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Exposure to blast shock waves via the ear canal induces deficits in vestibular afferent function in rats

Journal of Otology 2020年第3期15卷 77-85页

作者： Yue Yu Jun Huang Xuehui Tang Jerome Allison David Sandlin Dalian Ding Yi Pang Chunming Zhang Tianwen Chen nathan yin Lan Chen William Mustain Wu Zhou Hong Zhu Departmant of Otolaryngology and Communicative Sciences University of Mississippi Medical CenterJacksonMSUSA Department of Neurobiology and Anatomical Sciences University of Mississippi Medical CenterJacksonMSUSA Department of Pediatric University of Mississippi Medical CenterJacksonMSUSA Program in Neuroscience University of Mississippi Medical CenterJacksonMSUSA Center for Hearing and Deafness University at BuffaloBuffaloNYUSA Department of Otolaryngology First Affiliated HospitalShanxi Medical UniversityTaiyuan Shanxi030001China Department of Neurology University of Mississippi Medical CenterJacksonMSUSA

The ears are air-filled structures that are directly impacted during blast *** addition to hearing loss and tinnitus,blast victims often complain of vertigo,dizziness and unsteady posture,suggesting that blast exposure induces damage to the vestibular end organs in the inner ***,the underlying mechanisms remain to be *** this report,single vestibular afferent activity and the vestibuloocular reflex(VOR)were investigated before and after exposure to blast shock waves(~20 PSI)delivered into the left external ear canals of anesthetized *** vestibular afferent activity was recorded from the superior branch of the left vestibular nerves of the blast-treated and control rats one day after blast *** exposure reduced the spontaneous discharge rates of the otolith and canal *** exposure also reduced the sensitivity of irregular canal afferents to sinusoidal head rotation at *** exposure,however,resulted in few changes in the VOR responses to sinusoidal head rotation and *** the best of our knowledge,this is the first study that reports blast exposure-induced damage to vestibular afferents in an animal *** results provide insights that may be helpful in developing biomarkers for early diagnosis of blast-induced vestibular deficits in military and civilian populations.

关键词： Primary blast injury Vestibular end organ Vestibulo-ocular reflex Vestibular afferent Vestibular hair cell

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Functional trait space and redundancy of plant communities decrease toward cold temperature at high altitudes in Southwest China

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Science China(Life Sciences) 2023年第2期66卷 376-384页

作者： Lan Zhang Xiaojuan Liu Zhenhua Sun Wensheng Bu Franca J.Bongers Xiaoyang Song Jie Yang Zhenkai Sun yin Li Shan Li Min Cao Keping Ma nathan G.Swenson State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China Key Laboratory of State Forestry Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed College of ForestryJiangxi Agricultural UniversityNanchang 330045China Key Laboratory of Tree Breeding and Cultivation Forestry and Grassland AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091China Fujian Provincial Key Laboratory of Resources and Environmental Monitoring and Sustainable Management and Utilization Sanming UniversitySanming 365004China Department of Biological Sciences University of Notre DameNotre DameIndiana 46556USA

Plant communities in mountainous areas shift gradually as climatic conditions change with altitude. How trait structure in multivariate space adapts to these varying climates in natural forest stands is unclear. Studying the multivariate functional trait structure and redundancy of tree communities along altitude gradients is crucial to understanding how temperature change affects natural forest stands. In this study, the leaf area, specific leaf area, leaf carbon, nitrogen, and phosphorous content from 1,590 trees were collected and used to construct the functional trait space of 12 plant communities at altitudes ranging from 800 m to 3,800 m across three mountains. Hypervolume overlap was calculated to quantify species trait redundancy per community. First,hypervolumes of species exclusion and full species set were calculated, respectively. Second, the overlap between these two volumes was calculated to obtain hypervolume overlap. Results showed that the functional trait space significantly increased with mean annual temperature toward lower altitudes within and across three mountains, whereas species trait redundancy had different patterns between mountains. Thus, warming can widen functional trait space and alter the redundancy in plant communities. The inconsistent patterns of redundancy between mountains suggest that warming exerts varying influences on different ecosystems. Identification of climate-vulnerable ecosystems is important in the face of global warming.

关键词： leaf trait plant community hypervolume redundancy altitude natural forest

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Spatial–temporal distribution and potential ecological risk assessment of nonylphenol and octylphenol in riverine outlets of Pearl River Delta, China

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Journal of Environmental Sciences 2014年第11期26卷 2340-2347页

作者： Ru Chen Pinghe yin Ling Zhao Qiming Yu Aihua Hong Shunshan Duan Department of Chemistry College of Life Science and Technology Jinan University Center of Analysis and Test Department of Environmental Engineering Jinan University Griffith School of Engineering Griffith University Nathan Campus Brisbane Queensland 4111 Australia Center of Analysis and Test Guangzhou Research Center of Hydrobiology College of Life Science and TechnologyJinan University

The aquatic environments of the Pearl River Delta in Southern China are subjected to contamination with various industrial chemicals from local industries. In this paper, the occurrence, seasonal variation and spatial distribution of alkylphenol octylphenol （OP） and nonylphenol （NP） in fiver surface water and sediments in the runoff outlets of the Pearl River Delta were investigated. NP and OP were detected in all water and sediment samples and their mean concentrations in surface water during the dry season ranged from 810 to 3366 ng/L and 85.5 to 581 ng/L, respectively, and those in sediments ranged from 14.2 to 95.2 ng/g dw and 0.4 to 3.0 ng/g dw, respectively. In surface water, much higher concentrations were detected in the dry season than those in the wet season. In sediments, the concentrations in the dry season were also mostly higher. High concentrations of NP and OP were found in Humen outlet, likely due to high levels of domestic and industrial wastewater discharges. An ecological risk assessment with the use of hazard quotient （HQ） was also carried out and the HQvalues ranged from 3.6 × 10^-5 to 35 and 64% of samples gave a HQ 〉 1, indicating that the current levels of NP and OP pose a significant risk to the relevant aquatic organisms in the region.

关键词： Nonylphenol Octylphenol Environmental concentration Ecological risk assessment Pearl River Delta

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Effect of time resolution of rainfall measurements on the erosivity factor in the USLE in China

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International Soil and Water Conservation Research 2020年第4期8卷 373-382页

作者： Tianyu Yue Yun Xie Shuiqing yin Bofu Yu Chiyuan Miao Wenting Wang State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal University100875BeijingChina Australian Rivers Institute School of Engineering and Built Environment Griffith UniversityNathanQueenslandAustralia

Rainfall erosivity,one of the factors in the Universal Soil Loss *** the effect of rainfall and runoffon soil ***-resolution data are required to compute rainfall erosivity,but are not widely available in many parts of the *** the temporal resolution of rainfall measurement decreases,computed rainfall erosivity *** objective of the paper is to derive a series of conversion factors as a function of the time interval to compute rainfall erosivity so that the R factor computed using data at different time intervals could be converted to that computed using 1-min *** data at 1-min intervals from 62 stations over China were collected to first compute the~ue'R factor *** of the R factor was systematically evaluated using data aggregated at 5,6.10,15,20,30,and 60-min to develop conversion factors for the R factor and the 1-in-10-year storm EI30 *** with true values,the relative error in R factor using data at fixed intervals of≤10min was10%using 15-min data for 66.1%of stations and>20%using 30-min data for 61.3%of *** conversion factors for the R factor,ranging from 1.051 to 1.871 for 5 to 60-min data,are higher than those for the 1-in-10-years storm EI30,ranging from 1.034 to 1.489 for the 62stations.

关键词： Soil erosion Rainfall erosivity 1-in-10-year EI30 USLE CSLE

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Transitioning antimicrobials from intravenous to oral in pediatric acute uncomplicated osteomyelitis

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World Journal of Clinical Pediatrics 2016年第3期5卷 244-250页

作者： nathan Batchelder Tsz-yin So Department of Pharmacy Moses H.Cone Memorial Hospital

Osteomyelitis is a bone infection that requires prolonged antibiotic treatment and potential surgical *** left untreated,acute osteomyelitis can lead to chronic osteomyelitis and overwhelming *** treatment is necessary to prevent complications,and the standard of care is progressing to a shorter duration of intravenous(Ⅳ) antibiotics and transitioning to oral therapy for the rest of the treatment *** systematically reviewed the current literature on pediatric patients with acute osteomyelitis to determine when and how to transition to oral antibiotics from a short Ⅳ *** have shown that switching to oral after a short course(i.e.,3-7 d) of Ⅳ therapy has similar cure rates to continuing long-term Ⅳ *** Ⅳ use is also associated with increased risk of *** that help guide clinicians on making the switch include a downward trend in fever,improvement in local tenderness,and a normalization in C-reactive protein *** on the available literature,we recommend transitioning antibiotics to oral after 3-7 d of Ⅳ therapy for pediatric patients(except neonates) with acute uncomplicated osteomyelitis if there are signs of clinical improvement,and such regimen should be continued for a total antibiotic duration of four to six weeks.

关键词： Antimicrobials C-reactive protein Intravenous Oral Osteomyelitis Pediatrics

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Mini-review on initiatives to interfere with the propagation and clearance of alphasynuclein in Parkinson’s disease

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Translational Neurodegeneration 2017年第1期6卷 333-337页

作者： Daniel Kam yin Chan ying Hua Xu Luke Kar Man Chan Nady Braidy George D.Mellick Department of Aged Care and Rehabilitation Bankstown HospitalBankstownNSW 2200Australia Ingham Institute LiverpoolNSW 2170Australia University of New South Wales Faculty of MedicineSydneyAustralia Faculty of Medical Science Griffith UniversityNathanQLDAustralia Griffith Institute for Drug Discovery Griffith UniversityNathanQLDAustralia

In this mini-review,we summarize recent findings relating to the prion-like propagation ofα-synuclein(α-syn)and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s disease(PD).We link the Braak’s staging hypothesis of PD with the recent evidence from in-vivo and in-vitro studies for the prion-like cell-to-cell propagation ofα-syn(via exocytosis and endocytosis).The classical accumulation of aggregatedα-syn in PD may result from an increased production or a failure in the mechanisms of clearance ofα-*** discuss novel agents,currently in clinical trial for PD including the ones that impact the aggregation ofα-syn and others that interfere withα-syn endocytosis as a means to target the progression of the disease.

关键词： Parkinson’s disease α-synuclein Endocytosis Aggregation

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Adsorption models for heavy metal biosorption

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化工学报 2007年第1期58卷 145-148页

作者：郑成虞启明尹平和 School of Chemistry and Chemical Engineering Guangzhou University School of Environmental Engineering Griffith UniversityNathan CampusBrisbane Department of Chemistry Jinan University

Heavy metal biosorption is an effective process for the removal and recovery of heavy metal *** isotherms obtained experimentally are usually correlated empirically with commonly used adsorption models, without considering the underlying mechanisms of *** used models for correlating biosorption isotherm data are briefly reviewed and the use of the adsorption models in correlating the desorption processes is analysed.A set of biosorption/desorption experiments for a marine alga derived biosorbent are carried out to test the use of the adsorption models in the desorption *** data indicate that the amount of the heavy metal ions desorbed from the biomass could not be calculated with the adsorption *** suggests that the empirical use of adsorption models in the correlation may not be valid when the reversibility of the biosorption equlibrium in the desorption process needs to be ***,mechanism based biosorption models are needed for better correlation of equilibrium isotherm data.

关键词： biosorption model heavy metal ion

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不同水平男子武术套路运动员心功能的初步研究

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体育与科学 2000年第6期21卷 28-32+35页

作者：崔振海尹斯年盐城工学院体育部

本文旨为探讨在长期武术运动训练中 ,运动员心脏形态、结构、功能发生的特异性变化。通过对不同运动技术水平的男子武术套路运动员的动力性负荷实验 ,结合超声心动图仪的检查 ,发现长期运动训练使得武术套路运动员心脏机能水平得到了很... 详细信息

本文旨为探讨在长期武术运动训练中 ,运动员心脏形态、结构、功能发生的特异性变化。通过对不同运动技术水平的男子武术套路运动员的动力性负荷实验 ,结合超声心动图仪的检查 ,发现长期运动训练使得武术套路运动员心脏机能水平得到了很大的改善。由于训练全面 ,尤其是对身体素质训练的重视 ,优秀运动员的心脏收缩能力、心肌弹性、心肌厚度、泵血能力等指标明显好于对照组。

关键词：武术运动员心脏形态机能

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Neuro-plasticity studies based on dorsal and ventral attention networks across the human lifespan

Neuro-plasticity studies based on dorsal and ventral attenti...

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第三届全国神经动力学学术会议

作者： Zhongyan Wang Wei Xu Ting Liu Shuxing Zheng Haiyong Zhang Yupan Shi Zhangyong Li Yu Pang yin Tian Biomedical Engineering Department Chong Qing University of Posts and Telecommunications

Objective: A large number of cognitive impairment and imaging studies found that attentional systems includes both bottom-up and top-down control, i.e., ventral attention network(VAN) and dorsal attention network(DAN). However, the relationship within-and between-DAN and VAN across the human lifespan are ***:Rest-f MRI data from the nathan Kline Institute(http://***/indi/pro/***) included 90 healthy individuals(age from 7 to 85 years old). We used independent component analysis to investigate DAN/VAN, and explored the functional connectivity within-and between-DAN/VAN. In order to investigate the functional connectivity within-and betweenDAN/VAN with aging, we constructed a linear regression model and quadratic linear regression *** & Discussion: Results showed that the functional connectivity within DAN/VAN was inverted U-shaped trajectories with aging. And increase linearly trends across the human lifespan was obtained between DAN and VAN. The results were associated with the decline of cognitive function,which involved the performance of working memory, vocabulary, learning and other cognitive ***: With aging, the lifespan trajectories of within DAN/VAN presented the inverted U-shape, the stronger functional connectivity between DAN and VAN is positively correlated with older age. The findings provide a good research or clinical basis for cognitive dysfunction across the human lifespan.

关键词： DAN VAN Age Functional connectivity Neuro-plasticity

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