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Efficacy and tolerability of chitin-glucan combined with simethicone(GASTRAp^(■)DIRECT)in irritable bowel syndrome:A prospective,open-label,multicenter study

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World Journal of Gastrointestinal pharmacology and Therapeutics 2024年第3期15卷 10-22页

作者： nathalie Talbodec pauline Le Roy peggy Fournier Benoit Lesage Elodie Lepoutre François Castex Jean Michel Godchaux Lionel Vandeville Benjamin Bismuth Xavier Lesage pauline Bayart Michael Genin Christel Rousseaux Veronique Maquet Salvatore Modica pierre Desreumaux Caroline Valibouze Department of Gastroenterology Hôpital privéLe BoisLille 59000France Department of Gastroenterology Hôpital privéde Villeneuve d’AscqVilleneuve d’Ascq 59650France Univ.Lille CHU LilleULR 2694–METRICSÉvaluation des Technologies de Santéet des Pratiques MédicalesLille 59000France Development of Intestinal Biotech 1 Avenue Oscar LambretLille 59045France KitoZyme SA Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium BiOkuris A Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium Department of Hepato-Gastroenterology Lille University HospitalLille 59000France U1286-INFINITE Institute for Translational Research in InflammationUniv.LilleInsermCHU LilleLille 59000France Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel ***-line recommended treatments are limited to combining drugs targeting predominant symptoms,particularly pain(antispasmodics),constipation(laxatives),and diarrhea(loperamide),yielding only a limited therapeutic ***^(■)DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of *** To evaluate the efficacy,tolerability,and safety of 4-week GASTRAp^(■)DIRECT treatment in patients with *** In this prospective,multicenter,open-label trial,120 patients with IBS received three sticks of GASTRAp^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone)per day for 4 *** primary endpoint was the responder rate,defined as the number of patients whose abdominal pain score decreased by≥30%from baseline to week(W)*** analysis was performed using the per-protocol *** symptoms,impact of global symptoms on daily life,change in stool consistency,and improvement in defecatory disorders were *** Overall,100 patients were *** W4,67%(95%CI:57-75)showed improvement in abdominal pain(score:5.8±2.4 vs 2.9±2.0,pprovements were observed for bloating[8.0±1.7 vs 4.7±2.9,pponders],abdominal distension[7.2±2.1 vs 4.4±3.1,pponders],and impact of global symptoms on daily life[7.1±2.0 vs 4.6±2.9,pponders].Stool consistency improved in most patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very much/considerable improvements by *** severe adverse event occurred,and tolerabil

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Flatulence Defecatory disorders Stool consistency Natural non-pharmacological treatment

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Identification of secondary raw materials in mold powders and their melting behavior

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Journal of Iron and Steel Research International 2019年第4期26卷 403-411页

作者： Irmtraud Marschall nathalie Kolbl Harald Harmuth Christina Atzenhofer KI-MET GmbH 8700 LeobenAustria Department Mineral Resources Engineering Chair of CeramicsMontanuniversitaet Leoben8700 LeobenAustria

Commercial mold powders use a limited number of main mineral constituents,but may differ significantly in chemical *** main mineral raw materials of specimens investigated here are quartz,fluorite and free carbon,as well as wollastonite and *** investigations revealed the use of secondary raw materials like blast furnace slag,fly ash,glass scrap and phosphorous slag as further *** the formation of cuspidine was one major point of interest,the influence of the silica source on its formation was identified.A replacement of wollastonite by blast furnace slag reduced the temperature of the first precipitation of cuspidine by about 100℃;the dissociation of sodium carbonate was lowered by-40℃.The lowest temperature of the first Na2CO3 dissociation could be achieved by using fluorine in combination with blast furnace *** formation from the melt is further decreased if sodium and fluorine are both *** use of glass scrap and phosphorous slag strongly reduced the temperature of first melt formation and enhanced cuspidine formation.

关键词： Mold powder Cuspidine Melting Crystallization behavior

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Thermal effects on clay rocks for deep disposal of high-level radioactive waste

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第3期9卷 81-96页

作者： Chun-Liang Zhang nathalie Conil Gilles Armand Gesellschaft für Anlagen- und Reaktorsicherheit (GRS) Braunschweig 38122 Germany Agence nationale pour la gestion des déchets radioactifs (Andra) Bure 55290 France

Thermal effects on the Callovo-Oxfordian and Opalinus clay rocks for hosting high-level radioactive waste were comprehensively investigated with laboratory and in situ experiments under repository relevant conditions:(1) stresses covering the range from the initial lithostatic state to redistributed levels after excavation,(2) hydraulic drained and undrained boundaries, and(3) heating from ambient temperature up to 90℃-120℃ and a subsequent cooling phase. The laboratory experiments were performed on normal-sized and large hollow cylindrical samples in various respects of thermal expansion and contraction, thermally-induced pore water pressure, temperature influences on deformation and strength, thermal impacts on swelling, fracture sealing and permeability. The laboratory results obtained from the samples are consistent with the in situ observations during heating experiments in the underground research laboratories at Bure and Mont-Terri. Even though the claystones showed significant responses to thermal loading, no negative effects on their favorable barrier properties were observed.

关键词： Clay rock Thermal effects pore pressure Deformation Strength permeability Sealing of fractures Repository

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家禽红螨(鸡皮刺螨)侵染期间蛋鸡的生产损失

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养禽与禽病防治 2024年第10期 25-30页

作者： nathalie Sleeckx Stefaan Van Gorp RikKoopman Ine Kempen Kristof Van Hoye KrisDe Baere Johan Zoonsl peter De Herdt 刘红(校) Experimental poultry Centre-province of Antwerp GeelBelgium MSD Animal Health Belgium BrusselsBelgium MSD Animal Health International BoxmeerNetherlands 默沙东动物保健品(上海)有限公司

本观察在一家禽研究中心进行的。共30568只蛋鸡,分48个单元饲养。富集型鸡笼和大笼散养系统养殖模式,48个单元中的32个单元被家禽红螨(pRM)自然侵染。52周龄时,所有母鸡都给予氟雷拉纳饮水给药。给药后,未观察到红螨的存在。由于所有禽... 详细信息

本观察在一家禽研究中心进行的。共30568只蛋鸡,分48个单元饲养。富集型鸡笼和大笼散养系统养殖模式,48个单元中的32个单元被家禽红螨(pRM)自然侵染。52周龄时,所有母鸡都给予氟雷拉纳饮水给药。给药后,未观察到红螨的存在。由于所有禽类日龄相同,并且所有48个单元的鸡群的日产蛋数据均有记录,这就提供了一个独特的机会来研究pRM对家禽生产成绩的影响。通过统计学方法,将肉眼未见红螨的单元和不同感染压力的单元鸡群的用药前后生产数据的变化情况进行了比较,生产标准曲线由育种公司提供作为参考。结果表明,与未被红螨侵染的对照组相比,本研究中1种或2种养殖模式下,受红螨重度侵染的母鸡,其给药后产蛋率、蛋重、产蛋总量、一级蛋比例、采食量和体重均显著增加。这些数据证实,pRM侵染会影响蛋鸡养殖场的主要盈利指标以及母鸡的健康状况。

关键词：皮刺螨属螨虫家禽母鸡生产成绩产蛋氟雷拉纳

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High doses of catecholamines activate glucose transport in human adipocytes independently from adrenoceptor stimulation or vanadium addition

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World Journal of Diabetes 2022年第1期13卷 37-53页

作者： Christian Carpéné nathalie Boulet Jean-Louis Grolleau nathalie Morin Institut des Maladies Métaboliques et Cardiovasculaires INSERM UMR1297Toulouse 31432France Team Dinamix Institute of Metabolic and Cardiovascular Diseases(I2MC)Paul Sabatier UniversityToulouse 31432France Department of plastic Surgery CHU RangueilToulouse 31059France Facultéde pharmacie de paris Universitéde ParisINSERM UMR-S 11393PHMParis 75006France

BACKGROUND When combined with vanadium salts,catecholamines strongly activate glucose uptake in rat and mouse *** To test whether catecholamines activate glucose transport in human *** The uptake of 2-deoxyglucose(2-DG)was measured in adipocytes isolated from pieces of abdominal subcutaneous tissue removed from women undergoing reconstructive *** approaches with amine oxidase inhibitors,adrenoreceptor agonists and antioxidants were performed to unravel the mechanisms of action of noradrenaline or adrenaline(also named epinephrine).RESULTS In human adipocytes,45-min incubation with 100μmol/L adrenaline or noradrenaline activated 2-DG uptake up to more than one-third of the maximal response to *** stimulation was not reproduced with millimolar doses of dopamine or serotonin and was not enhanced by addition of vanadate to the incubation *** various natural amines and adrenergic agonists tested,no other molecule was more efficient than adrenaline and noradrenaline in stimulating 2-DG *** effect of the catecholamines was not impaired by pargyline and semicarbazide,contrarily to that of benzylamine or methylamine,which are recognized substrates of semicarbazide-sensitive amine *** peroxide at 1 mmol/L activated hexose uptake but not pyrocatechol or benzoquinone,and only the former was potentiated by *** and the phosphoinositide 3-kinase inhibitor wortmannin inhibited adrenaline-induced activation of 2-DG *** High doses of catecholamines exert insulin-like actions on glucose transport in human *** submillimolar doses,vanadium did not enhance this catecholamine activation of glucose ***,this dismantles our previous suggestion to combine the metal ion with catecholamines to improve the benefit/risk ratio of vanadium-based antidiabetic approaches.

关键词： Human adipocytes Amine oxidases Insulin Diabetes Vanadium Obesity

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S1p: the elixir of life for naive T cells

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Cellular & Molecular Immunology 2018年第7期15卷 657-659页

作者： Michaël pérès Anne Montfort nathalie Andrieu-Abadie Céline Colacios Bruno Ségui INSERM UMR1037 Centre de Recherches en Cancérologie de ToulouseToulouse 31037France Facultéde pharmacie UniversitéToulouse III Paul-SabatierToulouse 31062France Laboratoire d’hématologie CHU de ToulouseToulouse 31059France Equipe Labellisée Ligue Contre Le Cancer Toulouse 31037France Correspondence:Professor B SéguiPhDINSERMUMR1037 CRCTCentre de Recherches en Cancérologie de Toulouse2 avenue Hubert CurienToulouse 31037France

During their life,T cells are constantly circulating throughout the ***-1-phosphate(S1p),a sphingolipid metabolite,triggers T cell egress from the thymus and secondary lymphoid organs(SLO)into the lymph and the *** phenomenon is dependent on the S1p gradient between lymphoid organs(including thymus and SLO)and the lymphatic and blood vessels,which exhibit low,intermediate and high S1p levels,respectively.T cells follow the S1p gradient via the engagement of the G-protein-coupled receptor S1p receptor 1(S1p1)expressed on T cells.1 S1p production is regulated by various sphingolipid-metabolizing *** sphingosine kinases 1 and 2(SKs),encoded by Sphk1 and Sphk2,phosphorylate the sphingosine(Sph)into ***,S1p can be dephosphorylated to Sph by S1p phosphatases 1 and 2,encoded by Sgpp1 and ***,S1p can be irreversibly degraded by the S1p Lyase(SpL),encoded by Sgpl1,into phosphoethanolamine and hexadecenal.

关键词： organs al. lymphoid

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Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes

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World Journal of Gastroenterology 2012年第14期18卷 1579-1589页

作者： Sébastien AB Roy Marie-Josée Langlois Julie C Carrier Franois Boudreau nathalie Rivard nathalie perreault Canadian Institutes of Health Research Team on Digestive Epithelium Department of Anatomy and Cell BiologyFaculty of Medicine and Health SciencesUniversité de SherbrookeSherbrooke J1H 5N4QCCanada Canadian Institutes of Health Research Team on Digestive Epithelium Service of GastroenterologyFaculty of Medicine and Health SciencesUniversité de SherbrookeSherbrooke J1H 5N4QCCanada

AIM:To investigate the impact of phosphatase and tensin homolog(pten) in the specification of intestinal enteroendocrine ***:Using the Cre/loxp system,a mouse with conditional intestinal epithelial pten deficiency was *** mutant mice and controls were sacrificed and small intestines collected for immunofluorescence and quantitative real-time polymerase chain *** was collected on 16 h fasted mice by cardiac ***-linked immunosorbent assay was used to measure blood circulating ghrelin,somatostatin(SST) and glucose-dependent insulinotropic peptide(GIp) ***:Results show an unexpected dual regulatory role for epithelial pten signalling in the specification/differentiation of enteroendocrine cell subpopulations in the small *** data indicate that pten positively regulates chromogranin A(CgA) expressing subpopulations,including cells expressing secretin,ghrelin,gastrin and cholecystokinin(CCK).In contrast,pten negatively regulates the enteroendocrine subtype specification of non-expressing CgA cells such as GIp and SST expressing ***:The present results demonstrate that pten signalling favours the enteroendocrine progenitor to specify into cells expressing CgA including those producing CCK,gastrin and ghrelin.

关键词： phosphatase and tensin homolog Enteroendocrine cells Intestinal epithelial cell specification Chromogranin A

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Double-ejection micro-cathode arc thruster applied to micro-satellite

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High Voltage 2023年第1期8卷 102-110页

作者： Jia Tian Wenzheng Liu Anton Nikiforov nathalie De Geyter Rino Morent School of Electrical Engineering Beijing Jiaotong UniversityBeijingChina Research Unit plasma Technology(RUpT) Department of Applied PhysicsGhent UniversityGhentBelgium

An innovative double-ejection micro-cathode arc thruster(AC_(d-μ)CAT),which consists of a cylindrical inner anode,a cylindrical outer cathode and two insulating sleeves(an inner insulating sleeve and an outer insulating sleeve),was *** differences in electrical characteristics,plasma parameters and propulsion performance between the newly proposed AC_(d-μ)CAT and a traditionalμCAT were *** results showed that compared to the traditionalμCAT structure,by using the AC_(d-μ)CAT,the peak value of produced thrust was increased 9.3 times,while the amplitude of the ion current and the ion-to-arc ratio were increased 5.4 and 5.9 times(from 1.2%to 7.1%),*** addition,data from Langmuir probe experiments indicated that peak values of the directional propagation speed and density of plasma plume were increased 3.1 times and 4.2 times,***,plasma plume directional ejection performance was also significantly *** study result will provide support for the development of a new-generationμCAT.

关键词： cylindrical inner outer

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Sinusoidal disturbance induced topology identification of Hindmarsh-Rose neural networks

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Science China(Information Sciences) 2016年第11期59卷 83-91页

作者： Junchan ZHAO M.A.AZIZ-ALAOUI Cyrille BERTELLE nathalie CORSON The School of Mathematics and Statistics Hunan University of Commerce Key Laboratory of Hunan province for Mobile Business Intelligence Hunan University of Commerce UNIHAVRE LMAH Normandie University 4. UNIHAVRE LITIS Normandie University

Topology identification of complex networks is an important problem. Existing research shows that the synchronization of network nodes is an obstacle in the identification of network topology. Identification of the structure of the network presents an interesting challenge during the synchronization of complex *** developed a new method using the sinusoidal disturbance to identify the topology when the complex network achieves synchronization. Compared with the disturbance of all the nodes, the disturbance of the key nodes alone can achieve a very good effect. Finally, numerical simulation data are provided to validate our hypothesis.

关键词： complex network topology identification sinusoidal disturbance persistently exciting condition Hindmarsh-Rose system

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The GATK joint genotyping workflow is appropriate for calling variants in RNA-seq experiments

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Journal of Animal Science and Biotechnology 2019年第3期10卷 811-816页

作者： Jean-Simon Brouard Flavio Schenkel Andrew Marete nathalie Bissonnette Sherbrooke Research and Development Centre Agriculture and Agri-Food CanadaSherbrookeQC J1M 0C8Canada Center of Genetic Improvement of Livestock University of GuelphGuelphON N1G 2W1Canada

The Genome Analysis Toolkit(GATK) is a popular set of programs for discovering and genotyping variants from next-generation sequencing *** current GATK recommendation for RNA sequencing(RNA-seq) is to perform variant calling from individual samples,with the drawback that only variable positions are *** 3.0 and above of GATK offer the possibility of calling DNA variants on cohorts of samples using the HaplotypeCaller algorithm in Genomic Variant Call Format(GVCF) *** this approach,variants are called individually on each sample,generating one GVCF file per sample that lists genotype likelihoods and their genome *** a second step,variants are called from the GVCF files through a joint genotyping *** strategy is more flexible and reduces computational challenges in comparison to the traditional joint discovery *** a GVCF workflow for mining SNp in RNA-seq data provides substantial advantages,including reporting homozygous genotypes for the reference allele as well as missing *** advantage of RNA-seq data derived from primary macrophages isolated from 50 cows,the GATK joint genotyping method for calling variants on RNA-seq data was validated by comparing this approach to a so-called "per-sample" *** addition,pair-wise comparisons of the two methods were performed to evaluate their respective sensitivity,precision and accuracy using DNA genotypes from a companion study including the same 50 cows genotyped using either genotyping-by-sequencing or with the Bovine SNp50 Beadchip(imputed to the Bovine high density).Results indicate that both approaches are very close in their capacity of detecting reference variants and that the joint genotyping method is more sensitive than the per-sample *** that the joint genotyping method is more flexible and technically easier,we recommend this approach for variant calling in RNA-seq experiments.

关键词： GATK GVCF Joint genotyping RNA-seq SNp

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