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Polymeric assembled nanoparticles through kinetic stabilization by confined impingement jets dilution mixer for fluorescence switching imaging

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Chinese Journal of Chemical Engineering 2023年第4期56卷 89-96页

作者： Jingran Liu Yue Wu Jie Tang Tao Wang Feng Ni Qiumin Wu Xijiao Yang Ayyaz Ahmad naveed Ramzan Yisheng Xu State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Shyndec Pharmaceutical Co. LtdShanghai 200040China Department of Chemical Engineering Muhammad Nawaz Sharif University of Engineering and TechnologyMultanPakistan Faculty of Chemical Metallurgicaland Polymer EngineeringUniversity of Engineering&TechnologyLahorePakistan

Traditional fluorescence switching molecules achieving the state change between on and off states commonly based on UV irradiation. However, it is worth noting that UV irradiation is harmful to both the cancer cells and the normal cells. To achieve fluorescence switching under visible wavelength and avoid complicate molecular design, a fluorophore of 2,4,5,6-tetrakis(carbazol-9-yl)-1,3-dicyanobenzene(4Cz IPN) and a quencher of diarylethene(DAE) were physically incorporated within the biocompatible block copolymer poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)(PLGA-b-PEG) to form 4Cz IPNDAE nanoparticles(NPs) through flash nanoprecipitation(FNP). By using the FNP method, the NPs were prepared within milliseconds in a confined impingement jets dilution(CIJ-D) mixer. Quenching and recovery of fluorescence could achieve in the presence of DAE under 475 nm and 560 nm *** structure and fluorescent properties of the nanoparticles can be tuned by external conditions for their efficient fluorescence resonance energy transfer(FRET) in a kinetic stabilization process. This NPs formation process was further optimized by varying the dilution ratio, Reynolds number(Re) and polymer concentration to modulate the mixing and particle nucleation and growth process. The size and fluorescence switching properties of the NPs were systematically investigated in solution and in cellular uptake experiments. This work is anticipated to provide a simple and highly effective engineering strategy for the modulation of fluorescence switching nanoparticles and beneficial to its engineering application.

关键词： Preparation Kinetic stabilization Flash nanoprecipitation Nanoparticles Fluorescence switch

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Analysis of Pneumonia Model via Efficient Computing Techniques

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Computers, Materials & Continua 2022年第3期70卷 6073-6088页

作者： Kamaledin Abodayeh Ali Raza Muhammad Rafiq Muhammad Shoaib Arif Muhammad naveed Zunir Zeb Syed Zaheer Abbas Kiran Shahzadi Sana Sarwar Qasim naveed Badar Ul Zaman Muhammad Mohsin Department of Mathematics and General Sciences Prince Sultan University Riyadh66833Saudi Arabia Department of Mathematics Govt.Maulana Zafar Ali Khan Graduate College Wazirabad52000Punjab Higher Education Department(PHED)Lahore54000Pakistan Department of Mathematics National College of Business Administration and Economics Lahore54660Pakistan Department of Mathematics Faculty of SciencesUniversity of Central PunjabLahore54500Pakistan Department of Mathematics Air UniversityIslamabad44000Pakistan Department of Mathematics Technische Universitat Chemnitz6209111Germany

Pneumonia is a highly transmissible disease in *** to the World Health Organization(WHO),the most affected regions include south Asia and sub-Saharan ***,15%of pediatric deaths can be attributed to *** techniques have a significant role in science,engineering,and many other *** this study,we focused on the efficiency of numerical techniques via computer *** studied the dynamics of the pneumonia-like infections of epidemic models using numerical *** discuss two types of analysis:dynamical and *** dynamical analysis included positivity,boundedness,local stability,reproduction number,and equilibria of the *** also discusswell-known computing techniques including Euler,Runge Kutta,and non-standard finite difference(NSFD)for the *** non-standard finite difference(NSFD)technique shows convergence to the true equilibrium points of the model for any time step ***,Euler and Runge Kutta do not work well over large time *** techniques are the suitable tool for crosschecking the theoretical analysis of the model.

关键词： Pneumonia disease epidemic model computing techniques convergence analysis

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Automatic Speaker Recognition Using Mel-Frequency Cepstral Coefficients Through Machine Learning

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Computers, Materials & Continua 2022年第6期71卷 5511-5521页

作者： U˘gur Ayvaz Hüseyin Gürüler Faheem Khan naveed Ahmed Taegkeun Whangbo Abdusalomov Akmalbek Bobomirzaevich Department of Computer Engineering Istanbul Technical UniversityIstanbul34485Turkey Department of Information Systems Engineering Mugla Sitki Kocman UniversityMugla48000Turkey Artificial Intelligence Lab Department of Computer EngineeringGachon UniversitySeongnam13557Korea Department of Computer Science College of Computing and InformaticsUniversity of SharjahSharjah27272UAE

Automatic speaker recognition(ASR)systems are the field of Human-machine interaction and scientists have been using feature extraction and feature matching methods to analyze and synthesize these *** of the most commonly used methods for feature extraction is Mel Frequency Cepstral Coefficients(MFCCs).Recent researches show that MFCCs are successful in processing the voice signal with high *** represents a sequence of voice signal-specific *** experimental analysis is proposed to distinguish Turkish speakers by extracting the MFCCs from the speech *** the human perception of sound is not linear,after the filterbank step in theMFCC method,we converted the obtained log filterbanks into decibel(dB)features-based spectrograms without applying the Discrete Cosine Transform(DCT).A new dataset was created with converted spectrogram into a 2-D *** learning algorithms were implementedwith a 10-fold cross-validationmethod to detect the *** highest accuracy of 90.2%was achieved using Multi-layer Perceptron(MLP)with tanh activation *** most important output of this study is the inclusion of human voice as a new feature set.

关键词： Automatic speaker recognition human voice recognition spatial pattern recognition MFCCs spectrogram machine learning artificial intelligence

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Electrical and optical measurements in the early hydrogen discharge of GLAST-Ⅲ

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Plasma Science and Technology 2017年第8期19卷 66-75页

作者： S HUSSAIN A QAYYUM Z AHMAD S AHMAD R KHAN M A naveed R ALI F DEEBA G M VOROBYOV GLAST Team National Tokamak Fusion Program 3329 Islamabad Pakistan Saint-Petersburg State University 198504 Saint-Petersburg Russia

This work presents the first electrical and optical measurements of the initial phase of hydrogen discharge in the upgraded spherical tokamak GLAST-III, initiated with electron cyclotron heating（ECH）. Diagnostic measurements provide insights into expected and unexpected physics issues related to the initial phase of discharge. A triple Langmuir probe（TLP） has been developed to measure time series of the floating potential, plasma electron temperature and number density over the entire discharge, allowing monitoring of the two phases of the discharge： the ECH pre-ionization phase following by the plasma current formation phase. A TLP has the ability to give time-resolved measurements of the floating potential（V_（float））, electron temperature（T_e） and ion saturation current（I_（sat）∝n_e√kT_e）.sat e eThe evolution of the ECH-assisted pre-ionization and subsequent plasma current phases in one shot are well envisioned by the probe. Intense fluctuations in the plasma current phase advocate for efficient equilibrium and feedback control systems. Moreover, the emergence of some strong impurity lines in the emission spectrum, even after only a few shots, suggests a crucial need for improvements in the base vacuum level. A noticeable change in the shape of the temporal profiles of the floating potential, electron temperature, ion saturation current（I_（sat）） and light emission has been observed with changing hydrogen fill pressure and vertical magnetic field.

关键词： floating saturation subsequent spherical heating triple unexpected impurity noticeable advocate

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Novel Analytical Thermal Performance Rate Analysis in ZnO-SAE50 Nanolubricant: Nonlinear Mathematical Model

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Computers, Materials & Continua 2021年第4期67卷 477-489页

作者： Adnan Abbasi Umar Khan naveed Ahmed Syed Tauseef Mohyud-Din Ilyas Khan El-Sayed M.Sherif Department of Mathematics Mohi-ud-Din Islamic UniversityNerian SharifAJ&K12080Pakistan Department of Mathematics and Statistics Hazara UniversityMansehra21120Pakistan Department of Mathematics HITEC UniversityTaxilaCantt47070Pakistan University of Multan Multan66000Pakistan Department of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh City72915Vietnam Department of Mechanical Engineering College of EngineeringKing Saud UniversityAl-Riyadh11421Saudi Arabia Department of Physical Chemistry Electrochemistry and Corrosion LaboratoryNational Research CentreCairo12622Egypt

The investigation of local thermal transport rate in the nanolubricants is *** lubricants are broadly used in environmental pollution,mechanical engineering and in the paint industry due to high thermal performance ***,thermal transport in ZnO-SAE50 nanolubricant under the impacts of heat generation/absorption is *** colloidal suspension is flowing between parallel stretching disks in which the lower disk is positioned at z=0 and upper disk apart from distance *** problem is transformed in dimensionless version via described similarity *** the next stage,an analytical technique(VPM)is implemented for the solution *** graphical results against multiple flow parameters were furnished over the region of interest and explained *** is imperative to mention that the results are plotted for ZnO-SAE50 and conventional liquid as ***,rapid motion of the fluid is perceived against high Reynolds andγ*** wall shear stresses at the upper end rises for multiple Reynolds andγwhile;decrement is detected at the lower *** significant contribution of an internal heat source is noted for thermal performance rate at the upper ***,the local heat transport rate declines at the lower *** altering Reynolds number,prompt heat transfer rate is gained at the upper disk and increasing behavior of the local heat transport rate is slow at the lower *** the study,it is concluded that the nanolubricants have high thermal ***,such fluids are reliable to use in above stated areas.

关键词： Zno-SAE50 nanolubricant thermal performance local heat transport numerical algorithm skin friction

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Foliar application of micronutrients enhances crop stand, yield and the biofortification essential for human health of different wheat cultivars

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Journal of Integrative Agriculture 2019年第6期18卷 1369-1378页

作者： Muhammad Zahir Aziz Muhammad Yaseen Tanveer Abbas Muhammad naveed Adnan Mustafa Yasir Hamid Qudsia Saeed XU Ming-gang Institute of Soil and Environmental Sciences University of AgricultureFaisalabad 38040Pakistan National Engineering Laboratory for Improving Quality of Arable Land Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081P.R.China College of Environmental and Resources Science Zhejiang UniversityHangzhou 310058P.R.China College of Natural Resources and Environment Northwest Agriculture and Forestry UniversityYangling 712100P.R.China

Globally about half of the world’s population is under micronutrient malnutrition due to poor quality food *** overcome this problem,fortification and biofortification techniques are often *** is considered a better option than fortification due to the easy control of nutrient deficiencies present in daily *** field experiment was conducted to evaluate the effects of foliar application of a micronutrient mixture(MNM)consisting of zinc(Zn),iron(Fe),copper(Cu),manganese(Mn)and boron(B)on yield and flour quality of *** results show the effectiveness of foliar feeding for growth and yield parameters,in addition to the enriching of wheat grains with Zn,Cu,Fe,Mn and *** to the control without foliar feeding,foliar application on wheat crop increased tillering ability,spike length,grain yield and the contents of Zn,Cu,Mn,Fe and B by 21,47,22,22 and 25%in wheat flour,***,foliar feeding of micronutrients could be an effective approach to enrich wheat grains with essential nutrients for correcting malnutrition.

关键词： enrichment biofortification malnutrition micronutrients wheat flour

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Flower Pollination Heuristics for Nonlinear Active Noise Control Systems

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Computers, Materials & Continua 2021年第4期67卷 815-834页

作者： Wasim Ullah Khan Yigang He Muhammad Asif Zahoor Raja naveed Ishtiaq Chaudhary Zeshan Aslam Khan Syed Muslim Shah School of Electrical Engineering and Automation Wuhan UniversityWuhan430072China Future Technology Research Center National Yunlin University of Science and TechnologyYunlin64002Taiwan Department of Electrical Engineering International Islamic UniversityIslamabadPakistan Department of Electrical Engineering Capital University of Science and TechnologyIslamabadPakistan

In this paper,a novel design of the flower pollination algorithm is presented for model identification problems in nonlinear active noise control *** recently introduced flower pollination based heuristics is implemented to minimize the mean squared error based merit/cost function representing the scenarios of active noise control system with linear/nonlinear and primary/secondary paths based on the sinusoidal signal,random and complex random signals as noise *** flower pollination heuristics based active noise controllers are formulated through exploitation of nonlinear filtering with Volterra *** comparative study on statistical observations in terms of accuracy,convergence and complexity measures demonstrates that the proposed meta-heuristic of flower pollination algorithm is reliable,accurate,stable as well as robust for active noise control *** accuracy of the proposed nature inspired computing of flower pollination is in good agreement with the state of the art counterpart solvers based on variants of genetic algorithms,particle swarm optimization,backtracking search optimization algorithm,fireworks optimization algorithm along with their memetic combination with local search ***,the central tendency and variation based statistical indices further validate the consistency and reliability of the proposed scheme mimic the mathematical model for the process of flower pollination systems.

关键词： Active noise control computational heuristics volterra filtering flower pollination algorithm

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<i>In-Vivo</i>Models for Management of Pain

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Pharmacology & Pharmacy 2014年第1期5卷 92-96页

作者： naveed Muhammad Department of Pharmacy Abdul Wali Khan University Mardan Pakistan

Natural products are mostly considered safe, effective and with fewer side effects. For testing the natural products for their analgesic potential various in-vivo methods are used including chemical induced methods and thermal induced method. In the present review article we have discussed various in-vivo paradigms along with their merits and drawbacks. This mini review will help pharmacologist in performing various analgesic experiments.

关键词： Natural Products Analgesic Potential Chemical Induced and Thermal Induced

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Clinical course of suspected small gastrointestinal stromal tumors in the stomach

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World Journal of Gastrointestinal Surgery 2020年第4期12卷 171-177页

作者： Lian-Song Ye Yan Li Wei Liu Ming-Hong Yao naveed Khan Bing Hu Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Epidemiology and Health Statistics West China School of Public HealthSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Gastric subepithelial lesions are frequently encountered during endoscopic examinations,and the majority of them are small and *** these lesions,gastrointestinal stromal tumors(GISTs)are the major concern for patients and clinicians owing to their malignant *** previous guidelines suggested periodic surveillance for such small(≤20 mm)lesions,several patients and clinicians have still requested or prescribed repeated examinations or radical resection,posing extra medical burdens and *** To describe the clinical course of suspected small gastric GISTs and provide further evidence for surveillance strategy for tumor *** This single-center,retrospective study was conducted at West China Hospital,Sichuan *** patients with suspected small gastric GISTs were reviewed from November 2004 to November *** was suspected according to endoscopic ultrasonography features:hypoechoic lesions from muscularis propria or muscularis *** patients with suspected small(≤20 mm)GISTs were included for ***’demographic data,lesions’characteristics,and follow-up medical records were *** A total of 383 patients(male/female,121/262;mean age,54 years)with 410 suspected small gastric GISTs(1 lesion in 362 patients,2 lesions in 16,3 lesions in4,and 4 lesions in 1)were included for *** most common location was gastric fundus(56.6%),followed by body(29.0%),cardia(12.2%),and antrum(2.2%).After a median follow-up of 28 mo(interquartile range,16-48;range,3-156),402 lesions(98.0%)showed no changes in size,and size of 8 lesions(2.0%)was increased(mean increment,10 mm).Of the 8 lesions with size increment,endoscopic or surgical resection was performed in 6 patients(5 GISTs and 1 leiomyoma).For other 2 remaining patients,unroofing biopsy or endoscopic ultrasound-guided fine-needle aspiration was carried out(2 GISTs),while no further change in size was noted over a period of 62

关键词： Endoscopic ultrasound-guided fine-needle aspiration Gastrointestinal stromal tumor Hypoechoic lesions Stomach Surveillance strategy Unroofing biopsy

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A distributed modeling approach to water balance implications from changing land cover dynamics in permafrost environments

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Geography and Sustainability 2024年第4期5卷 561-576页

作者： naveed Ahmed Haishen Lu Zhongbo Yu Oluwafemi E.Adeyeri Muhammad Shahid Iqbal Jinbin Su The National Key Laboratory of Water Disaster Prevention College of Hydrology and Water ResourcesHohai UniversityNanjing 210098China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China School of Energy and Environment City University of Hong KongKowloonHong Kong Special Administrative Regions of China Australian Rivers Institute Griffith UniversityNathanQLD 4111Australia International Water Management Institute(IWMI) Lahore 54000Pakistan National Tibetan Plateau Data Center State Key Laboratory of Tibetan Plateau Earth SystemEnvironment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

There is 78%permafrost and seasonal frozen soil in the Yangtze River’s Source Region(SRYR),which is situated in the middle of the Qinghai-Xizang *** distinct scenarios were developed in the Soil and Water Assessment Tool(SWAT)to model the effects of land cover change(LCC)on various water balance *** and percolation of groundwater have decreased by *** demonstrates the seasonal contributions of subsurface water,which diminish when soil *** winter,when surface water inputs are low,groundwater storage becomes even more critical to ensure water supply due to this periodic *** impermeable layer underneath the active layer thickness decreases GWQ and PERC in LCC+permafrost *** water transport and storage phase reached a critical point in August when precipitation,permafrost thawing,and snowmelt caused LATQ to *** prevent waterlogging and save water for dry periods,it is necessary to control this peak flow *** processes,permafrost dynamics,and land cover changes in the SRYR are difficult,according to the *** interactions enhance water circulation throughout the year,recharge of groundwater supplies,surface runoff,and lateral *** the region’s water resource management to be effective in sustaining ecohydrology,ensuring appropriate water storage,and alleviating freshwater scarcity,these dynamics must be considered.

关键词： Cold region Land cover change Permafrost hydrology SWAT model Source region Yangtze river

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