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Validity of long-term and short-term recall of occupational sitting time in Finnish and Chinese office workers

作者： neil Gaiman.

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Journal of Sport and Health Science 2020年第4期9卷 345-351页

作者： Ying Gao neil J.Cronin Nina Nevala Taija Finni Neuromuscular Research Center Faculty of Sport and Health SciencesUniversity of Jyv€askyl€aJyv€askyl€a FI-40014Finland Finnish Institute of Occupational Health Helsinki FI-00250Finland

Background:As sedentary behavior is a global health issue,there is a need for methods of self-reported sitting *** accuracy and reliability of these methods should also be tested in various populations and different cultural *** study examined the validity of longterm and short-term recall of occupational sitting time in Finnish and Chinese ***:Two cohort groups of office-based workers(58.6%female,age range 2267 years)participated:a Finnish group(FIN,n=34)and a Chinese group(CHI,n=36).Long-term(past 3-month sitting)and short-term(daily sitting assessed on 5 consecutive days)single-item measures were used to assess self-reported occupational sitting *** from each participant were compared to objectively measured occupational sitting time assessed via thigh-mounted accelerometers,with Spearman’s rho(r)used to assess validity and the Bland-Altman method used to evaluate *** of variation depicted day-to-day variability of time spent on sitting at ***:In the total study sample,the results showed that both long-term and short-term recall correlated with accelerometer-derived sitting time(r=0.532,95%confidence intervals(CI):0.3360.684,p<0.001;r=0.533,95%CI:0.4490.607,p<0.001,respectively).Compared to objectively measured sitting time,self-reported occupational sitting time was 2.4%(95%CI:0.5%to 5.3%,p=0.091)and 2.2%(95%CI:0.7%3.6%,p=0.005)greater for long-term and short-term recall,*** agreement level was within the range21.2%to 25.9%for long-term recall,and24.2%to 28.5%for short-term *** a 5-day work week,day-to-day variation of sitting time was 9.4%§11.4%according to short-term recall and 10.4%§8.4%according to accelerometry-derived occupational sitting ***:Overall,both long-term and short-term self-reported instruments provide acceptable measures of occupational sitting time in an office-based workplace,but their utility at the individual level is limited due

关键词： Accelerometry Daily recall Office workers Questionnaire Self-report Sitting time Validity

The role of lactose in weanling pig nutrition:a literature and meta-analysis review

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Journal of Animal Science and Biotechnology 2021年第2期12卷 462-478页

作者： Jinbiao Zhao Zeyu Zhang Shuai Zhang Greg Page neil W.Jaworski State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityNo.2 Yuanmingyuan West RoadBeijing 100193China Trouw Nutrition Innovation Stationsstraat 773800AG AmersfoortNetherlands

Lactose plays a crucial role in the growth performance of pigs at weaning because it is a palatable and easily digestible energy source that eases the transition from milk to solid ***,the digestibility of lactose declines after weaning due to a reduction in endogenous lactase activity in *** a result,some lactose may be fermented in the gastrointestinal tract of *** of lactose by intestinal microbiota yields lactic acid and volatile fatty acids,which may positively regulate the intestinal environment and microbiome,resulting in improved gastrointestinal health of weanling *** hypothesize that the prebiotic effect of lactose may play a larger role in weanling pig nutrition as the global feed industry strives to reduce antibiotic usage and pharmacological levels of zinc oxide and supra-nutritional levels of *** presented in this review indicates that high dietary lactose improves growth performance of piglets,as well as the growth of beneficial bacteria,particularly Lactobacillus,with the positive effects being more pronounced in the first 2 weeks after ***,the risk of post-weaning diarrhea may increase as pigs get older due to reduced lactase activity,high dietary lactose concentrations,and larger feed intakes,all of which may lead to excessive lactose fermentation in the intestine of the ***,dietary lactose levels exert different effects on growth performance and gastrointestinal physiological functions in different feeding phases of weanling ***,no formal recommendation of lactose for weanling pigs has been reported.A meta-analysis approach was used to determine that diets fed to swine should include 20%,15%,and 0 lactose from d 0-7,d 7-14,and d 14-35 post-weaning,***,sustainable swine production demands that economics must also be taken into account as lactose and lactose containing ingredients are ***,alternatives to lactose,so called“lactose equivalents

关键词： Growth performance Gut health Gut microbiota Lactose Lactose equivalents Weanling pig

Recent progress in the green synthesis of rare-earth doped upconversion nanophosphors for optical bioimaging from cells to animals

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Chinese Journal of Chemical Engineering 2018年第10期26卷 2206-2218页

作者： Yuan Pu Jingning Leng Dan Wang Jiexin Wang neil R.Foster Jianfeng Chen Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical Technology State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Department of Chemical Engineering Curtin University

Rare-earth doped upconversion nanophosphors(UCNPs), which convert low energy near-infrared(NIR) photons into high energy photons such as ultraviolet, visible light and NIR light, have found various applications in optical bioimaging. In this review article, we summarize recent advances in the synthesis and applications of UCNPs achieved by us and other groups in the past few years. The approaches for the synthesis of UCNPs are presented,with an emphasis on the role of green chemistry in the advancement of this field, followed by a focused overview on their latest applications in optical bioimaging from subcellular structures through cells to living animals. Challenges and opportunities for the use of UCNPs in biomedical diagnosis and therapy are discussed.

关键词： Green synthesis Upconversion luminescence Nanomaterials Biomedical engineering Imaging

Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury

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World Journal of Gastroenterology 2004年第12期10卷 1699-1708页

作者： neil Kaplowitz Gastroenterology/Liver Division Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA

Deficiencies in vitamins or other factors(B6,B12,folic acid, betaine)and genetic disorders for the metabolism of the non-protein amino acid-homocysteine(Hcy)lead to hyperhomocysteinemia(HHcy).HHcy is an integral component of several disorders including cardiovascular disease,neurodegeneration,diabetes and alcoholic liver *** unleashes mediators of inflammation such as NFκB,IL-1β,IL-6,and IL-8,increases production of intracellular superoxide anion causing oxidative stress and reducing intracellular level of nitric oxide(NO),and induces endoplasrnic reticulum(ER)stress which can explain many processes of Hcy-promoted cell injury such as apoptosis, fat accumulation,and *** models have played an important role in determining the biological effects of *** stress may also be involved in other liver diseases such as α_1-antitrypsin(α_1-AT)deficiency and hepatitis C and/or B virus *** research should evaluate the possible potentiative effects of alcohol and hepatic virus infection on ER stress-induced liver injury,study potentially beneficial effects of lowering Hcy and preventing ER stress in alcoholic humans,and examine polymorphisrn of Hcy metabolizing enzymes as potential risk-factors for the development of HHcy and liver disease.

关键词： Animals Endoplasmic Reticulum Humans Hyperhomocysteinemia Liver Diseases, Alcoholic Oxidative Stress

Controlling human platelet activation with calcium-binding nanoparticles

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Nano Research 2020年第10期13卷 2697-2705页

作者： David Cabrera Karen Walker Sandhya Moise neil D.Telling Alan G.S.Harper School of Pharmacy and Bioengineering Keele UniversityGuy Hilton Research CenireThormburrow DriveHartshill Stoke-on Trent ST47QBUK ?Central Electron Microscope Unit School of Life SciencesKeele UniversityNewcastle-under LIymeStaffordshireST55BGUK Department of Chemical Engineering University of BathBath BA27AYUK School of Medicine Keele UniversityNewcastle-under-LymeStaffordshireST55BGUK

Human platelets aggregate at sites of blood vessel damage in response to a rise in their cytosolic calcium *** these cytosolic calcium rises would provide a method to inhibit platelet activation and prevent the unwanted blood clots that causes heart attack and *** we have predicted that calcium accumulation within the lumen of an infolded portion of the platelet plasma membrane called the open canalicular system(OCS)is essential for maintaining this cytosolic calcium *** to its nanometer dimensions of the OCS,it has been difficult to measure or interfere with the predicted luminal calcium *** we utilise iron oxide magnetic nanoparticles coated with the known calcium chelator,citrate,to create calcium-binding *** were used to assess whether an OCS calcium store plays a role in controlling the dynamics of human platelet activation and *** demonstrate that citrate-coated nanoparticles are rapidly and selectively uptaken into the OCS of activated human platelets,where they act to buffer the accumulation of calcium *** with these calcium-binding nanoparticles reduced thrombin-evoked cytosolic calcium rises,and slowed platelet aggregation and clot retraction in human *** contrast,nanoparticles that cannot bind calcium have no *** study demonstrates that the OCS acts as a key source of calcium for maintaining cytosolic calcium rises and accelerating platelet aggregation,and that calcium-binding nanoparticles targeted to the OCS could provide an anti-platelet therapy to treat patients at risk of suffering heart attacks or strokes.

关键词： nanochelators human platelets open canalicular system calcium signaling nanoparticles

Online AUV Path Replanning Using Quantum-Behaved Particle Swarm Optimization with Selective Differential Evolution

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Computer Modeling in Engineering & Sciences 2020年第10期125卷 33-50页

作者： Hui Sheng Lim Christopher K.H.Chin Shuhong Chai neil Bose National Centre for Maritime Engineering and Hydrodynamics Australian Maritime CollegeUniversity of TasmaniaLauncestonTAS7250Australia Memorial University of Newfoundland St.John’sNLA1C 5S7Canada

This paper presents an online AUV(autonomous underwater vehicle)path planner that employs path replanning approach and the SDEQPSO(selective differential evolution-hybridized quantum-behaved particle swarm optimization)algorithm to optimize an AUV mission conducted in an unknown,dynamic and cluttered ocean *** proposed path replanner considered the effect of ocean currents in path optimization to generate a Pareto-optimal path that guides the AUV to its target within minimum *** optimization was based on the onboard sensor data measured from the environment,which consists of a priori unknown dynamic obstacles and spatiotemporal *** sensor arrangements for the forward-looking sonar and horizontal acoustic Doppler current profiler(H-ADCP)were considered in 2D and 3D *** on the simulation results,the SDEQPSO path replanner was found to be capable of generating a time-optimal path that offered up to 13%reduction in travel time compared to the situation where the vehicle simply followed a path with the shortest *** proposed replanning technique also showed consistently better performance over a reactive path planner in terms of solution quality,stability,and computational *** of the replanner was verified under stochastic process using the Monte Carlo *** generated path fulfilled the vehicle’s safety and physical constraints,while intelligently exploiting ocean currents to improve the vehicle’s efficiency.

关键词： Autonomous underwater vehicle path planning particle swarm optimization sonar detection Monte Carlo methods

Thermo-analytical study on stainless steelmaking dust

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Journal of Central South University of Technology 2003年第4期10卷 301-306页

作者：彭及彭兵余笛唐谟堂 neil Souza Janusz A.Kozinski Jonathan Lobel School of Metallurgical Science and Engineering School of Information Science and Engineering Department of Metallurgical Engineering

Thermo-gravimetric analyzer (TGA) was used to determine the thermal behavior of stainless steelmaking dust and FTIR was used to detect the components of off-gas. The TGA results indicate that three mass loss/gain stages exist in the thermal process. The mass loss of the dust in the first stage results from the evaporation of moisture and the reaction between dissociated carbon and metal oxides in the dust. The evaporation of moisture within the dust happens at 90-350 ℃ and the formation of carbon dioxide happens at 250-470 ℃. The mass gain of the dust in the second stage results from the oxidation of metals in the dust by the oxygen at 470-950 ℃. The third stage is a slow mass loss process, and some metals in the dust are evaporated into the atmosphere in this stage. The evaporation of metals is carried out mainly at 900-1 200 ℃ and the dust is sintered at high temperature over 1 200 ℃.

关键词： thermal analysis stainless steelmaking dust environmental protection

Current status and future of targeted peptide receptor radionuclide positron emission tomography imaging and therapy of gastroenteropancreatic-neuroendocrine tumors

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World Journal of Gastroenterology 2022年第17期28卷 1768-1780页

作者： neil Grey Michael Silosky Christopher H Lieu Bennett B Chin Radiology-Nuclear Medicine University of Colorado School of MedicineAnschutz Medical CampusAuroraCO 80045United States Department of Radiology University of Colorado School of MedicineAnschutz Medical CampusAuroraCO 80045United States Medical Oncology University of Colorado School of MedicineAnschutz Medical CampusAuroraCO 80045United States

Theranostics is the highly targeted molecular imaging and therapy of *** peptide receptor radionuclide therapy has taken the lead in demonstrating the safety and effectiveness of this molecular approach to treating ***,well-differentiated gastroenteropancreatic neuroendocrine tumors may be most effectively imaged and treated with DOTATATE *** review the current practice,safety,advantages,and limitations of DOTATATE based ***,we briefly describe the exciting new areas of development and future directions of gastroenteropancreatic neuroendocrine tumor theranostics.

关键词： DOTATATE Theranostics Gastroenteropancreatic neuroendocrine tumors 68Ga DOTATATE 177Lu DOTATATE Review

Genetic diversity and population structure of Pisum sativum accessions for marker-trait association of lipid content

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The Crop Journal 2015年第3期3卷 238-245页

作者： Sajjad Ahmad Simerjeet Kaur neil Dylan Lamb-Palmer Mark Lefsrud Jaswinder Singh Department of Plant Science Mc Gill University Ste Anne de Bellevue Quebec H9X 3V9 Canada Department of Bioresource Engineering Mc Gill University Ste Anne de Bellevue Quebec H9X 3V9 Canada

Field pea(Pisum sativum L.) is an important protein-rich pulse crop produced globally. Increasing the lipid content of Pisum seeds through conventional and contemporary molecular breeding tools may bring added value to the crop. However, knowledge about genetic diversity and lipid content in field pea is limited. An understanding of genetic diversity and population structure in diverse germplasm is important and a prerequisite for genetic dissection of complex characteristics and marker-trait associations. Fifty polymorphic microsatellite markers detecting a total of 207 alleles were used to obtain information on genetic diversity, population structure and marker-trait associations. Cluster analysis was performed using UPGMA to construct a dendrogram from a pairwise similarity matrix. Pea genotypes were divided into five major clusters. A model-based population structure analysis divided the pea accessions into four groups. Percentage lipid content in 35 diverse pea accessions was used to find potential associations with the SSR markers. Markers AD73, D21, and AA5 were significantly associated with lipid content using a mixed linear model(MLM) taking population structure(Q) and relative kinship(K) into account. The results of this preliminary study suggested that the population could be used for marker-trait association mapping studies.

关键词： Diversity Field Pea Lipid content Marker-trait association Mixed linear model SSR