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Psychiatric comorbidities in epilepsy:population co-occurrence,genetic correlations and causal effects

General Psychiatry 2024年第1期37卷 103-111页

作者： Viktor H Ahlqvist Christina Dardani Paul madley-Dowd Harriet Forbes Jessica Rast Caichen Zhong Renee m Gardner Christina Dalman Kristen Lyal cRAIG Newschaffer Torbjorn Tomson michael Lundberg Daniel Berglind neil m Davies Brian K Lee Cecilia magnusson Dheeraj Rai Department of Global Public Health Karolinska InstitutetStockholmSweden medical Research Council Integrative Epidemiology Unit Bristol Medical SchoolUniversity of BristolBristolUK Centre for Academic mental Health Population Health SciencesBristol Medical SchoolUniversity of BristolBristolUK Faculty of Epidemiology and Population Health London School of Hygiene and Tropical MedicineLondonUK A.J.Drexel Autism Institute Drexel UniversityPhiladelphiaPAUSA Department of Epidemiology and Biostatistics School of Public HealthDrexel UniversityPhiladelphiaPAUSA College of Health and Human Development Pennsylvania State UniversityState CollegePAUSA Department of Clinical Neuroscience Karolinska InstitutetStockholmSweden Centre for Epidemiology and Community medicine Region StockholmStockholmSweden K.G Jebsen Center for Genetic Epidemiology Department of Public Health and NursingNorwegian University of Science and TechnologyTrondheimNorway Division of Psychiatry University Collge LondonLondonUK Department of Statistical Sciences University Cllge LondonLondonK NIHR Biomedical Research Centre University of BristoBristolUK Avon and Wiltshire Partnership NHS Mental Health TrustBristolUK

Background Psychiatric comorbidities are common in patients with *** for the co-occurrence of psychiatric conditions and epilepsy remain poorly *** We aimed to triangulate the relationship between epilepsy and psychiatric conditions to determine the extent and possible origins of these *** Using nationwide Swedish health registries,we quantified the lifetime prevalence of psychiatric disorders in patients with *** then used summarydata from genome-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium score ***,we assessed the potential bidirectional relationships using two-sample mendelian *** In a cohort of 7628495 individuals,we found that almost half of the 94435 individuals diagnosed with epilepsy were also diagnosed with a psychiatric condition in their lifetime(adjusted lifetime prevalence,44.09%;95%confidence interval(Cl)43.78%to 44.39%).We found evidence for a genetic correlation between epilepsy and some neurodevelopmental and psychiatric *** example,we observed a genetic correlation between epilepsy and attention-deficit/hyperactivity disorder(r,=0.18,95%Cl 0.09 to 0.27,pmore pronounced in focal epilepsy(r=0.23,95%CI 0.09 to 0.36,pm mendelian randomisation using common genetic variants did not support bidirectional effects between epilepsy and neurodevelopmental or psychiatric *** Psychiatric comorbidities are common in patients with *** correlations may partially explain some comorbidities;however,there is little evidence of a bidirectional relationship between the genetic liability of epilepsy and psychiatric *** findings highlight the need to understand the role of environmental factors or rare genetic variations in the origins of psy

关键词： epilepsy Psychiat lifetime

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An acoustofluidic device for the automated separation of platelet-reduced plasma from whole blood

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microsystems & Nanoengineering 2024年第3期10卷 293-303页

作者： Zhehan ma Jianping Xia neil Upreti Emeraghi David Joseph Rufo Yuyang Gu Kaichun Yang Shujie Yang Xiangchen Xu Jean Kwun Eileen Chambers Tony Jun Huang Thomas Lord Department of mechanical Engineering and materials Science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Pediatrics Duke UniversityDurhamNCUSA Duke Transplant Center Department of SurgeryDuke University School of MedicineDurhamNCUSA

Separating plasma from whole blood is an important sample processing technique required for fundamental biomedical research,medical diagnostics,and therapeutic *** protocols for plasma isolation require multiple centrifugation steps or multiunit microfluidic processing to sequentially remove large red blood cells(RBCs)and white blood cells(WBCs),followed by the removal of small ***,we present an acoustofluidic platform capable of efficiently removing RBCs,WBCs,and platelets from whole blood in a single *** leveraging differences in the acoustic impedances of fluids,our device generates significantly greater forces on suspended particles than conventional microfluidic approaches,enabling the removal of both large blood cells and smaller platelets in a single *** a result,undiluted human whole blood can be processed by our device to remove both blood cells and platelets(>90%)at low voltages(25 Vpp).The ability to successfully remove blood cells and platelets from plasma without altering the properties of the proteins and antibodies present creates numerous potential applications for our platform in biomedical research,as well as plasma-based diagnostics and ***,the microfluidic nature of our device offers advantages such as portability,cost efficiency,and the ability to process small-volume samples.

关键词： remove separation removing

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Twenty-nine million intrinsic Q-factor monolithic microresonators on thin-film lithium niobate

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Photonics Research 2024年第8期12卷 I0001-I0006页

作者： XINRUI ZHU YAOWEN HU SHENGYUAN LU HANA KWARNER XUDONG LI YUNXIANG SONG LETÍCIA mAGALHÃES AmIRHASSAN SHAmS-ANSARI ANDREA CORDARO neil SINCLAIR mARKO LONČAR John A.Paulson School for Engineering and Applied Sciences Harvard UniversityCambridgeMassachusetts 02138USA State Key Laboratory for mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China DRS Daylight Solutions San DiegoCalifornia 92127USA

The recent emergence of thin-film lithium niobate(TFLN)has extended the landscape of integrated *** has been enabled by the commercialization of TFLN wafers and advanced nanofabrication of TFLN such as high-quality dry ***,fabrication imperfections still limit the propagation loss to a few dB/m,restricting the impact of this ***,we demonstrate TFLN microresonators with a record-high intrinsic quality(Q)factor of twenty-nine million,corresponding to an ultra-low propagation loss of 1.3 dB/*** present spectral analysis and the statistical distribution of Q factors across different resonator *** work pushes the fabrication limits of TFLN photonics to achieve a Q factor within 1 order of magnitude of the material limit.

关键词： resonator lithium film

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How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

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Journal of Sport and Health Science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van Ierssel Olivia Galea Kirsten Holte Caroline Luszawski Elizabeth Jenkins Jennifer O’neil Carolyn A Emery Rebekah mannix Kathryn Schneider Keith Owen Yeates Roger Zemek Children’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada The Centre for Health Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Alberta Children’s Hospital Research Institute University of Calgary CalgaryAB T2N 1N4Canada Hotchkiss Brain Institute University of CalgaryCalgaryAB T2N 4N1Canada Department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Rehabilitation Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research Institute OttawaON K1N 5C8Canada Departments of Pediatrics and Emergency medicine Harvard Medical SchoolBostonMA 02115USA Departments of Pediatrics and Emergency medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RCTs)of non-pharmacological interventions following ***:We searched mEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up to may *** reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),Consensus on Exercise Reporting Template(CERT),and international Consensus on Therapeutic Exercise aNd Training(i-CONTENT)*** information was sought my study authors where reporting was *** of bias(ROB)was assessed with the Cochrane ROB-2 *** examining non-pharmacological interventions following ***:We included 89 RCTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck *** scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified *** completeness improved after TIDieR and CERT publication,but p

关键词： Concussion Intervention Randomized controlled trial Systematic review

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A midgut transcriptional regulatory loop favors an insect host to withstand a bacterial pathogen

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The Innovation 2024年第5期5卷 36-45,35页

作者： Zhaojiang Guo Liuhong Zhu Zhouqiang Cheng Lina Dong Le Guo Yang Bai Qingjun Wu Shaoli Wang Xin Yang Wen Xie neil Crickmore Xuguo Zhou RenéLafont Youjun Zhang State Key Laboratory of Vegetable Biobreeding Department of Plant ProtectionInstitute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China School of Life Sciences University of SussexBrighton BN19QEUK Department of Entomology School of Integrative BiologyCollege of Liberal Arts&SciencesUniversity of Illinois Urbana-ChampaignUrbanaIL 61801-3795USA Sorbonne Université CNRS-IBPS(BIOSIPE)75005 ParisFrance

mounting evidence suggests that insect hormones associated with growth and development also participate in pathogen *** have discovered a previously undescribed midgut transcriptional control pathway that modulates the availability of 20-hydroxyecdysone(20E)in a worldwide insect pest(Plutella xylostella),allowing it to defeat the major virulence factor of an insect pathogen Bacillus thuringiensis(Bt).A reduction of the transcriptional inhibitor(PxDfd)increases the expression of a midgut microRNA(miR-8545),which in turn represses the expression of a newly identified ecdysteroid-degrading glucose dehydrogenase(PxGLD).Downregulation of PxGLD reduces 20E degradation to increase 20E titer and concurrently triggers a transcriptional negative feedback loop to mitigate 20E *** moderately elevated 20E titer in the midgut activates a mAPK signaling pathway to increase Bt tolerance/*** findings deepen our understanding of the functions attributed to these classical insect hormones and help inform potential future strategies that can be employed to control insect pests.

关键词： elevated transcriptional loop

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Rescue from complications after pancreaticoduodenectomies at a low-volume Caribbean center:Value of tailored peri-pancreatectomy protocols

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 681-688页

作者： Shamir O Cawich Elijah Dixon Parul J Shukla Shailesh V Shrikhande Rahul R Deshpande Fawwaz mohammed neil W Pearce Wesley Francis Shaneeta Johnson Johann Bujhawan Department of Surgery University of the West IndiesSt Augustine 000000Trinidad and Tobago Department of Surgery Faculty of MedicineUniversity of CalgaryCalgaryAlberta T2N2T9Canada Department of Surgery Weill Cornell Medical CollegeNew YorkNY 10065United States Department of Surgical Oncology Tata Memorial CenterHomi Bhabha National UniversityMumbai 400012India Department of Surgery Manchester Royal InfirmaryManchester M139WLUnited Kingdom University Surgical Unit Southampton General HospitalSouthampton SO166YDUnited Kingdom Department of Surgery University of the West IndiesNassau N-1184Bahamas Department of Surgery Morehouse School of MedicineAtlantaGA 30310United States Department of Surgery General Hospital in Port of SpainPort of Spain 000000Trinidad and Tobago

BACKGROUND Pancreaticoduodenectomy(PD)is a technically complex operation,with a re-latively high risk for *** ability to rescue patients from post-PD complications is as a recognized quality *** protocols were instituted at our low volume facility in the year *** To document the rate of rescue from post-PD complications with tailored protocols in place as a measure of *** A retrospective audit was performed to collect data from patients who experienced major post-PD complications at a low volume pancreatic surgery unit in Trinidad and Tobago between January 1,2013 and June 30,***-dardized definitions from the International Study Group of Pancreatic Surgery were used to define post-PD complications,and the modified Clavien-Dindo classification was used to classify post-PD *** Over the study period,113 patients at a mean age of 57.5 years(standard deviation[SD]±9.23;range:30-90;median:56)underwent PDs at this *** complications were recorded in 33(29.2%)patients at a mean age of 53.8 years(SD:±7.9).Twenty-nine(87.9%)patients who experienced major morbidity were salvaged after aggre-ssive treatment of their ***(3.5%)died from bleeding pseudoaneurysm(1),septic shock secondary to a bile leak(1),anastomotic leak(1),and myocardial infarction(1).There was a significantly greater salvage rate in patients with American Society of Anesthesiologists scores≤2(93.3%vs 25%;P=0.0024).CONCLUSION This paper adds to the growing body of evidence that volume alone should not be used as a marker of quality for patients requiring *** low volumes at our facility,we demonstrated that 87.9%of patients were rescued from major *** attributed this to several factors including development of rescue protocols,the competence of the pancreatic surgery teams and continuous,and adaptive learning by the entire institution,cul-minating in the development of tailored peri-pancreatectomy protoc

关键词： Pancreas Complication Rescue Failure morbidity mortality Pancreaticoduodenectomy

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Leukocyte DNA methylation and colorectal cancer among male smokers

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World Journal of Gastrointestinal Oncology 2012年第8期4卷 193-201页

作者： Keith Killian Stephanie Weinstein Jarmo Virtamo margaret Tucker Philip Taylor Demetrius Albanes Paul meltzer neil Caporaso Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD 20852 United States Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of HealthBethesda MD 20852 United States National Public Health Institute Helsinki FI-00271 Finland

AIm: To explore the association between methylation in leukocyte DNA and colorectal cancer (CRC) risk in male smokers using the α-tocopherol, β-carotene cancer prevention study. mETHODS: About 221 incident CRC cases, and 219 controls, frequency-matched on age and smoking intensity were included. DNA methylation of 1505 CpG sites selected from 807 genes were evaluated using Illumina GoldenGate methylation Cancer Panel I in pre-diagnostic blood leukocytes of study subjects. Tertiles of methylation level classified according to the distribution in controls for each CpG site were used to analyze the association between methylation level and CRC risk with logistic regression. The time between blood draw to cancer diagnosis (classifying cases according to latency) was incorporated in further analyses using proportional odds regression. RESULTS: We found that methylation changes of 31 CpG sites were associated with CRC risk at P mained statistically significant after Bonferroni correction, the most statistically significant CpG site associated with CRC risk achieved a P value of 1.0 × 10-4. The CpG site is located in DSP gene, and the risk estimate was 1.52 (95% CI: 0.91-2.53) and 2.62 (95% CI: 1.65-4.17) for the second and third tertile comparing with the lowest tertile respectively. Taking the latency information into account strengthened some associations, suggesting that the methylation levels of corresponding sites might change over time with tumor progression. CONCLUSION: The results suggest that the methylation level of some genes were associated with cancer susceptibility and some were related to tumor development over time. Further studies are warranted to confirm and refine our results.

关键词： DNA methylation Colorectal cancer Susceptibility

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Gamma-ray bursts and their links with supernovae and cosmology

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Research in Astronomy and Astrophysics 2012年第8期12卷 1139-1161页

作者： Peter mszros neil Gehrels Center for Particle and Gravitational Astrophysics Dept.of Astronomy&Astrophysics and Dept.of Physics Pennsylvania State UniversityUniversity ParkPA 16802USA Astrophysics Science Division NASA Goddard Space Flight CenterGreenbeltMD 20771USA

Gamma-ray bursts are the most luminous explosions in the Universe, whose origin and mechanism are the focus of intense interest. They appear connected to su- pernova remnants from massive stars or the merger of their remnants, and their bright- ness makes them temporarily detectable out to the largest distances yet explored in the universe. After pioneering breakthroughs from space and ground experiments, their study is entering a new phase with observations from the recently launched Fermi satellite, as well as the prospect of detections or limits from large neutrino and gravitational wave detectors. The interplay between such observations and theoretical models of gamma-ray bursts is reviewed, and cosmology. as well as their connections to supernovae

关键词： gamma-ray sources -- gamma-ray bursts -- cosmic rays -- neutrinos-- supernovae -- cosmology -- intergalactic medium

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National Soil Organic Carbon Stocks Inventories under Different mangrove Forest Types in Gabon

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Open Journal of Forestry 2024年第2期14卷 127-140页

作者： Rolf Gaël mabicka Obame neil-Yohan musadji Jean Hervé mve Beh Lydie-Stella Koutika Jean Aubin Ondo Farrel Nzigou Boucka michel mbina mounguengui Claude Geffroy Dé partement de Phytotechnologie Institut National d&#8217Agronomie et de Biotechnologies Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Dé partement des Sciences Fondamentales de l&#8217Ing&#233nieur Institut National d&#8217Agronomie et de Biotechnologies Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Institut Agronomiques et Forestiè res Centre National des Recherches Scientifiques et Technologiques Libreville Gabon Research Centre on the Durability and the Productivity of Industrial Plantations (CRDPI) Pointe Noire Republic of Congo Laboratoire Pluridisciplinaire des Sciences &#201cole Normale Sup&#233rieure Libreville Gabon Agence Gabonaise d’ &#201tude et d&#8217Observation Spatiale Immeuble les Arcades Libreville Gabon Dé partement de G&#233ologie Faculte des Sciences Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Institut de Chimie des milieux et maté riaux de Poitiers (IC2MP) Universit&#233 de Poitiers Poitiers France

Gabonese’s estuary is an important coastal mangrove setting and soil plays a key role in mangrove carbon storage in mangrove forests. However, the spatial variation in soil organic carbon (SOC) storage remain unclear. To address this gap, determining the SOC spatial variation in Gabonese’s estuarine is essential for better understanding the global carbon cycle. The present study compared soil organic carbon between northern and southern sites in different mangrove forest, Rhizophora racemosa and Avicennia germinans. The results showed that the mean SOC stocks at 1 m depth were 256.28 ± 127.29 mgC ha−1. Among the different regions, SOC in northern zone was significantly (p p mgC ha−1) than upper layers (55.42 ± 25.37 mgC ha−1). The study highlights that low deforestation rate have led to less CO2 (705.3 mg CO2e ha−1 - 922.62 mg CO2e ha−1) emissions than most sediment carbon-rich mangroves in the world. These results highlight the influence of soil texture and mangrove forest types on the mangrove SOC stocks. The first national comparison of soil organic carbon stocks between mangroves and upland tropical forests indicated SOC stocks were two times more in mangroves soils (51.21 ± 45.00 mgC ha−1) than primary (20.33 ± 12.7 mgC ha−1), savanna and cropland (21.71 ± 15.10 mgC ha−1). We find that mangroves in this study emit lower dioxide-carbon equivalent emissions. This study highlights the importance of national inventories of soil organic carbon and can be used as a baseline on the role of mangroves in carbon sequestration and climate change mitigation but the variation in SOC stocks indicates the need for further national data.

关键词： mangroves Forest Soil Organic Carbon Stocks Rizophora Racemose Avicenia germinans Gabon

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卒中医疗体系之急诊医疗服务的实施策略美国心脏协会/美国卒中协会急诊医疗服务体系专家组和卒中委员会的政策声明

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中华脑血管病杂志（电子版） 2008年第6期2卷 354-370页

作者： Joe E.AckerⅢ Arthur m.Pancioli Todd J.Crocco marc K.Eckstein Edward C.Jauch Hollynn Larrabee neil m.meltzer William C.mergendahl John W.munn Susanne m.Prentiss Charles Sand Jeffrey L.Saver Brian Eigel Brian R.Gilpin mark Schoeberl Penelope Solis JoAnne R.Bailey Katie B.Horton Steven K.Stranne 曹勇军李瑞霞刘建芳刘春风苏州大学附属第二医院神经内科 215004

尽管卒中的预防、诊断、治疗和康复已取得一些进展，但卒中在美国仍然是第三大死亡原因和长期残疾的主要原因。每年约有70万人新发或复发卒中。在过去10年里，急性卒中诊治的一些进展，包括纤溶和其他短期疗法的引入，

关键词：美国心脏协会急诊医疗服务体系卒中协会医疗体系委员会专家组死亡原因急性卒中

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