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Pediatric dysphagia overview:best practice recommendation study by multidisciplinary experts

World Journal of Pediatrics 2022年第11期18卷 715-724页

作者： Ebru Umay Sibel Eyigor Esra Giray Evrim Karadag Saygi Bulent Karadag Nihal Durmus Kocaaslan Deniz Yuksel Arzu Meltem Demir Engin Tutar Canan Tikiz Eda Gurcay Zeliha Unlu Pelin Celik Ece Unlu Akyuz Guven Mengu Serkan Bengisu Sibel Alicura necati unver Nida Yekteusaklari Cuma Uz Merve Cikili Uytuni Fatih Bagcier Elif Tarihci Mazlum Serdar Akaltun Iclal Ayranci Sucakli Damla Cankurtaran Zeynep Aykin Resa Aydin Fatma Nazli Department of Physical Medicine and Rehabilitation Ankara University of Health Sciences TurkeyAnkara Diskapi Yildirim Beyazit Training and Research HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Ege UniversityIzmirTurkey Department of Physical Medicine and Rehabilitation Fatih Sultan Mehmet Training and Research HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Marmara UniversityIstanbulTurkey Department of Pediatric Pulmonology Marmara UniversityIstanbulTurkey Department of Plastic Reconstructive and Aesthetic SurgeryMarmara UniversityIstanbulTurkey Department of Pediatric Neurology University of Health SciencesAnkara Dr Sami Ulus MaternityChildren's Health and Diseases Training and Research HospitalAnkaraTurkey Department of Pediatric Gastroenterology Ankara City HospitalAnkaraTurkey Department of Pediatric Gastroenterology Marmara UniversityAnkaraTurkey Department of Physical Medicine and Rehabilitation Celal Bayar UniversityManisaTurkey University of Health Sciences Turkey Gaziler Physical Medicine and Rehabilitation Training and Research HospitalAnkaraTurkey Department of Developmental Pediatric Ankara City HospitalAnkaraTurkey Department of Western Languages and Literatures Ankara Haci Bayram Veli UniversityEnglish Language and Literature DivisionAnkaraTurkey Department of Speech and Language Therapy Uskudar UniversityIstanbulTurkey Department of Otolaryngology Head and Neck SurgeryUniversity of Health SciencesAnkara Diskapi Yildirim Beyazit Training and Research HospitalAnkaraTurkey Department of Otolaryngology Head and Neck SurgeryMarmara UniversityIstanbulTurkey Department of Child and Adolescent Psychiatry Ankara UniversityAnkaraTurkey Department of Physical Medicine and Rehabilitation Istanbul Basaksehir Cam and Sakura City HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Istanbul UniversityIstanbulTurkey Department of Physical Medicine and Rehabilitation Gaziantep UniversityGazian

Background Currently,there is no comprehensive and multidisciplinary recommendation study covering all aspects of pediatric dysphagia(PD).This study aimed to generate PD management recommendations with methods that can be used in clinical practice to fill this gap in our country and in the world,from the perspective of experienced multidisciplinary *** This recommendation paper was generated by a multidisciplinary team,using the seven-step process and a three-round modified Delphi survey via ***,ten open-ended questions were created,and then detailed recommendations including management,diagnosis,treatment,and follow-up were created with the answers from these *** recommendation item was voted on by the experts as overall consensus(strong recommendation),approaching consensus(weak recommendation)and divergent consensus(not recommended).Results In the 1st Delphi round,a questionnaire of 414 items was prepared based on the experts’responses to ten open-ended *** the 2nd Delphi round,59.2%of these items were accepted as *** the 3rd Delphi round,62.6%of 246 items were accepted for inclusion in the *** final version recommendations consisted of 154 *** This study includes comprehensive and detailed answers for every problem that could be posed in clinical practice for the management of PD,and recommendations are for all pediatric patients with both oropharyngeal and esophageal dysphagia.

关键词： Diagnosis Dysphagia Pediatric Recommendation Rehabilitation

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Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study

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World Journal of Stem Cells 2024年第1期16卷 19-32页

作者： ErdinçCivelek Serdar Kabatas Eyüp Can Savrunlu Furkan Diren necati Kaplan Demet Ofluoğlu Erdal Karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalÇorlu 59860TekirdağTurkey Department of Physical Medicine and Rehabilitation Ofluoğlu KlinikGöztepe 34728IstanbulTurkey Liv Hospital Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell)Beşiktaş34340IstanbulTurkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineZeytinburnu 34010IstanbulTurkey Istinye University Center for Stem Cell and Tissue Engineering Research and PracticeBeşiktaş34340IstanbulTurkey

BACKGROUND Peripheral nerve injury can result in significant clinical complications that have uncertain ***,there is a lack of effective pharmacological interventions for nerve damage,despite the existence of several small compounds,Despite the objective of achieving full functional restoration by surgical intervention,the persistent challenge of inadequate functional recovery remains a significant concern in the context of peripheral nerve *** To examine the impact of exosomes on the process of functional recovery following a complete radial nerve *** A male individual,aged 24,who is right-hand dominant and an immigrant,arrived with an injury caused by a knife *** cut is located on the left arm,specifically below the *** neurological examination and electrodiagnostic testing reveal evidence of left radial nerve *** sural autograft was utilized for repair,followed by the application of 1 mL of mesenchymal stem cell-derived exosome,comprising 5 billion *** exosome was split into four equal volumes of 0.25 mL each and delivered microsurgically to both the proximal and distal stumps using the subepineural *** patient was subjected to a period of 180 d during which they had neurological examination and electrodiagnostic *** The duration of the patient’s follow-up period was 180 *** increasing Tinel’s sign and sensory-motor recovery were detected even at the 10th wk following nerve *** the conclusion of the 6-mo post-treatment period,an evaluation was conducted to measure the extent of improvement in motor and sensory functions of the *** assessment was based on the British Medical Research Council scale and the Mackinnon-Dellon *** results indicated that the level of improvement in motor function was classified as M5,denoting an excellent ***,the level of improvement in sensory function was classified as S3+,indicating a good *** is

关键词： Mesenchymal stem cell Exosomes Radial nerve Sural nerve

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Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı Serdar Kabatas ErdinçCivelek Omer Ozdemir Yeliz Bahar-Ozdemir necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34360Turkey Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and *** in motor functions constitute the main body of CP *** symptoms surface in early childhood and patients are affected for the rest of their ***,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal ***,none of these methods can provide full symptom *** has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MSCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MSCT in CP *** Our sample consists of four CP patients who cannot stand or walk without external *** of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional Independence Measure(WeeFIM),Gross Motor Function Classification System(GMFCS),and Manual Ability Classification Scale(MACS)*** utilized the Modified Ashworth Scale(MAS)to measure *** We found significant improvements in MAS scores after the intervention on both *** months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=***,there was no significant difference in motor functions based on WeeFIM results(P>0.05).GMFCS and MACS scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUSION In light of our findings,we believe that UC-MSC therapy has a positive effect on spasticity

关键词： Cerebral palsy Mesenchymal stem cell Transplantation Wharton’s jelly Muscle spasticity

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Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan Sezen Omer Ozdemir Yeliz Bahar-Ozdemir necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MSC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MSCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAS),motor function according to the Medical Research Council Muscle Strength Scale,quality of life was assessed by the Functional Independence Measure(FIM)scale and Karnofsky Performance Status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(P<0.001).The FIM scale includes both motor scores(P<0.05)and cognitive scores(P<0.001)and showed a significant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance Scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therapy Transplantation Mesenchymal stem cell

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The genesis of the slab window-related Arzular low-sulfidation epithermal gold mineralization(eastern Pontides,NE Turkey)

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Geoscience Frontiers 2013年第4期4卷 409-421页

作者： Enver Akaryali necati Tysz Gumushane University Department of Geology Karadeniz Technical University.Department of Geology

The Arzular mineralization is one of the best examples of epithermal gold deposits in the eastern Pontides orogenic belt. The mineralization is hosted by the subduction-related basaltic andesites and is mainly controlled by E W and NE SW trending fracture zones. The main ore minerals are galena. sphalerite, pyrite, chalcopyrite, tetrahedrite and gold. Homogenization temperatures of fluid inclu- sions are between 130 and 295 C for quartz and between 90 and 133 C for sphalerite. Sulphur isotope values obtained fiom pyrite, galena and sphalerite vary between 1.2‰ and 3‰ indicating that sulphur belongs to magmatic origin and was derived from the Lutetian non-adakitic granitic intrusions in the region. Oxygen isotope values are between 15.0‰, and 16.7‰ and hydrogen isotope values are between -87‰ and 91‰ The sulphur isotope thermometer yielded temperatures in the range of 244-291 C for the ore formation. Our results support the hypothesis that the Arzular mineralization is a low-sulfidation epithermal gold deposit associated with non-adakitic subduction- related granitic magmas that were generated by slab window-related processes in a south-dipping subduction zone during the Lutetian.

关键词： Slab windowEpithermal goldIsotopeFluid inclusionMineralizationTectonics

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Rapid detection of total phenolics,antioxidant activity and ascorbic acid of dried apples by chemometric algorithms

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Food Bioscience 2022年第3期47卷 662-669页

作者： necatiÇetin Cevdet Sağlam Erciyes University Faculty of AgricultureDepartment of Biosystems EngineeringKayseriTurkey

Multivariate approaches like machine learning are commonly used in estimation of biochemical traits from spectral and color characteristics of foodstuffs and agricultural *** present study,windfall apples of Golden Delicious,Oregon Spur and Granny Smith cultivars were dried in open-sun,controlled greenhouse,microwave oven(200W),hybrid system(100W+60℃),convective dryer(70℃)and freeze-dryer(−55℃).Spectral,chromatic and biochemical characteristics of dried apples were determined and assessed through machine learning *** phenolic matter,DPPH(2,2-Diphenyl-1-picrylhydrazyl),FRAP(Ferric Reducing Antioxidant Power)and ascorbic acid content were estimated with the use of five different machine learning algorithms(artificial neural networks,k-nearest neighbor,random forest,gaussian processes and support vector regression).The most successful results were achieved in estimation of total phenolic content(R≥0.85).Additionally,Multilayer Perceptron,Support Vector Regression and Gaussian Processes were identified as the best machine learning algorithms in estimation of biochemical compositions of dried apples.

关键词： Apple Drying Biochemical composition VIS/NIR spectra Machine learning

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Measurement of choroidal thickness and macular thickness during and after pregnancy

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 321-325页

作者： DondüMelek Ulusoy necati Duru Mustafa Atas Hasan Altinkaynak Zeynep Duru Gokhan Acmaz Department of Ophthalmology Kayseri Education and Research Hospital Department of Ophthalmology Ankara Atatürk Education and Research Hospital Department of Ophthalmology Ankara Numune Education and Research Hospital Department of Obstetrics and Gynecology Kayseri Education and Research Hospital

AIM: To investigate the effect of pregnancy on subfoveal choroidal thickness(SFCT) and macular thickness in both pregnant and not pregnant healthy ***: Twenty-nine healthy pregnant women in their third trimester and 36 age-matched healthy women were enrolled in a prospective, cross-sectional *** and parafoveal thickness in the four quadrants and SFCT were measured by optical coherence tomography(OCT) in the healthy pregnant women(*** group) and healthy women(i.e. control group).OCT measurements were again measured 3mo after delivery in the study ***: Mean SFCT measurements in the control group, pregnant women of the study group, and after delivery of the study group were 320.86 ±59.18 μm,387.97 ±59.91 μm, and 332.40 ±26.03 μm, *** was a statistically significant difference in the mean SFCT values between pregnant women of the study group and the control group(P =0.000). Foveal and parafoveal thickness values were not statistically significant in either the study or control ***: SFCT increases during pregnancy and returns to normal range in the three months after delivery. Macular thickness does not show any change during pregnancy.

关键词： choroidal thickness enhanced depth imaging optical coherence tomography foveal thickness pregnancy

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QT interval dispersion in the patients with central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 61-65页

作者： necati Dagli Burak Turgut Rumeysa Tanyildizi Sabiha Kobat Mehmet Ali Kobat Orhan Dogdu Department of Cardiology School of MedicineFirat University Department of Ophthalmology School of MedicineFirat University Elazig Education and Research Hospital

AIM: To evaluate QT dispersion(QTD) in patients with central serous chorioretinopathy(CSC).METHODS: This clinical, comperative, case-control study included 30 patients with CSC at acute phase(Group 1) and 30 age- and sex-matched healthy subjects(Group 2, the control group). From all subjects, a 12-lead surface electrocardiography was obtained. The heart rate(HR), QT maximum(QT max), QT minimum(QT min), QT corrected(QT c), QTD and T mean were manually measured and analyzed. Student’s t-test and Pearson’s method of correlation were used for statistical analysis.· RESULTS: The patient and control groups were matched for age, smoking status(rate and duration) and gender. There were no significant differences with regard to these among the groups(P >0.05). The participants included 19 men(63.3%) and 11 women(36.7%) in Group1, 20 men(66.7%) and 10 women(33.3%) in Group *** max, QTD and QT c were significantly higher than those of healthy controls(P 0.05 for HR). No significant correlation was found between duration of the disorder and QTD values(r =0.13, P >0.05).CONCLUSION: These findings suggest that CSC may be associated with an increase in QTD and that the patients might be at risk for ventricular arrhythmia.

关键词： central serous chorioretinopathy electrocardiography QT dispersion ventricular arrhythmia

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HCC incidence and recurrence after DAAs: new insights

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Hepatoma Research 2019年第4期5卷 9-15页

作者： necati Örmeci Department of Gastroenterology Ankara University Medical SchoolAnkara 06590Turkey

Hepatit C virus(HCV)infection is a global health and economic problem in the *** is the cause of chronic active hepatitis,liver cirrhosis,hepatic decompensation,hepatocellular carcinoma(HCC)and extrahepatic *** 2013,standard care of HCV infection was the combination of Pegylated Interferon(PEG IFN)and *** Virologic Response(SVR)rate of this combination was approximately 50%after 48 weeks of *** fifth of patients who had this combination had to stop treatment because of severe side *** of Telaprevir or Boceprevir(first generation of protease inhibitors)to PEG IFN and Ribavirin therapy for 24 or 48 weeks result in a SVR rate around 70%.However,because of severe adverse events,these combinations are not recommended.

关键词： infection hepatic cirrhosis

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A practical approach to imaging characteristics and standardized reporting of COVID-19:A radiologic review

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Military Medical Research 2021年第3期8卷 424-432页

作者： Deniz Esin Tekcan Sanli Duzgun Yildirim Ahmet necati Sanli Suha Turkmen Neval Erozan Guray Husmen Aytug Altundag FilizTuzuner Department of Radiology Acibadem Kozyatagi Hospital19 Mayis Mahinonu CadOkur SokNo.24/Af Kozyatagi34734 IstanbulTurkey Department of Radiology Acibadem Taksim Hospital34373 IstanbulTurkey Cerrahpasa Medical Faculty Department of General SurgeryIstanbul University-Cerrahpasa34098 IstanbulTurkey Department of Emergency Acibadem Taksim Hospital34373 IstanbulTurkey Department of Otolaryngology Acibadem Taksim Hospital34373 IstanbulTurkey Department of Anesthesiology Acibadem Taksim Hospital34373 IstanbulTurkey

Novel coronavirus(2019-nCoV),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is a pathogen that has caused a rapidly spreading pandemic all over the *** primary mean of transmission is inhalation with a predilection for respiratory system involvement,especially in the distal *** disease that arises from this novel coronavirus is named coronavirus disease 2019(COVID-19).COVID-19 may have a rapid and devastating course in some cases leading to severe complications and *** imaging methods have an invaluable role in diagnosis,follow-up,and *** this review,radiological imaging findings of COVID-19 have been systematically reviewed based on the published literature so *** reporting templates are also emphasized from a different point of view,considering specific distinctive patterns of involvement.

关键词： Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Computed tomography Pneumonia Acute respiratory distress syndrome Ground-glass opacities Crazy-paving pattern

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