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性别差异和动态磁敏感对比增强mRI肿瘤血流量与直肠癌放化疗后的治疗反应和长期生存率相关

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国际医学放射学杂志 2021年第1期44卷 105-106页

作者： K.m.Bakke S.meltzer E.Gr?vik A.Neg?rd S.H.Holmedal K.I.Gjesdal 李晨菲

摘要mRI是直肠癌分期的标准工具,然而有必要进行更精确的诊断试验,以评估决定治疗结果的肿瘤生物学特征。肿瘤血流灌注和缺氧是2个重要的特征,但目前临床应

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Westhazel GP油藏:盐溶形成圈闭的史例

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国外油气勘探 1994年第2期6卷 204-213页

作者： neil L.Anderson 马作彬

加拿大萨斯喀彻淐省中西部的Westhazel General Petroleums(GP)油藏的生产层段为下白垩统mannville群的GP段。该油藏的储县是由构造圈闭的。这些构造的形成与下伏中泥盆统Prairie组Leofnard段的盐溶东部上倾边缘有关。Westhazel地区的... 详细信息

加拿大萨斯喀彻淐省中西部的Westhazel General Petroleums(GP)油藏的生产层段为下白垩统mannville群的GP段。该油藏的储县是由构造圈闭的。这些构造的形成与下伏中泥盆统Prairie组Leofnard段的盐溶东部上倾边缘有关。Westhazel地区的岩盐淋滤作用出现在mannville群之后并且使区域性西南倾的General Petroleums段出现局部反倾。从地球物理资料来看,Westhazel GP油藏代表着Prairie盐溶解边缘分布的许多浅的下白垩统油藏。Westhagel地区10m厚的薄储层相在地震或重力资料上都未能显示出鉴别特征。相反,用地球物理技术却可以测绘出引起储层圈闭的岩盐上倾边缘。在地震资料上,Prairie盐溶解边缘具有以下特征:(1)代表着下伏Winnipegosis组地层的同相轴的振幅和横向相干性稍有降低;(2)作为主要围岩的古生界地层包含的主要层段逐渐变薄;(3)沿Beaverhill Lake(晚泥盆世)同相轴出现反向牵引;(4)沿mannvill(下白垩统)同相轴出现反向牵引;(5)在近代盐溶地区,下白垩统和下伏反射的时间构造出现"视拗陷"现象。在重力剖面上,盐边缘表现为1.5mGal的异常。两种地球物理数据集的解释结果都与可靠的地质控制一致。

关键词：圈闭储集层油藏

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Natural and anthropogenic forest fires recorded in the Holocene pollen record from a Jinchuan peat bog,northeastern China

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Natural and anthropogenic forest fires recorded in the Holoc...

Evaluation of a modified Scleral Contact Lens as a Riboflavin Delivery Device for Corneal Collagen Crosslinking

中国科学院地质与地球物理研究所2008学术年会

作者： Suzanne A.G.Leroy neil Ogle Institute for the Environment Brunel University(West London)Uxbridge UB8 3PHUK Environmental Engineering Research Centre The Queen's University of BelfastBelfast BT9 5AGUK

Pollen and charcoal particles from a Jinchuan peat(northeastern China) were examined to investigate the fire origin and interaction between climate,vegetation,fire and human activity during the *** results show that:(i)a broadleaved deciduous forest was dominant during the early Holocene;(ii)from～5500 *** *** was a gradual increase in coniferous trees(mainly Finns),and a decrease in broadleaved deciduous trees(***,Juglans,and Ulmus-Zelkova);(iii)after～4200 *** B.P.,the deciduous forest was replaced by a mixed forest of coniferous and deciduous trees;(iv)coniferous trees including Pinus,Abies and Picea further increased after～2000 *** B.P.,reflecting a cooler and drier climate after～5500-4200 *** *** layers of abundant microfossil charcoal particles(250-10μm) and the coexistence of macrofossil particles(>2 mm) suggest two local fires:fire event 1(5120±66 *** B.P.) and fire event 2(1288±8 *** B.P.,AD 662±8). Charcoal layer 1,with a large amount of monolete psilate spores,is superimposed on the long-term trend of vegetation changes,indicating a natural origin for fire event 1 that was probably facihtated by drying environmental conditions since the ***-type pollen and a low percentage of monolete psilate spores were observed in charcoal layer 2,indicating that fire event 2 was caused by *** suggest that fire event 2 may be related to the spread of the Han fanning culture accompanied by the territorial expansion of the Tang Dynasty to the studied area in AD 668.

关键词： Pollen record Fire Vegetation Human activity Holocene Northeastern China

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Open Journal of Ophthalmology 2017年第4期7卷 273-280页

作者： Ricardo Torres Soares neil F.Novo Willy marcus Franca Faculty of medical and Health Science Catholic University of Sao PauloSao PauloBrazil

Introduction: Keratoconus is a complex corneal disease that reduces visual acuity by progressively modifying the corneal shape and thickness, usually producing myopia and irregular astigmatism. Corneal collagen crosslinking with riboflavin + ultraviolet-A radiation (CXL) has become a widely accepted treatment for progressive keratoconus. During CXL, riboflavin administration is performed by repeated manual instillation of solution drops on the cornea for 30 minutes, a procedure that is often uncomfortable for many patients and that consumes surgical facilities and staff resources. In this study, especially modified scleral contact lenses (mSCL) were employed for delivering riboflavin to the cornea during CXL. Objective: The study aimed at evaluating the safety and efficacy of mSCL as a drug delivery system, verifying if anterior chamber flare confirms riboflavin penetration and describes the impact on patient comfort and optimization of surgical staff and facility resources. material and method: This study included 8 eyes of 6 patients aged 16 - 25 years old with history of progressive keratoconus. After mechanical removal of corneal epithelium, the concave surface of the modified scleral contact lens was filled with riboflavin solution and the lens was placed on the patient’s eye during 30 minutes. The lens design allows the formation of a riboflavin layer between the lens and the exposed corneal stroma to facilitate riboflavin penetration. Patients with lens were allowed to stand up and wait for the second UVA phase outside the surgical room. Riboflavin diffusion was confirmed by biomicroscopic examination of the corneal stroma and anterior chamber with the lens in place. Patients returned and the lens was removed before UV-A irradiation at 3 mW/cm2 for 30 minutes. Statistical analysis was performed by comparing the following parameters of each patient pre- and post-CXL: Spherical equivalent (***.), mean simulated keratometry (SimK-m) and corrected distance vis

关键词： Keratoconus Riboflavin UVA Rigid Contact Lens Cross-Linking

Recent developments on PET radiotracers for TSPO and their applications in neuroimaging

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Acta Pharmaceutica Sinica B 2021年第2期11卷 373-393页

作者： Lingling Zhang Kuan Hu Tuo Shao Lu Hou Shaojuan Zhang Weijian Ye Lee Josephson Jeffrey H.meyer ming-Rong Zhang neil Vasdev Jinghao Wang Hao Xu Lu Wang Steven H.Liang Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine and PET/CT-MRI CenterThe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Neurology the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Radiopharmaceuticals Development National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan Division of Nuclear medicine and molecular Imaging Massachusetts General Hospital&Department of RadiologyHarvard Medical SchoolBostonMA 02114USA Azrieli Centre for Neuro-Radiochemistry Brain Health Imaging CentreCentre for Addiction and Mental Health&Department of PsychiatryUniversity of TorontoToronto ON M5T 1R8Canada Department of Pharmacy the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

The 18 kDa translocator protein(TSPO),previously known as the peripheral benzodiazepine receptor,is predominately localized to the outer mitochondrial membrane in steroidogenic *** TSPO expression is relatively low under physiological conditions,but is upregulated in response to glial cell *** the primary index of neuroinflammation,TSPO is implicated in the pathogenesis and progression of numerous neuropsychiatric disorders and neurodegenerative diseases,including Alzheimer’s disease(AD),amyotrophic lateral sclerosis(ALS),Parkinson’s disease(PD),multiple sclerosis(mS),major depressive disorder(mDD)and obsessive compulsive disorder(OCD).In this context,numerous TSPO-targeted positron emission tomography(PET)tracers have been *** them,several radioligands have advanced to clinical research *** this review,we will overview the recent development of TSPO PET tracers,focusing on the radioligand design,radioisotope labeling,pharmacokinetics,and PET imaging ***,we will consider current limitations,as well as translational potential for future application of TSPO *** review aims to not only present the challenges in current TSPO PET imaging,but to also provide a new perspective on TSPO targeted PET tracer discovery *** these challenges will facilitate the translation of TSPO in clinical studies of neuroinflammation associated with central nervous system diseases.

关键词： TSPO microglial activation Neuroinflammation Positron emission tomography(PET) CNS disorders

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Associations between partial foot amputation level,gait parameters,and minimum impairment criteria in para-sport:A research study protocol

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Sports medicine and Health Science 2022年第1期4卷 70-73页

作者： Fabio C.Lucas de Oliveira Samuel Williamson Clare L.Ardern neil Heron Dina Christa Janse van Rensburg marleen G.T.Jansen Sean O'Connor Linda Schoonmade Jane Thornton Babette m.Pluim Center for Interdisciplinary Research in Rehabilitation and Social Integration CIUSSS-CNUniversite LavalQuebec CityQuebecCanada Research Unit in Sport and Physical Activity(CIDAF) Faculty of Sport Sciences and Physical EducationUniversity of CoimbraCoimbraPortugal English Institute of Sport LondonUK Division of Physiotherapy Karolinska InstituteStockholmSweden Center for Public Health Queen's University BelfastBelfastUK Department of General Practice Keele UniversityStaffordshireUK Section Sports medicine Faculty of Health SciencesUniversity of PretoriaPretoriaSouth Africa Royal Dutch Lawn Tennis Association(KNLTB) Amstelveenthe Netherlands Centre for Human movement Sciences University Medical Centre GroningenUniversity of GroningenGroningenthe Netherlands School of medicine Dentistry and Biomedical Sciences Centre for Public HealthQueen's University BelfastBelfastUK medical Library Vrije Universiteit AmsterdamAmsterdamthe Netherlands Department of Family medicine Schulich School of Medicine&DentistryUniversity of Western OntarioLondonOntarioCanada Department of Epidemiology&Biostatistics Schulich School of Medicine&DentistryUniversity of Western OntarioLondonOntarioCanada AmC/VUmc IOC Research Center of Excellence Amsterdam Collaboration on Health&Safety in Sports(ACHSS)AmsterdamNetherlands

Altered biomechanics due to amputation can contribute to substantial limitations,influencing sporting *** with lower extremity amputations or congenital lower limb deficiency are encouraged to participate in ***,to compete in Paralympic sports,the candidate must have an impairment that results in lower extremity loss of function and meets or exceeds the sport's minimum impairment criteria(mIC).This review will focus on the mIC for competitive wheelchair *** deficiency is known as one of the mIC used to regulate participation in competitive para-sports since it impacts gait,kinematics,and biomechanics of both the upper and lower ***,it is questionable whether the mIC concerning limb deficiency is set at the correct level for determining eligibility for participating in Paralympic *** study aims to provide an overview of the evidence examining the impact of different partial foot amputation(PFA)levels on gait as a proxy for sporting *** scoping review will be based on a 6-step methodological framework and Preferred Reporting Items for Systematic Reviews and meta-Analysis,extension for scoping reviews(PRISmA-ScR).Studies will be selected from Pubmed,Embase,CINAHL,and *** authors will screen the titles/abstracts *** studies will be scrutinised,and the same authors will extract *** will be relevant to informing the evidence-based development of mIC for lower limb impairment after PFA and may be extrapolated to specific Paralympic sports,including wheelchair *** will be disseminated through scientific publications and conferences to audiences interested in Paralympic sports.

关键词： Amputees Congenital deficiency Gait analysis Paralympic sport Partial foot amputation Wheelchair tennis

Development of a pH-Stat method to measure in vitro degree of protein hydrolysis using enzymes from pyloric caeca of Atlantic cod(Gadus morhua L.)

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Development of a pH-Stat method to measure in vitro degree o...

A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation

The 14th International Symposium on Fish Nutrition & Feeding

作者： Sean m.Tibbetts Joyce E.milley neil W.Ross Santosh P.Lall National Research Council of Canada Institute for Marine Biosciences1411 Oxford StreetHalifaxNova ScotiaCanadaB3H 3Z1 National Research Council of Canada Industrial Research Assistance Program1411 Oxford StreetHalifaxNova ScotiaCanadaB3H 3Z1

Ingredients used in aquafeeds can vary considerably in protein quality which is a concern for feed *** and reproducible methods to screen ingredients are *** vitro methods,which do not use large numbers of fish and yield data quickly,offer an attractive complement to traditional in vivo methods and may be more suitable for research and industrial *** results obtained using certain in vitro methods for finfish and shellfish are promising,reproducibility of results has been *** modifications are necessary to improve existing methods and to standardize the *** method described here involves extraction and partial purification of an enzyme solution from pyloric caeca of Atlantic *** of the two major proteolytic enzymes(trypsin and chymotrypsin) significantly(Pmethod to test the digestibility of feed ingredients,a study was conducted to determine the most suitable substrate/enzyme(S/E) ratio to use in subsequent degree of hydrolysis(DH) assays. This trial used a standard purified protein source(vitamin-free casein,IFN 5-01-162) with four S/E ratios(0.25,0.50,0.75 and 1.00 mg N/mL) and a true blank for *** observation of the curve data combined with best-fit curve modelling with minimum R of 0.99 resulted in maximum DH values in a tight range(25.3-27.5%) with no significant differences between S/E ratios *** assay duration time and volume of NaOH titrant required to achieve maximum DH was,however,highly influenced by S/E ratio ranging frommL to>21 *** the 10-hour assay,the casein DH curve of the 0.50 mg N/mL ratio displayed a rapid increase and reached a clear plateau at maximum DH of 27%.This maximum period was also achieved within a moderate assay duration(6-8 hours)

关键词： Gadoids Atlantic cod Protein Digestibility In vitro Feed ingredients

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Science China(Life Sciences) 2023年第12期66卷 2939-2942页

作者： Yuxuan Guo Yangpo Cao Blake D.Jardin neil mazumdar Congting Guo Luzi Yang Junsen Lin Zhan Chen Qing ma mingming Zhao Erdan Dong William T.Pu Peking University Health Science Center School of Basic Medical SciencesBeijing 100191China Peking University Institute of Cardiovascular Sciences Beijing 100191China State Key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityBeijing100191China Beijing Key Laboratory of Cardiovascular Receptors Research Beijing 100191China Boston Children’s Hospital Department of CardiologyBoston MA 02115USA Peking University Third Hospital Department of Cardiology and Institute of Vascular MedicineBeijing 100191China Research Unit of medical Science Research management/Basic and Clinical Research of metabolic Cardiovascular Diseases Chinese Academy of Medical SciencesHaihe Laboratory of Cell EcosystemBeijing 100191China National Health Commission Key Laboratory of Cardiovascular molecular Biology and Regulatory Peptides Beijing 100191China Harvard Stem Cell Institute Cambridge MA 02138USA

Dear Editor,In development,after cells make a commitment to their fates,they undergo a continuous and adaptive maturation process to eventually reach their terminal *** maturity often decays during aging and *** immat... 详细信息

关键词： states eventually decay

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Surgical relevance of anatomic variations of the right hepatic vein

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World Journal of Transplantation 2021年第6期11卷 231-243页

作者： Shamir O Cawich Vijay Naraynsingh neil W Pearce Rahul R Deshpande Robbie Rampersad michael T Gardner Fawwaz mohammed Roma Dindial Tanzilah Afzal Barrow Department of Surgery University of the West IndiesSt Augustine 000000Trinidad and Tobago Department of Surgery Port of Spain General HospitalPort of Spain 000000Trinidad and Tobago University Surgical Unit Southampton General HospitalSouthampton SO166YDUnited Kingdom Department of Surgery Manchester Royal InfirmaryManchester M139WLUnited Kingdom Department of Radiology University of the West IndiesSt.Augustine 000000Trinidad and Tobago Department of Radiology Port of Spain General HospitalPort of Spain 000000Trinidad and Tobago Section of Anatomy Basic Medical SciencesUniversity of the West IndiesKingston 000000Jamaica Department of Radiology University of the West IndiesSt Augustine 000000Trinidad and Tobago

BACKGROUND Variations in the anatomy of hepatic veins are of interest to transplant surgeons,interventional radiologists,and other medical practitioners who treat liver *** drainage patterns of the right hepatic veins(RHVs)are particularly relevant to transplantation *** The aim was to identify variations of the patterns of venous drainage from the right side of the *** the best of our knowledge,there have been no reports on RHV variations in in a Caribbean *** Two radiologists independently reviewed 230 contrast-enhanced computed tomography scans performed in 1 year at a hepatobiliary referral *** outflow patterns were observed and RHV variants were described as:(1)Tributaries of the RHV;(2)Variations at the hepatocaval junction(HCJ);and(3)Accessory *** A total of 118 scans met the inclusion *** 39%of the scans found conventional anatomy of the main hepatic *** RHVs were present 49.2%and included a well-defined inferior RHV draining segment VI(45%)and a middle RHV(4%).At the HCJ,83 of the 118(70.3%)had a superior RHV that received no tributaries within 1 cm of the junction(Nakamura and Tsuzuki type I).In 35 individuals(29.7%)there was a short superior RHV with at least one variant *** to the Nakamura and Tsuzuki classification,there were 24 type II variants(20.3%),six type III variants(5.1%)and,five type IV variants(4.2%).CONCLUSION There was significant variation in RHV patterns in this population,each with important relevance to liver *** radiologists and hepatobiliary surgeons practicing in the Caribbean must be cognizant of these differences in order to minimize morbidity during invasive procedures.

关键词： Liver Variant Hepatic Vein Anomaly Venous,Drainage,Vena cava