检索结果-南通市图书馆

Acta Pharmaceutica Sinica B 2021年第5期11卷 1341-1354页

作者： naveed ullah khan Jiang Ni Xiufeng Ju Tongtong Miao Haiyan Chen Liang Han Jiangsu Key Laboratory of Neuropsychiatric Diseases Research and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Department of Pharmacy Affiliated Hospital of Jiangnan UniversityWuxi 214000China

Breast cancer brain metastases(BCBMs)are one of the most difficult malignancies to treat due to the intracranial location and multifocal *** and molecular targeted therapy are extremely ineffective for BCBMs due to the inept brain accumulation because of the formidable bloodbrain barrier(BBB).Accumulation studies prove that low density lipoprotein receptor-related protein 1(LRP1)is promising target for BBB ***,as the primary clearance receptor for amyloid beta and tissue plasminogen activator,LRP1 at abluminal side of BBB can clear LRP1-targeting *** metalloproteinase-1(MMP1)is highly enriched in metastatic niche to promote growth of ***,it is reported that nanoparticles(NPs-K-s-A)tethered with MMP1-sensitive fusion peptide containing HER2-targeting K and LRP1-targeting angiopep-2(A),can surmount the BBB and escape LRP1-mediated clearance in metastatic ***-K-s-A revealed infinitely superior brain accumulation to angiopep-2-decorated NPs-A in BCBMs bearing mice,while comparable brain accumulation in normal *** delivered doxorubicin and lapatinib synergistically inhibit BCBMs growth and prolongs survival of mice bearing *** to the efficient BBB penetration,special and remarkable clearance escape,and facilitated therapeutic outcome,the fusion peptide-based drug delivery strategy may serve as a potential approach for clinical management of BCBMs.

关键词： Breast cancer brain metastases Blood-brain barrier Amyloid beta Abluminal LRP1 Brain clearance Fusion peptide MMP Nanoparticles

Comparative assessment of clinical profile and outcomes after primary percutaneous coronary intervention in young patients with single vs multivessel disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Cardiology 2020年第4期12卷 136-143页

作者： Atif Sher Muhammad Tariq Ashraf Ayaz Mir Syed Alishan Faiza Farooq Ali Ammar Musa Karim Syed Nadeem Hassan Rizvi Tahir Saghir Jawaid Akbar Sial naveed ullah khan Department of Adult Cardiology National Institute of Cardiovascular DiseasesKarachi 75510Pakistan Department of Clinical Research National Institute of Cardiovascular DiseasesKarachi 75510Pakistan

BACKGROUND Even though percutaneous coronary intervention(PCI)improved the survival of patients with acute myocardial infarction,still multivessel coronary artery disease remains an important factor burdening prognosis and it is being associated with a worse prognosis compared to single-vessel disease(SVD).AIM To compare the clinical profile and outcomes after the primary PCI in young patients with SVD vs multivessel disease(MVD).METHODS The retrospective cohort of patients were divided into two groups:SVD and MVD *** study population consisted of both male and female young(≤45 years)patients presented with ST-elevation myocardial infarction(STEMI)at the National Institute of Cardiovascular Disease,Karachi,Pakistan and undergone primary PCI from 1 st July 2017 to 31 st March *** and postprocedure management of the patients was as per the guidelines and institutional *** A total of 571 patients with STEMI,≤45 years were stratified into two groups by the number of vessels involved,342(59.9%)with SVD and 229(40.1%)with *** average age of these patients was 39.04±4.86 years.A lower prevalence of hypertension and diabetes was observed in SVD as compare to MVD group(25.1%vs 38%,P<0.01;11.7%vs 27.5%,P<0.001)***,smoking was more prevalent among the SVD group as compare to MVD group(36.3%vs 28.4%,P=0.05).The high-C Lesion was observed in a significantly higher number of younger patients with MVD as compared to SVD group(48.8%vs 39.2%,P=0.021).Post-procedure thrombolysis in myocardial infarction flow grade was found to be not associated with the number of diseased vessels with a P value of 0.426 and thrombolysis in myocardial infarction flow grade III was observed in 98%vs 96.5%of the patients is SVD vs MVD *** The MVD comprised of around 40%of the young patients presented with ***,this study shows that diabetes and hypertension have a certain role in the pathogenesis of multivessel diseases,therefore,preventive

关键词： Young Multivessel disease Primary percutaneous coronary intervention STelevation myocardial infarction Premature coronary artery diseases Single-vessel disease

Comparative study of living donor kidney transplants:Right vs left

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2025年第1期15卷 115-123页

作者： Taqi khan Nadeem Ahmad Qaisar Iqbal Muneeb Hassan Lajward Asnath naveed khan Sajid Shakeel Kidney Transplant Unit Rehman Medical InstitutePeshawar 25100Khyber PakhtunkhwaPakistan Department of Surgery Princess Noura Binti AbdulRehman UniversityRiyadh 84428Saudi Arabia

BACKGROUND Transplant teams often hesitate to use the right kidney(RK)in living donor(LD)transplants due to the complexities of anastomosing the short,thin-walled right renal veins,which can potentially lead to graft loss or graft ***,circumstances may arise where selecting the RK over the left kidney(LK)is ***,it is crucial to thoroughly examine the implications of such a choice on the overall transplant *** To compare transplant outcomes between recipients of RK and LK while examining the factors that influence these *** We retrospectively analyzed data from adult patients who received LD kidney transplants involving meticulous patient selection and surgical techniques at our center from January 2020 to December *** included all kidney donors who were over 18,fit to donate,and had undergone diethylenetriamine pentaacetic acid split function and/or computed tomography based *** variables examined comprised donor and recipient demographics,and outcome measures included technical graft loss(TGL),delayed or slow graft function(SGF),and post-transplant serum creatinine(SC)*** used a logistic regression model to assess the likelihood of adverse outcomes considering the donor kidney *** Of the 250 transplants performed during the period,56(22%)were *** recipient demographics and transplant factors were comparable for the right and LKs,except that the donor warm and cold ischemia time were shorter for *** and SGF each occurred in 2%(n=1)of RKs and 0.5%(n=1)of LKs,the difference being *** complications,however,were not related to the venous *** RK(2%)developed delayed graft function after 48 hours,which was attributable to postoperative hypoxia rather than the surgical *** post-transplant SC trend and mean SC at the last follow-up were similar across both kidney *** The donor kidney side has little impact on post-transplant

关键词： Living donor Right kidney Right renal vein Venous anastomosis Technical graft loss Early graft function

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.naveed M.IMRAN T.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词：

Alternative Strategy for Development of Dielectric Calcium Copper Titanate‑Based Electrolytes for Low‑Temperature Solid Oxide Fuel Cells

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 310-332页

作者： Sajid Rauf Muhammad Bilal Hanif Zuhra Tayyab Matej Veis MAKYousaf Shah naveed Mushtaq Dmitry Medvedev Yibin Tian Chen Xia Martin Motola Bin Zhu College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova684215 BratislavaSlovakia Energy Storage Joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096People’s Republic of China Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia School of Microelectronics Hubei UniversityWuhan 430062People’s Republic of China

The development of low-temperature solid oxide fuel cells(LT-SOFCs)is of significant importance for realizing the widespread application of *** has stimulated a substantial materials research effort in developing high oxide-ion conductivity in the electrolyte layer of *** this context,for the first time,a dielectric material,CaCu_(3)Ti_(4)O_(12)(CCTO)is designed for LT-SOFCs electrolyte application in this *** individual CCTO and its heterostructure materials with a p-type Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ)(NCAL)semiconductor are evaluated as alternative electrolytes in LT-SOFC at 450–550℃.The single cell with the individual CCTO electrolyte exhibits a power output of approximately 263 mW cm^(-2) and an open-circuit voltage(OCV)of 0.95 V at 550℃,while the cell with the CCTO–NCAL heterostructure electrolyte capably delivers an improved power output of approximately 605 mW cm^(-2) along with a higher OCV over 1.0 V,which indicates the introduction of high hole-conducting NCAL into the CCTO could enhance the cell performance rather than inducing any potential short-circuiting *** is found that these promising outcomes are due to the interplay of the dielectric material,its structure,and overall properties that led to improve electrochemical mechanism in CCTO–***,density functional theory calculations provide the detailed information about the electronic and structural properties of the CCTO and NCAL and their heterostructure CCTO–*** study thus provides a new approach for developing new advanced electrolytes for LT-SOFCs.

关键词： LT-SOFCs Dielectric CaCu_(3)Ti_(4)O_(12) Semiconductor Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ) Ionic conductivity Heterostructure electrolyte

Lattice-Based Authentication Scheme to Prevent Quantum Attack in Public Cloud Environment

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2023年第4期75卷 35-49页

作者： naveed khan Zhang Jianbiao Intikhab ullah Muhammad Salman Pathan Huhnkuk Lim Faculty of Information Technology Beijing University of TechnologyBeijing100124China Lecture in Computer Science Shaheed Benazir Bhutto UniversitySheringal18050Pakistan Department of Computer Science Maynooth UniversityMaynoothW23 A3HYIreland Department of Computer Engineering Hoseo UniversityAsan-si31499Korea

Public cloud computing provides a variety of services to consumersvia high-speed internet. The consumer can access these services anytimeand anywhere on a balanced service cost. Many traditional authenticationprotocols are proposed to secure public cloud computing. However, therapid development of high-speed internet and organizations’ race to developquantum computers is a nightmare for existing authentication schemes. Thesetraditional authentication protocols are based on factorization or discretelogarithm problems. As a result, traditional authentication protocols arevulnerable in the quantum computing era. Therefore, in this article, we haveproposed an authentication protocol based on the lattice technique for publiccloud computing to resist quantum attacks and prevent all known traditionalsecurity attacks. The proposed lattice-based authentication protocolis provably secure under the Real-Or-Random (ROR) model. At the sametime, the result obtained during the experiments proved that our protocol islightweight compared to the existing lattice-based authentication protocols,as listed in the performance analysis section. The comparative analysis showsthat the protocol is suitable for practical implementation in a quantum-basedenvironment.

关键词： Lattice authentication quantum attack ProVerif

Flower Pollination Heuristics for Nonlinear Active Noise Control Systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2021年第4期67卷 815-834页

作者： Wasim ullah khan Yigang He Muhammad Asif Zahoor Raja naveed Ishtiaq Chaudhary Zeshan Aslam khan Syed Muslim Shah School of Electrical Engineering and Automation Wuhan UniversityWuhan430072China Future Technology Research Center National Yunlin University of Science and TechnologyYunlin64002Taiwan Department of Electrical Engineering International Islamic UniversityIslamabadPakistan Department of Electrical Engineering Capital University of Science and TechnologyIslamabadPakistan

In this paper,a novel design of the flower pollination algorithm is presented for model identification problems in nonlinear active noise control *** recently introduced flower pollination based heuristics is implemented to minimize the mean squared error based merit/cost function representing the scenarios of active noise control system with linear/nonlinear and primary/secondary paths based on the sinusoidal signal,random and complex random signals as noise *** flower pollination heuristics based active noise controllers are formulated through exploitation of nonlinear filtering with Volterra *** comparative study on statistical observations in terms of accuracy,convergence and complexity measures demonstrates that the proposed meta-heuristic of flower pollination algorithm is reliable,accurate,stable as well as robust for active noise control *** accuracy of the proposed nature inspired computing of flower pollination is in good agreement with the state of the art counterpart solvers based on variants of genetic algorithms,particle swarm optimization,backtracking search optimization algorithm,fireworks optimization algorithm along with their memetic combination with local search ***,the central tendency and variation based statistical indices further validate the consistency and reliability of the proposed scheme mimic the mathematical model for the process of flower pollination systems.

关键词： Active noise control computational heuristics volterra filtering flower pollination algorithm

Thermo-diffusion effects on MHD stagnation point flow towards a stretching sheet in a nanofuid

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Propulsion and Power Research 2014年第3期3卷 151-158页

作者： Umar khan naveed Ahmed Sheikh Irfan ullah khan Syed Taluseef Mohyud-din Deparment of Mathematics Faculty of SciencesHITEC UniversityTarila CantPakistan COMSA IS Institute of Information Technology University RoadAbbottabadPakistan

Thermodiffusion effects on stagnation point flow of a nanofuid towards a stretching surface with applied magnetic field is *** transforms are applied to reduce the equations that govem the flow to a system of nonlinear ordinary differential ***-K utta-Fehlberg method is applied to solve the sy *** are compared with existing solutions that are special cases to our *** graphical analysis is carried out to study the effects of different emerging parameters such as stretching ratio A,mag netic infuence parameter M,Prandtl number Pr,Lewis number Le,Brownian motion parameter Nb,thermophoresis parameter Nr,nanofluid Lewis number Ln,modified Dufour parameter Nd and Dufour solutal number Ld coupled with comprehensive *** effects of local Nusselt number,local Sherwood number and nanofluid Sherwood number are also discussed.

关键词： Nanofluid Stretching sheet Thermodiffusion Numerical solution Nusselt number Sherwood number Nanofluid Sherwood number

Th-Shaped Tunable Multi-Band Antenna for Modern Wireless Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2023年第2期74卷 2517-2530页

作者： Wasi Ur Rehman khan Muhammad Fawad khan Muhammad Irfan Sadiq ullah naveed Mufti Usman Ali Rizwan ullah Fazal Muhammad Saifur Rahman Faisal Althobiani Mohammed Alshareef Mohammad E.Gommosani Department of Telecommunication Engineering University of Engineering and TechnologyMardanPakistan Electrical Engineering Department College of EngineeringNajran UniversityNajranSaudi Arabia Department of Electrical Engineering University of Engineering and TechnologyMardan23200Pakistan Faculty of Maritimes Studies King Abdulaziz UniversityJeddahSaudi Arabia Ports&Maritime Transportation Faculty of Maritimes StudiesKing Abdulaziz UniversityJeddahSaudi Arabia Natural Science Department Faculty of Maritimes StudiesKing Abdulaziz UniversityJeddahSaudi Arabia

A compact,reconfigurable antenna supporting multiple wireless services with a minimum number of switches is found lacking in literature and the same became the focus and outcome of this *** was achieved by designing a Th-Shaped frequency reconfigurable multi-band microstrip planar antenna,based on use of a single switch within the radiating structure of the *** frequency bands(i.e.,2007–2501 MHz,3660–3983MHz and 9341–1046 MHz)can be operated with the switch in the ON switch *** the OFF state of the switch,the antenna operates within the 2577–3280MHz and 9379–1033MHz *** proposed antenna shows an acceptable input impedance match with Voltage Standing Wave Ratio(VSWR)less than *** peak radiation efficiency of the antenna is 82%.A reasonable gain is obtained from 1.22 to 3.31 dB within the operating bands is *** proposed antenna supports UniversalMobile Telecommunication System(UMTS)-1920 to 2170 MHz,Worldwide Interoperability and Microwave Access(WiMAX)/Wireless Broadband/(Long Term Evolution)LTE2500–2500 to 2690 MHz,Fifth Generation(5G)-2500/3500 MHz,Wireless Fidelity(Wi-Fi)/Bluetooth-2400 to 2480 MHz,and Satellite communication applications in X-Band-8000 to 12000 *** overall planar dimension of the proposed antenna is 40×*** antennawas designed,along with the parametric study,using Electromagnetic(EM)simulation *** antenna prototype is fabricated for experimental validation with the simulated *** proposed antenna is low profile,tunable,lightweight,cheap to fabricate and highly efficient and hence is deemed suitable for use in modern wireless communication electronic devices.

关键词： Antenna design reconfigurable antenna satellite communication frequency bands

Sliding Mode Control-Based Autonomous Control of a Tri-rotor Unmanned Aerial Vehicle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Guidance, Navigation and Control 2021年第3期1卷 52-75页

作者： Abid Raza Fahad Mumtaz Malik Rameez khan naveed Mazhar Hameed ullah Nigar Ahmed Department of Electrical Engineering College of Electrical and Mechanical EngineeringNational University of Sciences and Technology46000IslamabadPakistan College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjingJiangsu 210016P.R.China

A nonlinear control technique for autonomous control of a tri-rotor unmanned aerial vehicle is presented in this ***,a comprehensive mathematical model is developed using the Newton–Euler approach for a tri-rotor,which is found to be highly nonlinear and ***,the equivalent input a±ne model is extracted by applying a suitable ***,the sliding mode control for trajectory tracking is chosen which is immune to matched external disturbances,parametric uncertainties,and modeling *** proposed controller performance has been veri¯ed for appropriate inputs under wind disturbances using MATLAB,and the simulation results are presented.

关键词： Autonomous control nonlinear control sliding mode control unmanned aerial vehicle tri-rotor