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Chinese journal of Cancer 2014年第1期33卷 40-45页

作者： Linda Dirven neil K.Aaronson jan j.Heimans Martin j.B.Taphoorn Department of Neurology VU University Medical CenterPO Box 7057 1007 MB Amsterdam Netherlands Division of Psychosocial Research and Epidemiology The Netherlands Cancer InstitutePO Box 90203 1006 BE Amsterdam Netherlands Department of Neurology Medical Center HaaglandenPO Box 432 2501 CK The Hague Netherlands

Gliomas are malignant primary brain tumors and yet incurable. Palliation and the maintenance or improvement of the patient's quality of life is therefore of main importance. For that reason, health-related quality of life(HRQoL) has become an important outcome measure in clinical trials, next to traditional outcome measures such as overall and progression-free survivals, and radiological response to treatment. HRQoL is a multidimensional concept covering physical, psychological, and social domains, as well as symptoms induced by the disease and its treatment. HRQoL is assessed by using self-reported, validated questionnaires. Various generic HRQoL questionnaires, which can be supplemented with a brain tumor- specific module, are available. Both the tumor and its treatment can have a negative effect on HRQoL. However, treatment with surgery, radiotherapy, chemotherapy, and supportive treatment may also improve patients' HRQoL, in addition to extending survival. It is expected that the impact of HRQoL measurements in both clinical trials and clinical practice will increase. Hence, it is important that HRQoL data are collected, analyzed, and interpreted correctly. Methodological issues such as selection bias and missing data may hamper the interpretation of HRQoL data and should therefore be accounted. In clinical trials, HRQoL can be used to assess the benefits of a new treatment strategy, which should be weighed carefully against the adverse effects of that treatment. In daily clinical practice, HRQoL assessments of an individual patient can be used to inform physicians about the impact of a specific treatment strategy, and it may facilitate the communication between the physicians and the patients.

关键词：生活质量胶质瘤健康患者放射治疗临床试验质量评估临床实践

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Use of the reported Edmonton frail scale in the assessment of patients for transcatheter aortic valve replacement： a possible selection tool in very high-risk patients？

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journal of Geriatric Cardiology 2018年第6期15卷 463-466页

作者： Louis Koizia Sarosh Khan Angela Frame Ghada W Mikhail Sayan Sen neil Ruparelia Geriatric Medicine St Mary's Hospital Praed Street London UK Department of Cardiology Western Sussex Hospitals NHS Foundation Trust West Sussex UK Department of Cardiology lmperial College Healthcare NHS Trust London UK

Transcatheter aortic valve replacement （TAVR） has revolutionised the treatment of patients with aortic stenosis （AS） over the last 15 *** is a well-established procedure for the treatment of patients considered high risk for open surgery. Results from the PARTNER （Placement of AoRTic traNscathetER） trial showed that inoperable patients randomly assigned to TAVR, had a 20% reduction in all-cause mortality, as well as hospitalisation, at one year compared to best medical management.

关键词： Edmonton frail scale Frailty Transcatheter aortic valve replacement

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Breast Cancer Induced Bone Osteolysis Prediction Using Temporal Variational Autoencoders

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Biomedical Engineering Frontiers 2022年第1期3卷 116-125页

作者： Wei Xiong neil Yeung Shubo Wang Haofu Liao Liyun Wang jiebo Luo Department of Computer Science University of RochesterRochesterUSA Department of Mechanical Engineering University of DelawareUSA Amazon Web Services USA

Objective and Impact *** adopt a deep learning model for bone osteolysis prediction on computed tomography(CT)images of murine breast cancer bone *** the bone CT scans at previous time steps,the model incorporates the bone-cancer interactions learned from the sequential images and generates future CT *** ability of predicting the development of bone lesions in cancer-invading bones can assist in assessing the risk of impending fractures and choosing proper treatments in breast cancer bone *** cancer often metastasizes to bone,causes osteolytic lesions,and results in skeletal-related events(SREs)including severe pain and even fatal *** current imaging techniques can detect macroscopic bone lesions,predicting the occurrence and progression of bone lesions remains a *** adopt a temporal variational autoencoder(T-VAE)model that utilizes a combination of variational autoencoders and long short-term memory networks to predict bone lesion emergence on our micro-CT dataset containing sequential images of murine *** the CT scans of murine tibiae at early weeks,our model can learn the distribution of their future states from *** test our model against other deep learning-based prediction models on the bone lesion progression prediction *** model produces much more accurate predictions than existing models under various evaluation *** develop a deep learning framework that can accurately predict and visualize the progression of osteolytic bone *** will assist in planning and evaluating treatment strategies to prevent SREs in breast cancer patients.

关键词： Breast prediction utilize

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Effect of oxygen and nitrogen functionalization on the physical and electronic structure of graphene

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Nano Research 2015年第8期8卷 2620-2635页

作者： Alexander j. Marsden Peter Brommer james j. Mudd M. Adam Dyson Robert Cook Maria Asensio jose Avila Ana Levy jeremy Sloan David Quigley Gavin R. Bell neil R. Wilson Department of Physics University of Warwick Coventry UK Centre for Scientific Computing University of Warwick Coventry UK Synchrotron SOLEIL L'Orme des Merisiers Saint Aubin-BP 48 91192 Gifsur Yvette Cedex France

Covalent functionalization of graphene offers opportunities for tailoring its properties and is an unavoidable consequence of some graphene synthesis techniques. However, the changes induced by the functionalization are not well understood. By using atomic sources to control the extent of the oxygen and nitrogen functionalization, we studied the evolution in the structure and properties at the atomic scale. Atomic oxygen reversibly introduces epoxide groups whilst, under similar conditions, atomic nitrogen irreversibly creates diverse functionalities including substitutional, pyridinic, and pyrrolic nitrogen. Atomic oxygen leaves the Fermi energy at the Dirac point （i.e., undoped）, whilst atomic nitrogen results in a net n-doping; however, the experimental results are consistent with the dominant electronic effect for both being a transition from delocalized to localized states, and hence the loss of the signature electronic structure of graphene.

关键词： graphene functionalization chemical vapor deposition density functional theory

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Atypical organic dyes used as sensitizers for efficient dye-sensitized solar cells

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Frontiers of Optoelectronics 2016年第1期9卷 38-43页

作者： Yue Hu neil Robertson School of Chemistry University of Edinburgh Edinburgh EH9 3F J UK

Since their invention, dye-sensitized solar cells （DSSCs） have received enormous research attention from scientists with different background due to the possibility of low-cost production and fabrication on flexible substrates. One of the most important components in DSSCs is the sensitizing dye, including metal-complexes and metal-free organic dyes. The donor-π bridge-acceptor （D-π-A） structure is the mainstream in the design of organic sensitizers because it facilitates efficient chargetransfer toward the Ti02 upon excitation. However, some sensitizers that do not follow this structure, or have some modification upon this structure, also present good efficiency when applied in DSSC devices. This review summarizes these atypical dyes in order to inspire more diverse designs toward highly efficient DSSCs.

关键词： donor- acceptor-π bridge-acceptor (D-A-π-A),donor-free di-anchoring

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Life-Cycle Cost Analysis of an Installed Multiunit Seasonal Thermal Energy Store

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journal of Energy and Power Engineering 2017年第7期11卷 439-445页

作者： Shane Colelough neil j. Hewitt Philip Griffiths Centre for Sustainable Technologies 26 B 16 Ulster University Newtownabbey BT37 OQB Northern Ireland UK

The financial viability of a solar STES （seasonal thermal energy store） installed in a mixed commercial and residential multiunit development of low-energy buildings located in Lysekil, Sweden, a maritime Scandinavian Climate has been investigated. Using recorded figures for the installation costs and performance, a financial life cycle analysis has been undertaken to determine the cost effectiveness of the system. The time value of money is considered and an LCC （life cycle cost） analysis undertaken to identify the cost-effectiveness of the solution. It shows that while a direct heating and hot water system incorporating STES can be economically viable in a Swedish maritime climate in the long term, assistance such as that provided by government incentives is required to assist with the high capital cost of the initial investment.

关键词： STES passive house fmancial analysis nZEB passivhaus seasonal thermal energy storage storage LCC analysis

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Long-term, in vivo therapeutic effects of a single dose of miR-145 micelles for atherosclerosis

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Bioactive Materials 2023年第9期27卷 327-336页

作者： Deborah D.Chin neil Patel Woori Lee Sonali Kanaya jackson Cook Eun ji Chung Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA90089United States Division of Vascular Surgery and Endovascular Therapy Department of SurgeryKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA90033United States Mork Family Department of Chemical Engineering and Materials Science University of Southern CaliforniaLos AngelesCA90089United States Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA90033United States Division of Nephrology and Hypertension Department of MedicineKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA90033United States Norris Comprehensive Cancer Center Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA90089United States

Atherosclerosis is a chronic inflammatory disease that is characterized by the build-up of lipid-rich plaques in the arterial walls. The standard treatment for patients with atherosclerosis is statin therapy aimed to lower serum lipid levels. Despite its widespread use, many patients taking statins continue to experience acute events. Thus, to develop improved and alternative therapies, we previously reported on microRNA-145 (miR-145 micelles) and its ability to inhibit atherosclerosis by targeting vascular smooth muscle cells (VSMCs). Importantly, one dose of miR-145 micelles significantly abrogated disease progression when evaluated two weeks post-administration. Thus, in this study, to evaluate how long the sustained effects of miR-145 micelles can be maintained and towards identifying a dosing regimen that is practical for patients with chronic disease, the therapeutic effects of a single dose of miR-145 micelles were evaluated for up to two months in vivo. After one and two months post-treatment, miR-145 micelles were found to reduce plaque size and overall lesion area compared to all other controls including statins without causing adverse effects. Furthermore, a single dose of miR-145 micelle treatment inhibited VSMC transdifferentiation into pathogenic macrophage-like and osteogenic cells in plaques. Together, our data shows the long-term efficacy and sustained effects of miR-145 micelles that is amenable using a dosing frequency relevant to chronic disease patients.

关键词： MicroRNA-145 Atherosclerosis Vascular smooth muscle cell Nanoparticle Gene therapy

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Disabling of ARC1 through CRISPR–Cas9 leads to a complete breakdown of self-incompatibility responses in Brassica napus

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Plant Communications 2023年第2期4卷 8-11页

作者： Kumar Abhinandan neil M.N.Hickerson Xingguo Lan Marcus A.Samuel University of Calgary Department of Biological Sciences2500 University Drive NWCalgaryAB T2N 1N4Canada 20/20 Seed Labs Inc. NiskuAB T9E 7N5Canada Key Laboratory of Saline-Alkali Vegetation Ecology Restoration Ministry of EducationCollege of Life SciencesNortheast Forestry UniversityHarbin 150040China

Dear Editor,Many flowering plants utilize the self-incompatibility(SI)response as a genetic mechanism to prevent self-pollen from establishing on the stigmas,thereby promoting outcrossing and genetic *** Brassica during SI,recognition of the pollen ligand SP11 by S-locus receptor kinase(SRK)results in activation of the E3 ligase ARM-Repeat-Containing protein(ARC1),which leads to proteasomal degradation of compatibility factors required for successful pollen acceptance.

关键词： utilize breakdown thereby

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Triple combination targeting PI3K,ER,and CDK4/6 inhibits growth of ER-positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor

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Cancer Communications 2023年第6期43卷 720-725页

作者： Mikkel G.Terp Martina Tuttolomondo neil Portman Sidse Ehmsen Lene E.johansen Martin Bak Elgene Lim Henrik j.Ditzel Department of Cancer and Inflammation Research Institute of Molecular MedicineUniversity of Southern DenmarkOdenseDenmark Garvan Institute of Medical Research DarlinghurstSydneyNew SouthWalesAustralia St.Vincent’s Clinical School Faculty of MedicineUniversity of New SouthWales SydneySydneyNew South WalesAustralia Department of Oncology Institute of Clinical ResearchOdense University HospitalOdenseDenmark Department of Pathology Sydvestjysk SygehusEsbjergDenmark Academy of Geriatric Cancer Research(AgeCare) Odense University HospitalOdenseDenmark

Dear Editor,Despite the improved outcome of advanced estrogen receptor-positive(ER+)breast cancer patients treated with endocrine therapy in combination with either a cyclindependent kinase 4/6 inhibitor(CDK4/6i)or a phosphoinositide 3-kinase inhibitor(PI3Ki),the disease will eventually progress,and the optimal treatment strategy upon progression remains undefined[1-4].To address this,we developed MCF-7-and T47D-derived PIK3CAmutated breast cancer cell lines[5]resistant to combined CDK4/6i palbociclib and fulvestrant(MPF-R and TPFR)or combined PI3Ki alpelisib and fulvestrant(MAF-R and TAF-R),respectively(Supplementary Materials and Methods).Drug-sensitive isogenic cells(M-S and T-S)grown in parallel with MPF-R and TPF-R cells and the original MCF-7/S0.5 and T47D cells were analyzed for comparison.

关键词： PIK3CA breast cancer

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A Role for GIBBERELLIN 2-OXIDASE6 and Gibberellins in Regulating Nectar Production

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Molecular Plant 2016年第5期9卷 753-756页

作者： Lisa B. Wiesen Ricci L. Bender Travis Paradis Alexie Larson M. Ann D.N. Perera Basil j. Nikolau neil E. Olszewski Clay j. Carter Department of Plant Biology University of Minnesota Saint PaulMN 55108 USA Department of Biochemistry Biophysics & Molecular Biology Iowa State University Ames IA 50011 USA W.M.Keck Metabolomics Research Laboratory Iowa State University Ames IA 50011 USA Department of Plant Biology University of Minnesota Twin Cities 1445 Gortner Avenue 250 Biological Sciences Center Saint Paul MN 55108 USA

Dear Editor The regulation of nectar production is dependent on hormonal signaling. For example, Arabidopsis PIN6, which encodes an auxin efflux transporter family protein, was identified as a nectary-enriched gene whose expression level was positively correlated to total nectar production （Bender et al., 2013）. Furthermore, jasmonic acid （jA） levels peak in Brassica flowers just prior to anthesis and promote nectar secretion （Radhika et al., 2010）. While auxin and jA have been demonstrated to play roles in the regulation of nectar production,

关键词： GIBBERELLIN genetics NECTARINE RESEARCH

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