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Is cardiac resynchronisation therapy feasible, safe and beneficial in the very elderly？

Journal of Geriatric Cardiology 2015年第5期12卷 497-501页

作者： Bartosz Olechowski Rebecca Sands Donah Zachariah neil P andrews Richard Balasubramaniam Mark Sopher John Paisey Paul R Kalra Royal Bournemouth Hospital NHS Foundation Trust Bournemouth UK Queen Alexandra Hospital Portsmouth Hospitals NHS Trust Portsmouth UK

Objective To evaluate whether cardiac resynchronisation therapy （CRT） implantation was feasible and safe in octogenarians and the asso- ciation with symptoms. Methods Consecutive patients undergoing CRT implantation were recruited from two UK centers. Patients grouped according to age：〈 80 ＆ ≥ 80 years. Baseline demographics, complications and outcomes were compared between those groups. Results A total of 439 patients were included in this study, of whom 26% were aged ≥ 80 years. Octogenarians more often received cardiac resynchronization therapy pacemaker in comparison to cardiac resynchronisation therapy-defibrillator. Upgrade from pacemaker was common in both groups （16% 〈 80 years vs. 22% ≥ 80 years, P = NS）. Co-morbidities were similarly common in both groups （overall diabetes： 25%, atrial fibrillation： 23%, hypertension： 45%）. More patient age ≥ 80 years had significant chronic kidney disease （CKD, estimated glomerular filtration rate 〈 45 mL/min per 1.73 m^2, 44% vs. 22%, P 〈 0.01 ）. Overall complication rates （any） were similar in both groups （16% vs. 17%, P = NS）. Both groups demonstrated symptomatic benefit. One-year mortality rates were almost four fold greater in octogenarians as compared with the younger cohort （13.9% vs. 3.7%, P 〈 0.01）. Conclusions CRT appears to be safe in the very elderly despite extensive co-morbidity, and in particular frequent severe CKD. Symptomatic improvement appears to be meaningful. Strategies to increase the appropriate identification of elderly patients with CHF who are potential candidates for CRT are required.

关键词： Cardiac resynchronisation therapy Heart failure Left ventricular dysfunction Safety The elderly

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香港合同法之主要特徵及其未來發展方向

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中国法律（中英文版） 2020年第5期 63-67,146-149页

作者： neil andrews 揚帆英國劍橋大學國際爭議解決研究院(IDRA)

一、香港合同法的特色1按照《香港特別行政區基本法》第8條及第18條的規定,除與基本法相抵觸或經香港特別行政區的立法機關作出修改以外,香港合同法繼續保留原有的普通法、衡平法、條例、附屬立法和習慣法。香港合同法與英國合同法一樣... 详细信息

一、香港合同法的特色1按照《香港特別行政區基本法》第8條及第18條的規定,除與基本法相抵觸或經香港特別行政區的立法機關作出修改以外,香港合同法繼續保留原有的普通法、衡平法、條例、附屬立法和習慣法。香港合同法與英國合同法一樣,由不同的主題組成。這些主題構成了香港合同法的一般原則。許多學者指出,英國合同法的一般原則和理論架構約於十九世紀形成。

关键词：合同法衡平法基本法普通法立法香港

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Risk factors for clinical coronary events in patients with SLE:a multicentre case-control study

Risk factors for clinical coronary events in patients with S...

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The 8th International Congress on SLE

作者： Sahena Haque Donna Taylor-Fesler Caroline Gordon Veronica Toescu David Isenberg Anisur Rahman Aubrey Bell Peter Lanyon neil McHugh David GI Scott Paul Emery Lee Suan Teh Jacqueline andrews Hazem Youssef Bridget Griffiths John McLaren Ian Bruce The University of Manchester Oxford RoadManchesterMI3 910 The University of Manchester Oxford RoadManchesterMI3 910 British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group The University of Manchester Oxford RoadManchesterM139HJ British Isles Lupus Assessment Group BSR Lupus Special Interest Group

＜正＞Purpose:To identify risk factors（RF）for clinical coronary heart disease（CHD）in SLE and to study the role of traditional RF,SLE disease distribution,serology and therapy. Methods:This was a multicentre case,control *** recruited 48 SLE patients with verified clinical CHD （myocardial infarction or angina pectoris）and 78 SLE

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Weak mismatch epitaxy and structural feedback in graphene growth on copper foil

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Nano Research 2013年第2期6卷 99-112页

作者： neil R. Wilson Alexander J. Marsden Mohammed Saghir Catherine J. Bromley Renald Schaub Giovanni Costantini Thomas W. White Cerianne Partridge Alexei Barinov Pavel Dudin Ana M. Sanchez James J. Mudd Marc Walker Gavin R. Bell Department of Physics University of Warwick Coventry CV4 7AL UK EaStCHEM School of Chemistry University of St Andrews St Andrews KY16 9ST UK Department of Chemistry University of Warwick Coventry CV4 7AL UK Sincrotrone Trieste S.Cp.A. Area Science Park 1-34012 Basovizza Trieste Italy

Graphene growth by low-pressure chemical vapor deposition on low cost copper foils shows great promise for large scale applications. It is known that the local crystallography of the foil influences the graphene growth rate. Here we find an epitaxial relationship between graphene and copper foil. Interfacial restructuring between graphene and copper drives the formation of （nl0） facets on what is otherwise a mostly Cu（100） surface, and the facets in turn influence the graphene orientations from the onset of growth. Angle resolved photoemission shows that the electronic structure of the graphene is decoupled from the copper indicating a weak interaction between them. Despite this, two preferred orientations of graphene are found, ±8° from the Cu[010] direction, creating a non-uniform distribution of graphene grain boundary misorientation angles. Comparison with the model system of graphene growth on single crystal Cu（110） indicates that this orientational alignment is due to mismatch epitaxy. Despite the differences in symmetry the orientation of the graphene is defined by that of the copper. We expect these observations to not only have importance for controlling and understanding the growth process for graphene on copper, but also to have wider implications for the growth of two-dimensional materials on low cost metal substrates.

关键词： graphene chemical vapordeposition mismatch epitaxy structural feedback low energy electrondiffraction angle resolvedphoto-emissionspectroscopy (ARPES)

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