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A new role for T cells in dampening innate inflammatory responses

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Science china(Life Sciences) 2010年第2期53卷 190-194页

作者： TANG Hong1 & FU YangXin1,2.1 Key laboratory of Infection and Immunity,institute of{2.,Chinese Academy of Sciences,beijing 100101,china 2.Department of Pathology,Committee of Immunology,University of Chicago,Chicago,IL 60637,USA Key laboratory of Infection and Immunity Institute of Biophysics Chinese Academy of Sciences Beijing China Department of Pathology Committee of Immunology University of Chicago Chicago USA

The inflammatory response is an attempt by a host to protect itself against injurious stimuli and initiate the tissue healing process [1,2.. Although the production of both pro-and anti-inflammatory mediators which oc... 详细信息

关键词： cell BTLA A new role for T cells in dampening innate inflammatory responses NLRP

Absolute radiometric calibration of CBERS-02.IRMSS thermal band

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Science china(Technological Sciences) 2005年第S2期48卷 72-90页

作者： ZHANG Yong1,2.3, GU Xingfa1,3,4, YU Tao1,3, ZHANG Yuxiang5, CHEN Liangfu1,3, LI Xiaoying1,2.3, LI Xiaowen1,3 & HE Liming6 1. State Key laboratory of Remote Sensing Science, Jointly Sponsored by the institute of Remote Sensing Applications of Chinese Academy of Sciences and{2. Normal University, beijing 100101, china 2. Graduate University of Chinese Academy of Sciences,{2. 100039, china 3. The Center for national Spaceborne Demonstration, beijing 100101, china 4. Institut national de la Recherche Agronomique, Climat Sol Environnement, 84914 Avignon, France 5. national Satellite Meteorological Center,{2. 100081, china 6. State Environmental Protection Administration,{2. 10002., china State Key laboratory of Remote Sensing Science Beijing Normal University Chinese Academy of Sciences Beijing 100101 China Graduate University Chinese Academy of Sciences Beijing 100039 China Center for national Spaceborne Demonstration Beijing 100101 China national Satellite Meteorological Center Beijing 100081 China Institut national de la Recherche Agronomique Climat Sol Environnement 84914 Avignon France State Environmental Protection Administration Beijing 100029 China

Based on the laboratory calibration before launch of CBERS-02.IRMSS thermal infrared channel, the onboard blackbody calibration, the radiometric cross- calibration against TERRA MODIS corresponding channel and the in-flight field calibration at Lake Qinghai: water surface radiometric calibration test site of china on Aug. 17, 2.04 are carried out in this research. When making onboard blackbody calibration of CBERS-02.IRMSS, it is necessary to understand inside structures and light path in IRMSS camera and receive and process calibration blackbody signals at normal and high temperatures. Onboard blackbody calibration results of each detector are very important to relative radiometric calibration of images processing and absolute radiometric calibration of each detector. In-flight field calibration mainly contains field experiments, obtaining synchronous images, spectrum marching and MODTRAN radiative transmi- ssion computation. Radiometric cross-calibration of CBERS-02.IRMSS thermal band against TERRA MODIS selected 6 times synchronous images of two sensors passing through Lake Qinghai and Lake Taihu from August to December, 2.04 to compute the cross calibration data. Combining the in-flight field calibration and radiometric cross calibration data, the absolute radiometric calibration coefficients are calculated by the linear regression method. This new calibration model can obviously control the radiometric calibration uncertainties aroused by the single point method used in the in-flight calibration of CBERS-02.IRMSS, this kind of sensors cannot receive the cosmic background radiation. In this research, the radiometric calibration coefficients obtained through the linear regression model are 8.53 (gain, unit: DN/W m?2.r?1μm?1) and 44.92.(offset, unit: DN).

关键词： CBERS-02 IRMSS thermal band in-flight field calibration onboard blackbody calibration cross calibration.

Knockdown of CD146 reduces the migration and proliferation of human endothelial cells

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Cell Research 2006年第3期16卷 313-318页

作者： Yanyong Kang~(1,3) Fengcai Wang~(1,2. Jing Feng~1 Dongling Yang~1 Xu Yang~3 Xiyun Yan~11 national laboratory of biomacromolecules,institute of{2.,Chinese Academy of Science beijing 100101,china 2.Chemistry Department,Anyang teacher's College,Anyang 455000,china 3 College of Life Science,Central china Normal University,Wuhan 430079,china national laboratory of biomacromolecules Institute of Biophysics Chinese Academy of Science Beijing China College of Life Science Central China Normal University Wuhan China Chemistry Department Anyang teacher's College Anyang China

Our previous study has demonstrated that CD 146 molecule is a biomarker on vascular endothelium,which is involvedin angiogenesis and tumor *** the mechanism behind is not *** we have for the first time devel-oped a novel CD146 blockade system using CD146 siRNA to study its function on endothelial *** data showedthat CD146 siRNA specifically blocked the expression of CD146 on both mRNA and protein levels,leading to thesignificant suppression of HUVEC proliferation,adhesion and *** results demonstrate that CD146 playsa key role in vascular endothelial cell activity and angiogenesis,and CD146 siRNA can be used as a new inhibitor foranti-angiogenesis therapy.

关键词： small interfering RNA adhesion molecule CD 146 vascular endothelial cell

A distributed hydrological model with its application to the Jinghe watershed in the Yellow River Basin

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Science china(Technological Sciences) 2004年第Z1期47卷 60-71页

作者： WANG Zhonggen1, ZHENG Hongxing1, LIU Changming1, , WU Xianfeng2.2.& ZHAO Weimin3 1. Key laboratory of Water Cycle & Related Land Surface Processes, institute of Geographic Science and Natural Resources Research, Chinese Academy of Sciences,{2., china 2. institute of Environmental Science, beijing Normal University, beijing 100875, china 3. Water Resources Conservation Committee of Yellow River, Zhengzhou 450003, china Key laboratory of Water Cyde & Related Land Surface Processes Institute of Geographic Science and Natural Resources Research Chinese Academy of Sciences Beijing China institute of Environmental Science Beijing Normal University Beijing China Water Resources Conservation Committee of Yellow River Zhengzhou China

For the purpose of water resources management in the Yellow River Basin with highly spatial difference, a daily distributed hydrological model was proposed, of which the determination of spatially-distributed parameters and model inputs processing were performed by means of GIS/RS. In the model, the computation of runoff yield was based on the topography index method and flow routing was modeled by Maskingum method. The operation of the model is followed by means of “command structure” technique based upon the topography of river network. A case study using the model was conducted for the Jinghe watershed, which locates at the middle Yellow River Basin. The simulation of the hydrological processes in 1996 has shown that water quantity balance errors were less than 5% and the Nash-Sutcliffe coefficient arrived at 0.7, indicating that the model structure is justifiable, and the precision of the model can satisfy the purpose of water resources management.

关键词： distributed hydrological model, structure and equation, GIS and RS, Jinghe Basin, Yellow River Basin.

Interfacial behaviors of PMMA-PEO block copolymers at the air/water interface

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Science china Chemistry 2005年第6期48卷 567-573页

作者： CHENG Caixia1, JIAO Tifeng2. TANG Rupei1, LIU Minghua2.& XI Fu1 1. State Key laboratory of Polymer Physics and Chemistry, Joint laboratory of Polymer Science and Materials,{2. of Chemistry, Chinese Academy of Sciences, beijing 100080, china 2. CAS Key laboratory of Colloid and Interface Science,{2. of Chemistry, Chinese Academy of Sciences, beijing 100080, china State Key laboratory of Polymer Physics and Chemistry Joint Laboratory of Polymer Science and Materials Institute of Chemistry Chinese Academy of Sciences Beijing China CAS Key laboratory of Colloid and Interface Science Institute of Chemistry Chinese Academy of Sciences Beijing China

Diblock copolymer of PMMA2.1-b-PEO114 and triblock copolymer of PMMA12.-b- PEO2.7-b-PMMA12. were synthesized and their interfacial properties at the air-water interface were investigated, where both blocks of polyethylene oxide (PEO) and poly(methyl methacrylate) (PMMA) are surface active but the former is soluble in water while the latter is not. Both the block copolymers could form monolayers with two obvious transition regions. The first transition point is around 10 mN/m, which could be assigned to the pancake-brush change of the PEO chains. The other is around 18 mN/m, which could be ascribed to the condensed packing of PMMA. The surface morphological changes during the compression of the Langmuir monolayers are inves-tigated by using the AFM and SEM methods for the films deposited at different surface pressure or molecular areas. At a lower surface pressure, a typical morphology of PEO-con- taining lipopolymers is observed. Upon compression, sphere-dominant morphologies were observed. While the diblock copolymer is easy to folding, the triblock copolymer is in favor of formation of circular domains through vesiculation.

关键词： PMMA-PEO, block copolymers, monolayer, Langmuir-Blodgett films, AFM.

Influence of magnetic current on the ground state entanglement in an isotropic transverse XY chain

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Progress in Natural Science:Materials International 2007年第10期17卷 1147-1151页

作者： Liu Dan1,2., Zhang Yong3 and Long Guilu1,2.1. Key laboratory for Atomic and Molecular NanoSciences, and Department of Physics, Tsinghua University, beijing 100084,{2. 2. Center of Quantum Information Science and Technology, Tsinghua national laboratory for information Science and Technology, beijing 100084,{2. 3. institute of Physics, School of Sciences, beijing University of Posts and Telecommunications, beijing 100876,{2.) Key laboratory for Atomic and Molecular NanoSciences Department of Physics Tsinghua University Beijing 100084 China Center of Quantum Information Science and Technology Tsinghua National Laboratory for Information Science and Technology Beijing 100084 China institute of Physics School of Sciences Beijing University of Posts and Telecommunications Beijing 100876 China

We study the ground state entanglement in a three-qubit XY chain under the influence of a magnetization current. It is found that the ground state changes from a W state to a disentangled state as the magnetic field varies. When the Lagrange multiplier λ>3, namely under a strong magnetic current, the ground state holds onto a W state for a large range of the magnetic field strength. A phase transition to the magnetization-current phase occurs under a certain condition.

关键词： Heisenberg-XY chain magnetic-current phase transition.

Oxygen pressure dependent electro-resistance in La_(0.9)Sr_(0.1)MnO_3 thin films grown by laser molecular beam epitaxy

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Science china(Physics,Mechanics & Astronomy) 2008年第3期51卷 232-236页

作者： OUYANG SiHua1,2.WANG ChunChang2.LIU GuoZhen2.HE Meng2. JIN KuiJuan2.DANG ZhiMin1 & L HuiBin2. College of Materials Science and Engineering,beijing University of Chemical Technology,beijing 10002.,{2. 2.beijing national laboratory for Condensed Matter Physics,institute of Physics,Chinese Academy of Sciences,beijing 100080,{2. College of Materials Science and Engineering Beijing University of Chemical Technology Beijing China beijing national{2. for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing China

We report here studies on the influence of oxygen pressure on the electroresis-tance behavior of La0.9Sr0.1MnO3 thin films fabricated by laser molecular beam epi-taxy. It was found that the film deposited at lower oxygen pressure shows larger c-axis parameter,higher resistance,and more distinct electroresistance. These results reveal that the electroresistance of manganite thin films can be tuned by the conditions of film fabrication.

关键词： La0.9Sr0.1MnO3 thin film electroresistance effect laser molecular beam epitaxy

Studies on the Temperature Effect on Bacteriorhodopsin of Purple and Blue Membrane by Fluorescence and Absorption Spectroscopy

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Acta Biochimica et Biophysica Sinica 2006年第10期38卷 691-696页

作者： Lan-Ying CHENG~(1,2. Yue ZHANG~3 Shi-Gui LIU~1 Kun-Sheng HU~3 Kang-Cheng RUAN~2. 1 College of Life Science,Sichuan University,Chengdu 610064,china 2.State Key laboratory of Molecular Biology,{2. of Biochemistry and Cell Biology,Shanghai {2.s for Biological Sciences,Chinese Academy of Sciences,Shanghai 2.0031,china 3 institute of biophysics,Academia Sinica,beijing 100101,china College of Life Science Sichuan UniversityChengdu 610064 China State Key laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031 China institute of biophysics Academia SinicaBeijing 100101 China

Fluorescence and absorption spectra were used to study the temperature effect on theconformation of bacteriorhodopsin (bR) in the blue and purple membranes (termed as bRb and bRprespectively).The maximum emission wavelengths of tryptophan fluorescence in both proteins at roomtemperature are 340 nm,and the fluorescence quantum yield of bRb is about 1.4 fold higher than that of *** temperature increases,the tryptophan fluorescence of bRb decreases,while the tryptophan fluorescenceof bRp *** binding study of extrinsic fluorescent probe bis-ANS indicated that the probe can bindonly to bRb,but not to *** results suggest that significant structural difference existed between bRband *** was also found that both kinds of bR are highly thermal *** maximum wavelength of theprotein fluorescence emission only shifted from 340 nm to 346 nm at 100℃.More interestingly,as tempera-ture increased,the characteristic absorption peak of bRb at 605 nm decreased and a new absorption peak at380 nm *** transition occurred at a narrow temperature range (65℃-70℃).These facts indicatedthat an intermediate can be induced by high *** phenomenon has not been reported before.

关键词： bacteriorhodopsin purple membrane blue membrane fluorescence and absorption spectroscopy

Gasdynamic characteristics of toroidal shock and detonation wave converging

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Science china(Physics,Mechanics & Astronomy) 2005年第6期48卷 739-749页

作者： TENG Honghui1,2.& JIANG Zonglin2.1. Key laboratory of High Temperature Gas Dynamics, institute of Mechanics, Chinese Academy of Sci- ences,{2. 100080, china 2. Graduate University of Chinese Academy of Sciences,{2. 100039, china Key laboratory of High Temperature Gas Dynamics Institute of Mechanics Chinese Academy of Sciences Beijing China Graduate University of Chinese Academy of Sciences Beijing China

The modified CCW relation is applied to analyzing the shock, detonation wave converging and the role of chemical reactions in the process. Results indicate that the shock wave is strengthened faster than the detonation wave in the converging at the same initial Mach number. Euler equations implemented with a detailed chemical reaction model are solved to simulate toroidal shock and detonation wave converging. Gasdynamic characteristics of the converging are investigated, including wave interaction patterns, observable discrepancies and physical phenomena behind them. By comparing wave diffractions, converging processes and pressure evolutions in the focusing area, the different effects of chemical reactions on diffracting and converging processes are discussed and the analytic conclusion is demonstrated through the observation of numerical simulations.

关键词： converging, CCW relation, shock wave, detonation wave.