检索结果-南通市图书馆

The 4th Asian-Pacific Organization for Cell Biology Congress Cell Biology in the Post-Genomic Era

作者： Pimentel,SS Matias,RR Inoue,S. Buerano,CC natividad,ff Institute of Biology University of the PhilippinesDilimanQuezon City St. Luke’s Medical Center Quezon City

Dengue fever and dengue hemorrhagic fever (DF/DHF) are one of the most common infectious diseases transmitted by the mosquito vector Aedes aegypti, in both tropical and subtropical regions. Active surveillance has bec...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

On the development of optical peripheral nerve interfaces

引用

Neural Regeneration Research 2019年第3期14卷 425-436页

作者： Hans E.Anderson Richard F.ff.Weir Department of Bioengineering University of Colorado Denver|Anschutz Medical Campus

Limb loss and spinal cord injury are two debilitating conditions that continue to grow in prevalence. Prosthetic limbs and limb reanimation present two ways of providing affected individuals with means to interact in the world. These techniques are both dependent on a robust interface with the peripheral nerve. Current methods for interfacing with the peripheral nerve tend to suffer from low specificity, high latency and insufficient robustness for a chronic implant. An optical peripheral nerve interface may solve some of these problems by decreasing invasiveness and providing single axon specificity. In order to implement such an interface three elements are required:(1) a transducer capable of translating light into a neural stimulus or translating neural activity into changes in fluorescence,(2) a means for delivering said transducer and(3) a microscope for providing the stimulus light and detecting the fluorescence change. There are continued improvements in both genetically encoded calcium and voltage indicators as well as new optogenetic actuators for stimulation. Similarly, improvements in specificity of viral vectors continue to improve expression in the axons of the peripheral nerve. Our work has recently shown that it is possible to virally transduce axons of the peripheral nerve for recording from small fibers. The improvements of these components make an optical peripheral nerve interface a rapidly approaching alternative to current methods.

关键词： peripheral nerve interfaces optogenetics optical neural interface optical peripheral nerve interface GCaMP ArcLight adenoassociated viral vector lentiviral vectors viral vectors implantable microscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The future of adenoassociated viral vectors for optogenetic peripheral nerve interfaces

引用

Neural Regeneration Research 2021年第7期16卷 1446-1447页

作者： Hans EAnderson Richard F.ff.Weir Department of Bioengineering University of Colorado–Anschutz Medical CampusAuroraColoradoUSA

Prostheses have a several thousand year history for treating limb *** time, these prostheses have become more sophisticated and closer to replicating the natural *** advances have culminated in the myoelectrically con... 详细信息

关键词： closer advances thousand

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Knowledge of aflatoxin contamination in groundnut and the risk of its ingestion among health workers in Ibadan,Nigeria

引用

Asian Pacific Journal of Tropical Biomedicine 2011年第6期1卷 493-495页

作者： Ilesanmi ff Ilesanmi OS Nigerian Stored Products Research Institute Department of Community Medicine University College Hospital

Objective:To assess the awareness and knowledge of aflatoxin contamination in groundnut and the risk of its ingestion among health workers in ***:The study was a descriptive cross-sectional *** instrument was a semi-structured self administered questionnaire. The respondents were health workers from a public health ***:A total of 417 health workers participated out of which males were 60.2%.The mean age of respondents was(28.0±4.9) years *** made up 83.0%while others were nurses.95%of the respondents had previous awareness of aflatoxin and class room lectures was the most common source of information(56%).Occupation and religion both showed a significant association with previous awareness of aflatoxin(P<0.05).Knowledge regarding aflatoxin contamination in groundnut and the risk of its ingestion was obtained showing knowledge score range of 0 to *** all,80.6%had good scores of 11 to *** of the respondents had ever told their patients about the risk of aflatoxin ingestion. Conclusions:There is a need to explore the possibility of incorporating aflatoxin awareness into routine health talk to increase the level of awareness of patients and their relatives.

关键词： Mycotoxins Groundnut Contamination Health risks Ingestion Neoplasm Aflatoxin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between interleukin-1 type I and 2 receptor gene polymorphisms and the expression level of membrane-bound receptors

引用

Cellular & Molecular Immunology 2015年第2期12卷 222-230页

作者： ff Vasilyev AN Silkov SV Sennikov Laboratory of Molecular Immunology Federal State Budgetary Institution 'Research Institute of Clinical Immunology' Russian Academy of Medical Sciences Siberian Branch. Novosibirsk. Russia

The biological activity of the multifunctional cytokine interleukin-1 （IL-1） is mediated by its receptors. The aim of this study was to determine if an association exists between single nucleotide polymorphisms （SNPs） in the IL-1 type I and 2 receptor genes （ILIR1 and ILIR2） and the expression level of membrane-bound ILIRs on subpopulations of mononuclear cells or serum levels of soluble IL-1 receptors. It was observed that healthy individuals with the genotype TT in SNP rs2234650.C〉T had a lower percentage of intact CD14＋ monocytes expressing ILIR1 on their surface. The SNP rs4141134-T〉C in ILIR2 has also been associated with the percentage of intact CD3＋ T cells expressing ILIR2. Furthermore, individuals carrying the CC allele of SNP rs4141134.T〉C and the TT allele of SNP rs2071008-T〉G in ILIR2 had a lower density of ILIR2s on the surface of CD14＋ monocytes in lipopolysaccharide （LPS）-stimulated PBMC cultures. In summary, this study demonstrated that IL-1 receptor gene polymorphisms could be one of the factors influencing the expression of membrane-bound IL-1 receptors （ILIR） on immunocompetent cells.

关键词： interleukin-1 membrane-bound receptor SNPs soluble receptor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

人白细胞髓过氧化物酶代谢活化致癌物4－氨基联苯

引用

中国药理学与毒理学杂志 1994年第3期8卷 221-226页

作者：林东昕 Kadl.,ff 福建医学院卫生系

本文研究人白细胞髓过氧化物酶（ＭＰＯ）体外代谢芳胺类致癌物４－氨基联苯（４－ＡＢＰ〕在Ｈ２Ｏ２存在下，ＭＰＯ代谢活化４－ＡＢＰ生成二种可与ＤＮＡ共价结合的代谢产物。高效液相色谱和质谱分析表明。在没有ＤＮＡ存在时４－Ａ... 详细信息

本文研究人白细胞髓过氧化物酶（ＭＰＯ）体外代谢芳胺类致癌物４－氨基联苯（４－ＡＢＰ〕在Ｈ２Ｏ２存在下，ＭＰＯ代谢活化４－ＡＢＰ生成二种可与ＤＮＡ共价结合的代谢产物。高效液相色谱和质谱分析表明。在没有ＤＮＡ存在时４－ＡＢＰ的主要代谢产物是偶氮二联苯。抗坏血酸和谷胱甘肽显著抑制活化的４－ＡＢＰ与ＤＮＡ结合。而且可将活化产物还原成４－ＡＢＰ．这些结果结合质谱资料提示活性中间产物可能是４－ＡＢＰ自由基。３２Ｐ－后标记实验证实ＤＮＡ加合物形成，用此种方法检测出８个４－ＡＢＰ－ＤＮＡ加合物。并表明ＭＰＯ介导产生的４－ＡＢＰ－ＤＮＡ加合物与细胞色素Ｐ４５０代谢产物Ｎ－羟基－４－ＡＢＰ和ＤＮＡ反应产生的加合物性质不同．这些结果提示。ＭＰＯ代谢活化途径可能在４－ＡＢＰ诱发肝外组织肿瘤过程中起一定的作用．

关键词：致癌物氨基联苯髓过氧化物酶

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Klatskin tumor treated by inter-disciplinary therapies including stereotactic radiotherapy: A case report

引用

World Journal of Gastroenterology 2005年第31期11卷 4923-4926页

作者： Gerhild Becker Felix Momm Henning Schwacha Norbert Hodapp Henning Usadel Michael GeiBler Annette Barke Annette Schmitt-Gr(a|¨)ff Karl Henne Hubert E. Blum Department of Medicine Ⅱ Department of Radiotherapy Institute of Pathology

In view of the poor prognosis of patients with cholangiocarcinoma （CCC）, there is a need for new therapeutic strategies. Inter-disciplinary therapy seems to be most promising. Radiotherapy is an effective alternative to surgery for hilar CCC （Klatskin tumors） if an adequate radiation dose can be delivered to the liver hilus. Here, we describe a patient for whom we used a stereotactic radiotherapy technique in the context of an inter-disdplinary treatment concept. We report a 45-year-old patient with a locally advanced Klatskin tumor. Explorative laparotomy showed that the tumor was not resectable. A metallic stent was implanted and the patient was treated by stereotactic radiotherapy using a body frame. A total dose of 48 Gy （3×4 Gy/wk） was administered. Therapy was well tolerated. After 32 too, local tumor recurrence and a chest wall metastasis developed and were controlled by radio-chemotherapy. After more than 56 mo with a good quality of life, the patient died of advanced neoplastic disease. Stereotactic radiotherapy led to a long-term survival of this patient with a locally advanced Klatskin tumor. In the context of inter-disciplinary treatment concepts, this radiotherapy technique is a promising choice of treatment for patients with hilar CCC.

关键词： Klatskin tumor Stereotactic radiotherapy Inter-disciplinary treatment

来源：

维普期刊数据库评论