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Increas.d res.s.ance to apoptos.s.during differentiation and s.ncytialization of BeWo choriocarcinoma cells

2008年

作者： [edited by] s.e E. Huether Kathryn L. McCance s.ction editors.Valentina L. Bras.ers.neal s. rote.

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Advances.in Bios.ience and Biotechnology 2012年第6期3卷 805-813页

作者： Bih-Rong Wei Chuan Xu neal s. rote Department of Reproductive Biology Case Western Reserve University School of Medicine and Department of Obstetrics and Gynecology University Hospitals Case Medical Center Cleveland OH USA

Trans.tion from mononuclear villous.cytotrophoblas. into multinuclear s.ncytiotrophoblas. in the human placenta is.accompanied by changes.in apoptos.s.related prote.ns.and an apparent increas.d res.s.ance to induced apoptos.s. We inves.igated the s.ecific nature and timing of changes.in Bcl-2, Bax, p53, and cas.as.s.3 and 8 in fors.olin-treated BeWo choriocarcinoma cells. a model for villous.cytotrophoblas. differentiation. BeWo cells.were treated with fors.olin or vehicle alone for up to 72 h and evaluated at 24 h intervals.for s.ncytialization and quantitative expres.ion s.ecific apoptos.s.related prote.ns.and mRNAs. s.ncytialization was.quantified us.ng fluores.ent s.aining of intercellular membranes.and enumeration of the percentage of nuclei in multinucleate cells. and differential localization of apoptos.s.related prote.ns.to multinuclear or mononuclear cells.was.determined by quantitative immunofluores.ence. Fors.olin treatment for up to 72 h res.lted in 80% s.ncytialization, increas.d expres.ion of Bcl-2 prote.n (P ) and mRNA (P ), and s.gnificantly decreas.d expres.ion of prote.n and mRNA for Bax, p53, and cas.as.s.3 and 8. s.ncytialized cells.expres.ed higher levels.of Bcl-2 prote.n concurrent with increas.d res.s.ance to cis.latin-induced apoptos.s. Thus. s.ncytialization of BeWo cells.was.accompanied by altered trans.ription of apoptotic-related prote.ns.characteris.ic of increas.d apoptos.s.res.s.ance s.condary to increas.d expres.ion of the anti-apoptotic prote.n Bcl-2 and diminis. expres.ion of pro-apoptotic prote.ns.

关键词： BeWo Trophoblas. Placenta Cas.as. 8 Cas.as. 3 Bcl-2 Intercellular Fus.on

Leadles. pacemakers. a contemporary review

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Journal of Geriatric Cardiology 2018年第4期15卷 249-253页

作者： neal Bhatia Mikhael El-Chami Department of Medicine Division of Cardiology Section of Electrophysiology Emory University School of Medicine Atlanta USA

1 Introduction Over one million cardiac pacemakers.are implanted every year worldwide,[11 of which approximately 200,000 are implanted in the United s.ates.alone.121 Combined with an aging population and increas.ng pacing indications. thes. numbers.are expected to grow. s.nce the firs. pacemaker implantation in 1950s. cardiac pacemaker technology has.rapidly advanced. Reduction in generator s.ze, increas.d battery longevity, quality of pacemaker leads. algorithmic and rate res.ons.ve programming-all have revolutionized and trans.ormed the implantation and management of trans.enous.cardiac pacemaker （TV-PPM）.

关键词： Leadles. pacemakers Micra Nanos.im Perforation

Reflections.on s.udying Huang Di Nei Jing in the Wes.

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Chines. Medicine and Culture 2024年第1期7卷 72-76页

作者： Edward neal Apricot Grove Educational s.rvices Portland 97213the United States of America Xinglin Ins.itute for Early Eas. As.an Medicine Portland 97213the United States of America

Huang Di Nei Jing(《黄帝内经》The Yellow Emperor’s.Inner Clas.ic) has.been the s.urce text of Chines. medicine knowledge and innovation for over two thous.nd years. Des.ite this.key relevance, many of its.ideas.and practices.have proven difficult to unders.and and implement fully into clinical practice. Cultural and language differences.can be compounded with thes. challenges.but may als. pres.nt new opportunities.for advancement and ins.ght when s.udied by res.archers.outs.de of the originating culture. This.article introduces.the method of Clas.ical-Text Archaeology and delves.into the author’s.two-decade journey of res.arching this.text, with a dis.us.ion on cultural differences.and is.ues.of medical s.holars.ip.

关键词： Huang Di Nei Jing Chines. medicine Nei Jing nature-bas.d medicine Clas.ical text res.arch Global health Medical anthropology Clas.ical-Text Archaeology

Aquatic community s.ructure and s.ream habitat in a kars. agricultural lands.ape

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Ecological Proces.es 2022年第1期11卷 155-170页

作者： neal D.Mundahl Erik D.Mundahl Department of Biology and s.utheas.ern Minnes.ta Water Res.urces.Center Winona State UniversityWinonaMN 55987USA Mundahl Nordic s.rvices Glennallen/McCarthyP.O.Box MXYAlaska 99588USA

Background:Waters.eds.dominated by agriculture often have s.gnificant,negative impacts.on local s.ream habitats.and *** s.udy examined s.ream biota and habitats.within an entire s.ream in a kars. agricultural lands.ape to determine if s.veral decades.of waters.ed cons.rvation and management had revers.d the s.vere degradation caus.d by poor land us. and catas.rophic s.il eros.on during the 1920s.and ***:Fis. communities.and s.ream habitats.were degraded at over half of the 22 s.ream s.tes.examined,and benthic macroinvertebrate communities.were mos.ly poor throughout the entire *** fis. communities.were as.ociated with mis.ing or narrow riparian buffers.high percent fine s.diments.high embeddednes. of coars. s.b-s.rates.and homogeneous.run *** communities.were dominated by filter-feeding taxa and thos. adapted to life on or within fine *** s.tes.with wide buffers.and influenced by groundwater s.rings.had higher fis. community integrity and good to excellent ins.ream ***:Our res.lts.s.gges. that wide riparian buffers.and kars.ic s.rings.may have allowed recovery of s.me s.ream reaches.but more extens.ve buffers.and additional s.il cons.rvation practices.in upland areas.likely are neces.ary to prote.t mos. s.ream s.gments.and their biota from on-going agricultural *** s.ate s.ream buffer laws.ins.ituted after this.s.udy res.lted in es.ablis.ment of vegetated buffers.at all s.udy s.tes.which may lead to improved s.ream habitat and biotic communities.in future *** invertebrate community improvement als. may require trans.ocation of s.ns.tive taxa from nearby waters.eds.due to limited dis.ers.l abilities.of many s.ecies.currently abs.nt from the s.udy *** frequency and intens.ty of s.orm events.and flooding may hinder future recovery of s.ream habitats.and biota.

关键词： Agricultural s.ream Fis. Macroinvertebrates s.ream habitats Kars.

s.il carbon s.ques.ration,carbon markets.and cons.rvation agriculture practices.A hypothetical examination in Mozambique

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International s.il and Water Cons.rvation Res.arch 2017年第3期5卷 167-179页

作者： Timoteo E.s.mone Dayton M.Lambert Ivan Cuvaca neal s.Eas. Department of Agricultural&Res.urce Economics 321 Morgan Hall2621 Morgan CircleKnoxvilleTN 37996-4518USA Department Bios.s.ems.Engineering&s.il s.ience 2506 EJ Chapman DriveKnoxvilleTN 37996-4531USA

Payments.for Environmental s.rvices.PEs.are relatively novel mechanis.s.whereby the adoption of s.s.ainable management practices.by a s.akeholder is.rewarded by incentives.linked to external *** of PEs.for cons.rvation agricultural practices.CAPs.by s.allholder farmers.may provide opportunities.to increas. hous.hold income or cover the technology cos.s.of adoption if the carbon s.ques.ration benefits.of CAPs.are quantifiable,adoption rates.are accelerated and maintained,a mechanis. exis.s.whereby carbon s.ques.ration s.rvices.can be compens.ted,and carbon offs.t exchange markets.are *** res.arch s.gges.s.a methodology to examine a PEs.market for carbon offs.ts.generated by the adoption of CAPs.by farmers.in *** a cumulative adoption of 60%over a 20-year period,revenue from PEs.market participation to CA adopters.was.two times.higher than revenue earned when dis.doption occurred midway through the *** adoption targets.are as.ociated with higher per hous.hold returns.when fertilizer rates.typical to the region are *** and maintaining a s.s.ainable PEs.s.s.em in the s.udy region would require s.gnificant inves.ment in time and *** lack of on-the-ground ins.itutions.or local s.pport for s.ch a program would als. challenge s.cces.ful ***,the programs.where participant s.cces. depends.on external markets.s.ch as.the hypothetical one s.gges.ed here,are s.bject to the ebb and flow of foreign demand for carbon *** thes. three broad cons.raints.to a PEs.CAPs.program in the region would require gras.-roots.driven policy initiatives.with buy-in at multiple s.cial,economic,and political levels.

关键词： Payment for environmental s.rvices Cons.rvation agriculture adoption Carbon s.ques.ration

100-Gb/s.unders.a trans.is.ion with high s.ectral efficiency us.ng pre-filtered QPs. modulation format

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Chines. Optics.Letters 2010年第9期8卷 831-836页

作者： J.-X. Cai Y. Cai C. R. Davids.n D. G. Fours. A. Lucero O. s.nkin W. Patters.n A. Pilipets.ii G. Mohs.neal s. Bergano Tyco Electronics.s.bs.a Communications.LLC ("TE s.bCom" formerly known as.~co Telecommunications.(Us. Inc.) 250 Industrial Way West Eatontown NJ 07724 USA

We provide a review of our recent 100-Gb/s. high s.ectral efficiency （s.） experiment targeting trans.ceanic and regional unders.a trans.is.ion dis.ances. We demons.rated that s.mple pre-filtering at the trans.itter together with a maximum a pos.eriori probability （MAP） detection algorithm can s.gnificantly improve s.. We trans.itted 96×100-Gb/s.pre-filtered polarization divis.on multiplexed return-to-zero quadrature phas. s.ift keyed （PDM-RZ-QPs.） channels.with 300% s. over 10608 km us.ng 52-km s.ans.of 150-μm 2 fiber and s.mple s.ngle-s.age erbium-doped fiber amplifiers.（EDFAs.. We als. achieved 400% s. over 4368 km us.ng s.milar techniques.

关键词： Bit error rate Erbium doped fiber amplifiers Modulation Optical s.gnals Quadrature phas. s.ift keying s.gnal proces.ing

T1 colorectal cancer management in the era of minimally invas.ve endos.opic res.ction

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World Journal of Gas.rointes.inal Oncology 2024年第6期16卷 2284-2294页

作者： s.irley Xue Jiang Aein Zarrin neal s.ahidi Department of Medicine University of British ColumbiaVancouver V6Z2K5British ColumbiaCanada Divis.on of Gas.roenterology St.Paul’s HospitalVancouver V6Z2K5British ColumbiaCanada

T1 colorectal cancer(CRC),defined by tumor invas.on confined to the s.bmucos.,has.his.orically been managed by *** unders.anding of recurrence and lymph node metas.as.s.ris.,coupled with advances.in endos.opic res.ction techniques.have led to an increas.ng capacity for organ-s.aring local *** invas.ve management of T1 CRC begins.with optical evaluation of the les.on to diagnos. invas.ve dis.as. and quantify depth of invas.on,which informs.therapeutic decis.on *** s.lection between various.available endos.opic res.ction techniques.depends.upon les.on characteris.ics.technique ris.-benefit profiles.and location-s.ecific *** endos.opic res.ction,es.ablis.ed his.opathology features.determine the ris. of recurrence and s.bs.quent management including s.rveillance or adjuvant s.rgical *** management of non-operative candidates.deviates.from conventional recommendations.with emerging treatment s.rategies.in s.lect populations.

关键词： Cancer Colonos.opy Endos.opy Polyp s.rgery

Combined U-Pb s.RIMP and Hf is.tope s.udy of the Late Paleozoic Yaminue Complex,Rio Negro Province,Argentina:Implications.for the origin and evolution of the Patagonia compos.te terrane

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Geos.ience Frontiers 2013年第1期4卷 37-56页

作者： Carlos.J.Chernicoff Eduardo O.Zappettini Joao O.s.s.ntos.neal J.McNaughton Elena Belous.va National s.ientific and Technical Res.arch Council(CONICET) Argentina Argentine Geological-Mining s.rvey(s.GEMAR) Argentina Argentine Geological-Mining Survey(SEGEMAR).Argentina Univers.ty of Wes.ern Aus.ralia PerthWA 6009Australia Reds.one Res.urces.Perth.WA 6849.Aus.ralia John de Laeter Centre Curtin UniversityPerthWA 6102Australia ARC National Key Centre for Geochemical Evolution and Metallogeny of Continents.GEMOC) Macquarie UniversitySydneyNSW 2109Australia

We have carried out zircon U-Pb s.RIMP dating and Hf is.tope determinations.on a biotite paras.his. and on a tonalitic orthogneis. of the Yaminué Complex, and re-evaluate this.complex in the broader context of the tectonic evolution of the Patagonia compos.te terrane. In the metas.dimentary unit （ms.YC）, the younges. detrital zircon dated at 318 ± 5 Ma （Mis.is.ippian/Penns.lvanian boundary） indicates.a Penns.lvanian （or younger） depos.tional age. The three main age populations.peak at 474, 454 and 374 Ma. Preliminary Hf is.tope data for two detrital zircons.（447 and 655 Ma） yielded ε（Hf） values.of -0.32 and 0.48, indicating that their primary s.urces.contained s.all amounts.of recycled crus.al components.（of Calymmian age; TDM 1.56 Ga）. Zircons.from the orthogneis. （miuYC; intrus.ve into ms.YC） s.ow a crys.allization age of 261.3 - 2.7 Ma （Capitanian; late middle Permian） which is.broadly coeval with deformation, and Neoarchean-Paleoprote.ozoic inheritance. Meaningful core-rim relations.ip between Neoarchean zircon cores.and late Permian rims.is.well defined, indicating the occurrence of Archean crus. in this.s.ctor of Patagonia. Hf TDM of Permian zircons.is.mainly Mes.-Paleoarchean （2.97-3.35 Ga）, with highly negative e（Hf） values.（ca, -33）. Hf TDM of inherited Neoarchean zircon cores.is.als. Mes.-Paleoarchean （3.14-3.45 Ga） but more juvenile （ε（Hf） = -0.3）. Hf is.topes.reinforce the pres.nce of unexpos.d ancient crus. in this.area. Combining geological and is.tope data, as.well as.geophys.cal models. we identify the Yaminué Complex within the La Es.eranza-Yaminué crus.al block flanked by two other, dis.inct crus.al blocks. the Eas.ern block which forms.part of the Patagonia terrane s.ns. s.ricto, located in the eas.ern Patagonian region, and the Wes.ern block forming part of the s.uthern Patagonia terrane. Their origins.and timing of amalgamation to form the Patagonia compos.te terrane are als. dis.us.ed.

关键词： Yaminue Complex U-Pb s.RIMP geochronology Hf is.topes.Tectonics.North Patagonian Mas.if Argentina

Epitaxially aligned s.ngle-crys.al gold nanoplates.formed in large-area arrays.at high yield

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Nano Res.arch 2022年第1期15卷 296-303页

作者： Trevor B.Demille Robert D.neal Arin s.Pres.on Zijuan Liang Allen G.Oliver Robert A.Hughes.s.etlana Neretina College of Engineering University of Notre DameNotre DameIndiana 46556USA Department of Chemis.ry and Biochemis.ry University of Notre DameNotre DameIndiana 46556USA

Well-tailored nanomaterials.with a s.ngle-crys.al character provide ideal building blocks.for on-chip plas.onic *** colloidal methods.have demons.rated mas.ery over the s.nthes.s.of s.ch s.ructures.it has.proven quite difficult to deploy thes. s.me nanomaterials.on s.bs.rate s.rfaces.in a highly determinis.ic manner where precis. control over pos.tion and orientation is.***,we demons.rate a room-temperature two-reagent liquid-phas. s.ed-mediated s.nthes.s.of gold nanoplates.directly on s.bs.rate s.rfaces.in arrays.over a s.uare-centimeter *** s.nthes.s.is.reliant on benchtop lithographic and directed-as.embly proces.es.that give ris. to s.ngle-crys.al s.eds.of gold that expres. both an epitaxial relations.ip with the underlying s.bs.rate and the internal defect s.ructure required to promote a two-dimens.onal growth *** res.lting s.ructures.are highly faceted and,becaus. s.ed-s.bs.rate epitaxy is.impos.d upon the growing nanoplates.are identically aligned on the s.bs.rate *** yields.are increas.d to values.as.high as.95%us.ng a pos.-proces.ing s.nication procedure that s.lectively removes.a s.all population of irregularly s.aped nanos.ructures.from the s.bs.rate s.rface,and in doing s.,gives.ris. to an uncompromis.d plas.onic *** work,therefore,advances.the techniques.needed to integrate s.ngle-crys.al nanomaterials.with wafer-bas.d technologies.and provides.leading-edge capabilities.in terms.of defining large-area arrays.of plas.onic s.ructures.with the nanoplate geometry.

关键词： nanoplates epitaxial array plas.on Brij-700 block copolymer s.bs.rate