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Neuroscience & Medicine 2013年第3期4卷 134-139页

作者： Ari L. Mendell neil j. maclusky Csaba Leranth Department of Biomedical Sciences Ontario Veterinary College University of Guelph Guelph Canada Department of Obstetrics Gynecology & Reproductive Sciences Yale University School of Medicine New Haven USA

Dehydroepiandrosterone (DHEA), the most abundant adrenal androgen in primates, is also synthesized from cholesterol in the brain. Like testosterone, DHEA induces spine synapse formation in the hippocampus. In female rats, this response is blocked by co-administration of an inhibitor of aromatase, the enzyme responsible for estrogen biosynthesis. In males, by contrast, the hippocampal synaptic response to DHEA is unaffected by treatment with an aromatase inhibitor. We hypothesized that this sex difference might reflect differential dependence of the hippocampal responses on subcortical afferents from the basal forebrain. To test this hypothesis, we examined the effects of unilateral fimbria/ fornix transection (FFX) on DHEA-induced synapse formation in the cornu ammonis 1 (CA1) hippocampal subfield of gonadectomized female and male rats. In ovariectomized females, CA1 spine synapse density after DHEA treatment was reduced by more than 60% ipsilateral to FFX. In males, however, unilateral FFX transection had no effect on spine synapse density after DHEA treatment. These results suggest that sex differences in the dependence on local estrogen biosynthesis of the CA1 synaptic response to androgen may at least in part be the result of sex differences in the relative contributions of afferents to the hippocampus from the basal forebrain.

关键词： Dehydroepiandrosterone Subcortical Mediation Synaptic Plasticity Hippocampus Sex Differences

Micro-optical fabrication by ultraprecision diamond machining and precision molding

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Frontiers of Mechanical Engineering 2017年第2期12卷 181-192页

作者： Likai LI neil j. NAPLES j.ffrey W. ROBLEE Allen Y. YI Department of Integrated System Engineering The Ohio StateUniversity Columbus OH 43210 USA Nistica Inc. Bridgewater NJ 08807 USA Ametek Precitech Keene NH 03431 USA

Ultraprecision diamond machining and high volume molding for affordable high precision high performance optical elements are becoming a viable process in optical industry for low cost high quality microoptical component manufacturing. In this process, first high precision microoptical molds are fabricated using ultraprecision single point diamond machining followed by high volume production methods such as compression or inj.ction molding. In the last two decades, there have been steady improvements in ultraprecision machine design and performance, particularly with the introduction of both slow tool and fast tool servo. Today optical molds, including freeform surfaces and microlens arrays, are routinely diamond machined to final finish without post machining polishing. For consumers, compression mold- ing or inj.ction molding provide efficient and high quality optics at extremely low cost. In this paper, first ultrapreci- sion machine design and machining processes such as slow tool and fast too servo are described then both compression molding and inj.ction molding of polymer optics are discussed. To implement precision optical manufacturing by molding, numerical modeling can be included in the future as a critical part of the manufacturing process to ensure high product quality.

关键词： ultraprecision machining slow tool servo fast tool servo compression molding inj.ction molding,microlens arrays optical fabrication

Ileal pouch surgery for ulcerative colitis

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World j.urnal of Gastroenterology 2007年第24期13卷 3288-3300页

作者： Simon P Bach neil j.Mortensen Department of Colorectal Surgery John Radcliffe Hospital Oxford OX3 9DU United Kingdom

Ulcerative colitis (UC) is a relapsing and remitting disease characterised by chronic mucosal and submucosal inflammation of the colon and rectum. Treatment may vary depending upon the extent and severity of inflammation. Broadly speaking medical treatments aim to induce and then maintain remission. Surgery is indicated for inflammatory disease that is refractory to medical treatment or in cases of neoplastic transformation. Approximately 25% of patients with UC ultimately require colectomy. Ileal pouch-anal anastomosis (IPAA) has become the standard of care for patients with ulcerative colitis who ultimately require colectomy. This review will examine indications for IPAA, patient selection, technical aspects of surgery, management of complications and long term outcome following this procedure.

关键词： Ulcerative colitis Ileal Pouch Ileal pouch anal anastomosis

High-density lipoproteins:an emerging target in the prevention of cardiovascular disease

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Cell Research 2006年第10期16卷 799-808页

作者： Belinda A Cutri neil j.Hime Stephen j.Nicholls The Heart Research Institute CamperdownSydneyNSW 2050Australia Department of Immunology The Scripps Research InstituteLa JollaCA 92037USA Department of Cardiovascular Medicine The Cleveland Clinic FoundationMail Code JJ659500 Euclid AvenueClevelandOH 44195USA

High-density lipoproteins (HDLs) have been well established to protect against the development of atheroscleroticcardiovascular *** has become apparent that in addition to the promotion of reverse cholesterol transport,HDLspossess a number of additional functional properties that may contribute to their beneficial influence on the arterial wall.A number of exciting therapeutic strategies have been developed that target HDL and its ability to protect against thedevelopment of atherosclerotic *** paper will review how the promotion of the functional properties of HDLinhibits the formation of atherosclerotic plaque and stabilises lesions in patients with established disease.

关键词： high-density lipoproteins cardiovascular disease atherosclerotic plaque stabilises lesions

Validity of long-term and short-term recall of occupational sitting time in Finnish and Chinese office workers

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j.urnal of Sport and Health Science 2020年第4期9卷 345-351页

作者： Ying Gao neil j.Cronin Nina Nevala Taij. Finni Neuromuscular Research Center Faculty of Sport and Health SciencesUniversity of Jyv€askyl€aJyv€askyl€a FI-40014Finland Finnish Institute of Occupational Health Helsinki FI-00250Finland

Background:As sedentary behavior is a global health issue,there is a need for methods of self-reported sitting *** accuracy and reliability of these methods should also be tested in various populations and different cultural *** study examined the validity of longterm and short-term recall of occupational sitting time in Finnish and Chinese ***:Two cohort groups of office-based workers(58.6%female,age range 2267 years)participated:a Finnish group(FIN,n=34)and a Chinese group(CHI,n=36).Long-term(past 3-month sitting)and short-term(daily sitting assessed on 5 consecutive days)single-item measures were used to assess self-reported occupational sitting *** from each participant were compared to obj.ctively measured occupational sitting time assessed via thigh-mounted accelerometers,with Spearman’s rho(r)used to assess validity and the Bland-Altman method used to evaluate *** of variation depicted day-to-day variability of time spent on sitting at ***:In the total study sample,the results showed that both long-term and short-term recall correlated with accelerometer-derived sitting time(r=0.532,95%confidence intervals(CI):0.3360.684,pj.ctively measured sitting time,self-reported occupational sitting time was 2.4%(95%CI:0.5%to 5.3%,p=0.091)and 2.2%(95%CI:0.7%3.6%,p=0.005)greater for long-term and short-term recall,*** agreement level was within the range21.2%to 25.9%for long-term recall,and24.2%to 28.5%for short-term *** a 5-day work week,day-to-day variation of sitting time was 9.4%§11.4%according to short-term recall and 10.4%§8.4%according to accelerometry-derived occupational sitting ***:Overall,both long-term and short-term self-reported instruments provide acceptable measures of occupational sitting time in an office-based workplace,but their utility at the individual level is limited due

关键词： Accelerometry Daily recall Office workers Questionnaire Self-report Sitting time Validity

Essential biology neil A. Campbell, j.ne B. Reece, Eric j. Simon. 2nd ed.

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Essential biology Neil A. Campbell, Jane B. Reece, Eric J. S...

The role of digital technologies in supporting and improving fishery and aquaculture across the supply chain-Quo Vadis?

2004年

作者： neil A. Campbell j.ne B. Reece Eric j. Simon.

Student CD-ROM includes: Activities, process of sciences, quizzes, flashcards, glossary.

ISBN: (纸本)0805374957

Student CD-ROM includes: Activities, process of sciences, quizzes, flashcards, glossary.

关键词： Biology.

来源：畅想之星图书光盘版（南... 评论

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Aquaculture and Fisheries 2023年第4期8卷 365-374页

作者： neil j.Rowan Bioscience Research Institute Technological University of the ShannonMidlands Midwest(TUS)AthloneN37 HD68Ireland Empower Eco^(™)Innovation Hub TUSAthloneN37 HD68Ireland CURAM Research Centre NUIGalwayH91 TK33Ireland

Fish constitute important high protein products to meet the demands of an increasing global ***,the continued depletion of wild fish stocks is leading to increased strain on the aquaculture sector in terms of sustaining the supply of fish and seafood to global *** the fact that aquaculture is more diversified than other agriculture sectors,there are significant pressures on the industry to continue innovating in order to enable sustainability including increased fish production,improved appropriate selection of species,disease mitigation,reduced wastage,preventing environmental pollution and generating more employment *** viewpoint article addresses how digital transformation can help support and meet expansion needs of the fisheries/aquaculture industries that includes exploiting and harnessing ICT,IoT,Cloud-edge computing,AI,machine learning,immersive technologies and *** technologies are bringing significant operational benefits for global food chain,improving efficiencies and productivity,reducing waste,contamination and food *** focus on digital technologies has recently evolved to Industry 5.0 where AI and robotics are coupled with the human mind in order to advance human-centric *** viewpoint describes the role of Quadruple helix Hub(academic-industry-government and society)in delivering a convergent holistic approach to meeting the diversity of fishery industry needs by connecting and placing fisheries centrally in a defined ecosystem of *** includes specialist training,testing technologies,providing access to finance and fostering disruption through aquaculture accelerator initiatives such as that provided by Hatch *** digital Innovation Hubs trans-regionally,nationally and internationally will also help mitigate against significant risks for the fisheries and aquaculture industry including climate change,global pandemics and conflicts that can j.opardize fish an

关键词： Digital transformation Sustainability End-to-end monitoring Food processing Disruptive innovation

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Myth and writing

Myth and writing

The synthesis of polymers of intrinsic microporosity (PIMs)

作者： j. neil C. Garcia.

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Science China Chemistry 2017年第8期60卷 1023-1032页

作者： neil B.McKeown School of Chemistry University of Edinburgh David Brewster Road Edinburgh EH9 3F J U

Polymers of intrinsic microporosity （PIMs） are a class of porous organic polymer （POP） that form microporous solids due to the inefficient packing of their rigid and contorted macromolecular chains. In contrast to other types of POP, PIMs are not comprised of a network of cross-linked covalent bonds so that they can be dissolved in organic solvents and processed into robust films, coatings or fibres. Here, over twelve years＇ accumulated research on the synthesis of PIMs is reviewed. To date, three types of polymerisation reaction have been used successfully to prepare PIMs of sufficient molecular mass to form robust self-standing films. These involve the formation of dibenzodioxin, Tr6ger＇s base and imide linkages between monomeric units. This rapid development of synthetic methods for preparing PIMs has been driven by their rich potential for numerous diverse applications and this synergistic relationship between synthesis and functionality is set to continue.

关键词： polymers of intrinsic microporosity synthesis porous organic polymers

Policy Blending, Fuzzy Chronology, and Local Understandings of National Initiatives in Early 1950s China

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Frontiers of History in China 2014年第1期9卷 83-101页

作者： neil j. Diamant Department of East Asian Studies Dickinson College Carlisle PA 17013 USA

This article proposes the concept of policy blending to improve our understanding of the densely interactive quality of political initiatives in early 1950s China. Using three cases studies, I argue that policy blending, defined as the process by which previous political experiences shaped the implementation and interpretation of those subsequent to them （sometimes in ways contrary to the government＇s intentions）, occurred frequently during this period, to the extent that people＇s understanding of the first years of Chinese Communist Party rule cannot be separated from this phenomenon. Using examples from marriage registration, the Marriage Law and the national discussion of the 1954 draft Constitution, I advance the historiographical argument that the early 1950s should not be demarcated by, or taught mainly with reference to, ＂temporally encapsulated＂ policies with clear beginnings and ends （i.e., policy ＂a＂ occurred in year ＂b,＂ followed by policy ＂c＂ in year ＂d＂）. Rather, policies seeped into each other, producing a blurry--but sometimes accurate--＂impression＂ of state power. I further suggest that the concept of policy blending can be helpful in understanding subsequent political initiatives as well.

关键词： 1950s political campaigns historiography Marriage Law constitution