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Crohn’s disease in low and lower-middle income countries: A scoping review

World Journal of Gastroenterology 2020年第43期26卷 6891-6908页

作者： Ruma Rajbhandari Samantha Blakemore neil gupta Alma J Adler Christopher Allen Noble Sara Mannan Klejda Nikolli Alison Yih Sameer Joshi Gene Bukhman Division of Global Health Equity Department of MedicineBrigham and Women’s HospitalBostonMA 02115United States Department of Global Health and Social Medicine Harvard Medical SchoolBostonMA 02199United States Partners in Health NCD SynergiesBostonMA 02199United States Western Reserve Health Education Trumbull Regional Medical CenterWarrenOH 44483United States

BACKGROUND While Crohn’s disease has been studied extensively in high-income countries,its epidemiology and care in low and lower-middle income countries(LLMICs)is not well established due to a lack of disease registries and diagnostic *** To describe the published burden,diagnostic/treatment capacity,service utilization,challenges/barriers to individuals with Crohn’s in LLMICs and their *** We conducted a scoping review utilizing a full search strategy was developed and conducted in PubMed,Embase and World Health Organization Global Index *** independent reviewers screened the titles and abstracts of all of the publications found in this search,reviewed selected publications,and extracted relevant data,which underwent descriptive review and was analyzed in *** The database search yielded 4486 publications,216 of which were determined to be relevant to the research *** all 79 LLMICs,only 21(26.6%)have publications describing individuals with Crohn’***,the highest number of studies came from India,followed by Tunisia,and *** mean number of Crohn’s patients reported per study is 57.84 and the median is 22,with a wide range from one to *** This scoping review has shown that,although there is a severe lack of populationbased data about Crohn’s in LLMICs,there is a signal of Crohn’s in these settings around the world.

关键词： Crohn’s disease Low and lower-middle income countries Scoping review Service utilization Diagnostic/Treatment capacity

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Predictors of mortality and endoscopic intervention in patients with upper gastrointestinal bleeding in the intensive care unit

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Gastroenterology Report 2020年第4期8卷 299-305,I0002页

作者： Vijaya L.Rao Nina gupta Eric Swei Thomas Wagner Andrew Aronsohn KGautham Reddy neil Sengupta Section of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineUniversity of Chicago MedicineChicagoILUSA Department of Internal Medicine University of Chicago MedicineChicagoILUSA

Background:The outcomes of patients undergoing esophagogastroduodenoscopy(EGD)in the intensive care unit(ICU)for upper gastrointestinal bleeding(UGIB)are not well *** aims were to determine predictors of 30-day mortality and endoscopic intervention,and assess the utility of existing clinical-prediction tools for UGIB in this ***:Patients hospitalized in an ICU between 2008 and 2015 who underwent EGD were identified using a validated,machine-learning *** regression was used to determine factors associated with 30-day mortality and endoscopic *** under receiver-operating characteristics(AUROC)analysis was used to evaluate established UGIB scoring systems in predicting mortality and endoscopic intervention in patients who presented to the hospital with ***:A total of 606 patients underwent EGD for UGIB while admitted to an *** median age of the cohort was 62 years and 55.9%were *** analysis revealed that predictors associated with 30-day mortality included American Society of Anesthesiologists(ASA)class(odds ratio[OR]4.1,95%confidence interval[CI]2.2-7.9),Charlson score(OR 1.2,95%CI 1.0-1.3),and duration from hospital admission to EGD(OR 1.04,95%CI 1.01-1.07).Rockall,Glasgow-Blatchford,and AIMS65 scores were poorly predictive of endoscopic intervention(AUROC:0.521,0.514,and 0.540,respectively)and in-hospital mortality(AUROC:0.510,0.568,and 0.506,respectively).Conclusions:Predictors associated with 30-day mortality include ASA classification,Charlson score,and duration in the hospital prior to *** risk tools are poorly predictive of clinical outcomes,which highlights the need for a more accurate risk-stratification tool to predict the benefit of intervention within the ICU population.

关键词： upper gastrointestinal bleeding esophagogastroduodenoscopy intensive care unit

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The diagnostic conundrum in necrotizing otitis externa

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 59-65页

作者： Abiya A.Ahmed Shaan Rashid Vinay K.gupta neil C.Molony Keshav K.gupta Bradford Royal Infirmary Bradford Teaching Hospitals NHS Foundation TrustWest BromwichWest YorkshireUK Sandwell and West Birmingham Hospitals NHS Trust West BromwichUK Russells Hall Hospital DudleyUK

Necrotizing otitis externa(NOE)is an aggressive and fast‐evolving infection of the external auditory *** diagnoses and untreated cases can lead to severe,even fatal consequences and so early diagnosis and treatment are *** is a notoriously challenging diagnosis to *** is therefore important to understand what diagnostic modalities are available and how otolaryngologists can use them to accurately treat such an aggressive *** review aims to evaluate the different diagnostic options available in NOE and discuss their advantages and limitations,thus,providing an up‐to‐date picture of the multimodal approach required in the diagnosis of this disease.

关键词： diagnostic malignant otitis externa necrotizing osteomyelitis skull base osteomyelitis temporal bone osteomyelitis

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