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Phosphorylation of PHF2 by AmPK releases the repressive H3K9me2 and inhibits cancer metastasis

signal Transduction and Targeted Therapy 2023年第4期8卷 1857-1873页

作者： Ying Dong Hao Hu Xuan Zhang Yunkai Zhang Xin sun Hanlin Wang Weijuan kan min-jia Tan Hong shi Yi Zang Jia Li state Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of sciences Beijing 100049China school of Pharmacy Henan UniversityKaifeng 475004China Department of Pharmacology Fudan UniversityShanghai 201203China Department of Anesthesiology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Lingang laboratory Shanghai 201203China school of Pharmaceutical science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantaiShandong 264117China Open studio for Druggability Research of marine Natural Products Pilot National Laboratory for Marine Science and Technology(Qingdao)1 Wenhai RoadAoshanweiJimoQingdao 266237China

Epithelial to mesenchymal transition (EmT) plays a crucial role in cancer metastasis, accompanied with vast epigenetic ***-activated protein kinase (AmPK), a cellular energy sensor, plays regulatory roles in multiple biological processes. Although afew studies have shed light on AmPK regulating cancer metastasis, the inside epigenetic mechanisms remain unknown. Herein weshow that AmPK activation by metformin relieves the repressive H3K9me2-mediated silencing of epithelial genes (e.g., CDH1)during EmT processes and inhibits lung cancer metastasis. PHF2, a H3K9me2 demethylase, was identified to interact with AmPKα*** deletion of PHF2 aggravates lung cancer metastasis and abolishes the H3K9me2 downregulation and anti-metastasis effectof metformin. mechanistically, AmPK phosphorylates PHF2 at s655 site, enhancing PHF2 demethylation activity and triggering thetranscription of CDH1. Furthermore, the PHF2-s655E mutant that mimics AmPK-mediated phosphorylation status further reducesH3K9me2 and suppresses lung cancer metastasis, while PHF2-s655A mutant presents opposite phenotype and reverses the antimetastasiseffect of metformin. PHF2-s655 phosphorylation strikingly reduces in lung cancer patients and the higherphosphorylation level predicts better survival. Altogether, we reveal the mechanism of AmPK inhibiting lung cancer metastasis viaPHF2 mediated H3K9me2 demethylation, thereby promoting the clinical application of metformin and highlighting PHF2 as thepotential epigenetic target in cancer metastasis.

关键词： metastasis lung cancer

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THE sLOW TRAIN TO XINJIANG A ride through China's rapidly changing western frontier

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城市漫步（GBA版） 2015年第1期 22-24页

作者： WILL PHILIPPs KAROLINE kan(PHOTOs) 不详

"Keyi le!"exclaims the man I'm sharing a train compartment with,as I lay down on my cabin *** just proved to him that all 193 centimeters of me can comfortably lie straight on the sleeper berth(there had been some dou... 详细信息

关键词： frontier doubt straight

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叶顶泄漏流动对轴流泵反向发电能量特性的影响研究

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工程热物理学报 2023年第9期44卷 2416-2422页

作者：阚阚张清滢黄佳程龚严河海大学能源与电气学院南京211100 河海大学农业科学与工程学院南京210098

轴流泵端壁区存在叶顶间隙从而引起叶顶泄漏流动,严重限制了轴流泵反向发电(PAT)的能量性能和稳定性。为了研究叶顶泄漏流动(TLF)对轴流泵反向发电能量特性的影响,对轴流泵反向发电不同流量工况进行了数值模拟。计算结果表明:相比于不... 详细信息

轴流泵端壁区存在叶顶间隙从而引起叶顶泄漏流动,严重限制了轴流泵反向发电(PAT)的能量性能和稳定性。为了研究叶顶泄漏流动(TLF)对轴流泵反向发电能量特性的影响,对轴流泵反向发电不同流量工况进行了数值模拟。计算结果表明:相比于不考虑间隙的情况,考虑叶顶间隙时模拟的水头和效率较低,且两种间隙下的差异随着流量的增加而增大,TLF和其引起的叶顶间隙涡(TLV)是造成此差异的主要原因。入流角对TLV空间形式有影响,而TLV对叶轮叶片表面压力分布的影响取决于运行条件。涡输运方程表明,涡拉伸项在TLV的空间演化中起主导作用,黏性扩散项作用最小。

关键词：轴流泵叶顶泄漏流反向发电叶顶间隙

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Ultra-broadband,fast,and polarization-sensitive photoresponse of low-symmetry 2D Ndsb_(2)

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Nano Research 2022年第6期15卷 5469-5475页

作者： Gang Li Hanlin Zhang Yong Li shiqi Yin Xucai kan Wensen Wei Haifeng Du Binghui Ge Chao An mingliang Tian Feng Yan sanjun Yang Tianyou Zhai Liang Li Institutes of Physical science and Information Technology Anhui UniversityHefei 230601China Engineering Technology Research Center of magnetic materials School of Physics and Materials ScienceAnhui UniversityHefei 230601China Anhui Province Key Laboratory of Condensed matter Physics at Extreme Conditions High Magnetic Field Laboratory of the Chinese Academy of ScienceHefei 230031China Department of Applied Physics The Hong Kong Polytechnic UniversityKowloonHong Kong 999077China state Key Laboratory of materials Processing and Die and mould Technology School of Materials Science and EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074China

Broadband photodetectors with polarization-sensitive ability have received extraordinary attention for modern optoelectronic *** photodetectors should possess high responsivity,fast response,and good stability,which are rare to meet at the same time in one low-symmetric two-dimentional(2D)*** this work,neodymium diantimonides(Rsb_(2)),a member of light rare-earth diantimonides Rsb_(2)(R=La–Nd,sm)with low-symmetry structure,is introduced as a fascinating highly anisotropic 2D material for broadband detection(532 nm to 4μm).The photodetector exhibits a responsivity of 0.49 mA·W^(−1)with 15μs response time at 532 nm and highly stable performance under ambient conditions over 8 ***,we identify the polarization-sensitive photoresponse of the detector and demonstrate a high anisotropic factor~*** addition,strong inplane anisotropy is revealed by anisotropic phonon response and the photodetection mechanism is investigated by scanning photocurrent microscopy *** pioneer work on Rsb_(2)paves the way for further exploration of 2D Rsb_(2)for high performance polarized photodetectors with fast photothermoelectric response.

关键词： ultra-broadband fast response polarization-sensitive photodetector Rsb_(2)

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THE sLOW TRAIN TO XINJIANG A ride through Chinazs rapidly changing Western frontier

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城市漫步（上海版、英文） 2015年第1期 30-33页

作者： WILL PHILIPPs KAROL INE kan 不详

"Keyi le!"exclaims the man I'm sharing a train compart-ment with,as I lay down on my cabin bed.I've just proved to him that all 193 centimeters of me can comfortably lie straight on the sleeper berth(there had been some doubt when we first boarded).The man's name is Junfeng,and he's a mechanic from Turpan,an ancient city close to Urumqi,capital of the Uyghur Autonomous Region,and our next *** ethnically Han family moved from shandong two generations ago,and he continues to live in Xinjiang with his wife and *** has no plans to move back east.

关键词： frontier doubt straight

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Clinical analysis of pipeline dredging agent poisoning:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10201-10207页

作者： Ya-Qian Li Guang-Cai Yu Long-Ke shi Li-Wen Zhao Zi-Xin Wen Bao-Tian kan Xiang-Dong Jian Department of Poisoning and Occupational Diseases Emergency MedicineQilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina school of Public Health Shandong UniversityJinan 250012Shandong ProvinceChina school of Nursing and Rehabilitation Cheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Pipeline dredging agents are new household deep cleaning products used to dredge blockages in kitchen and bathroom pipeline caused by grease,hair,vegetable residue,paper cotton fibre,and other organic *** dredging agents are corrosive chemicals that can cause poisoning through corrosive damage to the digestive tract;however,this has not been reported ***,this report emphasises that oral pipeline dredging agent poisoning can cause corrosive damage to the digestive tract and may have serious health *** sUmmARY A 68-year-old man consumed liquor(200 m L) at approximately 13:00 on April 22,*** approximately 16:00,his family found him unresponsive with blackened lips,blood spots in the corners of the mouth,and blood stains on the ground,as well as an empty bottle of a pipeline dredging *** hour later,he was admitted to the emergency department of a local *** the empty bottle,he was suspected to have sustained severe corrosive damage to the digestive tract and was transferred to our department at 23:15 on April 22,*** developed dysphagia and intermittent fever and experienced difficulty in opening his mouth throughout his hospital *** patient’s condition gradually ***,he suddenly developed respiratory failure on day 12,and endotracheal intubation and ventilator-assisted ventilation were ***,the patient died after 1.5 h despite emergency rescue *** Pipeline dredging agents are highly corrosive and may cause corrosive damage to the digestive tract and asphyxia upon consumption.

关键词： Asphyxia Digestive tract injury Pipeline dredging agent Poisoning Respiratory failure Case report

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Adipose-derived stem cell/FGF19-loaded microfluidic hydrogel microspheres for synergistic restoration of critical ischemic limb

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Bioactive materials 2023年第9期27卷 394-408页

作者： Ruihan Wang Fangqian Wang shan Lu Bin Gao Yuanqing kan Tong Yuan Yisheng Xu Chen Yuan Daqiao Guo Weiguo Fu Xiaohua Yu Yi si Department of Vascular surgery Zhongshan Hospital Fudan UniversityShanghai200032PR China Institute of Vascular surgery Fudan UniversityShanghai200032PR China National Clinical Research Center for Interventional medicine Shanghai200032PR China Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou310009ZhejiangPR China Key Laboratory of motor system Disease Research and Precision Therapy of Zhejiang Province Hangzhou310000ZhejiangPR China state Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai200237China

The efficacy of stem cell therapy is substantially compromised due to low cell survival rate and poor local retention post-delivery. These issues drastically limit the application of stem cells for ischemic limb therapy, which requires effective blood perfusion and skeletal muscle regeneration. Herein, based on microfluidic technology, an integrated stem cell and cytokine co-delivery system designed for functional ischemic limb salvage was constructed by first incorporating the myogenic cytokine, fibroblast growth factor 19 (FGF19), into microspheres composed of methacrylate gelatin (GelmA). Then adipose-derived stem cells (ADsCs) were highly absorbed into the porous structure of the microspheres, overcoming the insufficient loading efficiency and activities by conventional encapsulation strategy. The fabricated ADsCs/FGF19@μsphere system demonstrated a uniform size of about 180 μm and a highly porous structure with pore sizes between 20 and 40 μm. The resultant system allowed high doses of ADsCs to be precisely engrafted in the lesion and to survive, and achieved sustained FGF19 release in the ischemic region to facilitate myoblast recruitment and differentiation and myofibrils growth. Furthermore, the combination of ADsCs and FGF19 exhibited a positive synergistic effect which substantially improved the therapeutic benefit of angiogenesis and myogenesis, both in vitro and in vivo. In summary, a stem cell and cytokine co-delivery system with the properties of easy preparation and minimal invasiveness was designed to ensure highly efficient cell delivery, sustained cytokine release, and ultimately realizes effective treatment of ischemic limb regeneration.

关键词： microfluidic technology stem cell Cytokine Porous microspheres Ischemic limb salvage

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福州、三明市城区大气Pm_(2.5)中多环芳烃成分分析及致癌风险评估

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海峡预防医学杂志 2024年第2期30卷 4-7页

作者：林少凯陈亮林侃黄建春黄丽婷王恺詹小海卢翠英福建省疾病预防控制中心福建福州350012 福州市疾病预防控制中心福建福州300209 三明市疾病预防控制中心福建三明365500

目的研究福州、三明市城区Pm_(2.5)中多环芳烃(PAHs)成分污染及其对人群健康的致癌风险,为制定大气污染治理措施提供依据。方法2019—2022年用滤膜法在福州、三明市城区4个采样点采集大气Pm_(2.5),用超高液相色谱法分析大气Pm_(2.5)中P... 详细信息

目的研究福州、三明市城区Pm_(2.5)中多环芳烃(PAHs)成分污染及其对人群健康的致癌风险,为制定大气污染治理措施提供依据。方法2019—2022年用滤膜法在福州、三明市城区4个采样点采集大气Pm_(2.5),用超高液相色谱法分析大气Pm_(2.5)中PAHs成分,用主成分分析法分析PAHs来源,用基于苯并[a]芘(BaP)毒性的终生超额致癌风险模型,评估PAHs的超额致癌风险(ECR)。结果福州、三明市城区大气Pm_(2.5)中16种PAHs浓度和分别为2.75ng/m^(3)和14.82ng/m^(3)。福州、三明市城区主成分分析法均提取出4个因子。福州市城区4个因子主要载荷成分,因子1:荧蒽(FLT)、芘(PYR)、[艹屈](CHR);因子2:二苯并[a,h]蒽(DahA)、苯并[g,h,i]苝(BghiP)、茚并[1,2,3-cd]芘(IcdP);因子3:萘(NAP)、苊烯(ACY);因子4:芴(FLU)、二氢苊(ACE),贡献占比分别为57.0%、8.0%、7.9%、6.8%,累积贡献占比为79.7%;三明市城区4个因子主要载荷成分:因子1:DahA、BghiP、IcdP;因子2:FLT、PYR;因子3:NAP、ACY;因子4:苯并[a]芘(BaP)、苯并[b]荧蒽(BbF),贡献占比为39.5%、15.4%、9.9%和7.8%,累积贡献占比为72.6%;福州、三明市城区大气Pm_(2.5)中PAHs致癌风险分别为0.84×10^(-6)和7.61×10^(-6)。结论三明市城区大气PAHs污染情况比福州市城区严重;提示福州、三明市城区Pm_(2.5)中PAHs污染来源以汽车尾气排放和扬尘为主,其大气PAHs污染对人群有潜在致癌风险。

关键词：大气污染大气Pm_(2.5) 多环芳烃机动车尾气致癌风险

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Ex vivo cartilage explant model for the evaluation of chondrocyte-targeted exosomes

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BIOCELL 2022年第6期46卷 1521-1526页

作者： kan OUYANG mEIQUAN XU YUJIE LIANG XIAO XU LImEI XU CAINING WEN ZHUAN QIN YIXIN XIE HUAWEI ZHANG LI DUAN DAPING WANG Guangzhou medical University Guangzhou510095China Department of sports medicine Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic TechnologyThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen518035China Deparment of Pathology The First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen518035China shenzhen Key Laboratory for Psychological Healthcare Shenzhen Institute of Mental HealthShenzhen Kangning HospitalShenzhen Mental Health CenterShenzhen518020China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen518055China

There is no efficient tracking system available for the therapeutic molecules delivered to *** dense matrix covering the cartilage surface is the main biological barrier that the therapeutic molecules must *** this study,we aimed to establish a system that can dynamically and effectively track the therapeutic molecules delivered to *** this aim,we adopted bovine and human cartilage explants as ex vivo models for chondrocyte-targeted exosome *** efficiency of drug delivery was evaluated using frozen *** results of this study showed that the penetration and distribution of chondrocyte-targeted exosomes in cartilage explants can be tracked ***,ex vivo cartilage explants provide an effective and economic system to evaluate therapeutic drugs encapsulated in chondrocyte-targeted exosomes in preclinical studies.

关键词： Cartilage explants Exosomes Targeted delivery

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mOF-Like 3D Graphene-Based Catalytic membrane Fabricated by One-step Laser scribing for Robust Water Purification and Green Energy Production

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Nano-micro Letters 2022年第11期14卷 48-61页

作者： Xinyu Huang Liheng Li shuaifei Zhao Lei Tong Zheng Li Zhuiri Peng Runfeng Lin Li Zhou Chang Peng kan-Hao Xue Lijuan Chen Gary J.Cheng Zhu Xiong Lei Ye school of Optical and Electronic Information and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Hubei Yangtze memory Laboratories Wuhan 430205People’s Republic of China Institute for Frontier materials Deakin UniversityGeelongVIC 3216Australia Key Laboratory of New Processing Technology for Nonferrous metal and materials(ministry of Education) Guangxi Key Laboratory of Optical and Electronic Materials and DevicesCollege of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004People’s Republic of China College of Chemistry and materials science Hunan Agricultural UniversityHunan 410128People’s Republic of China school of material science and Engineering Hunan University of Science and TechnologyXiangtanHunan ProvincePeople’s Republic of China school of Industrial Engineering and Birck Nanotechnology Centre Purdue UniversityWest LafayetteIN 47907USA Institute of Environmental Research at Greater Bay Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006GuangdongPeople’s Republic of China

Increasing both clean water and green energy demands for survival and development are the grand challenges of our ***,we successfully fabricate a novel multifunctional 3D graphene-based catalytic membrane(3D-GCm)with active metal nanoparticles(AmNs)loading for simultaneously obtaining the water purification and clean energy generation,via a“green”one-step laser scribing *** as-prepared 3D-GCm shows high porosity and uniform distribution with AmNs,which exhibits high permeated fluxes(over 100 L m^(−2) h^(−1))and versatile super-adsorption capacities for the removal of tricky organic pollutants from wastewater under ultra-low pressure-driving(0.1 bar).After adsorption saturating,the AmNs in 3D-GCm actuates the advanced oxidization process to self-clean the fouled membrane via the catalysis,and restores the adsorption capacity well for the next time membrane *** importantly,the 3D-GCm with the welding of laser scribing overcomes the lateral shear force damaging during the long-term ***,the 3D-GCm could emit plentiful of hot electrons from AmNs under light irradiation,realizing the membrane catalytic hydrolysis reactions for hydrogen energy ***“green”precision manufacturing with laser scribing technology provides a feasible technology to fabricate high-efficient and robust 3D-GCm microreactor in the tricky wastewater purification and sustainable clean energy production as well.

关键词： 3D graphene Laser scribing Catalytic membrane Water purification Hydrogen production

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