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Cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice

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Asian Pacific Journal of Tropical Biomedicine 2019年第7期9卷 278-283页

作者： Roopesh Poojary nayanatara arun kumar Reshma kumarchandra Vinodini NA Bhagyalakshmi K Ganesh Sanjeev Department of Physiology Kasturba Medical CollegeMangaloreManipal Academy of Higher EducationManipalKarnatakaIndia Department of Biochemistry Kasturba Medical CollegeMangaloreManipal Academy of Higher EducationManipalKarnatakaIndia Microtron Centre Department of Studies in PhysicsMangalore UniversityMangalagangotriKarnatakaIndia

Objective: To explore the effect of hydroalcoholic extract of Cynodon dactylon on the whole body radiation-induced oxidative status of the cerebellum and cognitive impairments in mice. Methods: Swiss albino mice were randomly divided into the control group, radiation control group, low dose and high dose Cynodon dactylon extract treated groups and pre-treated with Cynodon dactylon extract before irradiation. Cynodon dactylon extract was administered for 7 d daily in low dose(0.25 g/kg) and high dose(1 g/kg). On day 7, mice were irradiated with a sublethal dose of 5 Gy gamma rays. Motor coordination was assessed by elevated rotarod test and spatial memory was studied by water maze test. Subsequently, biochemical markers(glutathione, lipid peroxidation and nitric oxide levels) in the cerebellum were evaluated. Results: The gamma irradiated group showed significant impairment in motor coordination and spatial memory compared to normal mice. Mice treated by Cynodon dactylon extract prior to gamma radiation showed good improvement in both paradigms compared to the radiation control group. Moreover, glutathione level was increased, while lipid peroxidation and nitric oxide levels were significantly reduced in mice receiving low dose and high dose of Cynodon dactylon extract compared to the radiation control group. Conclusions: The present study suggests the neuroprotective role of Cynodon dactylon against radiation-induced cognitive impairment and oxidative stress on the cerebellum of mice.

关键词： Cerebellum Radiation Cognition Cynodon dactylon Memory

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