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头孢曲松钠短期治疗脑膜炎球菌性脑膜炎与长效氯霉素一样有效:一项随机非劣性研究

世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 4-5页

作者： nathan n. Borel T. Djibo A. P.J. Guerin.谢琰臣 Dr.Epicen.re 8 rue Saint Sabin 75011 Paris France

Backgroun.: In.sub-Saharan.Africa in.the 1990s, more than.600 000 people had epidemic men.n.ococcal men.n.itis, of whom 10%died. The curren. recommen.ed treatmen. by WHO is short-course lon.-actin. oily chloramphen.col. Con.in.ation.of the production.of this drug is un.ertain. so simple altern.tives n.ed to be foun.. We assessed whether the efficacy of sin.le-dose treatmen. of ceftriaxon. was n.n.in.erior to that of oily chloramphen.col for epidemic men.n.ococcal men.n.itis. Methods: In.2003, we un.ertook a ran.omised, open.label,n.n.in.er-iority trial in.n.n. health-care facilities in.n.ger. Participan.s with suspected disease who were older than.2 mon.hs were ran.omly assign.d to receive either chloramphen.col or ceftriaxon.. Primary outcome was treatmen. failure (defin.d as death or clin.cal failure) at 72 h, measured with in.en.ion.to-treat an. per-protocol an.lyses. Fin.in.s: Of 510 in.ividuals with suspected disease, 247 received ceftriaxon., 256 received chloramphen.col, an. seven.were lost to follow-up. The treatmen. failure rate at 72 h for the in.en.ion.to-treat an.lysis was 9%(22 patien.s) for both drug groups (risk differen.e 0.3%, 90%CI -3.8 to 4.5). Case fatality rates an. clin.cal failure rates were equivalen. in.both treatmen. groups (14 [6%] ceftriaxon. vs 12 [5%] chloramphen.col). Results were also similar for both treatmen. groups in.in.ividuals with con.irmed men.n.itis caused by n.isseria men.n.itidis. n. adverse side-effects were reported. In.erpretation. Sin.le-dose ceftriaxon. provides an.altern.tive treatmen. for epidemic men.n.ococcal men.n.itis-its efficacy, ease of use, an. low cost favour its use. n.tion.l an. in.ern.tion.l health partn.rs should con.ider ceftriaxon. as an.altern.tive first-lin. treatmen. to chloramphen.col for epidemic men.n.ococcal men.n.itis.

关键词：短期治疗替代药物脑膜炎患者远期疗效试验结果撒哈拉以南非洲地区奈瑟菌随机开放油剂

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负压吸脂术和第三代内超声吸脂术失血量的分析

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中国美容整形外科杂志 2009年第4期20卷 235-235页

作者： GARCIA O Jr nathan n. 王洁晴(摘译) 高景恒(审校) 不详中国医科大学

背景吸脂术在美国是最常见的美容手术。尽管在文献中超声吸脂术（UAL）有很好的临床效果，但目前该方法在所有的吸脂术中不到20％。目的本研究的目的是观察第三代内UAL中的出血量，并与传统的脂肪抽吸术比较。方法27例患者用传统的吸脂... 详细信息

背景吸脂术在美国是最常见的美容手术。尽管在文献中超声吸脂术（UAL）有很好的临床效果，但目前该方法在所有的吸脂术中不到20％。目的本研究的目的是观察第三代内UAL中的出血量，并与传统的脂肪抽吸术比较。方法27例患者用传统的吸脂术（SAL）抽吸背部和大腿后外侧；30例患者使用VASER内超声设备（soun. surgical techn.logies；louisville，CO），用第三代内UAL抽吸相同的部位，两者进行比较。两组使用肿胀液的量、成分相同。在Beckman.Coulter LH独立实验室，

关键词：超声吸脂术第三代负压吸脂术失血量脂肪抽吸术 Beckman Coulter 独立实验室

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Data-driven.models for groun. an. excited states for Sin.le Atoms on.Ceria

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n.j Computation.l Materials 2022年第1期8卷 1636-1643页

作者： Julian.Geiger Albert Sabadell-Ren.ón.nathan Daelman.n.ria López In.titute of Chemical Research of Catalon.a(ICIQ) The Barcelona Institute of Science and Technology(BIST)Avinguda Països Catalans 1643007TarragonaSpain Un.versitat Rovira i Virgili Avinguda Catalunya3543002TarragonaSpain

Ceria-based sin.le-atom catalysts presen. complex electron.c structures due to the dyn.mic electron.tran.fer between.the metal atoms an. the semicon.uctor oxide *** these materials implies retrievin. all states in.these electron.c en.embles,which can.be limitin. if don. via den.ity fun.tion.l ***,we propose a data-driven.approach to obtain.a parsimon.ous model iden.ifyin. the appearan.e of dyn.mic charge tran.fer for the sin.le atoms(SAs).We first con.tructed a database of(701)electron.c con.iguration. for the group 9–11 metals on.CeO_(2)(100).Feature Selection.based on.predictive Elastic n.t an. Ran.om Forest models highlights eight fun.amen.al variables:atomic n.mber,ion.zation.poten.ial,size,an. metal coordin.tion.metal–oxygen.bon. stren.ths,surface strain.an. Coulomb *** these variables a Bayesian.algorithm yields an.expression.for the adsorption.en.rgies of SAs in.groun. an. low-lyin. excited *** work paves the way towards un.erstan.in. electron.c structure complexity in.metal/oxide in.erfaces.

关键词： theory excited states

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Effect of power-law n.n.in.arity on.PT-symmetric optical system with fourth-order diffraction.

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Commun.cation. in.Theoretical Physics 2020年第5期72卷 32-40页

作者： nathan n.Tchepemen.Camus G L Tiofack Alidou Mohamadou Pure Physics Laboratory Group of Nonlinear Physics and Complex SystemsDepartment of PhysicsFaculty of scienceUniversity of DoualaPO Box 24157DoualaCameroon Con.en.ed Matter Laboratory Department of PhysicsFaculty of ScienceUniversity of MarouaPO Box 814MarouaCameroon Cen.re d'Excellen.e Africain.des Techn.logies de l'In.ormation.et de la Commun.cation.CETIC) University of Yaounde ICameroon The Abdus Salam In.ern.tion.l Cen.re for Theoretical Physics PO Box 538Strada costiera 11I-34014TriesteItaly

Gaussian.type soliton.solution. of the n.n.in.ar Schr?din.er(n.S)equation.with fourth order dispersion.an. power law n.n.in.arity in.the n.vel parity-time(TP)-symmetric quartic Gaussian.poten.ial are derived an.lytically an. *** exact an.lytical expression. of the solution. are obtain.d in.the first two-dimen.ion.l(1D an. 2D)power law n.S *** mean. of the lin.ar stability an.lysis,the effect of power law n.n.in.arity on.the stability of Gauss type soliton. in.differen. n.n.in.ar media is carried *** in.estigation. do con.irm the stability of our soliton.solution. in.both focusin. an. defocusin. cases,specially aroun. the propagation.parameters.

关键词： TP-symmetric quartic Gaussian.poten.ial fourth-order diffraction powerlaw n.n.in.arity stability Gaussian.soliton

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Late n.oproterozoic to early Cambrian.high-grade metamorphism from Mikir Hills(Assam-Meghalaya gn.issic Complex,n.rtheast In.ia):Implication. for eastern.Gon.wan. assembly

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Geoscien.e Fron.iers 2024年第5期15卷 256-282页

作者： Rahul n.g H.Hrushikesh nathan Cogn. n.Prabhakar Departmen. of Earth Scien.es Indian Institute of Technology BombayPowaiMumbaiMaharastra 400076India Geological Survey of In.ia Northeastern RegionGuwahatiAssam 781005India Géoscien.es Ren.es UMR6118CNRS Universitéde RennesFrance

Mikir Hills region.which represen.s the eastern.segmen. of the Assam-Meghalaya Gn.issic Complex(AMGC)in.n.rtheast In.ia,con.titutes part of the Eastern.*** Mikir Hills preserves multiple metamorphic an. magmatic even.s ran.in. from Early Mesoproterozoic to Early *** of these even.s,documen.in. the late n.oproterozoic to early Cambrian.tecton.thermal even.s is helpful in.correlatin. the con.in.n.al blocks of Eastern.*** presen. an.in.egrated study in.olvin. field relation.,petrology,P-T history an. zircon.mon.zite geochron.logy of hitherto poorly studied pelitic an. quartzo-feldspathic gn.isses from the Mikir Hills *** gn.isses have experien.ed at least three deformation.even.s(D_(1),D_(2) an. D_(3))with domin.n. foliation.in.icated by En.-WSW strikin. an. shallow-moderately dippin.(n.issic *** peak metamorphism in.pelitic an. quartzo-feldspathic gn.isses is characterized by garn.t(core)-K-feldspar-silliman.te-plagioclase-bio tite-rutile-quartz-ilmen.te-melt an. garn.t-plagioclase-K-feldspar-biotite-quartz-ilmen.te-melt assemblages,*** application.of thermobarometric methods con.train. the peak P-T con.ition. of 7.5-8.4 kbar at 674-778℃an. 6.7-7.4 kbar at 601-618℃for pelitic an. quartzofeldspathic gn.isses,*** results are con.isten. with the values estimated usin. phase equilibria modellin. an. melt rein.egration.*** results of pseudosection.modellin. suggests a clockwise P-T path for pelitic gn.isses in.olvin. migmatisation.durin. peak metamorphism followed by n.ar isothermal decompression.from 8.0 to 8.6 kbar at 768-780℃to 4.0-5.0 kbar at 720-765℃.In.con.rast,quartzo-feldspathic gn.isses preserved slightly lower peak P-T con.ition. at 3.8-4.6 kbar an. 590-650℃.The U-Pb zircon.datin. of migmatised pelitic an. quartzo-feldspathic gn.isses yielded con.ordan. ages of 1647±11 Ma an. 1590±7 Ma,*** dates represen. the in.erited ign.ous protolith compon.n.s,possibly

关键词： Gon.wan. Assam-Meghalaya Gn.issic Complex Migmatisation n.oproterozoic Geochron.logy P-T-t history

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Phylofloristics:an.example from the Lesser An.illes

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Journ.l of Plan. Ecology 2014年第2期7卷 166-175页

作者： nathan G.Swen.on.María n.Umaña Departmen. of Plan. Biology Michigan State UniversityEast LansingMichigan 48824USA

Aims The last decade has seen.man. plan. ecologists in.egratin. phylogen.tic an.lysis in.o ecology to explain.pattern. of species cooccurren.e an. composition.l similarity across *** the advan.es in.this area,there are still some challen.es that n.ed to be *** challen.e is that most of the phylogen.tic studies of plan. assemblages have focused on.y on.a small proportion.of all of the vascular plan.s that co-occur(*** plan.s),while much of the remain.n. co-occurrin. flora has been.*** Here we in.roduce an.an.lytical approach that we term phylofloristics that an.lyzes the composition.l similarity of floras in.relation.to spatial an. en.iron.en.al gradien.s to un.erstan. their *** an.illustration.we assembled a large phylogen.tic tree for the flora of the Lesser An.illes an. evaluated the pattern. of floristic an. phylofloristic similarity amon. the islan.-specific *** an.lyzed the relation.hip of these similarities with spatial an. en.iron.en.al distan.e an. compared the results for n.n.en.emic an. en.emic *** Fin.in.s The results show a major in.luen.e of en.iron.en.al heterogen.ity on.the assembly of islan. floras an. far less eviden.e for the importan.e of dispersal limitation.of lin.ages an. *** study highlights the importan.e of in.orporatin. broader taxon.mic samplin. to improve our un.erstan.in. of assembly processes in.*** expect future phylofloristic studies will improve the approach we have taken.by gen.ratin. more refin.d phylogen.tic trees an. by in.orporatin. phylogeographic in.ormation.

关键词： biogeography Caribbean flora phylogen. plan. geography

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Capacity of Old Trees to Respon. to En.iron.en.al Chan.e

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Journ.l of In.egrative Plan. Biology 2008年第11期50卷 1355-1364页

作者： nathan G.Phillips Thomas n.Buckley David T.Tissue Cen.re for Plan. an. Food Scien.e University of Western Sydney Departmen. of Geography an. En.iron.en. Boston University Departmen. of Biology Sonoma State University School of Biological Earth and Environmental SciencesUniversity of New South Wales Bushfire Cooperative Research Cen.re

Atmospheric carbon.dioxide [CO2] has in.reased dramatically within.the curren. life span. of lon.-lived trees an. old forests. Con.ider that a 500-year-old tree in.the early twen.y-first cen.ury has spen. 70% of its life growin. un.er prein.ustrial levels of [CO2], which were 30% lower than.curren. levels. Here we address the question.of whether old trees have already respon.ed to the rapid rise in.[CO2] occurrin. over the past 150 years. In.spite of limited data, agin. trees have been.shown.to possess a substan.ial capacity for in.reased n.t growth after a period of post-maturity growth declin.. Observation. of ren.wed growth an. physiological fun.tion.in.old trees have, in.some in.tan.es, coin.ided with In.ustrial Age in.reases in.key en.iron.en.al resources, in.ludin. [CO2], suggestin. the poten.ial for con.in.ed growth in.old trees as a fun.tion.of con.in.ed global climate chan.e.

关键词： carbon.dioxide hydraulic limitation old growth stomata tree rin.s.

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Dyn.mic Pattern. of Gen. Expression.Additivity an. Regulatory Variation.throughout Maize Developmen.

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Molecular Plan. 2019年第3期12卷 410-425页

作者： Pen. Zhou Can.ice n.Hirsch Steven.P.Briggs nathan M.Sprin.er Departmen. of Plan. an. Microbial Biology University of MinnesotaSaint PaulMN 55108USA Departmen. of Agron.my an. Plan. Gen.tics University of MinnesotaSaint PaulMN 55108USA Division.of Biological Scien.es University of CaliforniaSanDiegoLaJollaCA92093USA

Gen. expression.variation.is a key compon.n. un.erlyin. phen.typic variation.an. heterosis. Tran.criptome profilin. was performed on.23 differen. tissues or developmen.al stages of two maize in.reds, B73 an. Mo17, as well as their hybrid. The obtain.d large-scale datasets provided opportun.ties to mon.tor the developmen.al dyn.mics of differen.ial expression. additivity for gen. expression. an. regulatory variation. The tran.criptome can.be divided in.o .30 000 gen.s that are expressed in.at least on. tissue of on. in.bred an. an.addition.l ~10 000 “silen.” gen.s that are n.t expressed in.an. tissue of an. gen.type, 90% of which are n.n.syn.en.c relative to other grasses. Man. (.74%) of the expressed gen.s exhibit differen.ial expression.in.at least on. tissue. However, the majority of gen.s with differen.ial expression.do n.t exhibit con.isten. differen.ial expression.in.differen. tissues. These gen.s often.exhibit tissue-specific differen.ial expression.with equivalen. expression.in.other tissues, an. in.man. cases they switch the direction.lity of differen.ial expression.in.differen. tissues. This suggests widespread variation.for tissue-specific regulation.of gen. expression.between.the two maize in.reds B73 an. Mo17. n.arly 5000 gen.s are expressed in.on.y on. paren. in.at least on. tissue (sin.le paren. expression. an. 97% of these gen.s are expressed at mid-paren. levels or higher in.the hybrid, providin. exten.ive opportun.ties for hybrid complemen.ation.in.heterosis. In.gen.ral, additive expression.pattern. are much more common.than.n.n.additive pattern., an. this tren. is more pron.un.ed for gen.s with stron. differen.ial expression.or sin.le pare n. expressi on. There is relatively little eviden.e for n.n.additive expression.pattern. that are main.ain.d in.multiple tissues. The an.lysis of allele-specific expression.allowed classification.of cis. an. tran.-regulatory variation. Gen.s with c/s-regulatory variation.often.exhibit additive expression.an. ten.

关键词： maize gen. expression heterosis differen.ial expression n.n.additive expression allele-specific expression

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Spectral square momen.s of a reson.n.e sum for Maass forms

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Fron.iers of Mathematics in.Chin. 2017年第5期12卷 1183-1200页

作者： nathan SALAZAR Yan.bo YE Departmen. of Mathematics The University of Iowa Iowa City Iowa 52242-1419 USA

Let f be a Maass cusp form for Г0（n. with Fourier coefficien.s 1 k2. λf（n. an. Laplace eigen.alue 1/4 ＋k2 For real α≠0 an. β 〉 0, con.ider the sum Sx（f; α,β） = ∑n.λf（n.e（αn.）φ（n.X）, where φ is a smooth fun.tion.of compact support. We prove boun.s for the secon. spectral momen. of Sx （f;α, β）, with the eigen.alue ten.in. towards in.in.ty. When.the eigen.alue is sufficien.ly large, we obtain.an.average boun. for this sum in.terms of X. This implies that if f has its eigen.alue beyon. X1/2＋ε, the stan.ard reson.n.e main.term for Sx（f; ±2√q 1/2）, q ∈Z＋, can.ot appear in.gen.ral. The method is adopted from proofs of subcon.exity boun.s for Ran.in.Selberg L-fun.tion. for GL（2） × GL（2）. It con.ain. in.particular a proof of an.asymptotic expan.ion.of a well-kn.wn.oscillatory in.egral with an.en.arged ran.e of Kε≤ L≤ K1-ε. The same boun.s can.be proved in.a similar way for holomorphie cusp forms.

关键词： Cusp form Maass form Fourier coefficien. of cusp form Kuzn.tsovtrace formula reson.n.e sum first derivative test weighted station.ry phase

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REDOX IMAGIn. OF THE p53-DEPEn.En. MITOCHOn.RIAL REDOX STATE In.COLOn.CAn.ER EX VIVO

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Journ.l of In.ovative Optical Health Scien.es 2013年第3期6卷 1-10页

作者： HE n.XU MIn.FEn. LILY MOOn.nathan DOLLOFF WAFIKEL-DEIRY LIn.Z.LI Departmen. of Radiology University of Pennsylvania PhiladelphiaPAUSA Britton.Chan.e Laboratory of Redox Imagin. John.on.Research Foun.ation.Departmen. of Biochemistry an. Biophysics Perelman.School of Medicin. University of Pennsylvania PhiladelphiaPAUSA Departmen. of Medicin. Penn State Hershey Medical Center and Penn State College of MedicineHersheyPAUSA Hematology/On.ology Penn State Hershey Medical Center HersheyPAUSA Abramson.Can.er Cen.er University of Pennsylvania PhiladelphiaPAUSA In.titute of Tran.lation.l Medicin. an. Therapeutics Un.versity of Pen.sylvan.a PhiladelphiaPAUSA

The mitochon.rial redox state an. its heterogen.ity of colon.can.er at tissue level have n.t been.previously *** has how p53 regulates mitochon.ial respi ration.been.measured at(deep)tissue level,presumably due to the un.vailability of the techn.logy that has sufficien. spatial resolution.an. tissue pen.tration.*** prior work demon.trated that the mito-chon.rial redox state an. its in.n.tumor heterogen.ity is associated with can.er aggressiven.ss in.human.melan.ma an. breast can.er in.mouse models,with the more metastatic tumon. exhi-bit in. localized n.gion. of more oxidized redox *** the Chan.e redox scan.er with an.in.plan. spatial resolution.of 200 pm,we imaged the mitochon.rial redox state of the wild-type p53 colon.tumors(HCT116 p53 ut)an. the p5-deleted colon.tumors(HCT116 p53-/-)by cllctin. the fuorescen.e si gn.ls of n.cotin.mide aden.n. dimucleotide(n. DH)an. oxidized flavoprotein. [Fp,in.ludin. favin.aden.n. din.cleotide(FAD)]from the mouse xen.gmafts sn.p frozen.at low *** results show that:(1)both tumor lin.s have sign.fican. degree of in.ratumor heterogen.ity of the redox state,typically exhibitin. a distin.t bi modal distribution.that either correlates with the spatial core-rim pattern.or the“hot/oold”oxida tion.roduction.patches;.(2)the p531-group is sign.fican.ly more beterogen.ous in.the mitochon.rial redox state an. has a more oxidized turmor core compared to the p53 wt group when.the tun.r sizes of the two groups are matched;(3)the tumor size depen.en.e of the redox in.ices(such as Fp an. Fp redox ratio)is sign.fican. in.the p531-group with the larger on.s bein. more oxidized an. more hetero-gen.ous in.their redox state,particularly more oxidized in.the tumor cen.ral region.;(4)the H&E stain.n. images of tumor soction. grossly correlate with the redox *** presen. work is the first to reveal at the submillimeter scale the in.ratumor heterogen.ity pattem of the mitochon.drial redox state in.colon.can.er an.

关键词： n.DH favoprotein in.ratumor heterogen.ity HCT116 p53 n.ll n.crotic

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