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Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

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Chinese Journal of Polymer Science 2024年第5期42卷 604-611,I0007页

作者： Tatiana N.Nekrasova Andrei I.Fischer Natalia A.Nesterova Anatoliy V.Dobrodumov Anzhelika V.Garshinina Olga D.Shuvaeva natalya V.zakharova Evgenii F.Panarin Institute of Macromolecular Compounds Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia Smorodintsev Research Institute of Influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-soluble copolymers of p-methacrylamidobenzoic acid(MABA)with neutral comonomers(N-vinylpyrrolidone(VP),N-methyl-N-vinylacetamide(MVAA),N-methacryloyl glucosamine(MAG))and anionic comononer sodium styrene sulfonate(NaSS)were synthesized by radical *** interactions between the prepared copolymers and Tb^(3+)ions in aqueous solutions were studied;the significant influence of chemical structure of a comonomer on luminescence intensity of Tb^(3+)complexes with the copolymers was *** luminescence intensity of Tb^(3+)complexes with the copolymers containing N-vinylamide units(VP,MVAA)is three times more intense than that observed for the complexes between Tb^(3+)and MAG-containing *** the case of NaSS-containing copolymers,the luminescence intensity is controlled by the values of binding constants between Tb^(3+)and MABA and the content of MABA units in a *** studied copolymers and their complexes with Tb^(3+)have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.

关键词： Luminescence Water-soluble copolymers Lanthanide complexes Antiviral activity Cytotoxicity

Principal Features of Building Social Accounts Matrix and Improving Statistical Database for Eco-countries

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Chinese Business Review 2014年第10期13卷 611-623页

作者： Vilayat Valiyev, Malik Mehdiyev Arzu Suleymanov Elnur Alakbarov Rauf Musayev Elvira Nagoibaeva natalya zakharova Institute for Scientific Research on Economic Reforms (ISRER) Baku Azerbaijan Elvira Nagoibaeva Kyrgyz Economic University Bishkek Kyrgyzstan National Statistical Committee Bishkek Kyrgyzstan

With common borders of the population, total area, and GDP （PPP-based） of Economic Cooperation Organization （ECO） member states are estimated as 416 million persons, 7.9 million m2, and US$2.7 trillion respectively （2010 data）. Although heterogeneous in the extent, there is economic development, overall, with serious energy and transport-transit relations among countries that is reflected in growing trade turnover year-by-year. However, there are still rather unused resources and capacity in such areas of cooperation among countries as exchange of energy, transport services, agricultural and industrial goods, use of opportunities for tourism, promoting investment and innovation processes and other areas. Certainly, maximum and optimal use of these resources calls for availability of analytical means capable of accounting for relations both within member states and among them. The implementation of computable general equilibrium （CGE） modeling in each member state would thus be of great significance in resolution of these problems both in terms of accounting for input-output linkages within the countries as well as enabling impact of main trading partners and goods and services among countries. The analysis carried out indicates that there are a number of problems in application of CGE model in most of the member states. As such, input-output tables are not compiled in some countries, while in others despite the fact that these tables are compiled, there are no attempts to build the model, yet in other countries, even if the CGE model is implemented, there are difficulties in taking into account the real results in the face of serious problems related to improving national accounts system database. Summarizing these problems, it is possible to conclude that to ensure the application of a CGE model,there is a great need to work out procedures of compilation of a social accounts matrix （SAM） that lies on the basis of this model, for which the relevant statistics of a m

关键词： social accounts matrix (SAM) system of national accounts (SNA) input-output table CGE model ECO countries

Lower and upper motor neuron involvement and their impact on disease prognosis in amyotrophic lateral sclerosis

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Neural Regeneration Research 2022年第1期17卷 65-73页

作者： Maria N.zakharova Anna A. Abramova Research Center of Neurology MoscowRussia

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive muscle wasting,breathing and swallowing difficulties resulting in patient’s death in two to five years after disease *** amyotrophic lateral sclerosis,both upper and lower motor neurons of the corticospinal tracts are involved in the process of neurodegeneration,accounting for great clinical heterogeneity of the *** phenotype has great impact on the pattern and rate of amyotrophic lateral sclerosis progression and overall survival *** more homogenous patient groups in order to study the effects of drug agents on specific manifestations of the disease is a challenging issue in amyotrophic lateral sclerosis clinical *** amyotrophic lateral sclerosis has low incidence rates,conduction of multicenter trials requires certain standardized approaches to disease diagnosis and *** review focuses on the current approaches in amyotrophic lateral sclerosis classification and staging system based on clinical examination and additional instrumental methods,highlighting the role of upper and lower motor neuron involvement in different phenotypes of the *** demonstrate that both clinical and instrumental findings can be useful in evaluating severity of upper motor neuron and lower motor neuron involvement and predicting the following course of the *** disease heterogeneity in amyotrophic lateral sclerosis clinical trials could lead to study designs that will assess drug efficacy in specific patient groups,based on the disease pathophysiology and spatiotemporal *** clinical evaluation can be a sufficient screening method for dividing amyotrophic lateral sclerosis patients into clinical subgroups,we provide proof that instrumental studies could provide valuable insights in the disease pathology.

关键词： amyotrophic lateral sclerosis biomarkers of progression classification diagnostic biomarkers disease heterogeneity electrodiagnostic medicine electromyography motor neuron disease neuroimaging

Microstructure Characterization of a Biogenic Shale Gas Formation——Insights from the Antrim Shale,Michigan Basin

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Journal of Earth Science 2020年第6期31卷 1229-1240页

作者： Kouqi Liu Natalia zakharova Thomas Gentzis Adedoyin Adeyilola Humberto Carvajal-Ortiz Hallie Fowler Department of Earth and Atmospheric Sciences Central Michigan UniversityMount PleasantMI 48859USA Core Laboratories Reservoir Geology GroupHoustonTX 77040USA

Biogenic gas shales,predominantly microbial in origin,form an important class of organicrich shale reservoirs with a significant economic *** large gaps remain in the understanding of their gas generation,storage,and transport mechanisms,as previous studies have been largely focused on mature thermogenic shale *** this study,the pore structure of 18 Antrim Shale samples was characterized using gas adsorption(CO2 and N2).The results show that most of the Antrim Shale samples are rich in organic matter content(0.58 wt.%to 14.15 wt.%),with highest values found in the Lachine and Norwood *** from the Paxton Member,characterized by lower organic content,have smaller micropore surface area and micropore volume but larger meso-macro pore surface area and *** deconvolution results of the pore size distribution from the N2 adsorption indicate that all of the tested Antrim Shale samples have similar pore *** matter in the Antrim Shale hosts micro pores instead of meso-macro pores,while clay minerals host both micro and meso-macro *** pores play a primary role in the total *** biogenic Antrim Shale,therefore,has different pore structures from other well-studied thermogenic gas shales worldwide.

关键词： gas adsorption Antrim Shale biogenic shale organic matter

Intestinal microbiome analysis demonstrates azithromycin post-treatment effects improve when combined with lactulose

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World Journal of Pediatrics 2020年第2期16卷 168-176页

作者： Elpiniki Nikolaou Elena Kamilari Dragana Savkov Artemy Sergeev Irina zakharova Paris Vogazianos Marios Tomazou Athos Antoniades Christos Shammas Genetics Department AVVA Pharmaceuticals Ltd23A Spyrou Kyprianou4001 LimassolCyprus Research and Development MC Development LLCMoscowRussia Russian Medical Academy of Continuing Professional Education MoscowRussia Stremble Ventures Ltd LimassolCyprus

Background Next-generation sequencing has revolutionized our perspective on the gut microbiome composition,revealing the true extent of the adverse effects of *** impact of antibiotic treatment on gut microbiota must be considered and researched to provide grounds for establishing new treatment strategies that are less devastating on commensal *** study investigates the impact on gut microbiome when a commonly used antibiotic,azithromycin is administered,as well as uncovers the benefits induced when it is used in combination with lactulose,a prebiotic known to enhance the proliferation of commensal *** 16S rRNA gene sequencing analysis of stool samples obtained from 87 children treated with azithromycin in combination with or without lactulose have been ***'s gut microbial profile was established at the pre-and post-treatment *** Azithromycin caused an increase in the relative abundance of opportunistic pathogens such as Streptococcus that was evident 60 days after *** few days after treatment,children who also received lactulose started to show a higher relative abundance of saccharolytic bacteria such as Lactobacillus,Enterococcus,Anaerostipes,Blautia and Roseburia,providing a protective role against opportunistic *** addition,azithromycin-prebiotic combination was able to provide a phylogenetic profile more similar to the pre-treatment *** It is suggested that during azithromycin treatment,lactulose is able to reinstate the microbiome equilibrium much faster as it promotes saccharolytic microbes and provides a homeostatic effect that minimizes the opportunistic pathogen colonization.

关键词： Antibiotics Azithromycin Lactulose Microbiome Prebiotics

Hypoxic Preconditioning Eliminates Differences in the Innate Resistance of Rats to Severe Hypoxia

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Journal of Biomedical Science and Engineering 2016年第12期9卷 563-575页

作者： Elena I. zakharova Alexander M. Dudchenko Laboratory of General Pathology of Cardiorespiratory Systems Institute of General Pathology and Pathophysiology Moscow Russia

Hypoxic preconditioning is able to increase the body’s resistance to hypoxic/ischemic stress. Understanding how to apply the hypoxic response to initiate the protective mechanism of ischemic preconditioning is a high priority. However, the relationship between innate resistance to hypoxic stress and preconditioning efficiency of moderate hypoxia has been poorly studied. In our work, the efficiency of single moderate hypobaric hypoxia (HBH) for resistance to severe hypobaric hypoxia (SHBH) was studied on intact rats and those pre-tested under SHBH with low, intermediate and high resistance to hypoxia. HBH has a significant preconditioning action on the resistance to hypoxia over a wide range from 270 to 1464 s (4.5 to 24.5 min) and at the same time eliminates the differences in the endurance under SHBH between all rat groups. It is concluded that 1) HBH preconditioning efficiency does not depend on an innate resistance to SHBH and prior hypoxic experience of rats;and 2) the pretesting to severe hypoxia has no value for predicting the hypoxic preconditioning efficiency and study of adaptive mechanisms.

关键词： Resistance to Hypoxic Stress Severe Hypoxia Hypoxic Preconditioning

Enhanced potato tuber penetration of carboxin via ultradeformable liposomes

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Food Bioscience 2022年第6期50卷 201-209页

作者： Leysan A.Vasileva Gulnara A.Gaynanova Irek R.Nizameev Anna A.Petrova Marsil K.Kadirov Tatyana A.Gorshkova Lucia Ya.zakharova Arbuzov Institute of Organic and Physical Chemistry FRC Kazan Scientific Center of RAS8 Arbuzov str.Kazan420088Russian Federation Kazan Institute of Biochemistry and Biophysics FRC Kazan Scientific Center of RAS2/31 LobachevskyKazan420111Russian Federation

For the first time,a nanoformulated fungicide carboxin was obtained to solve the problem of infection of potato tubers with fungi *** of carboxin in ultra-deformable liposomes protects it from degradation by sunlight,increases solubility in water and penetration through potato *** fluorescent probes,rhodamine B and fluorescein,were used for optimization of original composition and for visualization of the transfersome localization in potato tubers,*** was encapsulated in lipid formulations with further evaluation of encapsulation efficiency,substrate release rate in vitro,and penetration through the Strat-M®membrane using Franz *** fluorescent microscopy,it was revealed that transfersomes penetrate through the periderm and enter cortex of potato *** the extraction it was shown that potato tubers weighing 100 g included 32 mg of carboxin after the transfersome *** inclusion of carboxin in transfersomes made it possible to increase the maximum concentration of carboxin in water from 0.57 mmol L−1 to 2.8–3.8 mmol L−1,i.e.,5–7 times.

关键词： Transfersomes Tween 20 Carboxin Adjuvant Potato tuber Franz cell

Pancreatic adenocarcinoma:Outstanding problems

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World Journal of Gastrointestinal Surgery 2012年第5期4卷 104-113页

作者： Olga P zakharova Grigory G Karmazanovsky Viacheslav I Egorov Department of Radiology Vishnevsky Institute of Surgery Hepatopancreatobiliary Surgery Vishnevsky Institute of Surgery

Pancreatic adenocarcinoma remains the fourth leading cause of cancer-related death and is one of the most aggressive malignant tumors with an overall 5-year survival rate of less than 4%.Surgical resection remains the only potentially curative treatment but is only possible for 15%-20% of patients with pancreatic *** 40% of patients have locally advanced nonresectable *** the past,determination of pancreatic cancer resectability was made at surgical *** development of modern imaging techniques has allowed preoperative staging of *** disagree about the criteria used to classify *** invasion in pancreatic cancers plays a very important role in determining treatment and *** is no evidence-based consensus on the optimal preoperative imaging assessment of patients with suspected pancreatic cancer and a unified definition ofborderline resectable pancreatic cancer is also ***,there is much room for improvement in all aspects of treatment for pancreatic ***-detector computed tomography has been widely accepted as the imaging technique of choice for diagnosing and staging pancreatic *** improved surgical techniques and advanced perioperative management,vascular resection and reconstruction are performed more frequently;patients thought once to be unresectable are undergoing radical ***,when attempting heroic surgery,a realistic approach concerning the patient's age and health status,probability of recovery after surgery,perioperative morbidity and mortality and life quality after tumor resection is necessary.

关键词： Pancreatic adenocarcinoma Multidetector computed tomography Borderline resectability Neo-adjuvant therapy Pancreaticoduodenectomy Vascular resection

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V_2O_5薄膜的电学性质及其应用

材料导报 2000年第10期14卷 36-38,10页

作者：童茂松戴国瑞高鼎三 Galina zakharova Olga Pozdniakova 吉林大学电子工程系集成光电子国家重点联合实验室长春130023 俄罗斯科学院乌拉尔分院固态化学研究所

综述了V_2O_5薄膜材料的结构、电学性质及其在电学中的应用。

关键词：电致变色敏感特性氧化钒薄膜结构电学性质