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Phanerozoic magmatism in the Proterozoic Cuddapah Basin and its connection with the Pangean supercontinent

Geoscience Frontiers 2019年第6期10卷 2239-2249页

作者： Th.Dhanakumar singh C.Manikyamba Li Tang sohini Ganguly M.santosh K.s.V.subramanyam Arubam C.Khelen CsIR-National Geophysical Research Institute(Council of scientific and Industrial Research) Uppal RoadHyderabad 500007India school of Earth sciences and Resources China University of Geosciences Beijing29 Xueyuan RoadBeijing 100083China Department of Earth sciences Goa UniversityTaleigao PlateauGoa 403206India Centre for Tectonics Exploration and ResearchUniversity of AdelaideAdelaideSA 5005Australia Key Lab of submarine Geosciences and Prospecting Techniques MOE AND College of Marine GeosciencesOcean University of ChinaQingdao 266100China

Magmatic pulses in intraplate sedimentary basins are windows to understand the tectonomagmatic evolution and paleaoposition of the *** present study reports the U-Pb zircon ages of mafic flows from the Cuddapah Basin and link these magmatic events with the Pangean evolution during late Carboniferous-Triassic/Phanerozoic *** U-Pb geochronology for the basaltic lava flows from Vempalle Formation,Cuddapah Basin suggests two distinct Phanerozoic magmatic events coinciding with the amalgamation and dispersal stages of Pangea at 300 Ma(Late Carboniferous)and 227 Ma(Triassic).Further,these flows are characterized by analogous geochemical and geochronological signatures with Phanerozoic counterparts from siberian,Panjal Traps,Emeishan and Tarim LIPs possibly suggesting their coeval and cogenetic *** the Phanerozoic Eon,the Indian subcontinent including the Cuddapah Basin was juxtaposed with the Pangean LIPs which led to the emplacement of these pulses of magmatism in the Basin coinciding with the assemblage of Pangea and its subsequent breakup between 400 Ma and 200 Ma.

关键词： Cuddapah Basin Mafic flows Zircon U-Pb geochronology Phanerozoic magmatism Pangea supercontinent

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New developments of the effect of melatonin on reproduction

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World Journal of Obstetrics and Gynecology 2013年第2期2卷 8-15页

作者： Fanuel Lampiao stefan s Du Plessis Division of Physiology Department of Basic Medical SciencesCollege of MedicineBlantyre 3Malawi Division of Medical Physiology Stellenbosch UniversityTygerberg CampusTygerberg 19063South Africa

In the past decades, a lot of advances in understanding the biochemistry and physiology of the pineal gland have been made. There is evidence that it interacts with many endocrine as well as non-endocrine tissues to influence their metabolic activity modulating many organs and functions. Melatonin is secreted by the pineal gland in the brain and plays an important role in regulating the neuroendocrine system. This hormone is one of the major role players in the regulation of the circadian sleep-wake cycle. It is normally released from the pineal gland during the night in response to environmental changes in light. studies have shown that melatonin plays a role in the regulation of many reproductive processes such as puberty, gonadal function, and pregnancy. Beside these, melatonin has been shown to be able to directly neutralize a number of free radicals and reactive oxygen and nitrogen species. The main objective of this review is to provide comprehensive information about the new developments in melatonin research regarding its role in reproduction. A review of international scientific literature was done and a question-and-answer format was used in an attempt to convey comprehensive information in a simple manner. This review discusses evidence currently available relating to the effect of melatonin on reproductive processes. It deliberates the mechanism of action of melatonin, its effect on puberty, testicular and ovafunction, pregnancy, and oxidative stress. A growing body of scientific evidence is suggesting that melatonin plays an important role in reproductive function. It is therefore imperative to highlight the beneficial effects of this hormone in improving the reproductive processes.

关键词： Melatonin Reproduction Reactive oxygen species Antioxidants Pineal gland

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超低剂量四联疗法治疗高血压的成本效益

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中华高血压杂志 2023年第11期31卷 1085-1085页

作者： Atkins ER Chye A Lung T Nolde JM Billot L Burke M Chalmers J Figtree GA Hay P Hillis Gs Jansen s Marschner s neal B Nelson MR Reid CM Usherwood T schlaich M Chow CK Rodgers A 刘青 (译) 练桂丽(审校) 不详

确定含有厄贝沙坦37.5 mg、氨氯地平1.25 mg、吲达帕胺0.625 mg和比索洛尔2.5 mg的四药联用与厄贝沙坦150 mg相比,对于未经治疗或接受单药治疗的高血压患者的成本效益和成本效用。方法:研究者对四联超低剂量治疗高血压试验进行内部试验... 详细信息

确定含有厄贝沙坦37.5 mg、氨氯地平1.25 mg、吲达帕胺0.625 mg和比索洛尔2.5 mg的四药联用与厄贝沙坦150 mg相比,对于未经治疗或接受单药治疗的高血压患者的成本效益和成本效用。方法:研究者对四联超低剂量治疗高血压试验进行内部试验和建模经济评估。分析是预先计划的,并在试验期间获取药物和卫生服务的使用情况。

关键词：卫生服务成本效用成本效益超低剂量单药治疗厄贝沙坦四联疗法吲达帕胺

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人种和族群对美国女性降压药使用的影响

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中华高血压杂志 2017年第3期25卷 294-294页

作者：刘莉叶鹏 Jackson EA Ruppert K Derby CA Lian Y neal-Perry G Habel LA Tepper PG Harlow sD solomon DH

在不同人种和族群中，抗高血压药物的使用可能会有所不同。尚无针对不同人种（族群）女性降压药使用模式的纵向研究。方法与结果：纳入美国全国女性健康研究（the study of women＇s health across the na-tion, sWAN，一个前瞻性女性... 详细信息

在不同人种和族群中，抗高血压药物的使用可能会有所不同。尚无针对不同人种（族群）女性降压药使用模式的纵向研究。方法与结果：纳入美国全国女性健康研究（the study of women＇s health across the na-tion, sWAN，一个前瞻性女性队列研究，n=3302，年龄42-52岁）中，任一年度随访确诊高血压或服用降压药人群。调整潜在的混杂因素后，应用Logistic回归模型，根据高血压药物种类进行分组，并按人种（族群）进行分析。

关键词：女性健康降压药人种 Logistic回归模型美国抗高血压药物队列研究混杂因素

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4种降压药血压反应的异质性:一项随机临床试验

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中华高血压杂志 2023年第7期31卷 604-604页

作者：刘青(译) 练桂丽(审) 不详

高血压是全世界过早死亡的主要危险因素。多种降压疗法可用,但通过个性化靶向药物的最大获益潜力尚不清楚。该研究旨在探讨并量化针对特定个体的特定药物的潜力,以最大限度地提高降压效果。方法:一项随机、双盲、重复交叉试验,在瑞典一... 详细信息

高血压是全世界过早死亡的主要危险因素。多种降压疗法可用,但通过个性化靶向药物的最大获益潜力尚不清楚。该研究旨在探讨并量化针对特定个体的特定药物的潜力,以最大限度地提高降压效果。方法:一项随机、双盲、重复交叉试验,在瑞典一家门诊研究诊所对心血管事件风险较低的1级高血压男性和女性进行研究。混合效应模型用于评估个体对一种治疗的反应比另一种更好的程度.

关键词：随机临床试验混合效应模型交叉试验靶向药物降压药降压效果主要危险因素男性和女性

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Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results

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World Journal of Virology 2017年第4期6卷 59-72页

作者： Kian Bichoupan Neeta Tandon James F Crismale Joshua Hartman David Del Bello neal Patel sweta Chekuri Alyson Harty Michel Ng Keith M sigel Meena B Bansal Priya Grewal Charissa Y Chang Jennifer Leong Gene Y Im Lawrence U Liu Joseph A Odin Nancy Bach scott L Friedman Thomas D schiano Ponni V Perumalswami Douglas T Dieterich Andrea D Branch Division of Liver Diseases Icahn School of Medicine at Mount Sinai Janssen scientific Affairs LLC Division of General Internal Medicine Icahn School of Medicine at Mount Sinai

AIM To assess the real-world effectiveness and cost of simeprevir(sMV), and/or sofosbuvir(sOF)-based therapy for chronic hepatitis C virus(HCV) *** The real-world performance of patients treated with sMV/sOF ± ribavirin(RBV), sOF/RBV, and sOF/RBV with pegylated-interferon(PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. Patients with genotypes 1 through 4 were included. Rates of sustained virological response-the absence of a detectable serum HCV RNA 12 wk after the end of treatment [sustained virological response(sVR) 12]-were calculated on an intention-to-treat basis. Costs were calculated from the payer's perspective using Medicare/Medicaid fees and Redbook Wholesale Acquisition Costs. Patient-related factors associated with sVR12 were identified using multivariable logistic *** sVR 12 rates were as follows: 86%(95%CI: 80%-91%)among 178 patients on sMV/sOF ± RBV; 62%(95%CI: 55%-68%) among 234 patients on sOF/RBV; and 78%(95%CI: 68%-86%) among 96 patients on sOF/PEG/RBV. Mean costs-per-sVR 12 were $174442(standard deviation: ± $18588) for sMV/sOF ± RBV; $223003(± $77946) for sOF/RBV; and $126496(± $31052) for sOF/PEG/RBV. Among patients on sMV/sOF ± RBV, sVR12 was less likely in patients previously treated with a protease inhibitor [odds ratio(OR): 0.20, 95%CI: 0.06-0.56]. Higher bilirubin(OR: 0.47, 95%CI: 0.30-0.69) reduced the likelihood of sVR12 among patients on sOF/RBV, while FIB-4 score ≥ 3.25 reduced the likelihood of sVR 12(OR: 0.18, 95%CI: 0.05-0.59) among those on sOF/PEG/RBV. CONCLUsION sVR 12 rates for sMV and/or sOF-based regimens in a diverse real-world population are comparable to those in clinical trials. Treatment failure accounts for 27% of costs.

关键词： Cirrhosis Cost sustained virological response Protease inhibitor Polymerase inhibitor

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A history of high-power laser research and development in the United Kingdom

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High Power Laser science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler sir Peter L.Knight steve Knight Adrian Knowles Ciaran L.s.Lewis Ken s.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel seddon MBE Zheng-Ming sheng David slater Roland A.smith Christopher spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin s.Wark Colin Webb s.Mark Wiggins Dave Willford Trevor Winstone AWE Aldermaston ReadingUK Oxford Centre for High Energy Density science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Central Laser Facility Rutherford LaboratoryDidcotUK Formerly of Ferranti Defence systems LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Formerly of AWE ReadingUK Formerly of Laser Lines Ltd BanburyUK Formerly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK specialised Imaging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Magna-Power Electronics Ltd ReadingUK DeBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK sPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK Department of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK Department of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optical surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance Manx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasma Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK Mirli Books ChelmsfordUK M squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK Department of Physics University of YorkYorkUK IC Optical systems Ltd BeckenhamUK Laser Micromachining Ltd St AsaphUK MBDA UK Ltd Brist

The first demonstration of laser action in ruby was made in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different materials,operating at different *** the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of *** historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

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Erdheim-Chester disease mimicking a primary brain *** report

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中国神经肿瘤杂志 2004年第2期2卷 137-137页

作者： Rushing E J Bouffard JP neal C J Koeller K Martin J Ozdemirli M Mena H Ecklund J M Department of Neuropathology Armed Forces Institute of PathologyWashingtonDC 20306-6000 USA.

Erdheim-Chester disease (ECD) is a rare systemic histiocytic disease. The authors present a case report detailing the presentation and treatment of a 26-year-old man diagnosed with seizures and a well - circumscribed temporoparietal mass that had been demonstrated on imaging studies. Both preoperative and intraoperative diagnoses were consistent with a low - grade astrocytic neoplasm. subsequent pathological examination indicated a histiocytic proliferation positive for CD68 and factor Ⅷ, and negative for CDla and s100, with Touton giant cells characteristic of ECD. This case represents the first isolated occurrence of intracranial ECD and its potential to mimic glial neoplasms.

关键词： Erdheim-Chester疾病原发性脑肿瘤 ECD 病例

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羊八井50m^2RPC地毯性能研究YBJ-ARGO合作组(英文)

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高能物理与核物理 2001年第1期25卷 79-85页

作者：何会海 C.Bacci 包克智 F.Barone B.Bartoli P.Bernardini s.Bussino E. Calloni R. Cardarelli s.Catalanotti s.Cavaliere F.Cesaroni 查敏 P.Creti 单增罗布 B.D'Ettorre Piazzoli M.DeVincenzi T.DiGirolamo G.Disciascio 冯振勇傅宇高晓宇庚庆喜郭宏伟何瑁黄庆 M.I 中国科学院高能物理研究所宇宙线和高能天体物理开放实验室 INFN and Dipartimento di Fisica dell’ Universtià di Roma Tre 郑州大学物理系 INFN and Dipartimento di Fisica dell'Università di Napoli INFN and Dipartimento di Fisica dell'Università di Lecce INFN and Dipartimento di Fisica dell’ Universtivà di Roma Tre INFN and Dipartimento di Fisica dell'Università di Napoli INFN and Dipartimento di Fisica dell'Università di Roma "Tor Verga" INFN and Dipartimento di Fisica dell'Università di Lecce 西藏大学数理系拉萨850000 西南交通大学物理系山东大学物理系云南大学物理系西藏大学数理系 Istituto di Cosmogeofisica del CNR and INFN Università della Basilicata INFN and Dipartimento di Fisica dell'Università di Padova

利用羊八井５０ｍ２ＲＰＣ地毯（ＹＢＪ－ＡＲＧＯ实验原型）的测试数据对其性能进行了分析研究，包括原初粒子方位角分布、天顶角分布、地毯的角分辨、探测时间系统误差对方位角分布的正弦调制、探测时间系统误差的离线修正、几何不对... 详细信息

利用羊八井５０ｍ２ＲＰＣ地毯（ＹＢＪ－ＡＲＧＯ实验原型）的测试数据对其性能进行了分析研究，包括原初粒子方位角分布、天顶角分布、地毯的角分辨、探测时间系统误差对方位角分布的正弦调制、探测时间系统误差的离线修正、几何不对称的小型地毯探测器上原初粒子到达方向重建误差造成的方位角分布的不均匀性等．

关键词： γ射线天文广延大气簇射 RPC 小型地毯探测器

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Creek Proximity and Flora Effects on Arthropod Populations in Riparian Buffers in Washington state, UsA

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Journal of Environmental science and Engineering 2010年第1期4卷 52-60,82页

作者： Timothy D. Waters Richard s. Zack Douglas B. Walsh Franklin and Benton County Extension Washington State University 1016 N. 4th Pasco WA 99301 （509） 545-3511 USA Department of Entomology Washington State University Pullman WA 99164 USA Department of Entomology Irrigated Agriculture Research and Extension Center Washington State University Prosser Wd 99350 USA

Due to federal, state, and local regulations pertaining to clean water and salmon recovery, stream health and water quality are major concerns in the Pacific Northwest of the United states. An integral component of most riparian rehabilitation efforts is the effective establishment of preferred vegetation. We conducted arthropod surveys in representative disturbed and rehabilitated riparian buffers directly adjacent to apple orchards and grape vineyards in the Lower Yakima Valley near Prosser, Benton County, Washington state UsA. Objectives of the study were to determine whether densities of select predatory and pest taxa changed with distance from the waterway and to test whether densities differed among disturbed, rehabilitated, or pristine riparian buffers. The studies suggest that populations of some beneficial arthropods, including spiders and ground beetles, were higher in the presence of exotic flowering plant species. In the riparian environments surveyed, more native woody plant species were found adjacent to the waterway, and this apparent stability appears to have had a positive effect on beneficial arthropods. Concurrently, data indicated that some exotic, flowering species of plants may be preferred over native plant species as hosts to certain arthropod pests. These plants tend to persist in degraded riparian buffers and at the interface of riparian habitats and cultivated areas, whereas native plant species are predominant in pristine or properly maintained and rehabilitated buffers.

关键词： Riparian buffer zone beneficial arthropod ground beetles spiders.

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