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World Journal of Clinical Oncology 2014年第5期5卷 858-864页

作者： navneet singh Aditya Jindal Digambar Behera Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research

Erlotinib and gefitinib are among the most widely researched, used and available molecularly targeted therapies for treatment of advanced non-small cell lung cancer(NSCLC). They are both tyrosine kinase inhibitors(TKIs) of the epidermal growth factor receptor(EGFR). In the past decade, there have been reports on clinical benefit from use of erlotinib after gefitinib failure in NSCLC patients. A review of published literature on this focussed topic is provided herein. Pooled analysis of published literature shows that majority of patients were female(60.6%), non-smokers(64.5%), had adenocarcinoma histology(88.3%) and were of East Asian ethnicity(92.3%). Presence of sensitizing EGFR mutation was detected in 48.4% of subjects. Disease control rates with prior gefitinib therapy and with subsequent erlotinib treatment were 79.4% and 45.4% respectively. Based upon our review, the most important predictive factor for clinical benefit from erlotinib identified was previous response to gefitinib. The exact explanations for the potential benefit from erlotinib use in this patient population is still not known and further studies are required to determine the role of molecular mechanismsespecially those related to resistance to initial EGFR TKI therapy.

关键词： Gefitinib Erlotinib Non-small cell lung cancer Epidermal growth factor receptor Tyrosine kinase inhibitor

Malignant pleural mesothelioma:The disdained member of thoracic oncology!

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World Journal of Experimental Medicine 2024年第3期14卷 1-10页

作者： Divya Khosla Pawan Kumar singh Bharath A Chhabria Vaishali Kataria navneet singh Rakesh Kapoor Department of Radiotherapy and Oncology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Pulmonary and Critical Care Medicine Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical SciencesRohtak 124001India Department of Pulmonary and Critical Care Medicine Ramaiah Memorial HospitalBengaluru 560054India Department of Pulmonary Medicine Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

Pleural mesothelioma is a very aggressive malignancy that arises from the pleural mesothelial cell lining and is linked strongly to prior asbestos *** ban on asbestos has helped to lower the incidence,but in developing countries like India,it is expected to *** has an extended latency period usually progressing over decades and presents with nonspecific *** has a median survival ranging between 10-22 *** diagnosis of malignant pleural mesothelioma is challenging and is done using computed tomography(CT),magnetic resonance imaging,or positron emission tomography-CT,with the last two predicting the resectability of the tumor better than CT alone.A pleural biopsy along with an array of immunohistochemical markers,such as p16,BRCA1 associated protein 1,and claudin-4,are required for a definitive *** genetic alterations have prognostic significance as *** current histological subtype identification is indispensable for decision making because of the new therapeutic avenues being *** combination of nivolumab and ipilimumab-based immunotherapy outperformed platinum and pemetrexed-based chemotherapy in terms of survival benefit and improved quality of life especially for non-epithelioid ***,the latter continues to be a robust treatment option for patients with the epithelioid *** is recommended for resectable cases with radiotherapy being indicated in neoadjuvant,adjuvant,and palliative settings along with systemic *** review article provides an overview of epidemiology,etiology,clinical manifestations,diagnostic approaches(including immunohistochemical and genetic markers),staging,and multidisciplinary approaches to current treatment for malignant pleural mesothelioma using surgery,chemotherapy,immunotherapy,and *** also sheds light on some recent studies(EMPHACIS,CALGB30901,Checkmate-743,etc.)that have led to significant developments in recent years with clinically mean

关键词： Chemotherapy Diagnosis Immunotherapy Malignant pleural mesothelioma Radiotherapy

Extrapulmonary small cell carcinoma of lymph node: Pooled analysis of all reported cases

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World Journal of Clinical Oncology 2016年第3期7卷 308-320页

作者： Inderpaul singh Sehgal Harpreet Kaur Sahajal Dhooria Amanjit Bal Nalini Gupta Digambar Behera navneet singh Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Department of Histopathology Postgraduate Institute of Medical Education and Research Department of Cytology and Gynecological Pathology Postgraduate Institute of Medical Education and Research

AIM: To study clinical outcomes and management of lymph nodes extrapulmonary small cell carcinoma(LNEPSCC). METHODS: Herein, we perform a systematic search of published literature in the PubMed and EMBASE databases for studies describing LNEPSCC. For uniformity of reporting, LNEPSCC was staged as limited if it involved either single lymph node station or if surgery with curative intent had been undertaken. The disease was staged extensive if it involved two or more lymph node ***: The systematic literature review yielded eight descriptions(n = 14) involving cervical, submandibular and inguinal lymph nodes. Eleven(64.7%) patients had limited disease(LD) and six(35.3%) had extensive disease(ED) at presentation. Chemotherapy(n = 6, 35.3%) or surgery(n = 4, 23.5%) were the most common form of treatment given to these patients. Complete response was achieved in 12(70.6%) of the patients. Median(interquartile range) progression free survival and overall survival was 15(7-42) mo and 22(12.75-42) mo respectively. Of the three illustrative cases, two patients each had ED at presentation and achieved complete remission with platinum based combination ***: LNEPSCC is a rare disease with less than 15 reported cases in world literature. Surgical resection with curative intent is feasible in those with LD while platinum based combination chemoradiation is associated with favorable outcomes in patients with ED. Prognosis of LNEPSCC is better than that of small cell lung cancer in general.

关键词： Extrapulmonary Small cell Carcinoma Lymph node Small cell lung cancer

Interconversion of two commonly used performance tools: An analysis of 5844 paired assessments in 1501 lung cancer patients

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World Journal of Clinical Oncology 2018年第7期9卷 140-147页

作者： Kuruswamy Thurai Prasad Harpreet Kaur Valliappan Muthu Ashutosh Nath Aggarwal Digambar Behera navneet singh Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER)

AIM To establish the Karnofsky performance status(KPS) categories which would facilitate the interconversion of the KPS scale to the Eastern Cooperative Oncology Group(ECOG) performance status(PS) *** This was a retrospective analysis of all patients attending the lung cancer clinic at a tertiary care center over a 5-year period(September 2009 to August 2014). All patients were assessed with both KPS and ECOG PS scales at each visit. Correlation between KPS and ECOG PS was assessed using Spearman's correlation coefficient. KPS categories equivalent to ECOG PS scores were compared using hit rate and weighted kappa(κw).RESULTS A total of 1501 patients were assessed over the study period, providing 5844 paired KPS and ECOG PS assessments. The study cohort had a mean(standard deviation; SD) age of 58.4(10.8) years, with the majority being current or ex-smokers(76.9%) and males(82.3%). Non-small cell lung cancer was the most common histological type(n = 1196, 79.7%) with the majority having advanced(stage ⅢB/Ⅳ) disease(83.4%). Mean baseline KPS and ECOG PS scores were 77.6(SD = 14.4) and 1.5(SD = 1) respectively. The most frequent KPS score was 80(29%), and the most frequent ECOG PS score was 1(43%). The overall correlation between KPS and ECOG PS was good(Spearman r =-0.84, P < 0.0001) but ranged from-0.727 to-0.972 between visits. KPS categories derived from our cohort [10-40(ECOG 4), 50-60(ECOG 3), 70(ECOG 2), 80-90(ECOG 1), 100(ECOG 0)] performed better [hit rate 78.1%, κw = 0.749(0.736-0.762) P < 0.0001] than those suggested in the past *** The current study provides the largest set of paired KPS-ECOG assessments to date. We suggest that the KPS categories 10-40, 50-60, 70, 80-90, and 100 are equivalent to ECOG PS categories of 4, 3, 2, 1, and 0 respectively.

关键词： Karnofsky performance status Eastern Cooperative Oncology Group Performance status Lung cancer Chemotherapy

Coagulopathy reversal in intracerebral haemorrhage

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Stroke & Vascular Neurology 2020年第1期5卷 29-33页

作者： Alexander Jacob Sweidan navneet Kaur singh Joseph Luke Conovaloff Matthew Bower Leonid I Groysman Mohammad Shafie Wengui Yu Neurology University of California Irvine Medical CenterOrangeCaliforniaUSA Medicine University of California Irvine Medical CenterOrangeCaliforniaUSA

As intracerebral hemorrahge becomes more frequent as a result of an aging population with greater comorbidities,rapid identification and reversal of precipitators becomes increasingly *** aformentioned population will ever more likely be on some form of anticoagulant *** the mechanisms of these agents and means by which to reverse them early on is critical in managing the acute intracerebral hemorrhage.

关键词： likely mentioned reversal

Non-syndromic hypo-hyperdontia—A rare case report and review of literature

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Open Journal of Stomatology 2013年第9期3卷 37-41页

作者： Kanika Gupta Verma Pradhuman Verma navneet singh Richa Bansal Rameen Khosa Gagandeep Kaur Sidhu Vikas Setia Department of Oral Medicine & Radiology Surendera Dental College & RI Sri-ganganagar India Department of Oral Pathology & Microbiology Darshan Dental College & Hospital Udaipur India Department of Oral Pathology & Microbiology Maharaja Ganga Singh Dental College & RI Sriganganagar India Department of Oral Pathology & Microbiology Seema Dental College & RI Rishikesh India Department of Pediatric & Preventive Dentistry Adesh Dental College & RI Ba-thinda India Department of Pediatric & Preventive Dentistry Surendera Dental College & RI Sriganganagar India

Abnormalities of tooth number in development of the dentition are quite common;however, concomitant hypo-hyperdontia is a rare mixed numeric anomalous condition, especially when it occurs in the same dental arch and in a non-syndromic situation. The presence of this condition specifically in the mandibular anterior region is reported very infrequently. This case report presents the case of a 9 years old non-syndromic male with missing mandibular central incisors and an erupted mandibular mesiodens along with the review of literature. To ensure optimum function and aesthetics, cosmetic recontouring was performed after oral prophylaxis. This is the ninth case reported in the dental literature till date, with the two anomalies manifesting in the anterior region of the mandible. This article also discusses the review of literature of concomitant hypo-hyperdontia.

关键词： Mesiodens Hypodontia Hyperdontia Mandibular Arch

Optimization of CMOS Repeater Driven Interconnect RC Line Using Genetic Algorithm

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Journal of Shanghai Jiaotong university(Science) 2017年第2期22卷 167-172页

作者： KAUR Jasmeet GILL Sandeep singh KAUR navneet Department of Electronics and Communication Engineering Guru Nanak Dev Engineering CollegeLudhiana 141006India

In this work, optimization of complementary metal oxide semiconductor (CMOS) repeater driven interconnect resistive-capacitive (RC) line is carried out using genetic algorithm (GA). This work is aimed at powerdelay- product (PDP) minimization of RC interconnect at 180 nm technology node. The algorithm simultaneously optimizes the values of supply voltage, number of repeaters and repeater width for delay and PDP minimization. The accuracy of results obtained is verified by simulations from Cadence virtuoso tool. For delay minimization, comparison of GA results with previous results of the literature shows an improvement of 44.4% in the value of the optimal number of repeaters required. This improvement is obtained by increasing the repeater size, which also increases power dissipation, so a tradeoff has also been achieved in terms of PDP minimization. The comparison of PDP results obtained in this work, with the results at 70, 100, and 130 nm technologies from literature shows improvement in optimal number of repeaters required. The results of algorithm and simulations are in good agreement and demonstrate the validity of proposed algorithm. © 2017, Shanghai Jiaotong University and Springer-Verlag Berlin Heidelberg.

关键词： complementary metal oxide semiconductor(CMOS) genetic algorithm interconnects optimal power-delay-product repeater

Responding to fire in an intensive care unit: Management and lessons learned

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World Journal of Emergency Medicine 2018年第2期9卷 154-156页

作者： navneet Dhaliwal Ranjitpal singh Bhogal Ashok Kumar Anil Kumar Gupta Department of Hospital Administration Postgraduate Institute of MedicalEducation and Research

Healthcare institutions are vulnerable to disruptionfrom events such as earthquakes, fires, and floods, andthe damage incurred can endanger the lives of patientsin the hospital.[1] In this type of scenario hospital staffhave primary responsibility for the hospitalized patients＇safety, since patients are neither fit to respond to sucha disaster, nor do they know how to respond.[2,3] Thesituation becomes more difficult and challenging if thedisaster occurs in critical care areas such as intensivecare units （ICUs） and operating rooms.

关键词： Responding to fire an intensive care unit:Management lessons learned

Maximizing Resource Efficiency in Cloud Data Centers through Knowledge-Based Flower Pollination Algorithm (KB-FPA)

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Computers, Materials & Continua 2024年第6期79卷 3757-3782页

作者： Nidhika Chauhan navneet Kaur Kamaljit singh Saini Sahil Verma Kavita Ruba Abu Khurma Pedro A.Castillo University Institute of Computing Department Chandigarh UniversityPunjab140413India Department of Computer Science and Engineering Chandigarh UniversityPunjab140413India Universidade Federal do Piauí TeresinaPiauí64049-550Brazil MEU Research Unit Faculty of Information TechnologyMiddle East UniversityAmman11831Jordan Applied Science Research Center Applied Science Private UniversityAmman11931Jordan Department of Computer Engineering Automatics and RoboticsUniversity of GranadaGranada18071Spain

Cloud computing is a dynamic and rapidly evolving field,where the demand for resources fluctuates *** paper delves into the imperative need for adaptability in the allocation of resources to applications and services within cloud computing *** motivation stems from the pressing issue of accommodating fluctuating levels of user demand *** adhering to the proposed resource allocation method,we aim to achieve a substantial reduction in energy *** reduction hinges on the precise and efficient allocation of resources to the tasks that require those most,aligning with the broader goal of sustainable and eco-friendly cloud computing *** enhance the resource allocation process,we introduce a novel knowledge-based optimization *** this study,we rigorously evaluate its efficacy by comparing it to existing algorithms,including the Flower Pollination Algorithm(FPA),Spark Lion Whale Optimization(SLWO),and Firefly *** findings reveal that our proposed algorithm,Knowledge Based Flower Pollination Algorithm(KB-FPA),consistently outperforms these conventional methods in both resource allocation efficiency and energy consumption *** paper underscores the profound significance of resource allocation in the realm of cloud *** addressing the critical issue of adaptability and energy efficiency,it lays the groundwork for a more sustainable future in cloud computing *** contribution to the field lies in the introduction of a new resource allocation strategy,offering the potential for significantly improved efficiency and sustainability within cloud computing infrastructures.

关键词： Cloud computing resource allocation energy consumption optimization algorithm flower pollination algorithm

Synthesis and evaluation of 4-substituted semicarbazones of levulinic acid for anticonvulsant activity

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第7期6卷 617-621页

作者： AGGARWAL navneet MISHRA Pradeep Lachoo Memorial College of Science and Technology Pharmacy Wing Jodhpur Rajasthan 342003 IndiaDepartment of Pharmaceutical Sciences Dr. Hari Singh Gour University Sagar M.P. 470003 India

Objective: A series of 4-aryl substituted semicarbazones of levulinic acid (4-oxo pentanoic acid) was designed and synthesized to meet the structural requirements essential for anticonvulsant activity. Methods: All the compounds were evaluated for anticonvulsant activity. Anticonvulsant activity was determined after intraperitoneal (i.p.) administration to mice by maximal electroshock (MES) and subcutaneous metrazol (ScMet) induced seizure methods and minimal motor impairment was determined by rotorod test. Results: A majority of the compounds exhibited significant anticonvulsant activity after intraperitoneal administration. In the present study 4-(4'-fluoro phenyl) levulinic acid semicarbazone emerged as the most active molecule, showing broad spectrum of activity with low neurotoxicity. Unsubstituted levulinic acid semicarbazone was found to be inactive in all the screens. Conclusion: The results obtained validate the hypothesis that presence of an aryl group near the semicarbazone moiety is essential for anticonvulsant activity. The results also indicate that the hydrophilic-hydrophobic site can accommodate hydrophilic groups.

关键词： Substituted semicarbazones Anticonvulsant Levulinic acid