TREM-1 and HLA-DR expressions were 56.8±20.85 HFI and 71±13.8% before surgery and 72.65±29.92 MFI and 72.82±22.55% after surgery. TREM-1 expression was significantly different （P = 0.0087） between the samples before and after surgery and svTREM-1 expression was 0.8590± 0.1451 MF1, 0.8820±0.1460 MF1, and 2.210±0.7873 MF1 in the healthy, surgical （after surgery） and septic groups, respectively. There was a significant difference （P = 0.048） in svTREM-1 expression between the healthy and surgical groups and the septic group. COnCLUSIOn： TREM-1 expression is increased during systemic inflammatory conditions such as sepsis and the postoperative phase. Simultaneous low expression of HLA-DR molecules correlates with the severity of illness and increases susceptibility to infection. Additionally, TREM-1 expression is distinctly different in surgical patients at different stages of the inflammatory response before and after surgery. Thus, surface TREM-1 appears to be an endogenous signal during the course of the inflammatory response, svTREM-1 expression is significantly increased during sepsis, appearing to be a

关键词： TRFM-1 HLA-DR SIRS CARS Sepsis

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Advancing respirable coal mine dust source apportionment:a preliminary laboratory exploration of optical microscopy as a novel monitoring tool

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International Journal of Coal Science & Technology 2024年第2期11卷 222-233页

作者： nestor Santa Emily Sarver Department of Mining and Minerals Engineering Virginia TechBlacksburgVA 24061USA

Exposure to respirable coal mine dust(RCMD)can cause chronic and debilitating lung ***-time monitoring capabilities are sought which can enable a better understanding of dust components and *** many underground mines,RCMD includes three primary components which can be loosely associated with three major dust sources:coal dust from the coal seam itself,silicates from the surrounding rock strata,and carbonates from the inert‘rock dust’products that are applied to mitigate explosion hazards.A monitor which can reliably partition RCMD between these three components could thus allow source *** tracking silicates,specifically,could be valuable since the most serious health risks are typically associated with this component-particularly if abundant in crystalline *** a monitoring concept based on field microscopy,and following up on prior research using polarized light,the aim of the current study was to build and test a model to classify respirable-sized particles as either coal,silicates,or *** model development,composite dust samples were generated in the laboratory by successively depositing dust from high-purity materials onto a sticky transparent substrate,and imaging after each deposition event such that the identity of each particle was known a *** testing followed a similar approach,except that real geologic materials were used as the source for each dust *** showed that the model had an overall accuracy of 86.5%,indicating that a field-microscopy based moni-tor could support RCMD source apportionment and silicates tracking in some coal mines.

关键词： Polarized light microscopy Image processing Dust monitoring Respirable silica Coal mining

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Dynamics analysis and cryptographic implementation of a fractional-order memristive cellular neural network model

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Chinese Physics B 2024年第4期33卷 418-433页

作者：周新卫蒋东华 Jean De Dieu nkapkop Musheer Ahmad Jules Tagne Fossi nestor Tsafack 吴建华 Department of Information Engineering Gongqing CollegeNanchang UniversityJiujiang 332020China School of Computer Science and Engineering Sun Yat-Sen UniversityGuangzhou 511400China Department of Electrical Engineering and Industrial Computing University Institute of TechnologyDoualaCameroon Department of Computer Engineering Jamia Millia IslamiaNew Delhi 110025India Department of Physics Faculty of ScienceUniversity of YaoundeCameroon Electrical Engineering Department and Industrial Computing of ISTAMA University of DoualaDoualaCameroon

Due to the fact that a memristor with memory properties is an ideal electronic component for implementation of the artificial neural synaptic function,a brand-new tristable locally active memristor model is first proposed in this ***,a novel four-dimensional fractional-order memristive cellular neural network(FO-MCnn)model with hidden attractors is constructed to enhance the engineering feasibility of the original Cnn model and its ***,its hardware circuit implementation and complicated dynamic properties are investigated on multi-simulation ***,it is used toward secure communication application *** it as the pseudo-random number generator(PRnG),a new privacy image security scheme is designed based on the adaptive sampling rate compressive sensing(ASR-CS)***,the simulation analysis and comparative experiments manifest that the proposed data encryption scheme possesses strong immunity against various security attack models and satisfactory compression performance.

关键词： cellular neural network memristor hardware circuit compressive sensing privacy data protection

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nodal user’s demand response based on incentive based programs

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Journal of Modern Power Systems and Clean Energy 2017年第1期5卷 79-90页

作者： nestor gonzález-CABRERA Guillermo GUTIéRREZ-ALCARAZ Instituto Tecnolo´gico Superior de Irapuato Irapuato 36620Mexico Instituto Tecnolo´gico de Morelia Morelia 58120Me´xico

This paper describes a practical approach to identify nodal price compensation payment for nodal consumers willing to reduce their energy consumption(consumers’ demand response). The implementation of a nodal reliability service pricing is based on contingency assessment of n-2 order for transmission lines. A representative annualized demand curve is used to reflect the system’s operation condition by seasons. Such curve is used to access the nodal reliability impact trough a whole year in order to determine back-payments(incentive payment) to users for service interruption. The IEEE_RTS 24 nodes system is used to implement the proposed approach.

关键词： nodal demand response Demand side management Reliability assessment Incentive based programs(IBP)

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Multi-Scale Approach for Gold Targeting in Côte d’Ivoire Paleoproterozoic Rocks

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Open Journal of Geology 2024年第2期14卷 155-176页

作者： Martial Pohn Koffi Adingra Yao Augustin Koffi n’guessan nestor Houssou Zié Ouattara Tokpa Kakeu Lionel-Dimitri Boya Marc Ephrem Allialy Training and Research Unit in Earth Sciences and Mineral Resources Laboratory of Geology Mineral and Energy Resources University Felix HOUPHOU&#203T-BOIGNY Abidjan C&#244te d’Ivoire Training and Research Unit in Geological Sciences and Mining Department of Geology and Material Man University Man C&#244te d’Ivoire

The aim of this study is to contribute to better targeting of gold prospecting areas using geospatial information. To this end, 3 mining sites were selected for the study. They are: the Sénoufo belt (Barrick Gold mine), the Yaouré complex (Perseus Mining mine) and the South Fetêkro belt (Bonikro, Hiré and Agbaou mines). For this study, a multi-scale approach was carried out at regional, mine and microscopic levels. At the regional scale, a comparative analysis of 1:200,000 scale geological maps revealed that 3 main lithologies are regularly repeated on and around the various mining sites. These are: undifferentiated volcanics, metagranodiorites and metasiltites dominated by meta-arenites. Most of these lithologies are affected by undifferentiated faults generally oriented nE-SW, n-S, EnE-WSW and WnW-ESE. In addition, gold and manganese occurrences are present on all the sites studied. At the mine scale, radarsat-1 images processing indicate that the main mining sites are generally located near or at the intersection of lineaments-oriented nE-SW or n-S on the one hand and E-W or EnE-WSW or WnW-ESE or again nW-SE on the other. These mines are also located at the interface between zones of high and low lineament density. At the microscopic scale, petrographic studies of undifferentiated volcanic samples from the various sites indicate that they consist of andesites, meta-andesites and tuffs.

关键词： Gold Targeting Undifferentiated Volcanics Mineral Occurrences Lineaments Côte d’Ivoire

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Male and Female Hypogonadisms: Etiological, Metabolic and Osteodensitometric Aspects

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Open Journal of Endocrine and Metabolic Diseases 2024年第2期14卷 39-52页

作者： nestor Ghislain Andzouana Mbamognoua Ikram Damoune Sana Doubi Asmae Lahlou Farida Ajdi Department of Metabolic and Endocrine Diseases Brazzaville University Hospital Brazzaville Republic of the Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo Department of Endocrinology Metabolic Diseases Hassan II University Hospital of Fez Fez Morocco

Introduction: Studies showed a high prevalence of metabolic abnormalities including dyslipidemia, type 2 diabetes in cases of low testosterone in men and which are associated with increased cardiovascular risk. Hypogonadism represents the second cause of endocrine osteoporosis. Objectives: The objectives of our work were: to determine the main causes of hypogonadism in women and men;to assess the frequency of metabolic and osteosdensitometric abnormalities in the hypogonadal population. Patients and methods: A retrospective descriptive study was carried out over 7 years on 120 patients, hospitalized in the Endocrinology department of the Hassan II University Hospital of Fez-Morocco for hypogonadism. The patients selected were those who had symptoms of hypogonadism confirmed in men by: low total testosterone for Tanner stage in adolescents, ng/ml or lower limit of normal for adults;in women, hypoestrogenia 30 pg/l. Gonadotropin dosage, karyotype, pelvic or testicular ultrasound and pituitary MRI, for etiological diagnosis, were performed. Bone densitometry was performed for bone impact and lipid profile for metabolic profile. Results: Out of 120 patients, there were 77 women and 43 men. The average age was 31.51 years. In men, the main causes were central hypogonadism in 67.4% and primary testicular failure in 32.6%. In women, central hypogonadism was also the most common cause noted in 63.7% and premature ovarian failure was observed in 36.4%. HypoHDL was significantly more frequent p (0.005) in women, osteopenia and osteoporosis were significantly more frequent in women than in men p (0.046). Conclusion: Central causes represent the most common etiology of hypogonadism in both sexes;abnormalities of bone mineralization and metabolic disorders were predominant in women.

关键词： Hypogonadism Etiological Metabolic Osteodensitometric Fez

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Aqueous extract of Ocimum tenuiflorum decreases levels of blood glucose in induced hyperglycemic tilapia(Oreochromis niloticus)

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Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 634-637页

作者： Amilcar Arenal Leonardo Martín nestor M Castillo Dainier de la Torre Ubaldo Torres Reinaldo gonzlez Biochemistry Laboratory Department of Morphophysiology University of Camagüey Km 51/2 74650Cuba Biochemistry Laboratory Department of BiochemistryUniversity of HavanaCuba Center for Genetic Engineering and Biotechnology.P.O.Box 387 Camagüey 70100 Policlinic "Julio Antonio Mella" CamagüeyCuba Biochemistry Laboratory Department of Morphophysiology University of Camagüey Km 5 1/2 74650Cuba

Objective:To evaluate,in hyperglycemic tilapia[Oreochromis niloticus(***)].the effect of this aqueous extract on blood glucose ***:The hyperglycemia in *** was induced by adding glucose to fish pond *** aqueous extract of Ocimum tenuiflorum (***) was prepared by boiling fresh leaves and the doses of 0,40,80,200 and 400 mg per liter of pond water were ***:The blood sugar concentration for tilapia with hyperglycemic induced was an average of 50%higher than the control *** blood glucose levels in tilapia after the induction of hyperglycemia were higher than the control group for 90 min after the *** treatment with the aqueous extract of *** dropped the serum glucose level of hyperglycemic tilapia until it was similar to that of the control group and was dose ***:The results indicated that *** was endowed with anti-hyperglycemic *** our knowledge,this is the first report on the use of fish as a diabetes model to test natural extracts from plants.

关键词： Ocimum tenuiflorum Fish model Diabetes mellilus Phytotherapy Tilapi

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Optimization of the Pretreatment of the Mixture of Cassava Peelings and Pineapple Fibers Using Response Surface Methodology and a Process Simulator for the Bioethanol Production

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Energy and Power Engineering 2024年第2期16卷 79-96页

作者： Paul nestor Djomou Djonga George Elambo nkeng Madjoyogo Hervé Sirma Ahmat Tom Thierry Tchamba Tchuidjang Department of Textile and Leather Engineering National Advanced School of Engineering of Maroua Maroua Cameroon Department of Civil Environmental and Architectural Engineering University of Padova Padova Italy Institut du Génie des Systèmes Industriels et textiles Ecole Polytechnique de Ouagadougou Ouagadougou Burkina-Faso Department of Energy Engineering University Institute of Technology University of Ngaoundere Ngaoundere Cameroon Department of Process Engineering National Advanced School of Agro-Industrial Sciences University of Ngaoundere Ngaoundere Cameroon

The increase in oil prices and greenhouse gas emissions has led to the search for substitutes for fossil fuels. In Cameroon, the abundance of lignocellulosic resources is inherent to agricultural activity. Production of bioethanol remains a challenge given the crystallinity of cellulose and the presence of the complex. The pretreatment aimed to solubilize the lignin fraction and to make cellulose more accessible to the hydrolytic enzymes, was done using the organosolv process. A mathematical modeling was performed to point out the effect of the temperature on the kinetics of the release of the reducing sugars during the pretreatment. Two mathematical model was used, SAEMAn’s model and Response surface methodology. The first show that the kinetic parameters of the hydrolysis of the cellulose and reducing sugar are: 0.05089 min-1, 5358.1461 J·mol-1, 1383.03691 min-1, 51577.6100 J·mol-1 respectively. The second model was used. Temperature is the factor having the most positive influence whereas, ethanol concentration is not an essential factor. To release the maximum, an organosolv pre-treatment of this sub-strate should be carried out at 209.08°C for 47.60 min with an ethanol-water ratio of 24.02%. Organosolv pre-treatment is an effective process for delignification of the lignocellulosic structure.

关键词： Bioethanol Cassava Peeling Pineapple Fibers Organosolv Process and Optimization

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Assessment of Cement-Lime as Stabilizer on Mud Bricks

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Journal of Materials Science and Chemical Engineering 2024年第7期12卷 1-13页

作者： Chrisdel Chancelice ndjeumi Djonga Paul nestor Djomou George Elambo nkeng Fatoumata Adda Souaibou Soulemane Anong Department of Environmental Sciences ENSPM University of Maroua Maroua Cameroon Department of Leather and Textile Engineering ENSPM University of Maroua Maroua Cameroon Department of Civil Environmental and Architectural Engineering University of Padova Padova Italy Laboratory of Analysis of CIMEnCAM Garoua Cameroon

The aim of this study was to evaluate the compressive strength of clay bricks and their stability to water absorption by inserting stabilizers such as lime and cement of 0%, 4%, 6%, 8%, 10%, 12% to 14%. Spectrometric analysis was used to characterize the various stabilizers and the clay used, and tests of resistance and water absorption were also carried out. The clay was found to be an aluminosilicate (15.55% to 17.17% Al2O3 and 42.12% to 44.15% SiO2). The lime contains 90.84% CaO and the cement has 17.80% SiO2, 3.46% Al2O3, 2.43% Fe2O3 and 58.47% CaO in the combined form of tricalcium silicate, dicalcium silicate, tricalcium aluminate and ferro-tetra calcium aluminate. The results showed that the insertion of locally available stabilizers (lime and cement) improved the strength of the material by almost 80% when the lime was increased from 0% to 14% for 14 days. For compressed cement, a 65% increase in strength was observed under the same conditions. Strength increases with drying time, with a 52% increase in strength at 28 days compared to 14 days. Furthermore, compressed cement bricks have a more compact structure, absorbing very little water (32%). In view of all these results, cement appears to be the best stabilizer, and compression improves compressive strength and reduces water absorption.

关键词： Cement-Stabilized Earth Lime-Stabilized Earth Compressed Earth Brick Compressive Strength Water Absorption Test

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Diversity of Macro Invertebrates of the River Rwizi in Western Uganda: A Citizen Science-BioBlitz Approach

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Open Journal of Ecology 2024年第4期14卷 343-365页

作者： John Bosco nkurunungi Godwin Muhairwe Upton nuwagira nickson Araka nestor Mugabe Osbert natwijuka Jeninah Atwebembeire Mbarara University of Science and Technology Mbarara Uganda Department of Directorate of Research and Graduate Training Makerere University Kampala Uganda

This study elucidates the pivotal role of citizen science-BioBlitz methodologies for rapid assessment of the macro-invertebrate taxa within the threatened River Rwizi of South-western Uganda. Utilizing a comprehensive mixed-methods approach, the investigation focused on six distinct river segments to demonstrate the efficacy of participatory citizen science-BioBlitz approaches conducted by experts, students and community volunteers. BioBlitz events included rigorous macro-invertebrate sampling at each of the selected sites along River Rwizi on nine occasions, incorporating collaborative taxonomic identification procedures involving experts, students, and the local community. Analyzing pollution concerns, diversity metrics, and community narratives yielded insights into river health and socio-ecological dynamics. A total of 43 macro-invertebrate families across 17 orders were documented with class Insecta dominating. Participants in BioBlitz events expressed predominantly positive sentiments, emphasizing satisfaction, education, and heightened awareness, besides negative sentiments rooted in historical mistrust. Intriguingly, the study unveiled an unforeseen trend in macro-invertebrate taxa richness, rising from upstream to urban sprawl and diminishing at peri-urban downstream sites. The study underscores the potential of citizen science-BioBlitz methodologies in advancing community science education and unraveling the intricate dynamics of threatened river ecosystems. The insights offered are invaluable for policymakers and conservationists seeking effective strategies to address challenges in the River Rwizi and comparable ecosystems. .

关键词： Diversity Macroinvertebrates Rwizi Citizen-Science-BioBlitz 6

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