检索结果-南通市图书馆

Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery

Natural Products and Bioprospecting 2023年第1期13卷 382-399页

作者： Phanankosi Moyo Luke Invernizzi Sephora M.Mianda Wiehan rudolph Warren A.Andayi Mingxun Wang neil r.crouch Vinesh J.Maharaj Biodiscovery Center Department of ChemistryFaculty of Natural and Agricultural SciencesUniversity of PretoriaPrivate Bag X 20HatfieldPretoria 0028South Africa Department of Physical and Biological Sciences Murang’a University of TechnologyMurang’aKenya Computer Science and Engineering University of California Riverside900 University AveRiversideCA 92521USA Biodiversity research and Monitoring Directorate South African National Biodiversity InstituteBerea RoadP.O.Box 52099Durban 4007South Africa School of Chemistry and Physics University of KwaZulu-NatalDurban 4041South Africa

The antimalarial drug-resistance conundrum which threatens to reverse the great strides taken to curb the malaria scourge warrants an urgent need to find novel chemical scaffolds to serve as templates for the development of new antimalarial *** represent a viable alternative source for the discovery of unique potential antiplasmodial chemical *** expedite the discovery of new antiplasmodial compounds from plants,the aim of this study was to use phylogenetic analysis to identify higher plant orders and families that can be rationally prioritised for antimalarial drug *** queried the PubMed database for publications documenting antiplasmodial properties of natural compounds isolated from higher ***,we manually collated compounds reported along with plant species of origin and relevant pharmacological *** systematically assigned antiplasmodial-associated plant species into recognised families and orders,and then computed the resistance index,selectivity index and physicochemical properties of the compounds from each taxonomic *** the generated phylogenetic trees and the biological data of each clade allowed for the identification of 3‘hot’plant orders and *** top 3 ranked plant orders were the(i)Caryophyllales,(ii)Buxales,and(iii)*** top 3 ranked plant families were the(i)Ancistrocladaceae,(ii)Simaroubaceae,and(iii)*** highly active natural compounds(IC_(50)≤1μM)isolated from these plant orders and families are structurally unique to the‘legacy’antimalarial *** study was able to identify the most prolific taxa at order and family rank that we propose be prioritised in the search for potent,safe and drug-like antimalarial molecules.

关键词： Natural products Plants Phylogenetics Malaria Drug-resistance ‘Hot’plants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prioritised identification of structural classes of natural products from higher plants in the expedition of antimalarial drug discovery

引用

Natural Products and Bioprospecting 2023年第1期13卷 348-367页

作者： Phanankosi Moyo Luke Invernizzi Sephora M.Mianda Wiehan rudolph Andrew W.Andayi Mingxun Wang neil r.crouch Vinesh J.Maharaj Department of Chemistry Faculty of Natural and Agricultural SciencesBiodiscovery CenterUniversity of PretoriaPrivate Bag X 20HatfieldPretoria 0028South Africa Department of Physical and Biological Sciences Murang’a University of Technology Murang’aMurang’aKenya Computer Science and Engineering University of California Riverside900 University AveRiversideCA 92521USA Biodiversity research and Monitoring Directorate South African National Biodiversity InstituteBerea RoadP.O.Box 52099Durban 4007South Africa School of Chemistry and Physics University of KwaZulu-NatalDurban 4041South Africa

The emergence and spread of drug-recalcitrant Plasmodium falciparum parasites threaten to reverse the gains made in the fight against *** measures need to be taken to curb this impending *** higher plant-derived sesquiterpene,quinoline alkaloids,and naphthoquinone natural product classes of compounds have previously served as phenomenal chemical scaffolds from which integral antimalarial drugs were *** successes serve as an inspiration for the continued investigation of plant-derived natural products compounds in search of novel molecular templates from which new antimalarial drugs could be *** aim of this study was to identify potential chemical scaffolds for malaria drug discovery following analysis of historical data on phytochemicals screened in vitro against *** identify these novel scaffolds,we queried an in-house manually curated database of plant-derived natural product compounds and their in vitro biological *** products were assigned to different structural classes using *** identify the most promising chemical scaffolds,we then correlated natural compound class with bioactivity and other data,namely(i)potency,(ii)resistance index,(iii)selectivity index and(iv)physicochemical *** used an unbiased scoring system to rank the different natural product classes based on the assessment of their bioactivity *** this analysis we identified the top-ranked natural product pathway as the *** top three ranked super classes identified were(i)pseudoalkaloids,(ii)naphthalenes and(iii)tyrosine alkaloids and the top five ranked classes(i)quassinoids(of super class triterpenoids),(ii)steroidal alkaloids(of super class pseudoalkaloids)(iii)cycloeudesmane sesquiterpenoids(of super class triterpenoids)(iv)isoquinoline alkaloids(of super class tyrosine alkaloids)and(v)naphthoquinones(of super class naphthalenes).Launched chemical space of these identified classes of compou

关键词： Natural products Compound classes Phytochemicals Plasmodium falciparum Antiplasmodial drug resistance Malaria Drug development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：