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Transmission of severe acute respiratory syndrome coronavirus 2 via fecal-oral:Current knowledge

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World Journal of Clinical Cases 2021年第28期9卷 8280-8294页

作者： Filipe Antônio França da silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Hanna Santos Marques Ronaldo Teixeira da silva Júnior Lorena Sousa de Carvalho Samuel de Sousa Cruz Gabriel Reis Rocha Gabriel Lima Correa Santos Kathlen Coutinho de souza Rebeca Gabrielle Almeida Maciel Daiana silva Lopes Natália Oliveira e silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45002175BahiaBrazil Departamento de Ciências Naturais Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45002175BahiaBrazil Departamento de Bioquímica e Biofísica Universidade Federal da BahiaSalvador 40.110-100BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 93 million cases and 2 million deaths in the ***-CoV-2 respiratory tract infection and its main clinical manifestations such as cough and shortness of breath are well known to the scientific ***,a growing number of studies have reported SARS-CoV-2-related gastrointestinal involvement based on clinical manifestations,such as diarrhea,nausea,vomiting,and abdominal pain as well as on the pathophysiological mechanisms associated with coronavirus disease ***,current evidence suggests SARS-CoV-2 transmission via the fecal-oral route and aerosol ***,studies have shown a high risk of contamination through hospital surfaces and personal ***,viable SARS-CoV-2 specimens can be obtained from aerosols,which raises the possibility of transmission through aerosolized viral particles from ***,the infection by SARS-CoV-2 via fecal-oral route or aerosolized particles should *** addition,a possible viral spread to sources of drinking water,sewage,and rivers as well as the possible risk of viral transmission in shared toilets become a major public health concern,especially in the least developed *** authors have emphasized the presence of viral RNA and even viable SARS-CoV-2 in human feces,studies on the possible fecal-oral coronavirus disease 2019 transmission become essential to understand better the dynamics of its transmission and,then,to reinforce preventive measures against this infection,leading to a more satisfactory control of the incidence of the infection.

关键词： COVID-19 SARS-CoV-2,Transmission Via fecal-oral

Surface runoff and soil erosion in a natural regeneration area of the Brazilian Cerrado

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International Soil and Water Conservation Research 2020年第2期8卷 124-130页

作者： Karina dos Santos Falcao elói Panachuki Felipe das Neves Monteiro Roniedison da silva Menezes Dulce B.B.Rodrigues Jullian souza Sone Paulo Tarso S.Oliveira Department of Agronomy State University of Mato Grosso do SulAgronomy DepartmentAquidauanaMS79200-000Brazil Federal University of Mato Grosso do Sul CxP 549Campo GrandeMS79070-900Brazil Department of Hydraulics and Sanitation Sao Carlos School of EngineeringUniversity of Sao PauloCxP.359Sao CarlosSP13566-590Brazil

The Brazilian Cerrado has been converted to farmland,and there is little evidence that this expansion will decrease,mainly because agriculture is the country's main economic ***,the impacts of intense modification of land use and land cover on surface runoff and soil erosion are still poorly un-derstood in this ***,we assessed surface runoff and soil loss in a woodland Cerrado area under a former pasture area,which was abandoned and has undergone a natural regeneration process for 7 years(RC).Its results were compared with that found in an undisturbed area of woodland Cerrado(Ce),40-month-old eucalyptus(3.0×1.8 m)(eU),and pasture under rotational grazing(PA).The study was conducted on Red Acrisol located in the Brazilian *** performed rainfall simulations on a plot of 0.7 m2 and using three constant rainfall intensities of 60,90,and 120 mm h-1 for 1 *** each rainfall intensity,we carried out four repetitions using different plots in each treatment,i.e.12 plots per treat-ment studied and 48 plots in *** noted that the soil physical properties were improved in RC and,consequently,water infiltration and soil erosion control;RC presented surface runoff and soil loss different from eU and PA(a=0.05).The macroporosity and soil bulk density affected surface runoff in RC and PA because the RC was used as pasture and is currently regenerating back to the cerrado *** the rainfall intensity increased,eU became more similar to PA,which showed the highest surface runoff and soil *** findings indicate that natural regeneration processes(pasture to the cerrado vegetation)tend to improve the soil ecosystem services,improving infiltration and reducing surface runoff and soil erosion.

关键词： Cerrado deforestation Forest regeneration Soil erosion

Virulence Factors and Biofilm Formation in Vancomycin Resistant enterococcus faecalis and enterococcus faecium Isolates in Brazil

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Advances in Microbiology 2023年第6期13卷 299-314页

作者： Bárbara de Azevedo Ramos Marília Manta Manta Sivoneide Maria da silva Rafael Artur Queiroz Cavalcanti de Sá Natália Lira de souza Henrique Douglas Melo Coutinho Márcia Vanusa da silva Túlio Diego da silva Maria Tereza dos Santos Correia Maria Betânia Melo de Oliveira Universidade Federal de Pernambuco Pernambuco Brazil Universidade Regional do Cariri Ceará Brazil Instituto de Tecnologia de Pernambuco Pernambuco Brazil

In this work, we evaluated biofilm formation of Vancomycin Resistant of e. faecalis and e. faecium (VRe) in different culture media and adhesion substrate, as well as cellular hydrophobicity and presence of virulence genes. For this, 35 isolates were collected from a public hospital in Recife, Pernambuco, Brazil and identified by the Matrix-Assisted Laser Desorption Ionization - Time-of-flight - Mass Spectrometry (MALDI-TOF-MS) technique. Biofilm formation was analyzed by the Crystal Violet (CV) method and fluorescence microscopy, cellular hydrophobicity by hydrocarbon interaction and the presence of gele, esp and asa1 genes by Polymerase Chain Reaction (PCR). 12 isolates were identified as e. faecalis and 23 as e. faecium. Most were obtained in Coronary Units (40.0%) and Intensive Care Unit (31.4%). e. faecium isolates were more resistant to the antibiotics tested than e. faecalis;however, e. faecalis stood out as a biofilm producer. Regarding the presence and gene frequency, it was observed that gele (54.3%) and esp (54.3%) were the most prevalent, followed by asa1 (22.9%). When comparing the gene frequency, it was observed that gele and esp were predominant (48.6% for both species), while asa1 was more frequent in e. faecalis (20.0%). The data presented here are worrying, because they reveal the virulence potential of isolates VRe, which contributes to the dissemination and persistence of these pathogens in the hospital environment.

关键词： Biofilm Cellular Hydrophobicity Gram-Positive Hospital environment Virulence Genes

Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures

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Bioactive Materials 2022年第10期7卷 173-186页

作者： Mauricio Gonçalves da Costa Sousa Gabriela Conceiçao de Almeida Danilo Cesar Martins Mota Rosiane Andrade da Costa Simoni Campos Dias Samuel Nunes Limberger Frank Ko Li Ting Lin evan FHaney Hashem etayash Beverlie Baquir Michael J.Trimble Ya Shen Zheng Su Markus Haapasalo Daniel Pletzer Letícia Chaves de souza Glaucia Schuindt Teixeira Renato M.silva Robert e.W.Hancock Octavio Luiz Franco Taia Maria Berto Rezende Post-Graduation Program in Genomic Sciences and Biotechnology Catholic University of BrasíliaBrasíliaBrazil Dentistry Course Catholic University of BrasíliaBrasíliaBrazil Post-Graduation Program in Health Sciences University of BrasíliaBrazil LIMA Chemistry InstituteUniversity of Brasília-UNBBrasíliaBrazil Animal Biology Department Campus Darcy RibeiroUniversidade de BrasíliaBrazil Department of Materials engineering Faculty of Applied ScienceUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of British ColumbiaVancouverBCCanada Department of Oral Biological and Medical Sciences Faculty of DentistryUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of OtagoDunedinNew Zealand Department of endodontics School of DentistryUniversity of Texas Health Science Center at HoustonHoustonUSA Department of Prosthesis Faculty of DentistryRio de Janeiro State UniversityRio de JaneiroBrazil Post-Graduation Program in Biotechnology Catholic University Dom BoscoCampo GrandeMato Grosso do SulBrazil

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for ***,different scaffolds were tested for use during the pulp revascularization process,including poly(vinyl alcohol)-PVA hydrogels or resins,collagen hydrogels and poly(vinyl alcohol)PVA/Chitosan(PVA/CS)*** on time to degradation(21 days),nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002(each at 50 mg/g).Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against enterococcus faecalis,Staphylococcus aureus and a multispecies oral biofilm,besides anti-inflammatory *** in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation,when compared to empty teeth ***,we designed a strong antimicrobial,immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.

关键词： Regenerative endodontics Scaffolds Nanofibers Host defense peptides Ciprofloxacin IDR-1002

Association between Helicobacterpylori, epstein-Barr virus, human papillomavirus and gastric adenocarcinomas

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World Journal of Gastroenterology 2018年第43期24卷 4928-4938页

作者： Carolina Rosal Teixeira de souza Marcelli Carolini Alves Almeida Andre Salim Khayat emerson Lucena da silva Paulo Cardoso Soares Luiz Claudio Chaves Rommel Mario Rodriguez Burbano Laboratory of Human Cytogenetics Institute of Biological Sciences Federal University of Para Belem Para 66075-110 Brazil Oncology Research Center Federal University of Para Joao deBarros Barreto University Hospital Belem Para 66073-000Brazil Ophir Loyola Hospital Belem Para 66060-281 Brazil

AIM To correlate Helicobacter pylori(H. pylori), epstein-Barr virus(eBV) and human papillomavirus(HPV) with gastric cancer(GC) cases in Pará State, *** Tissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori, and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement eber1 RNA was used to detect the presence of eBV in the samples, and the L1 region of HPV was detected using nested PCR. Positive HPV samples were genotyped and analyzed for e6 and e7 viral gene expression. Infections were also correlated with the clinical and pathological characteristics of the *** The majority of the 302 samples analyzed were obtained from men(65%) aged 55 years or older(67%) and were classified as the intestinal subtype(55%). All three pathogens were found in the samples analyzed in the present study(H. pylori : 87%, eBV: 20%, HPV: 3%). Overall, 78% of the H. pylori-positive(H. pylori+) samples were cag A +(H. pylori-cag A+), and there was an association between the cytotoxic product of this gene and eBV. Coinfections of H. pylori-cagA+ and eBV were correlated with the most advanced tumor stages. Although only 20% of the tumors were positive for eBV, infection with this virus was associated with distant metastasis. Only the HPV 16 and 18 strains were found in the samples, although no expression of the e6 and e7 oncoproteins was detected. The fundus of the stomach was the region least affected by the *** HPV was not involved in gastric tumorigenesis. Prophylactic and therapeutic measures against H. pylori and eBV may prevent the development of GC, especially the more aggressive forms.

关键词：乳头状瘤病毒协会腺癌胃区域检测测试设计 HPV eBV

Use of Agaricus bisporus mushroom in beef burgers:antioxidant,flavor enhancer and fat replacing potential

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食物生产加工与营养(英文) 2019年第1期1卷 64-78页

作者： Iliani Patinho erick Saldaña Miriam Mabel Selani Adriano Costa de Camargo Thais Cardoso Merlo Beatriz Schmidt Menegali Anna Paula de souza silva Carmen J.Contreras-Castillo Departamento de Agroindústria Alimentos e Nutrição(LAN)Escola Superior de Agricultura“Luiz de Queiroz”(ESALQ)Universidade de São Paulo(USP)Avenida Pádua Dias11PiracicabaSP 13418-900Brazil Centro de Ciências da Natureza Campus Lagoa do SinoUniversidade Federal de São CarlosRod.Lauri Simões de BarrosKm 12BuriSPBrazil Departamento de Ciencias Vegetales Facultad de Agronomía e Ingeniería ForestalPontificia Universidad Católica de ChileCasilla306-22 SantiagoChile Facultad de Ingeniería Agroindustrial Universidad Nacional de Moquegua(UNAM)MoqueguaPeru

This study aimed to evaluate the potential use of Agaricus bisporus mushroom as a natural antioxidant,fat/salt substitute and flavor enhancer in beef *** treatments were considered using a fractional factorial design(salt[0.5,1.25 and 2.0%],fat[10,15 and 20%]and mushroom content[0,15 and 30%]).Treatments were characterized by instrumental and sensory *** statistical design indicated that fat content had little influence on the *** principal component analysis showed that the incorporation of mushrooms and salt modified the texture,moisture and water *** stability decreased as the salt content increased,at a low-fat ***,the sensory profile was affected by the mushroom and salt contents,with the fat content exerting the least ***,mushroom incorporation in beef burger may be a feasible strategy to reduce the fat content of beef burgers.

关键词： Beef burger Agaricus bisporus Lipid oxidation Texture profile analysis Descriptive analysis

Synthesis, Characterization, and Study of PLGA Copolymer <i>in Vitro</i>Degradation

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Journal of Biomaterials and Nanobiotechnology 2015年第1期6卷 8-19页

作者： Anamaria Teodora Coêlho Rios silva Barbara Camilla Oliveira Cardoso Maria elisa Scarpelli Ribeiro e silva Roberto Fernando souza Freitas Ricardo Geraldo Sousa Polymer Science and Technology Laboratory Chemical Engineering Department School of Engineering Federal University of Minas Gerais Belo Horizonte Brazil

The poly(lactic-co-glycolic acid), known as PLGA, is one of the main bioreabsorbable polymers used in the field of medicine today. This copolymer is widely applied in sutures, devices geared toward the controlled release of medication, and the guided regeneration of bone tissue as it presents a short degradation time. This work aimed to synthesize the 82/18 PLGA (expressed by the mass ratio of D,L-lactide and glycolide, respectively), to characterize and study the in Vitro degradation in the form of rods in phosphate buffer solution (PBS). The copolymer was synthesized by opening the cyclic dimer rings of the monomers D,L-lactide and glycolide, in the presence of the tin octanoate initiator and of the lauryl alcohol co-initiator. The characterization of the copolymer and the follow-up of its in vitro degradation were studied using: Differential Scanning Calorimetry (DSC), Thermogravimetry (TG), Infrared Molecular Absorption Spectroscopy with Fourier Transform (FTIR), Rheometry, and Scanning electron Microscopy (SeM). Through these characterization techniques, it was possible to obtain the glass transition temperature, thermal stability, chemical composition, morphology, and molar mass of both the synthesized and the degraded copolymer. The molar mass of the synthesized copolymer was, approximately, 106 g·mol-1. The degradation rate of PLGA significantly increased from the 19th to the 28th day in PBS. After 28 days in PBS, the glass transition temperature and the molar mass reduced from 45°C to 17°C and from 1.5 × 106 g·mol-1?to 7.5 × 104?g·mol-1, respectively. The pH of the medium has a significant influence on the copolymer degradation profile. When it diminishes, it accelerates the degradation process, resulting in smaller PLGA polymer chains. This pH dependent degradation can be useful for drug release systems.

关键词： Synthesis Characterization In Vitro Degradation PLGA

Clusia nemorosa的叶提取物通过肾上腺素系统依赖机制对大鼠的镇痛作用(英文)

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中国天然药物 2013年第4期11卷 385-390页

作者： Jamylle Nunes de souza Ferro Juliane Pereira da silva Lucia Maria Conserva emiliano Barreto Laboratório de Biologia Celular Universidade Federal de AlagoasMaceió 57072-970ALBrazil Laboratório de Pesquisa em Química dos Produtos Naturais Universidade Federal de AlagoasMaceió 57072-970ALBrazil

Previous studies on the genus Clusia have shown anti-inflammatory and antiproliferative effects of the leaf extracts,but its antinociceptive activity has never been *** the present study,the antinociceptive activity of the hexane extract of the leaves of Clusia nemorosa ***,called HeCn,was *** activity was evaluated using acetic acid-induced writhing,formalin,and hot-plate *** experiments were carried out on male Swiss *** extract(1 400 mg kg 1),given by intraperitoneal route(i.p.) 1 h prior to testing,produced a dose-dependent inhibition on the number of abdominal writhings,with an ID50 of 62 mg kg *** addition,HeCn was able to prevent the visceral pain induced by acetic acid in mice for at least 2 *** the formalin test,HeCn had no effect in the first phase,but produced an analgesic effect on the second phase with the inhibition of licking *** HeCn did not show a significant analgesic effect in the hot plate *** with yohimbine attenuated the antinociceptive effect induced by HeCn in the writhing ***,naloxone,atropine,or haloperidol did not affect antinociception induced by HeCn in the writhing ***,these results indicate that the extract from the leaves of Clusia nemorosa produces antinociception in models of chemical pain through mechanisms that suggest participation of the adrenergic systems pathway.

关键词：实验药理学药理病理作用天然药物

Three-Dimensional Shear Wave Velocity Structure of the Northeastern Brazilian Lithosphere

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International Journal of Geosciences 2016年第6期7卷 849-872页

作者： Jorge Luis de souza Newton Pereira dos Santos Carlos da silva Vilar Coordena?ao de Geofísica MCTI/Observatório Nacional Rio de Janeiro Brazil Departamento de Física da Terra e do Meio Ambiente Universidade Federal da Bahia (UFBA) Brazil

A large number of Rayleigh wave dispersion curves recorded at twenty three seismic stations was used to investigate the 3-D shear wave velocity structure of the northeastern Brazilian lithosphere. A simple procedure to generate a three-dimensional image of Mohorovicic;discontinuity was applied in northeastern Brazil and the Moho 3-D image was in agreement with several isolated crustal thicknesses obtained with different geophysical methods. A detailed 3-D S wave velocity model is proposed for the region. In the crust, our model is more realist than CRUST2.0 global model, because it shows more details either laterally or in depth than global model, i.e., clear lateral variation and gradual increase of S wave velocity in depth. Down to 100 km depth, the 3-D S wave velocity model in northeastern Brazil is dominated by low velocities and this is consistent either with heat flow measurements or with measurements of the flexural strength of the lithosphere developed in the South American continent. Our 3-D S wave velocity model was also used to obtain the lithosphere thickness in each cell of the northeastern Brazil and the results were consistent with global studies about the Lithosphere-Asthenosphere Boundary worldwide.

关键词： Rayleigh Waves Group-Velocity Tomography Three-Dimensional Shear Wave Velocity Lithosphere Spatial Resolution Northeastern Brazil