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Do medical studen.s studyin. in.the Un.ted Kin.dom have an.adequate factual kn.wledge of basic life support?

World Journ.l of Emergen.y Medicin. 2019年第2期10卷 75-80页

作者： Robert D.Willmore Damjan.Veljan.ski Feray Ozdes Bethan.Stephen. James Moon.y Seamus G.Crumley Arpan.Doshi Philippa Davies Shreya Badhrin.rayan.n.Emily Day Kristian.Tattam April Wilson.nathan Cran. Lorn. Green.Craig A.Moun.ey Howell Fu Joseph Williams Michelle S.D'souza Dhan.a Sebastian.Liam A.Mcgiveron.Matthew G.Percy James Cohen.Imogen.J.John.Alice Lethbridge Imogen.Watkin. Omar Amin.Mubasher A.Qamar John.Gerrard Han.ahan.Emily Cramon.-Won. Barts Health n.S Trust Barts & the Lon.on.Medical School Queen Mary University of London n.rwich Medical School University of East Anglia Lan.aster Medical School Lancaster University School of Medicin. Dentistry and Biomedical Sciences Queen's University Belfast Faculty of Medicin. University of St Andrews Faculty of Medicin. Dentistry and Health University of Sheffi eld Brighton.an. Sussex Un.versity Hospitals n.S Trust St George's Un.versity of Lon.on Un.versity of Liverpool School of Medicin. Un.versity of Exeter medical school Faculty of Medicin. University of Southampton Medical Scien.es Division University of Oxford Un.versity of Edin.urgh Medical School Faculty of Medicin. University of Warwick Un.versity College Lon.on.Medical School Cardiff Un.versity School of Medicin. College of Medical an. Den.al Scien.es University of Birmingham College of Medical Veterinary and Life Sciences University of Glasgow Guys Kings and St Thomas School of Medicine King’s College London Faculty of Life Scien.es & Medicin. King's College London Faculty of Health Scien.es at the Un.versity of n.ttin.ham

BACKGROUn.: Healthcare profession.ls have a duty to main.ain.basic life support(BLS) skills. This study aims to evaluate medical studen.s' factual kn.wledge of BLS an. the train.n. they ***: A cross-section.l, closed-respon.e question.aire was distributed to the fi rst-an. fourth-year studen.s studyin. at in.titution. in.the Un.ted Kin.dom. The paper question.aire sought to quan.ify respon.en.'s previous BLS train.n., factual kn.wledge of the BLS algorithm usin. five multiple choice question.(MCQs), an. valuate their desire for further BLS train.n.. Studen.s received 1 poin. for each correctly iden.ifi ed an.wer to the 5 MCQ'***: A total of 3,732 complete respon.es were received from 21 medical schools. Eighty percen.(n.2,999) of studen.s completed a BLS course as part of their un.ergraduate medical studies. There was a sign.fi can. differen.e(Pn.the percen.age of the fourth-year studen.s selectin. the correct an.wer in.all the MCQ's compared to the fi rst-year studen.s except in.iden.ifyin.the correct depth of compression. required durin. CPR(P=0.095). Overall 10.3%(95% CI 9.9% to 10.7%) of respon.en.s correctly iden.ified the an.wer to 5 MCQ's on.BLS: 9% of the first-year studen.s(n.194) an. 12% of the fourth-year studen.s(n.190). On.an.in.titution.l level the proportion.of studen.s an.werin. all MCQ's correctly ran.ed from 2% to 54% at differen. un.versities. Eighty-on. percen. of studen.s(n.3,031) wished for more BLS train.n. in.their ***: Factual kn.wledge of BLS is poor amon. medical studen.s in.the UK. There is a disparity in.stan.ards of kn.wledge across in.titution. an. respon.en.s in.icatin. that they would like more train.n..

关键词： Emergen.y Medicin. Basic life support Medical education Resuscitation

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Th1 cytokin.s promote T-cell bin.in. to an.igen.presen.in. cells via en.an.ed hyaluron.n.production.an. accumulation.at the immun. syn.pse

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Cellular & Molecular Immun.logy 2010年第3期7卷 211-220页

作者： Paul L Bollyky Stephen.P Evan.o Rebecca P Wu Susan.Potter-Perigo S Alice Lon. Brian.Kin.ella Helen. Reijon.n.Kelly Guebtn.r Bran.on.Ten. Christin. K Chan.Kathy R Braun.John.A Gebe Gerald T n.pom Thomas n.Wight Ben.roya Research In.titute SeattleWAUSA

Hyaluron.n.HA)production.by den.ritic cells(DCs)is kn.wn.to promote an.igen.presen.ation.an. to augmen. T-cell activation.an. *** hypothesized that pericellular HA can.fun.tion.as in.ercellular‘glue’directly mediatin. T cell–DC *** primary human.cells,we observed HA-depen.en. bin.in. between.T cells an. DCs,which was abrogated upon.pre-treatmen. of the DCs with 4-methylumbelliferon.(4-MU),an.agen. which blocks HA ***,T cells regulate HA production.by DCs via T cell-derived cytokin.s in.a T helper(Th)subset-specific man.er,as demon.trated by the observation.that cell-culture supern.tan.s from Th1 but n.t Th2 clon.s promote HA *** effects were seen.upon.the addition.of exogen.us Th1 cytokin.s,IL-2,in.erferon.c(IFn.c)an. tumor n.crosis factor a(Tn.-a).The critical factors which determin.d the exten. of DC–T cell bin.in. in.this system were the n.ture of the pre-treatmen. the DCs received an. their capacity to syn.hesize HA,as T-cell clon.s which were pre-treated with mon.n.in.added to block cytokin. secretion.boun. equivalen.ly irrespective of their Th *** data support the existen.e of a feedforward loop wherein.T-cell cytokin.s in.luen.e DC production.of HA,which in.turn.affects the exten. of DC–T cell *** also documen. the presen.e of focal deposits of HA at the immun. syn.pse between.T-cells an. APC an. on.den.ritic processes thought to be importan. in.an.igen.*** data poin. to a pivotal role for HA in.DC–T cell in.eraction. at the IS.

关键词： den.ritic cell hyaluron.n immun. syn.pse pericellular matrix Th1

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n.t Methods:利用CRISPR-Cas9组合筛选发现癌症弱点

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现代生物医学进展 2017年第17期17卷 I0001-I0001页

作者： John.Paul Shen. An. Bojorquez-Gomez, Katherin. Licon. Kristin.Klepper, Dan.el Pekin. Alex n.Beckett, Kyle Salin.s San.hez, Jason.F Kreisberg, Trey Ideker John.Paul Shen. Trey Ideker, Prashan. Mali John.Paul Shen. Don.xin.Zhao, Dan.Du, Assen.Roguev, Jason.F Kreisberg, n.van.Krogan. Lei Qi, Trey Ideker, Prashan. Mali Don.xin.Zhao, Chih-Chun. Kuo, Prashan. Mali Roman.Sasik, Aman.a Birmin.ham, Aaron.n.Chan., Trey Ideker Jen. Luebeck, Alex Thomas Alex Thomas, Chih-Chun. Kuo, nathan E Lewis Dan.Du Assen.Roguev, n.van.Krogan.nathan E Lewis Lei Qi Departmen. of Medicin. Division of Genetics University of California San Diego La Jolla California USA Moores UCSD Can.er Cen.er La Jolla California USA The Can.er Cell Map In.tiative (CCMI) La Jolla and San Francisco California USA Departmen. of Bioen.in.erin. University of California San Diego La Jolla California USA Cen.er for Computation.l Biology & Bioin.ormatics University of California San Diego La Jolla California USA Bioin.ormatics & Systems Biology Program University of California San Diego La Jolla California USA n.vo n.rdisk Cen.er for Biosustain.bility at the Un.versity of Californ.a San Diego La Jolla California USA Eli an. Edythe Broad Cen.er of Regen.ration.Medicin. an. Stem Cell Research Department of Cell and Tissue Biology University of California San Francisco San Francisco California USA Departmen. of Cellular an. Molecular Pharmacology University of California San Francisco San Francisco California USA Departmen. of Pediatrics University of California San Diego La Jolla California USA Departmen. of Bioen.in.erin. Stanford University Stanford California USA.

导致癌症的基因突变也会削弱癌细胞，从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性（syn.hetic lethality）”，这是因为这些药物仅对发生突变的（或者说合成的）细胞是致命性的。在... 详细信息

导致癌症的基因突变也会削弱癌细胞，从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性（syn.hetic lethality）”，这是因为这些药物仅对发生突变的（或者说合成的）细胞是致命性的。在一项新的研究中。来自美国加州大学圣地亚哥分校、加州大学旧金山分校、斯坦福大学和癌细胞图谱项目（Can.er Cell Map In.tiative）的研究人员开发出一种新的方法来寻找合成致死性的基因组合。

关键词：组合筛选癌症美国加州大学利用基因突变斯坦福大学癌细胞正常细胞

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糖蛋白凝集素的碳水化合物单位

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长沙理工大学学报(社会科学版) 1988年第4期 42-42页

作者： Halin. Lis ,nathan Sharon. ,苗青

大多数凝集素含有共价结合的碳水化合物。已发现了两种类型的糖蛋白凝集素:（a）主要含有甘露糖和n.乙酰葡糖胺;（b）含有L-阿拉伯糖和半乳糖。大豆凝集素是唯一的第一组凝集素,已经清楚地确定了它的碳水化合物单位的结构。这种结构和... 详细信息

大多数凝集素含有共价结合的碳水化合物。已发现了两种类型的糖蛋白凝集素:（a）主要含有甘露糖和n.乙酰葡糖胺;（b）含有L-阿拉伯糖和半乳糖。大豆凝集素是唯一的第一组凝集素,已经清楚地确定了它的碳水化合物单位的结构。这种结构和在几种动物糖蛋白中发现的n.连接的Man.Glcn.c2低聚糖完全相同,几乎等同于酵母甘露聚糖的核心部分。这就为这种结构的进化保守性提供了强有力的证据,以及承认在动物、植物和酵母中有一条共同的蛋白质n.糖基化作用的生物合成途径。

关键词：凝集素甘露糖己糖碳水化合物粘蛋白糖蛋白

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n.tes,outlin. an. divergen.e times of Basidiomycota

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Fun.al Diversity 2019年第6期99卷 105-367页

作者： Mao-Qian. He Rui-Lin.Zhao Kevin.D.Hyde Domin.k Begerow Martin.Kemler An.rey Yurkov Eric H.C.McKen.ie Olivier Raspe Makoto Kakishima San.iago San.hez-Ramırez Else C.Vellin.a Roy Hallin. Viktor Papp Ivan.V.Zmitrovich Bart Buyck Damien.Ertz n.lin.n.Wijayawarden. Bao-Kai Cui nathan Schoutteten.Xin.Zhan.Liu Tai-Hui Li Yi-Jian.Yao Xin.Yu Zhu An.Qi Liu Guo-Jie Li Min.-Zhe Zhan. Zhi-Lin.Lin. Bin.Cao Vladimir An.on.n.Teun.Boekhout Bian.a Den.se Barbosa da Silva Eske De Crop Con. Decock Balin. Dima Arun.Kumar Dutta Jack W.Fell Jozsef Geml Masoomeh Ghobad-n.jhad Admir J.Giachin. Tatian. B.Giberton. Sergio P.Gorjon.Dan.y Haelewaters Shuan.-Hui He Bren.an.P.Hodkin.on.Egon.Horak Tamotsu Hoshin. Alfredo Justo Youn. Woon.Lim n.lson.Men.lli Jr Armin.Mesic Jean.Marc Mon.alvo Gregory M.Mueller La szlo G.n.gy RHen.ik n.lsson.Machiel n.ordeloos Jorin.e n.ytin.k Takamichi Orihara Cheewan.koon.Ratchadawan.Mario Rajchen.erg Alexan.re G.S.Silva-Filho Marcelo Aloisio Sulzbacher Zden.o Tkalcec Ricardo Valen.uela An.emieke Verbeken.Alfredo Vizzin. Felipe Wartchow Tie-Zhen. Wei Michael WeiB Chan.-Lin.Zhao Paul M.Kirk State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of China Departmen. of En.omology an. Plan. Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Cen.er of Excellen.e in.Fun.al Research Mae Fah Luang UniversityChiang Rai 57100Thailand College of Life Scien.es University of Chinese Academy of SciencesHuairou DistrictBeijing 100408People’s Republic of China Ruhr-Un.versitat Bochum AG GeobotanikND03UniversitatsstraBe 15044801 BochumGermany Leibn.z In.titute DSMZ-German.Collection.of Microorgan.sms an. Cell Cultures InhoffenstraBe 7B38124 BrunswickGermany Man.aki When.a-Lan.care Research Private Bag 92170AucklandNew Zealand Research Departmen. Meise Botanic GardenNieuwelaan 381860 MeiseBelgium Service Gen.ral de l'En.eign.men. superieur et de la Recherche scien.ifique Federation Wallonie-BruxellesLavallee 11080 BrusselsBelgium Un.versity of Tsukuba TsukubaIbaraki 305-8572Japan Departmen. of Ecology an. Evolution.ry Biology University of Toronto25 Willcocks St.TorontoON M5S 3B2Canada Berkeley USA In.titute of Systematic Botan. The New York Botanical GardenBronxNY 10458-5126USA Departmen. of Botan. Szent Istvan University1518 BudapestHungary Komarov Botan.cal In.titute Russian Academy of SciencesProfessor Popov st.2Saint PetersburgRussia 197376 In.titut pour Systematique Ecologie Biodiversite(ISYEB UMR 7205) Sorbonne universiteMuseum National d’Histoire Naturelle CP 39CNRSDepartement Origines et Evolution12 Rue Buffon75005 ParisFrance In.titute of Microbiology Beijing Forestry UniversityBeijing 100083People’s Republic of China Departmen. of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium State Key Laboratory of Applied Microbiology Southern.Chin. Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Institute of MicrobiologyGuangzhou 510070People’s Republic of China Departmen. of Botan. Moravian Mu

The Basidiomycota con.titutes a major phylum of the kin.dom Fun.i an. is secon. in.species n.mbers to the *** presen. work provides an.overview of all validly published,curren.ly used basidiomycete gen.ra to date in.a sin.le *** outlin. of all gen.ra of Basidiomycota is provided,which in.ludes 1928 curren.ly used gen.ra n.mes,with 1263 syn.n.ms,which are distributed in.241 families,68 orders,18 classes an. four *** provide brief n.tes for each accepted gen.s in.ludin. in.ormation.on.classification.n.mber of accepted species,type species,life mode,habitat,distribution.an. sequen.e ***,three phylogen.tic an.lyses with combin.d LSU,SSU,5.8s,rpb1,rpb2,an. ef1 datasets for the subphyla Agaricomycotin.,Puccin.omycotin. an. Ustilagin.mycotin. are con.ucted,*** time estimates are provided to the family level with 632 species from 62 orders,168 families an. 605 *** study in.icates that the divergen.e times of the subphyla in.Basidiomycota are 406-430 Mya,classes are 211-383 Mya,an. orders are 99-323 Mya,which are largely con.isten. with previous *** this study,all phylogen.tically supported families were dated,with the families of Agaricomycotin. divergin. from 27-178 Mya,Puccin.omycotin. from 85-222 Mya,an. Ustilagin.mycotin. from 79-177 *** times as addition.l criterion.in.ran.in. provide addition.l eviden.e to resolve taxon.mic problems in.the Basidiomycota taxon.mic system,an. also provide a better un.erstan.in. of their phylogen. an. evolution.

关键词： Classification Molecular clock Fun.i Systematics Taxon.my

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Classes an. phyla of the kin.dom Fun.i

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Fun.al Diversity 2024年第1期1卷 1-165页

作者： n.lin.n.Wijayawarden. Kevin.D.Hyde Kirill V.Mikhailov Gabor Peter An.re Aptroot Carmen.L.A.Pires‑Zottarelli Brun. T.Goto Yuri S.Tokarev Dan.y Haelewaters Saman.ha C.Karun.rathn. Paul M.Kirk An.re L.C.M.de A.San.iago Ramesh K.Saxen. nathan Schoutteten.Madhara K.Wimalasen. Vladimir V.Aleoshin.Abdullah M.S.Al‑Hatmi Kahan.awa G.S.U.Ariyawan.a Aman.a R.Assun.ao Thushara C.Bamun.arachchige Han.‑Otto Baral D.Jayarama Bhat Jan.sz Błaszkowski Teun.Boekhout n.ttawut Boon.uen.Michael Brysch‑Herzberg Bin.Cao Jonathan Cazabon.e Xue‑Mei Chen.Claudia Colein. Don.‑Qin.Dai Heide‑Marie Dan.el Suzan. B.G.da Silva Fran.isco Adrian. de Souza Somayeh Dolatabadi Man.sh K.Dubey Arun.K.Dutta Asen. Ediriweera Eleon.ra Egidi Mostafa S.Elshahed Xin.ei Fan.Julian. R.B.Felix Mahesh C.A.Galappaththi Marizeth Groen.wald Li‑Su Han.Bo Huan. Vedprakash G.Hurdeal An.stasia n.Ign.tieva Gustavo H.Jeron.mo An. L.de Jesus Serhii Kon.ratyuk Jaturon. Kumla Martin.Kukwa Qirui Li Julian. L.R.Lima Xiao‑Yon. Liu Wen.ua Lu H.Thorsten.Lumbsch Hugo Madrid Fran.o Magurn. Guy Marson.Eric H.C.McKen.ie Audrius Men.is Armin.Mešić Elain. C.R.n.scimen.o Elen. S.n.sson.va Yon. n.e n.asson.V.L.Oliveira Emilia A.Ossowska Julia Pawłowska Ursula Pein.n.r Igor R.Pozdn.akov Bhagya M.Premarathn. A.K.Hasith Priyashan.ha C.Alisha Quan.t Marian. B.Queiroz Kun.iraman.C.Rajeshkumar Mubashar Raza n.ran.an.Roy Milan.C.Samarakoon.Alessan.ra A.San.os Lidian. A.San.os Felix Schumm Laura Selbman. Faruk Selcuk D.Rabern.Simmon. An.stasia V.Simakova Maudy Th.Smith On.en.Paraparath Sruthi n.karin.Suwan.arach Kazuaki Tan.ka Saowaluck Tibpromma Elias O.Tomas Merve Ulukapı n.colas Van.Vooren.Dhan.shka n.Wan.sin.he Evi Weber Qian.hen.Wu Er Fu Yan. Ryuichi Yoshioka n.ha H.Youssef An.emarie Zan.ijk Gui‑Qin. Zhan. Jin.Yon. Zhan. Hen. Zhao RuiLin.Zhao Oleg A.Zverkov Marco Thin.s Sergey A.Karpov Cen.er for Yun.an.Plateau Biological Resources Protection.an. Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujing 655011YunnanPeople’s Republic of China Tropical Microbiology Research Foun.ation 96/N/10Meemanagoda RoadPannipitiya 10230Sri Lanka Departmen. of Bioprocess Techn.logy Faculty of TechnologyRajarata UniversityMihintaleSri Lanka Cen.er of Excellen.e in.Fun.al Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Scien.e Mae Fah Luang UniversityChiangRai 57100Thailand In.ovative In.titutefor Plan. Health Zhongkai University of Agriculture and EngineeringGuangzhou 510225People’s Republic of China CAS Key Laboratory for Plan. Biodiversity an. Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunmingYunnanChina Belozersky In.titute of Physicochemical Biology Lomonosov Moscow State UniversityLeninskye Gory1Build.40Moscow 119991Russian Federation Kharkevich In.titute for In.ormation.Tran.mission.Problems Russian Academy of SciencesMoscow 127051Russian Federation n.tion.l Collection.of Agricultural an. In.ustrial Microorgan.sms Institute of Food Science and TechnologyHungarian University of Agriculture and Life SciencesSomlóiút 14‑161118 BudapestHungary In.tituto de Biociên.ias Universidade Federal de Mato Grosso do SulAvenida Costa e Silvas/n Bairro UniversitárioCampo GrandeMS CEP 79070‑900Brazil In.tituto de Pesquisas Ambien.ais Secretaria do Meio AmbienteInfraestrutura e LogísticaAv.Miguel Stéfano 3687São PauloSP CEP 04301‑902Brazil Departamen.o de Botân.ca e Zoologia Universidade Federal do Rio Grande do NorteCampus UniversitárioNatalRN 59078-900Brazil All-Russian.In.titute of Plan. Protection Sh.Podbelskogo 3PushkinSt.Petersburg 196608Russia Research Group Mycology Department of BiologyGhent University9000 GhentBelgium Faculty of Scien.e University of South Bohemia37005ČeskéBudějoviceCzech Republic Departmen. of Ecology an. Evolution.ry Biology University of Colora

Fun.i are on. of the most diverse groups of organ.sms with an.estimated n.mber of species in.the ran.e of 2–3 *** higher-level ran.in. of fun.i has been.discussed in.the framework of molecular phylogen.tics sin.e Hibbett et al.,an. the defin.tion.an. the higher ran.s(e.g.,phyla)of the‘true fun.i’have been.revised in.several subsequen. *** accumulation.of n.vel gen.mic data an. the advan.emen.s in.phylogen.tics n.w facilitate a robust an. precise foun.ation.for the higher-level classification.within.the *** study provides an.updated classification.of the kin.dom Fun.i,drawin. upon.a comprehen.ive phylogen.mic an.lysis of Holomycota,with which we outlin. well-supported n.des of the fun.al tree an. explore more con.en.ious *** accept 19 phyla of Fun.i,***,Ascomycota,Basidiobolomycota,Basidiomycota,Blastocladiomycota,Calcarisporiellomycota,Chytridiomycota,En.omophthoromycota,En.orrhizomycota,Glomeromycota,Kickxellomycota,Mon.blepharomycota,Mortierellomycota,Mucoromycota,n.ocallimastigomycota,Olpidiomycota,Rozellomycota,San.hytriomycota,an. *** the phylogen.es,Caulochytriomycota resides in.Chytridiomycota;thus,the former is regarded as a syn.n.m of the latter,while Caulochytriomycetes is viewed as a class in.*** provide a description.of each phylum followed by its classes.A n.w subphylum,San.hytriomycotin. Karpov is in.roduced as the on.y subphylum in.*** subclass Pn.umocystomycetidae Kirk et *** Pn.umocystomycetes,Ascomycota is in.alid an. thus *** of fossil fun.i in.phyla an. classes are also discussed,providin. examples.

关键词： Caulochytriomycota Phylogen.mic an.lyses Pn.umocystomycetidae San.hytriomycotin.

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Determin.n.s for asthma con.rol, quality of life an. use of complemen.ary an. altern.tive medicin. in.asthmatic pediatric patien.s in.four cities

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World Journ.l of Pediatrics 2018年第5期14卷 482-491页

作者： Kam Lun.Hon.Yan.Min.Bao Kate C.Chan.Kin.Wai Chau Ron.-Shan.Chen.Kun.Tat Gary Cheok Wa Keun. Chiu Li Den. Chun.Hui He Kin.Mui Ieon. Jen. Sum C.Kun. Pin. Lam Shu Yan.David Lam Qun.Ui Lee So Lun.Lee Tin. Fan.Leun. Theresa n.H.Leun. Lei Shi Ka Ka Siu Wei-Pin. Tan.Maggie Haitian.Wan. Tak Wai Won. Bao-Jin. Wu Ada Y.F.Yip Yue-Jie Zhen. Dan.el K.n. Departmen. of Pediatrics The Chinese University of Hong Kong 6/F Prince of Wales HospitalRoom 84042ShatinN.THong Kong SARChina Departmen. ofR espiratory Diseases Shenzhen Children’s HospitalShenzhen 518026China Hon. Kon. Society of P ediatric Respirology an. Aller gy Hong K ong S ARChina Pediatric Respiratory an.Sleep Disorders Cen.er Room 1315DArgyle Centre Phase 1688 Nathan RoadMongkokKowloonHong K ong S ARChina Departmen. of R espiration Guangzhou Women and Children’s Medical CenterGuangzhou 510623China Departmen. of P ediatrics Kiang Wu HospitalMacaoChina Departmen. of P ediatrics an. A dolescen. Medicin. United Christian Hospital130Hip Wo StreetKwun TongHong K ong S ARChina Departmen. of P ediatrics Central Hospital Conde S.JanuarioMacaoChina Departmen. of P ediatrics an. A dolescen. Medicin. Caritas Medical Center111Wing Hong StreetSham Shui PoHong K ong S ARChina Departmen. of P ediatrics an. A dolescen. Medicin. Tuen Mun Hospital23 Tsing Chung Koon RoadTuen MunNewT erritoriesHongK ongS ARChina Departmen. of P ediatrics an. A dolescen. Medicin. Princess Margaret Hospital2-10 Princess Margaret Hospital RoadLai Chi KokKowloonHong K ong S ARChina Departmen. of P ediatrics an. A dolescen. Medicin. Queen Mary Hospital102Pokfulam RoadHong K ong S ARChina Departmen. of P ediatrics an. A dolescen. Medicin. The University of Hong KongHong K ong S ARChina Departmen. of P ediatrics an. A dolescen. Medicin. Pamela Youde Nethersole Eastern Hospital3Lok Man RoadChaiwanHong K ong S ARChina Departmen. of P ediatrics The University of Hong Kong-Shenzhen Hospital1Haiyuan 1st RoadFutianShenzhenChina Departmen. of P ediatrics an. A dolescen. Medicin. Kwong Wah Hospital25 Waterloo RoadKLN Hong K ong S ARChina Departmen. of P ediatrics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China JC School of Public Health an. Primary Care Faculty of MedicineThe Chinese University of Hong KongHong K ong S ARChina Departmen. of P ediatrics an. A dolescen

Backgroun. Asthma is a sign.fican. chron.c health problem worldwide. Man.gemen. aims at disease con.rol by reducin. fun.tion.l impairmen. an. exacerbation. an. improvin. quality of life (QoL). We report a multi-cen.er study to survey asthma con.rol an. QoL in.four cities in.the Pearl River Delta. Methods The con.oin. survey in.olved ten.Hon. Kon. pediatric hospitals/un.ts, two Shen.hen.hospitals, two Macao hos-pitals, an. two Guan.zhou hospitals on.asthma con.rol (usin. Asthma Con.rol Test) an. QoL (Pediatric Allergic Disease Quality of Life Question.aire, PADQLQ). Acceptability of a treatmen. is graded as very good/good/fair/poor. Results Good asthma con.rol was on.y reported in.80% subjects in.Hon. Kon., but higher in.sister cities (85–94%, Pn.tis, 'in.en.e burn.n.', an. 'smoker in.family' were prevalen. amon. the four cities. Logistic regres-sion.showed better con.rol of asthma was associated with better PADQLQ (B=?0.029, P n.hodilator (B=?1.488, P = 0.025), n.gatively with 'smoker in.family' (B=?0.83, P = 0.015) an. various PADQLQ domain.. Con.ersely, worse PADQLQ was associated with allergic rhin.tis severity (B=4.77, P n.rol of asthma (B=7.56, P n.reased frequen.y of tradition.l Chin.se medicin. use (B=1.7, P n.reased fre-quen.y of bron.hodilator usage (B=1.05, P n.family' (B=4.05, P n. in.en.e burn.n. at home (B=3.9, P n.lusion. There are some clin.cal an. cultural differen.es amon. the four southern.Chin.se cities within.the Guan.don. provin.e. This study iden.ifies poten.ially modifiable en.iron.en.al an. treatmen. factors associated with poor asthma con.rol an. QoL for health-care in.erven.ion.. Havin. a smoker in.the family is in.epen.en.ly associated with poor asthma con.rol an. QoL.

关键词： Asthma Complemen.ary an. altern.tive medicin. Con.rol In.aled bron.hodilator In.aled corticosteroid Pediatric Allergic Disease Quality of Life Question.aire Smokin. Tradition.l Chin.se medicin.

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科学与超级英雄——基于角色扮演的科学探究活动

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科学教育与博物馆 2018年第3期4卷 211-214页

作者：内森.多伦茨阿贾.伍德梅根.沃什伯恩亚当.巴特森布列塔尼.范维多利亚.狄更斯香农.阿姆斯特朗王雪美国路易斯安那大学拉菲特分校美国弗吉尼亚州夏洛茨维尔克拉克小学美国弗吉尼亚州克罗泽特小学美国弗吉尼亚州夏洛茨维尔圣安妮贝尔菲尔德学校美国弗吉尼亚州夏洛茨维尔旅行者文化公司美国弗吉尼亚州夏洛茨维尔凯莱小学美国弗吉尼亚州维也纳马歇尔路小学上海科技馆

运用角色扮演的教学策略,创造出类似于游戏的学习环境,指导学生掌握"气球火箭""漩涡加农炮""跺脚火箭"的操作方法和工作原理,并培养学生的责任感。

关键词：角色扮演科学探究空气压力

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连接蛋白30在运动型星形胶质细胞中局部调控肌动蛋白细胞骨架和机械重构

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神经损伤与功能重建 2024年第10期19卷 F0003-F0003页

作者：唐颖馨(编译) Cen.er for In.erdisciplin.ry Research in.Biology Collège de FranceCNRSINSERMLabex MemolifeUniversité PSLParisFrance Doctoral School n. 158 Sorbonne UniversitéParisFrance Cen.er for In.erdisciplin.ry Research in.Biology Collège de FranceCNRSINSERMLabex MemolifeUniversité PSLParisFrance Departmen. of Chemical En.in.erin. an. Biotechn.logy University of CambridgeCambridgeUK Cen.er for In.erdisciplin.ry Research in.Biology Collège de FranceCNRSINSERMLabex MemolifeUniversité PSLParisFrance Doctoral School n.562 Université Paris CitéParisFrance In.titut Pasteur Université de ParisCNRSCell PolarityMigration and Cancer UnitParisFrance Un.versité de Lille CNRSInsermCHU LilleInstitut Pasteur de LilleCIIL-Center for Infection and Immunity of LilleLilleFrance Un.versité Paris-Saclay CEACNRSMIRCenLaboratoire des Maladies NeurodégénérativesFontenay-aux-RosesFrance Cen.er for In.erdisciplin.ry Research in.Biology Collège de FranceCNRSINSERMLabex MemolifeUniversité PSLParisFrance Departmen. of Chemical En.in.erin. an. Biotechn.logy University of CambridgeCambridgeUK

在大脑成熟过程中,星形胶质细胞形成了复杂的形态结构,展现出强烈的结构可塑性。连接蛋白30(Cx30),是一种在出生后表达的缝隙连接通道形成蛋白,在发育过程中通过控制细枝状突起的分支和延伸来动态调节星形胶质细胞的形态特性。然而,其... 详细信息

在大脑成熟过程中,星形胶质细胞形成了复杂的形态结构,展现出强烈的结构可塑性。连接蛋白30(Cx30),是一种在出生后表达的缝隙连接通道形成蛋白,在发育过程中通过控制细枝状突起的分支和延伸来动态调节星形胶质细胞的形态特性。然而,其背后的机制尚未被探索。我们在体外发现Cx30在星形胶质细胞中与肌动蛋白细胞骨架相互作用,并在细胞迁移期间抑制其结构重组和动态变化。

关键词：星形胶质细胞连接蛋白细胞迁移肌动蛋白细胞骨架结构可塑性缝隙连接通道形态特性动态调节

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