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Therapeutic Benefits of Vernonia amygdalina in the Treatment of Inflammation and Its Associated Diseases

Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 44-53页

作者： Du-Bois Asante Gideon Akuamoah Wiafe Korantema Mawuena Tsegah nelson Kwabla Domey Department of Forensic Sciences School of Biological SciencesCollege of Agriculture and Natural SciencesUniversity of Cape CoastPMBCape CoastGhana Department of Biomedical Sciences School of Allied Health SciencesCollege Health and Allied SciencesUniversity of Cape CoastPMBCape CoastGhana School of Medical Sciences College Health and Allied SciencesUniversity of Cape CoastPMBCape CoastGhana

Background:In the presence of a stimulus that disrupts homeostasis,the body elicits a response known as *** inflammatory response is expected to restore the normal functioning of the body and initiate healing where ***,the persistent activity of acute inflammation results in chronic inflammation which causes adverse consequences associated with diseases such as diabetes and *** traditional medical practice,Vernonia amygdalina is used to treat several ailments such as malaria,fever,diabetes,and inflammatory conditions such as those related to pain and ***:This review seeks to explore and discuss the therapeutic benefits of *** in the treatment of inflammation and its associated ***:We reviewed the scientific literature indexed in PubMed,ScienceDirect and Springer,and discussed the reported anti-inflammatory properties of *** and its curative activity in inflammation-associated ***:A total of 30 published articles were identified describing the therapeutic effect of *** in predominately experimental *** anti-inflammatory properties of *** have been linked to the presence of bioactive phytoconstituents predominantly present in the leaves of the ***:Multiple studies have demonstrated that the aqueous and ethanolic extracts of *** can inhibit the production of proinflammatory cytokines and enzymes in inflammatory cells,reducing inflammation and its associated *** critically appraise the current evidence,and discuss the potential use of this medicinal plant in the treatment of inflammatory conditions.

关键词： Vernonia amygdalina Inflammation Cytokines Wound healing Analgesic Antipyretic

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科特迪瓦传统饮食生活方式下的产品设计风格——以餐具为例

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创意与设计 2024年第4期 61-69页

作者： Pokou Augustin nelson 南京艺术学院国际教育学院

本文过论了科特迪瓦传统生活方式与当代产品设计之间的交集。它紧跟产品设计趋势,致力于通过创新产品的开发改善和丰富生活方式。通过审视科特迪瓦丰富的文化遗产,特别是饮食方式和相关物品,我们强调了将传统价值观和实践融入现代产品... 详细信息

本文过论了科特迪瓦传统生活方式与当代产品设计之间的交集。它紧跟产品设计趋势,致力于通过创新产品的开发改善和丰富生活方式。通过审视科特迪瓦丰富的文化遗产,特别是饮食方式和相关物品,我们强调了将传统价值观和实践融入现代产品设计过程的重要性。通过文化分析的结合,本文一方面强调了向基于非洲哲学和智慧的产品设计范式转变的必要性。另一方面,本文突出了拥抱土著知识以促进设计产业更健康发展的重要性,从而加强科特迪瓦文化在全球范围内的身份认同。

关键词：传统生活方式产品设计科特迪瓦文化科特迪瓦哲学

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Telematics as a Transformative Agent for the Zimbabwean Auto Insurance Ecosystem

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Journal of Computer and Communications 2024年第7期12卷 39-58页

作者： Prosper Tafadzwa Denhere Joyce Denhere Gracious Mutipforo Chipo Katsande Allan Muzenda nelson Matanana Gibson Muridzi Department of Computer Science and Information Systems Manicaland State University of Applied Sciences Mutare Zimbabwe Department of Risk Advisory Manicaland State University of Applied Sciences Mutare Zimbabwe Department of Business Sciences Manicaland State University of Applied Sciences Mutare Zimbabwe

Zimbabwe has witnessed the evolution of Information Communication Technology (ICT). The vehicle population soared to above 1.2 million hence rendering the Transport and Insurance domains complex. Therefore, there is a need to look at ways that can augment conventional Vehicular Management Information Systems (VMIS) in transforming business processes through Telematics. This paper aims to contextualise the role that telematics can play in transforming the Insurance Ecosystem in Zimbabwe. The main objective was to investigate the integration of Usage-Based Insurance (UBI) with vehicle tracking solutions provided by technology companies like Econet Wireless in Zimbabwe, aiming to align customer billing with individual risk profiles and enhance the synergy between technology and insurance service providers in the motor insurance ecosystem. A triangulation through structured interviews, questionnaires, and literature review, supported by Information Systems Analysis and Design techniques was conducted. The study adopted a case study approach, qualitatively analyzing the complexities of the Telematics insurance ecosystem in Zimbabwe, informed by the TOGAF framework. A case-study approach was applied to derive themes whilst applying within and cross-case analysis. Data was collected using questionnaires, and interviews. The findings of the research clearly show the importance of Telematics in modern-day insurance and the positive relationship between technology and insurance business performance. The study, therefore revealed how UBI can incentivize positive driver behavior, potentially reducing insurance premiums for safe drivers and lowering the incidence of claims against insurance companies. Future work can be done on studying the role of Telematics in combating highway crime and corruption.

关键词： Telematics Vehicle Tracking Systems Usage Based Insurance Digital Insurance Vehicle Management Information Systems Intelligent Transportation Systems

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气流成网非织造布行业现状及发展趋势

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生活用纸 2024年第3期24卷 65-67页

作者： Tara Olivo John nelson 不详

本文编译整理自Nonwovens Industry关于气流成网非织造布的两篇文章——The Future of Airlaid Nonwovens to 2027《气流成网非织造布的未来(至2027年)》和Airlaid Nonwovens Report《气流成网非织造布报告》,详细阐述了气流成网非织造... 详细信息

本文编译整理自Nonwovens Industry关于气流成网非织造布的两篇文章——The Future of Airlaid Nonwovens to 2027《气流成网非织造布的未来(至2027年)》和Airlaid Nonwovens Report《气流成网非织造布报告》,详细阐述了气流成网非织造布的发展现状和未来趋势,以及在卫生用品市场中的增长机会。

关键词：气流成网非织造布现状和未来卫生用品市场

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Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph nelson Siewe Fodjo Olivia Kamoen Luis-Jorge Amaral Amber Hadermann Chiara Trevisan Mark J.Taylor Julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

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Macroalgal deep genomics illuminate multiple paths to aquatic,photosynthetic multicellularity

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Molecular Plant 2024年第5期17卷 747-771页

作者： David R.nelson Alexandra Mystikou Ashish Jaiswal Cecilia Rad-Menendez Michael J.Preston Frederik De Boever Diana C.El Assal Sarah Daakour Michael W.Lomas Jean-Claude Twizere David H.Green William C.Ratcliff Kourosh Salehi-Ashtiani Division of Science and Math New York University Abu DhabiAbu DhabiUAE Center for Genomics and Systems Biology(CGSB) New York University Abu DhabiAbu DhabiUAE Biotechnology Research Center Technology Innovation InstitutePO Box 9639Masdar CityAbu DhabiUAE Culture Collection of Algae and Protozoa Scottish Association for Marine ScienceObanScotlandUK National Center for Marine Algae and Microbiota Bigelow Laboratory for Ocean SciencesEast BoothbayMEUSA Laboratory of Viral Interactomes GIGA InstituteUniversity of LiegeLiegeBelgium School of Biological Sciences Georgia Institute of TechnologyAtlantaGAUSA

Macroalgae are multicellular,aquatic autotrophs that play vital roles in global climate maintenance and have diverse applications in biotechnology and eco-engineering,which are directly linked to their multicellularity ***,their genomic diversity and the evolutionary mechanisms underlying multicellularity in these organisms remain *** this study,we sequenced 110 macroalgal genomes from diverse climates and phyla,and identified key genomic features that distinguish them from their microalgal *** for cell adhesion,extracellular matrix formation,cell polarity,transport,and cell differentiation distinguish macroalgae from microalgae across all three major phyla,constituting conserved and unique gene sets supporting multicellular *** genes show phylum-and climate-specific expansions that may facilitate niche ***,our study reveals genetic determinants of convergent and divergent evolutionary trajectories that have shaped morphological diversity in macroalgae and provides genome-wide frameworks to understand photosynthetic multicellular evolution in aquatic environments.

关键词： macroalgae multicellularity comparative genomics evolution adhesome endogenous viral elements

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铁路新能源车辆应急响应专业培训

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国外铁道机车与动车 2024年第3期 22-23页

作者： [美]LEE nelson 石开文(译) 张静(校) 不详

随着锂离子电池和氢燃料新能源铁路车辆的不断涌现,对这类铁路车辆紧急情况下应急响应的专业培训需求也越来越迫切。文章介绍了美国Ambipar应急培训中心处置危险物料的综合培训方法。

关键词：锂离子蓄电池氢气火灾应急响应

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Geochemical and Petrological Insights into the Neoproterozoic Moumba Metabasites: Implications for Crustal Processes in the West Congo Belt (Republic of Congo)

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Journal of Geoscience and Environment Protection 2024年第2期12卷 1-29页

作者： Ulrich Verne Matiaba-Bazika nelson Lekeba Makamba Vicky Tendresse Télange Bouénitéla Nicy Carmelle Bazebizonza Tchiguina Timothée Miyouna Florent Boudzoumou Laboratory of Geosciences Faculty of Sciences and Technics Marien NGOUABI University Brazzaville Republic of Congo National Institute for Research in Exact and Natural Sciences (IRSEN) Brazzaville Republic of Congo Geographid Research and Cartographic Production Center (CERGEC) Brazzaville Republic of Congo

The West Congo Belt contains in its rocks of Neoproterozoic age from Nemba complex outcropping in the Moumba River. This West Congo belt is made up of a crustal segment of the Arcuaï-West Congo orogen which extends from southwest Gabon to the northeast of Angola. This study aims to constrain the geochemical signature Nemba complex of West Congo belt from the petrograhic and geochemical study on the whole rock. The petrographic data from this study show the Moumba metabasites are made up of amphibolites, metagabbros, epidotites and greenschists interstratified in the Eburnean metasediments and affected by mesozonal to epizonal metamorphism characterized by the retromorphosis of intermediate amphibolite facies minerals into greenschist facies. Whole-rock geochemical data indicate that these metabasites are continental flood basalts (CFB) of basic nature and transitional affinity emplaced in intraplate context. These continental flood basalts are generated from magma originating from a significantly enriched shallow mantle plume and this magma then contaminated by the continental crust during their ascent. The reconstruction of tectonic signature suggests that West Congo belt would result from closure of an ocean basin with subduction phenomena. This collision would be marked by the establishment of ophiolite complex. We show that this model is incompatible with the CFB nature of metabasites and the orogenic evolution of Neoproterozoic. It does not seem that we can evoke a genetic link with a subduction of oceanic crust, because the paleogeography of Neoproterozoic (Rodinia) is marked by intracontinental rifts linked to opening of Rodinia. We therefore suggest the non-existence of ophiolitic complex in western Congo belt and reject the collisional model published by certain authors. We confirm the currently available intracontinental orogen model.

关键词： Mayombe Metabasites Moumba Mantle Plume Continental Rifting Basalts Flood Continental

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Adjuvant Rectal Diclofenac for Post Operative Analgesia after Caesarean Section—A Randomized Controlled Study

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 591-609页

作者： Eziaha Eric S. Ede Ayodele A. Olaleye John C. Irechukwu Uchenna nelson Nwaedu Borniface N. Ejikeme Vincent Chidiebere Ali Bartholomew I. Olinya Department of Obstetrics and Gynaecology Alex Ekwueme Federal University Teaching Hospital Abakaliki Nigeria

BACKGROUND: Pain management following caesarean section still remains a challenge in our environment. Most potent analgesics are either not readily available or expensive. Diclofenac suppository is an NSAID that can be used for postoperative analgesia. It is available and affordable. OBJECTIVE: To compare the efficacy and safety of combined rectal diclofenac and intramuscular pentazocine with intramuscular pentazocine alone for post operative pain control following lower segment caesarean section. METHODOLOGY: A total of 120 women who met the selection criteria scheduled for caesarean section under spinal anaesthesia with bupivacaine were randomized into two equal groups to receive either 75 mg diclofenac suppository 12 hourly for 24 hours or one anusol suppository (the placebo) 12 hourly for 24 hours. Both groups received pentazocine as primary analgesia. RESULT: The primary outcome measure is the proportion of patients with severe pain at 24 hours using the visual analogue rating scale. Secondary outcome measures are the time from surgery to ambulation, Passage of flatus, maternal satisfaction and presence of complications. Statistical analysis was done using spss version 22 and graph pad statistical package. Student T-test was used for continuous variables whereas chi square was used for categorical variables P CONCLUSION: Adjuvant rectal diclofenac is superior to pentazocine alone in the management of pain after caesarean section. Less number of patients had moderate to severe pain at 24 hours post operation. Maternal satisfaction in relation to pain management is better with diclofenac suppository. The levels of complications were comparable in both groups.

关键词： Pain Caesarean Section Diclofenac Placebo Suppository

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Surgical Management of Mitral Valve Infective Endocarditis with Accidental Finding of Open Pulmonary Tuberculosis

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World Journal of Cardiovascular Surgery 2024年第5期14卷 61-67页

作者： Ahmad Al Khaddour Mohammed Alharthi Alawab M. Mesallam Mohamed Agawi Mahmoud Ghalwash Ahmed Gotbi Mohamed Abdel Hafez Fouly Marko Samanovic nelson David Vega Murad El Gharbi Fawaz Altaf King Abdullah Medical Complex Jeddah KSA

Objective: This case report aimed to highlight intersections of TB and Cardiovasular diseases which carry high morbidity and mortality rates. Methods: We are reporting the surgical management of forty seven years female who had back ground history of IDDM (Insulin dependent diabetic Mellitus), ESRD (End stage renal disease) on HD (haemodialysis) also she had left subclavian artery stenosis, and paroxysmal atrial fibrillation. She was diagnosed with mitral valve infective endocarditis and found accidently to have an open pulmonary tuberculosis (TB) on the day before surgery. Results: She was started on first line anti-TB treatment. She was isolated in her private room and airborne precautions measures applied. The patient underwent a tissue Mitral Valve replacement and tricuspid valve repair annuloplasty. Special precautions were applied in Theatre and on cardiopulmonary bypass Machine guided by KAMC-J disinfection protocol. The patient made good recovery postoperatively. She was discharged well on day 7 post operatively. Conclusion: Intersections of TB and cardiovasular diseases carry high morbidity and mortality rates. Early diagnosis and early anti tuberculosis treatment can surely improve the patient prognosis. Our decontamination and disinfective procedures are recommended. Cases like this should be monitored long term for the development of further cardiovascular complication.

关键词： Tuberculosis (TB) Mycobacterium tuberculosis (MTB) Heater-Cooler and Bypass Machine New York Heart Association (NYHA)

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