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Boric acid reduces axonal and myelin damage in experimental sciatic nerve injury

Neural Regeneration Research 2016年第10期11卷 1660-1665页

作者： Zahir Kizilay Haydar Ali Erken nesibe kahraman cetin Serdar Aktas Burcin lrem Abas Ali Yilmaz Department of Neurosurgery Faculty of Medicine Adnan Menderes University Aydin Turkey Department of Physiology Faculty of Medicine Balikesir University BalikesirTurkey Department of Pathology Faculty of Medicine Adnan Menderes University Aydin Turkey Department of Pharmacology and Toxicology Faculty of Medicine Adnan Menderes University Aydin Turkey Department of Clinical Biochemistry Faculty of Medicine Adnan Menderes University AydinTurkey

The aim of this study was to investigate the effects of boric acid in experimental acute sciatic nerve injury. Twenty-eight adult male rats were randomly divided into four equal groups （n = 7）： control （C）, boric acid （BA）, sciatic nerve injury （I） , and sciatic nerve injury ＋ boric acid treatment （BAI）. Sciatic nerve injury was generated using a Yasargil aneurysm clip in the groups I and BAI. Boric acid was given four times at 100 mg/kg to rats in the groups BA and BAI after injury （by gavage at 0, 24, 48 and 72 hours） but no injury was made in the group BA. In vivo electrophysiological tests were performed at the end of the day 4 and sciatic nerve tissue samples were taken for histopathological examination. The amplitude of compound action potential, the nerve conduction velocity and the number of axons were significantly lower and the myelin structure was found to be broken in group I compared with those in groups C and BA. However, the amplitude of the compound action potential, the nerve conduction velocity and the number of axons were significantly greater in group BAI than in group I. Moreover, myelin injury was significantly milder and the intensity of nuclear factor kappa B immunostaining was significantly weaker in group BAI than in group I. The results of this study show that administration of boric acid at 100 mg/kg after sciatic nerve injury in rats markedly reduces myelin and axonal injury and improves the electrophysiological function of injured sciatic nerve possibly through alleviating oxidative stress reactions.

关键词： nerve regeneration peripheral nerve injury sciatic nerve boric acid nerve conduction velocity axon myelin electrophysiology neural regeneration

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