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Combined effects of Joule heating and nonuniform heat source/sink on unsteady MHD mixed convective flow over a vertical stretching surface embedded in a Darcy-Forchheimer porous medium

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Propulsion and Power Research 2022年第2期11卷 276-292页

作者： B.K.Sharma Rishu gandhi Department of Mathematics Birla Institute of Technology and SciencePilani333031RajasthanIndia

This paper deals with an unsteady magnetohydrodynamics(MHD)heat and masstransfer for a viscous incompressible fluid through a vertical stretching surface embedded ina Darcy-Forchheimer porous medium in the presence of a non-uniform heat source/sink andfirst-order chemical *** porous surface is subjected to a uniform transverse *** influence of velocity,thermal,and concentration slip is also *** governing equations are coupled non-linear partial differential equations,which have been converted via similarity transformation into a set of ordinary differential *** resultantsystem of non-linear ordinary differential equations has been solved numerically with the helpof the“MATLAB”BVP4C *** are presented graphically to analyze the effects ofvarious physical parameters discovered in the problem such as Hartmann number(M),Forchheimer number(Fr),Grashof number(Gr),solutal Grashof number(Gc),suction parameter(S),porosity parameter(el),dimensionless velocity slip(Sv),Prandtl number(Pr),dimensionless thermal slip(St),space-dependent heat source/sink parameter(eA1),temperature-dependent heat source/sink(eB)1),Eckert number(Ec),Schmidt number(Sc),chemical reaction parameter(g),unsteadiness parameter(A),and dimensionless concentration slip(Sc)on non-dimensionalvelocity ec0ðhÞ,temperature zðhÞ,and concentration efðhÞ*** influence of these parameters on skin-friction coefficient(C)f),Nusselt number(Nu)x),and Sherwood number(Sh)x)areexpressed in tabular *** is observed that an enhancement in Fr and el results in the declination of the velocity *** is an enhancement in temperature with an increment in theeA)1 and eB)*** physical representation of flow characteristics that appeared in the problem ispresented using various graphs to depict real-world applications in industrial and *** results were compared to previous studies,revealing that the two are in *** nov

关键词： Magnetohydrodynamics(MHD) Unsteady Heat and mass transfer Non-Darcian porous medium Heat source Joule effect

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Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit;a critical review

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Genes & Diseases 2019年第2期6卷 109-119页

作者： Preeti Pachori Ragini Gothalwal Puneet gandhi Department of Biotechnology Barkatullah UniversityBhopal 462026Madhya PradeshIndia Department of Research Bhopal Memorial Hospital and Research Centre(BMHRC)Bhopal 462037Madhya PradeshIndia

The emergence of antibiotic resistant bacteria in the healthcare is a serious *** the Healthcare premises precisely intensive care unit are major sources of microbial *** findings have demonstrated not only microbial diversity but also drug resistant microbes largely habitat in *** aeruginosa found as a part of normal intestinal flora and a significant pathogen responsible for wide range of ICU acquired infection in critically ill *** infection associated with this organism including gastrointestinal infection,urinary tract infections and blood stream *** caused by this organism are difficult to treat because of the presence of its innate resistance to many antibiotics(b-lactam and penem group of antibiotics),and its ability to acquire further resistance mechanism to multiple class of antibiotics,including Beta-lactams,aminoglycosides and *** the molecular evolution microbes adopted several mechanism to maintain genomic *** tool microbe use for its survival is mainly biofilm formation,quorum sensing,and horizontal gene transfer and enzyme *** genomic plasticity provide an ideal habitat to grow and survive in hearse environment mainly antibiotics *** review focus on infection caused by Pseudomonas aeruginosa,its mechanisms of resistance and available treatment *** present study provides a systemic review on major source of Pseudomonas aeruginosa in ***,study also emphasizes virulence gene/s associated with Pseudomonas aeruginosa genome for extended drug *** gives detailed overview of antibiotic drug resistance mechanism.

关键词： Antibiotics Blood stream infections Infection Pathogen Resistance Urinary tract infections

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Investigation of 58Ni(n, p)58Co reaction cross-section with covariance analysis

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Chinese Physics C 2024年第2期48卷 78-90页

作者： Akash Hingu S.Mukherjee Siddharth Parashari Arora Sangeeta A.gandhi Mahima Upadhyay Mahesh Choudhary Sumit Bamal Namrata Singh G.Mishra Sukanya De Saurav Sood Sajin Prasad G.Saxena Ajay Kumar R.G.Thomas B.K.Agrawal K.Katovsky A.Kumar Department of Physics Faculty of ScienceThe M.S.University of BarodaVadodara 390002India Faculty of Electrical Engineering and Communication Brno University of TechnologyBrnoCzech Republic Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.32Zagreb 10000Croatia Department of Physics University Institute of SciencesChandigarh UniversityGharuanMohali 140413PunjabIndia Department of Physics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei National Institute for Physics and Nuclear Engineering Măgurele 077125Romania Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Health Physics Division Bhabha Atomic Research CentreMumbai 400085India Department of Physics(H&S) Government Women Engineering CollegeAjmer 305002India Saha Institute of Nuclear Physics Kolkata 700064India Homi Bhabha National Institute Anushakti NagarMumbai 400094India

The excitation function of the 58Ni(n,p)58Co reaction was measured using the well-established neutron activation technique andγ-ray *** in the energy range of 1.7 to 2.7 MeV were generated using the 7Li(p,n)*** neutron flux was measured using the standard 115In(n,n’)115mIn monitor *** results of the neutron spectrum averaged cross-section of 58Ni(n,p)58Co reactions were compared with existing cross-section data available in the EXFOR data library as well as with various evaluated data libraries such as ENDF/B-VIII.0,JEFF-3.3,JENDL-4.0,and *** calculations were performed using the nuclear reaction code *** nuclear level density(NLD)models were tested,and their results were compared with the present *** NLDs were also obtained through the spectral distribution method(SDM).The cross-section results,along with the absolute errors,were obtained by investigating the uncertainty propagation and using the covariance *** forγ-ray true coincidence summing,low-energy background neutrons,andγ-ray self attenuation were *** experimental cross-section obtained in the present study is consistent with previously published experimental data,evaluated libraries,and theoretical calculations carried out using the TALYS code.

关键词： nuclear reactions (n,p)reaction cross-section measurement covariance analysis nuclear level density

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Enhancement of solubility and mass transfer coefficient of salicylic acid through hydrotropy

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第5期10卷 739-745页

作者： S.THENESHKUMAR D.GNANAPRAKASH N.NAGENDRA gandhi Department of Chemical Engineering St. Peter's Engineering CollegeChennai 600054 India Department of Chemical Engineering Alagappa College of Technology Anna UniversityChennai 600025 India

This study deals with the effect of hydrotropes on the solubility and mass transfer coefficient of salicylic acid. The solubility and mass transfer studies were performed using the hydrotropes, i.e., sodium acetate, sodium salicylate, citric acid, and urea at concentrations of 0-3.0 mol/L and system temperatures of 303-333 K. It was found that the solubility and mass transfer coefficient of salicylic acid increases with increase in hydrotrope concentration and also with system temperature. All hydrotropes used in this work showed an enhancement in solubility and mass transfer coefficient to different degrees. The maximum enhancement factor values were determined for all hydrotropes used in this study. The highest value was 28.08 for solubility studies and 10.42 for mass transfer studies. The performance of hydrotropes was measured in terms of the Setschenow constant （Ks）. The highest value observed was 0.696.

关键词： Hydrotropy Hydrotropes Solubilization Mass transfer coefficient Separation

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Pharmacokinetic aspects and in vitro–in vivo correlation potential for lipid-based formulations

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Acta Pharmaceutica Sinica B 2014年第5期4卷 333-349页

作者： Sivacharan Kollipara Rajesh Kumar gandhi Formulations Department Pharmaceutical&Analytical DevelopmentTechnical R&DNovartis Healthcare Pvt.Ltd.Hyderabad 500078Andhra PradeshIndia

Lipid-based formulations have been an attractive choice among novel drug delivery systems for enhancing the solubility and bioavailability of poorly soluble drugs due to their ability to keep the drug in solubilized state in the gastrointestinal *** formulations offer multiple advantages such as reduction in food effect and inter-individual variability,ease of preparation,and the possibility of manufacturing using common excipients available in the *** these advantages,very few products are available in the present market,perhaps due to limited knowledge in the in vitro tests(for prediction of in vivo fate)and lack of understanding of the mechanisms behind pharmacokinetic and biopharmaceutical aspects of lipid formulations after oral *** current review aims to provide a detailed understanding of the in vivo processing steps involved after oral administration of lipid formulations,their pharmacokinetic aspects and in vitro in vivo correlation(IVIVC)*** pharmacokinetic and biopharmaceutical aspects such as formulation dispersion and lipid digestion,bioavailability enhancement mechanisms,impact of excipients on efflux transporters,and lymphatic transport are discussed with *** addition,various IVIVC approaches towards predicting in vivo data from in vitro dispersion/precipitation,in vitro lipolysis and ex vivo permeation studies are also discussed in detail with help of case studies.

关键词： Pharmacokinetics Lipolysis IVIVC Efflux transporters Lymphatic delivery Food effect

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Pancreatic paraganglioma diagnosed by endoscopic ultrasoundguided fine needle aspiration: A case report and review of literature

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World Journal of Gastroenterology 2021年第37期27卷 6322-6331页

作者： gandhi Lanke John M Stewart Jeffrey H Lee Department of Gastroenterology Hepatology and NutritionMD Anderson Cancer CenterLubbockTX 79407United States Pathology-lab Medicine Division MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastroenterology Hepatology and NutritionMD Anderson Cancer CenterHoustonTX 77030United States

BACKGROUND Pancreatic paragangliomas(PPGL)are rare benign neuroendocrine neoplasms but malignancy can *** are often misdiagnosed as pancreatic neuroendocrine tumor or pancreatic *** SUMMARY We reviewed 47 case reports of PPGL published in PubMed to *** patients(15/47)with PPGL underwent endoscopic ultrasound-guided fine needle aspiration(EUS-FNA).Only six(6/15)were correctly diagnosed as *** patients with PPGL underwent surgical resection except three(one patient surgery was aborted because of hypertensive crisis,two patients had metastasis or involvement of major vessels).Our patient remained on close surveillance as she was *** Accurate preoperative diagnosis of PPGL can be safely achieved by EUS-FNA with *** team approach should be considered to bring the optimal results in the management of PPGL.

关键词： Pancreatic paraganglioma Endoscopic ultrasound-guided fine needle aspiration Meta-iodobenzylguanidine scan Metanephrines GATA-3 Immunohistochemistry Case report

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How best to manage gastrointestinal stromal tumor

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World Journal of Clinical Oncology 2017年第2期8卷 135-144页

作者： gandhi Lanke Jeffrey H Lee Department of Gastroenterology Hepatology and NutritionUniversity of Texas MD Anderson Cancer Center

Gastrointestinal stromal tumors(GISTs) are rare but most common nonepithelial tumor of gastrointestinal tract. They are often found incidentally on computed tomography and endoscopic investigations. Increasing knowledge of the pathogenesis of GISTs and the advent of tyrosine kinase inhibitors revolutionized the management of GISTs. The newer advanced endoscopic techniques have challenged the conventional surgery although the true efficacy and safety of endoscopic approach is not clear at this time. This review article focuses on pathogenesis, diagnosis and management of GISTs.

关键词： Gastrointestinal stromal tumor Endoscopy Endoscopic ultrasound-fine-needle aspiration Tyrosine kinase inhibitor Imatinib

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Antidiabetic effect of Merremia emarginata *** streptozotocin induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第4期2卷 281-286页

作者： G Rajiv gandhi P Sasikumar Division of Ethnopharmacology Loyola College Department of Biochemistry School of Biological SciencesMadurai Kamaraj University

Objective:To investigate the antidiabetic property of Merremia emarginata(***) *** in streptozotocin induced diabetic ***:The dose dependent effects of 28 days oral treatment with methanol extract(100,200 and 400 mg/kg) from the plant oi *** on blood glucose level,body weight,insulin,total hemoglobin,glycosylated haemoglobin(HbA1C),total protein,serum urea,serum creatinine and carbohydrate metabolizing enzymes were evaluated in streptozotocin induced diabetic *** of pancreas was also ***:A significant decrease in blood glucose,serum urea and serum creatinine and significant increase in body weight,insulin and protein level were observed in diabetic rats treated with *** with *** resulted in a significant reduction of HbAlC and an increase in total hemoglobin *** activities of carbohydrate metabolizing enzymes such as hexokinase were significantly increased whereas glucose-6phosphatase,fructose-1,6-bisphosphatase were significantly decreased by the administration of *** in diabetic *** of diabetic rats treated with *** showed the pancreatic β-cells ***:These findings suggest that *** has potent antidiabetic activity in streptozotocin induced diabetic rats.

关键词： Merremia emarginata Diabetes mellitus Carbohydrate metabolizing enzymes Histology Antidiabetic effect Streptozotocin Blood glucose Insulin

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Revisiting the morphology of pelvicalyceal system in human cadaveric kidneys with a systematic review of literature

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Asian Journal of Urology 2019年第3期6卷 249-255页

作者： Kusum Rajendra gandhi Sushama Chavan Department of Anatomy All India Institute of Medical SciencesBhopalMadhya PradeshIndia Department of Anatomy Rural Medical CollegePravara Institute of Medical SciencesLoniMaharashtraIndia

Objective:Renal collecting system macroscopically consists of minor calyx,major calyx,renal pelvis and *** in renal collecting system is a common presentation in everyday urological *** prevalence of renal calculi ranges from 4%to 20%in different geographical *** variation in renal collecting system plays a significant role in formation of calculi in its *** large extra renal pelvis leads to stagnation of urine for longer durations and formation of *** stone free rate after percutaneous nephrolithotomy and extra corporeal shock wave lithotomy is significantly related to anatomical factors,particularly the type of renal pelvis and dimensions(length and width)of lower *** authors described the morphology of pelvicalyceal system in a highly variable manner and the available anatomical description of pelvicalyceal system is contradictory and *** an attempt has been made to provide the precise anatomy of pelvicalyceal system in adult human ***:We studied 196 formalin embalmed kidneys to note the number of infundibulum,major and minor *** location and shape of pelvis were also ***:The intra-renal pelvis was narrow and had funnel shaped appearance in 95 of total 196(48.5%)specimens,and the extra-renal pelvis was dilated as balloon shaped in 43 of 196(21.9%)*** 41(20.9%)specimens,the renal pelvis was having partially intra-and extra-renal in *** symmetry was found in only 27.1%of 196 renal collecting *** length of lower infundibulum was more than 22 mm in 19(9.7%)of 196 cases which directly affects the stone clearance rate during open and endoscopic surgeries on pelvicalyceal ***:This study provides the accurate morphological details of the shape and dimensions of renal pelvicalyceal system to help the urologists and nephrologists.

关键词： Renal pelvis Morphology Pelvicalyceal system Urologists Renal calculi Intra-renal pelvis

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Successful Vaginal Delivery after Implantable Cardiac Defibrillator Placement for Management of Ventricular Tachycardia

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Congenital Heart Disease 2021年第2期16卷 137-139页

作者： Sara Moufarrij Manisha gandhi Wilson Lam Angeline Opina Department of Obstetrics and Gynecology Baylor College of MedicineHoustonUSA Department of Pediatric Cardiology Baylor College of MedicineHoustonUSA

A 23-year-old female with Tetralogy of Fallot who is 30w6d pregnant presented with palpitations and syncope from an outside *** was found to have ventricular *** placement of a transvenous implantable cardiac defibril... 详细信息

关键词： Ventricular tachycardia pregnancy intracardiac defibrillatory

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