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The 100 top-cited articles on childhood obesity: a bibliometric analysis

Global Health Journal 2022年第3期6卷 136-148页

作者： Joseph Kawuki Taha Hussein Musa Upama Ghimire nathan obore Shireen Salome Papabathini Centre for Health Behaviours Research Jockey Club School of Public Health and Primary CareFaculty of MedicineThe Chinese University of Hong KongHong Kong999077China Ministry of Education Key Laboratory of Environmental Medicine EngineeringSchool of Public HealthSoutheast UniversityNanjingJiangsu 210096China Biomedical Research Institute Darfur CollegeNyalaSouth Darfur 63313Sudan

Background:Childhood obesity(CHO)is a serious global health challenge affecting both developed and developing *** feats attained in addressing this global health challenge can be reflected through the top-cited *** study’s aim was to analyze the features of the 100 top-cited articles concerning ***:We used a bibliometric analysis,and searched for relevant articles from the Web of Science(December 1,2021),using an appropriate keyword search-strategy((child OR childhood OR children OR adolescent)AND(obese OR obesity OR overweight)).The retrieved documents were analysed based on the citation number,publication year,authorship,institution,journal and *** analyses were performed mainly by the Bibliometrix application(using R-studio cloud)and ***:The 100 top-cited articles were published between 1976 and 2018,their citations ranged from 365 to 10789,with a mean citation of 1146.2 and 31 studies had more than 1000 *** articles were published in 31 journals,with the“Pediatrics”journal having the most publications(n=18).The studies were from 12 countries,with the most-productive being the USA(n=68),followed by the United Kingdom(n=12)and France(n=3).The leading institution was the University of Bristol(n=8),while Dietz WH(n=12),and Flegal KM(n=8)were the most productive *** most common research fields covered by these articles were;“General Internal Medicine”(n=34),“Pediatrics”(n=29),and“Nutrition Dietetics”(n=18).The study noted significant correlations between the total article citation and the number of authors(R=0.203),countries involved(R=0.407),institutions(R=0.407),and the publication year(R=0.847),all with P<***:Through these top-cited articles,this analysis provides discernment into the historical advancements,including the prime roles performed by various stakeholders in addressing the issue of ***,Asian countries’contribution is not adequately reflected in these articles,and thus

关键词： Childhood obesity Bibliometric analysis 100 top-cited Citation classics

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非洲国家耐多药结核病流行病学研究及室内空气污染与结核病关系的系统评价

非洲国家耐多药结核病流行病学研究及室内空气污染与结核病关系的...

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作者： nathan obore 东南大学

学位级别：硕士

目标:1.描述性分析非洲国家过去20年间耐多药结核病领域的研究进展和地区分布特征。2.分析乌干达2014至2018年间耐多药结核病的流行特征及治疗效果。3.系统评价暴露于室内空气污染(IAP)和烟草烟雾与结核病(TB)感染风险之间的关联。方法... 详细信息

目标:1.描述性分析非洲国家过去20年间耐多药结核病领域的研究进展和地区分布特征。2.分析乌干达2014至2018年间耐多药结核病的流行特征及治疗效果。3.系统评价暴露于室内空气污染(IAP)和烟草烟雾与结核病(TB)感染风险之间的关联。方法:1.对2000年至2020年(4月21日)在Web of Science文献数据库中发表和索引的,非洲国家和地区人群耐多药结核病相关研究论文进行了文献计量分析。使用Vosviewer进行网络地图可视化,使用Histcite和Rstudio对搜索结果进行了分析。2.对非洲乌干达国家电子健康管理信息系统中的结核病监测数据进行了回顾性研究,纳入数据的时间为2014年7月至2018年6月,包括每年新诊断和开始接受结核病治疗的患者人数,患有耐多药结核病的人数,以及有关耐多药结核病治疗结果的数据,并进行描述性分析。数据分析使用SPSS(V23.0)软件完成的。3.使用Web of Science和PubMed检索了2014年6月至2020年2月间发表的室内空气污染(IAP)和烟草烟雾与结核病(TB)感染风险的关联研究。纳入进行混杂因素控制的文献,研究人群包含暴露组和非暴露组,同时研究对象为非吸烟者时但存在被动吸烟时也被纳入。研究质量使用纽卡斯尔-渥太华量表(NOS)进行评估。使用STATA(V14.0)进行数据统计学合并分析,使用Cochran Q检验和I统计量测试异质性,I>30%,P<0.05判断为有异质性,使用随机效应模型合并效应,否则,使用固定效应模型,使用Egger’s test进行发表偏倚的检验。使用meta回归分析探讨可能的影响因素。结果1.文献计量分析,在研究期内,总共有561(561)种期刊文章在WOS中发表。这占在WOS上发表的全球耐多药结核病研究的18.2%。英语(550,98.4%)是最常见的语言,其次是法语(8,1.4%)和葡萄牙语(1,0.2%)。每份文件的平均被引次数为22.14,收到的总被引次数为12400。非洲大陆不同地区耐多药结核病研究的领先国家是南非(51.0%),南部非洲的埃塞俄比亚(9.7%)。非洲,西非的尼日利亚(3.6%)和北非的埃及(2.3%)。斯泰伦博斯大学是领先的机构。“国际结核和肺病杂志”发表的文章最多(占14.6%),而《南非医学杂志》(1.6%)也位列顶级期刊之列。目前,关于治疗结果的研究和新药的试验是结核病研究的重点领域。2.2014年7月至2018年6月,乌干达的耐多药结核病现患率从2015年的0.5%增至2018年的0.9%。同时,失去随访治疗的耐多药结核病患者人数逐年增长。3.系统评价与Meta分析,最终分析中总共包括26篇文章。接触IAP的人群患结核病的风险增加68%(RR=1.68,95%CI 1.108-2.542)。我们还观察到,接触二手烟草烟雾使患结核病的风险增加115%(RR=2.15,95%CI 1.42-3.24)。吸烟使患结核病的风险增加了一倍(RR=2.67,95%CI 2.02-3.53)。此外,与使用其他结核病诊断方法的研究相比,使用微生物学检查的研究显示较高的RR。结论:1.非洲国家和高收入西方国家之间在开展耐多药结核病研究方面进行了大量国际合作。但是,本研究发现有必要加强非洲区域内研究出版商和期刊,以提高该领域的研究产出率。2.在2014年至2018年的研究期内,全国耐多药结核病的流行有所增加。但是,乌干达耐多药结核病的百分比仍然很低。需要将更多的注意力集中在制止这种MDR-TB趋势的策略上,这种策略可能包括加强TB药物对一线药物的依从性。3.暴露于IAP和二手烟会增加患结核病的风险。各种疾病预防运动应包括对IAP的认识,并鼓励转向更清洁的能源。

关键词：结核烟草吸烟室内空气污染 Meta分析生物量文献计量分析耐多药结核非洲

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孕产期抑郁症生物标志物的研究进展

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中国药科大学学报 2022年第1期53卷 120-124页

作者：章柳宵 obore nathan 虞天一钱惠勤张媛于红东南大学医学院南京210009 东南大学附属中大医院南京210009

孕产期抑郁症是围产期常见的并发症之一,严重影响母儿身心健康。目前,早期诊断孕产期抑郁症尤为困难,客观有效的生物学标志物对早发现早治疗孕产期抑郁症意义重大。近年来探索孕产期抑郁症早期诊断的生物标志物成为研究热点,主要在性激... 详细信息

孕产期抑郁症是围产期常见的并发症之一,严重影响母儿身心健康。目前,早期诊断孕产期抑郁症尤为困难,客观有效的生物学标志物对早发现早治疗孕产期抑郁症意义重大。近年来探索孕产期抑郁症早期诊断的生物标志物成为研究热点,主要在性激素、神经内分泌相关激素、免疫炎症分子、遗传及表观遗传学等方面。本文就近年来孕产期抑郁症生物学标志物的研究进展进行综述。

关键词：孕产期抑郁症生物学标志物早期诊断进展

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中国人群产后抑郁状态与纯母乳喂养关联的Meta分析

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中华疾病控制杂志 2023年第11期27卷 1329-1335页

作者：李璇 obore nathan 陶昱辰胡燕王一枭洪翔王蓓于红东南大学医学院临床医学系南京210009 东南大学附属中大医院妇产科南京210009 东南大学公共卫生学院流行病与卫生统计学系南京210009

目的探究中国人群产后抑郁状态与纯母乳喂养的关联强度。方法检索万方、SinoMed、知网等数据库,查找中国人群产后抑郁状态与纯母乳喂养情况的观察性研究。采用Stata 12.0软件进行Meta分析。并根据地区、产后时间、分组依据及纳入人群进... 详细信息

目的探究中国人群产后抑郁状态与纯母乳喂养的关联强度。方法检索万方、SinoMed、知网等数据库,查找中国人群产后抑郁状态与纯母乳喂养情况的观察性研究。采用Stata 12.0软件进行Meta分析。并根据地区、产后时间、分组依据及纳入人群进行亚组分析。结果共纳入16篇观察性研究。总体分析抑郁状态组较对照组纯母乳喂养比例低,差异有统计学意义(OR=0.44,95%CI:0.36~0.54,P<0.001)。亚组分析提示处于产后抑郁状态的女性纯母乳喂养比例在东部地区显著降低(OR=0.45,95%CI:0.36~0.56,P<0.001),在中西部地区也降低(OR=0.41,95%CI:0.25~0.66,P<0.001);产后42 d内处于产后抑郁状态的产妇中纯母乳喂养比例降低(OR=0.48,95%CI:0.37~0.61,P<0.001),在产后42 d~6月降低更为显著(OR=0.35,95%CI:0.21~0.60,P<0.001);去除不同分组依据及纳入人群的研究,剩余研究结果与总体结果差异不大,差异均有统计学意义(OR=0.45,95%CI:0.36~0.56,P<0.001)。Meta回归分析提示研究间的异质性地区(P=0.906)、产后时间(P=0.528)、分组依据及纳入人群(P=0.722)差异无统计学意义。结论与对照组相比较,产后抑郁状态人群中纯母乳喂养的比例低。为提高中国人群6个月内纯母乳喂养率、降低产后抑郁患病率,建议从产前开始进行孕产期抑郁筛查及多学科协作干预。

关键词：抑郁症产后母乳喂养 Meta分析

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Pregnant Women with Severe Factor VII Deficiency Undergoing Cesarean Section Managed with a Short-Term Regimen of Recombinant Factor VIIa

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Maternal-Fetal Medicine 2023年第3期5卷 195-198页

作者： nathan obore Wan Jin Qian Huiqin Qian Wei Hu Yan Yu Hong Department of Obstetrics and Gynecology Zhongda HospitalSoutheast UniversityNanjing 210009China Guidance Center of Jiangsu Maternal Critical Care Nanjing 210009China

To editor:Factor VII(FVII)is a determining factor in activating the exogenous coagulation pathway;F7 gene mutation decreases the FVII number or *** VII deficiency(FVIID)is characterized by an isolated prolongation of the prothrombin time(PT)with a normal activated partial thromboplastin time(aPTT).Factor assay and genotyping for FVII can be done to confirm the diagnosis.1,2 Patients may present with menorrhagia,and bleeding tendencies may vary from slight gingival bleeding,epistaxis,and ecchymosis,to severe bleeding,such as gastrointestinal and intracranial bleeding.

关键词： Factor VII deficiency Recombinant factor VIIa Prophylaxis Pregnancy

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Solvation Effects on the Dielectric Constant of 1 M LiPF6 in Ethylene Carbonate:Ethyl Methyl Carbonate 3:7

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Energy & Environmental Materials 2024年第1期7卷 253-256页

作者： Julian Self nathan T.Hahn Kristin A.Persson Department of Chemical Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Material Physical and Chemical Sciences CenterSandia National LaboratoriesAlbuquerqueNM 87185USA

We report the dielectric constant of 1 M LiPF_(6)in EC:EMC 3∶7 w/w(ethylene carbonate/ethyl methyl carbonate)in addition to neat EC:EMC 3∶7 w/*** three Debye relaxations,the static permittivity value,or dielectric constant,is extrapolated to 18.5,which is compared to 18.7 for the neat solvent *** EC solvent is found to strongly coordinate with the Li^(+)cations of the salt,which results in a loss of dielectric contribution to the ***,the small amplitude and large uncertainty in relaxation frequency for EMC cloud definitive identification of the Li^(+)solvation ***,the loss of the free EC permittivity contribution due to Li^(+)solvation is almost completely balanced by the positive contribution of the associated LiPF_(6)salt,demonstrating that a significant quantity of dipolar ion pairs exists in 1 M LiPF_(6)in EC:EMC 3∶7.

关键词： batteries dielectric relaxation spectroscopy electrolytes

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Commentary on“The deterministic condition for the ground reaction force acting point on the combined knee valgus and tibial internal rotation moments in the early phase of cutting maneuvers in female athletes”

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Journal of Sport and Health Science 2024年第3期13卷 373-375页

作者： nathan D.Schilaty nathaniel A.Bates Department of Neurosurgery&Brain Repair University of South FloridaTampaFL 33620USA Department of Medical Engineering University of South FloridaTampaFL 33620USA Center for Neuromusculoskeletal Research University of South FloridaTampaFL 33620USA Department of Orthopaedics The Ohio State University Wexner Medical CenterColumbusOH 43210USA

*** For decades,substantial disagreement has persisted as to whether dynamic knee valgus is the cause of the majority of anterior cruciate ligament(ACL)injuries or rather the result of the ACL rupture.1 Consequently,great effort and expense has gone into capturing 3-dimensional kinetics and kinematics from live athletes to drive in vitro and in silico models of ACL injury in order to elucidate the actual mechanism of injury,as these factors have been demonstrated to be surrogates of intraarticular structural loading on the ACL.2,3 The elucidation of injury mechanisms for non-contact ACL injuries is of great medical value as such knowledge consequently permits quantified examination and validation of interventions and their respective effectiveness in both prevention and rehabilitation of these traumatic knee injuries.

关键词： injuries knee prevention

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Use of donepezil for neurocognitive recovery after brain injury in adult and pediatric populations:a scoping review

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Neural Regeneration Research 2024年第8期19卷 1686-1695页

作者： Avery L.Miller nathan K.Evanson J.Michael Taylor University of Cincinnati College of Medicine CincinnatiOHUSA Department of Pediatrics University of CincinnatiCincinnatiOHUSA Department of Neurology and Rehabilitation Medicine University of CincinnatiCincinnatiOHUSA Division of Pediatric Rehabilitation Medicine Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Division of Neurology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

There are few pharmacologic options for the treatment of cognitive deficits associated with traumatic brain injury in pediatric *** inhibitors such as donepezil have been evaluated in adult patients after traumatic brain injury,but relatively less is known about the effect in pediatric *** goal of this review is to identify knowledge gaps in the efficacy and safety of acetylcholinesterase inhibito rs as a potential a djuvant treatment fo r neurocognitive decline in pediatric patients with traumatic brain *** queried PubMed to identify literature published from database inception thro ugh June 2023 desc ribing the use of donepezil in young adult traumatic brain injury and pediatric patients with predefined *** on preselected search criteria,340 unique papers we re selected for title and abstra ct ***-two reco rds were reviewed in full after eliminating preclinical studies and pape rs outside the scope of the *** adult traumatic brain injury,we review results from 14 papers detailing 227 subjects where evidence suggests donepezil is well tole rated and shows both objective and patient-reported efficacy for reducing cognitive *** children,3 pape rs report on 5 children recovering from traumatic brain injury,showing limited *** additional 15 pediatric studies conducted in populations at risk for cognitive dysfunction provide a broader look at safety and efficacy in 210 patients in the pediatric age *** its promise for efficacy in adults with traumatic brain injury and tole rability in pediatric patients,we believe further study of donepezil for children and adolescents with traumatic brain injury is warranted.

关键词： acetylcholinesterase inhibitor adult cognition donepezil pediatrics traumatic brain injury

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Precise genome-editing in human diseases:mechanisms,strategies and applications

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1065-1085页

作者： Yanjiang Zheng Yifei Li Kaiyu Zhou Tiange Li nathan J.VanDusen Yimin Hua Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE Department of PediatricsWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Department of Cardiovascular Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pediatrics Herman B Wells Center for Pediatric ResearchIndiana University School of MedicineIndianapolisIN 46202USA

Precise genome-editing platforms are versatile tools for generating specific,site-directed DNA insertions,deletions,and *** continuous enhancement of these tools has led to a revolution in the life sciences,which promises to deliver novel therapies for genetic *** genome-editing can be traced back to the 1950s with the discovery of DNA’s doublehelix and,after 70 years of development,has evolved from crude in vitro applications to a wide range of sophisticated capabilities,including in vivo ***,precise genome-editing faces constraints such as modest efficiency,delivery challenges,and off-target *** this review,we explore precise genome-editing,with a focus on introduction of the landmark events in its history,various platforms,delivery systems,and ***,we discuss the landmark events in the history of precise ***,we describe the current state of precise genome-editing strategies and explain how these techniques offer unprecedented precision and versatility for modifying the human ***,we introduce the current delivery systems used to deploy precise genome-editing components through DNA,RNA,and ***,we summarize the current applications of precise genome-editing in labeling endogenous genes,screening genetic variants,molecular recording,generating disease models,and gene therapy,including ex vivo therapy and in vivo therapy,and discuss potential future advances.

关键词： precise generating editing

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Neurogenic potential of NG2 in neurotrauma:a systematic review

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Neural Regeneration Research 2024年第12期19卷 2673-2683页

作者： Yuri R.Rigo Radharani Benvenutti Luis V.Portela nathan R.Strogulski Departamento de Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublinIreland School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of *** is reflected in a large disparity between the number of studies investigating primary and secondary injury as therapeutic to rgets in spinal co rd and traumatic brain *** advances in biotechnology may have the potential to reshape the current state-of-the-art and bring focus to primary injury neurotrauma *** studies using neural-glial factor/antigen 2(NG2)cells indicate that they may differentiate into neurons even in the developed *** these cells show great potential to play a regenerative role,studies have been conducted to test various manipulations in neurotrauma models aimed at eliciting a neurogenic response from *** the present study,we systematically reviewed the experimental protocols and findings described in the scientific literature,which were peer-reviewed original research articles(1)describing preclinical experimental studies,(2)investigating NG2 cells,(3)associated with neurogenesis and neurotrauma,and(4)in vitro and/or in vivo,available in PubMed/MEDLINE,Web of Science or SCOPUS,from 1998 to ***,we have reviewed a total of 1504 papers,and summarized findings that ultimately suggest that NG2 cells possess an inducible neurogenic potential in animal models and in *** also discriminate findings of NG2 neurogenesis promoted by different pharmacological and genetic approaches over functional and biochemical outcomes of traumatic brain injury and spinal co rd injury models,and provide mounting evidence for the potential benefits of manipulated NG2 cell ex vivo transplantation in primary injury *** findings indicate the feasibility of NG2 cell neurogenesis strategies and add new players in the development of therapeutic alternatives for neurotrauma.

关键词： neural-glial antigen 2 neural-glial factor 2 neuron differentiation NG2 cell regeneration spinal cord injury(SCI) traumatic brain injury(TBI)

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