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Immune Profile of COVID-19 Survivors and Contacts During 9 Months:A Cohort Study

Infectious Diseases & Immunity 2023年第4期3卷 163-175页

作者： Valentina V.Tatarnikova natalya O.Kiseleva Valentina I.Dubrovina Vladimir A.Vishnyakov Darya D.Bryukhova Anna B.Pyatidesyatnikova Konstantin M.Korytov Munko B.Sharakshanov Sergey V.Balakhonov Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor Irkutsk 664047Russia

Background:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes a multi-organ systemic damage that can lead to long-term *** is known about the possible long-term effects of COVID-19 on circulating leukocyte kinetics and functional T-cell activity after *** investigate immune system changes,we designed a cohort ***:Volunteer screening and sample collectionwere performed at the Irkutsk Research Anti-Plague Institute of ***-four volunteers who have had COVID-19(recovered volunteers(RVs))betweenMay 2020 andMay 2021,33 volunteers who had been in contact with COVID-19 patients(contact volunteers(CVs))within the family setting but had not become ill,and 47 healthy volunteers(HVs)participated in the *** performed immunophenotyping of peripheral blood cells using flow *** was tested for SARS-CoV-2 anti-nucleocapsid immunoglobulin G antibodies by enzyme-linked immunosorbent assay(Ab(+),people with specific anti-N antibodies to SARS-CoV-2;Ab(−),people without specific antibodies).Results:There were no serious disturbances in the internal environment of the body in RVs and *** the evaluation of the general state of the immune system,the most informative indicator was the index of the ratio of neutrophils to bloodmonocytes–decreased on the 1st terms of observation(1 and 3 months post-symptom onset(PSO)/post-contact onset(PCO)),on average,1.3 times compared with HVs(8.6%(7.5%–10.5%),P<0.05),which recovered by the 6th month of *** of the cells responsible for the development of the adaptive immune response was noted only in RVs–increased B-lymphocyte content(HVs,9.1%(6.4%–10.2%))and immunoregulatory index ratio(HVs,1.6%(1.2%–2.1%))due to redistribution of T-helper and cytotoxic T cells throughout the follow-up period by an average of 1.2-fold compared with HVs(P<0.05).However,CVs with specific antibodies to SARS-CoV-2 N-protein also had an increased proportion of CD3−CD19+c

关键词： COVID-19 Flow cytometry Immunity Specific IgG T cells B cells

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Ecological Analysis of Species of the Genus Ferula L., Distributed in Navoi Region (Uzbekistan)

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American Journal of Plant Sciences 2023年第11期14卷 1248-1259页

作者： Abduraimov S. Ozodbek Shomurodov F. Habibullo Beshko Yu. natalya Maxmudov V. Azizbek Mavlanov J. Bekzod Allamurotov L. Akmal Sharipova K. Vasila Mamatkasimov T. Odilbek Abduraimov S. Azizbek Giyasiddinov L. Abduaziz Institute of Botany Academy Science of Republic of Uzbekistan Tashkent Uzbekistan Department of Medicinal Plants and Botany Faculty of Natural Science Gulistan State University Gulistan Uzbekistan Namangan Institute of Engineering and Technology Namangan Uzbekistan

Ferula L. is a perennial herbaceous plant belonging to the family Apiaceae Lindl. (Umbelliferae). Our research was carried out on the territory of Navoi region. The article presents an ecological analysis of the species of the Ferula L. in Navoi region. The species of genus Ferula mostly grows in mountainous regions and some are distributed in arid climates. According to that 15 species of the genus were found in the Navoi region, most of these species are considered to be plants that contain tar as well as have a strong medicinal property. In various parts of the world, different species of Ferula have been used in traditional medicine. In the course of studies, it was found that the species has medicinal, essential-oil, honey-juicy, nutritious, and fodder properties. According to ecological analysis, the genus Ferula grows Rocky, gravelly, fine-grained slopes and ridges of mountains, scree, rocks, outcrops of variegated rocks, rocky slopes, sandy, clay and gravelly deserts, foothill plains, fine-grained slopes. Considered rare, Ferula kyzylkumica Korovin is listed in the Red Book of the Republic of Uzbekistan, while Ferula nuratavica Pimenov is an endemic plant of the Aktau ridge.

关键词： Ferula L. Ecological Medicinal Navai Region Uzbekistan

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哈巴罗夫斯边疆区森林投资现状及趋势

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国际木业 2008年第5期38卷 10-10页

作者： Antonova natalya 俄罗斯经济研究院科学院远东地区分院

俄罗斯远东地区不但森林资源丰富，而且地理位置优越。该地区一向是俄岁斯通往亚太地区，开展对外经济联系的重要门户。其木材产量绝大部分用丁出口，而哈巴罗夫斯克是该地区主要的小材出口地区。

关键词：俄罗斯远东地区对外经济森林巴罗研究院科学院投资资源丰富

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Structures, cytotoxic and Na+,K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica

Structures, cytotoxic and Na+,K+-ATPase inhibitory activitie...

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中国化学会第十届全国天然有机化学学术会议

作者： Rong-Rong Zhang Hai-Yan Tian Ya-Fang Tan Tse-Yu Chung Xiao-Hui Sun Xue Xia Wen-Cai Ye David A.Middleton natalya Fedosova Mikael Esmann Jason T.C.Tzen Ren-Wang Jiang College of Pharmacy Jinan University Graduate Institute of Biotechnology National Chung-Hsing University Department of Chemistry University of Lancaster Department of Biomedicine Aarhus University

＜正＞Five new cardenolide lactates and one dioxane double linked cardenolide glycoside along with15 known compounds from the ornamental milkweed Asclepias *** structures and absolute stereochemistry were elucidated by NMR spectroscopic data,and were confirmed by ORD spectral data as well as X-ray crystallographic *** dioxane double linked cardenolide

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Ontogenetic Approach to the Study of Mechanisms of Copper-Induced Liver Fibrosis

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Advances in Aging Research 2017年第3期6卷 39-54页

作者： Anatoliy I. Bozhkov Olena M. Klimova Yuriy V. Nikitchenko Natalia I. Kurguzova Olena S. Linkevych Katherine M. Lebid Olena S. Protsenko natalya A. Remneva Ali M. M. Al-Bahadly Mohammad A. Y. Al-Begai Research Institute of Biology of V.N. Karazin Kharkov National University Kharkov Ukraine SI “Zaycev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine” Kharkov Ukraine Medical Department of V.N. Karazin Kharkov National University Kharkov Ukraine

On the model of Cu-induced liver fibrosis, the relationship between the activity of prooxidant-antioxidant system, immune system parameters, liver morphology and several physiological parameters (body temperature and performance ability of the animals, taking into account their ages) was investigated. Classical biochemical, immunological, histological and physiological methods of investigation were used. The subjects of the study were male Wistar rats of 3-month (young) and 20-month (old) age. For the induction of liver fibrosis, experimental animals were successively injected with copper sulfate (three times at intervals of 24 hours at a dose corresponding to 33% of the lethal one). It was shown that after five days of sulfate copper administration inflammatory reactions in the liver, damage of the vessel epithelium, an increase in collagen content, and other morphological changes were detected. At this time, the content of lipid hydroperoxides in the liver and blood serum was increased, the activity of a number of antioxidant enzymes was reduced, and the activity of aconitase was two times less compared to values in the control group. These changes correlated with a decrease in the amount and activity of phagocytic cells in the blood of experimental animals. Inhibition of the general metabolism was accompanied by a decrease in body temperature, loss of body weight and performance ability. The relationship between a specific metabolic pattern in animals with Cu-induced fibrosis was age-dependent. The formed specific adaptive metabolic pattern is unstable, and in the future it can be realized in one of three possible adaptive strategies, the choice of which is influenced by age.

关键词： Lipid Hydroperoxides Glutathione Peroxidase Aconitase Liver Fibrosis Ontogenesis

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可溶性GFRα1在肿瘤细胞神经周侵袭中的作用研究

可溶性GFRα1在肿瘤细胞神经周侵袭中的作用研究

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全国耳鼻咽喉头颈外科中青年学术会议

作者：何双八 Chun-Hao Chen natalya Chernichenko Richard Bakst 何时知 Sylvie Debordel 于振坤 Richard J Wong Department of Surgery Memorial Sloan-Kettering Cancer CenterNew YorkNY 北京同仁医院耳鼻咽喉头颈外科安徽省立医院耳鼻咽喉头颈外科 Department of Surgery Memorial Sloan—Kettering Cancer CenterNew YorkNY

目的头颈部肿瘤,特别是腺样囊腺癌常呈现出嗜神经性侵袭,这种肿瘤细胞的神经周侵袭(Perineural Invasion,PNI)是指特定的肿瘤细胞侵入、包绕并沿着神经侵袭而导致肿瘤的转移扩散,是一种肿瘤细胞侵犯神经的过程,也称为肿瘤的嗜神经性扩...

目的头颈部肿瘤,特别是腺样囊腺癌常呈现出嗜神经性侵袭,这种肿瘤细胞的神经周侵袭(Perineural Invasion,PNI)是指特定的肿瘤细胞侵入、包绕并沿着神经侵袭而导致肿瘤的转移扩散,是一种肿瘤细胞侵犯神经的过程,也称为肿瘤的嗜神经性扩散或神经周扩散。临床上,高达30%-80%的

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科学修辞学的地位问题

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当代修辞学 2024年第6期 1-10页

作者：格里夫佐娃·伊丽娜·尼古拉耶夫娜科兹洛娃·娜塔莉亚·尤里耶夫娜姜宏张凌闻莫斯科国立师范大学社会人文教育学院俄罗斯莫斯科复旦大学外文学院上海200433

文章从逻辑学阐释中发生的变化(即“逻辑学形象”变化)对科学修辞学的形成所产生的影响,以及形象性在科学话语中的作用两个方面探讨了科学修辞学的地位问题。由此得出结论:能否对科学进行修辞学阐释,在很大程度上取决于怎么理解科学逻... 详细信息

文章从逻辑学阐释中发生的变化(即“逻辑学形象”变化)对科学修辞学的形成所产生的影响,以及形象性在科学话语中的作用两个方面探讨了科学修辞学的地位问题。由此得出结论:能否对科学进行修辞学阐释,在很大程度上取决于怎么理解科学逻辑学。在这种情况下,建议将非形式逻辑视为论证理论或论证逻辑的一种变体。由此引发了对整体科学中论证性质的重新认识、对论证逻辑而非演绎逻辑的重视,以及对以逻辑蕴含关系为中心的严格形式论证方法(作为论证逻辑特例)的关注。通过分析形象性在科学话语中的作用,可以揭示修辞学地位与形象性感知之间的矛盾:尽管修辞学机制在科学交际中的应用不可避免,但多个世纪以来,修辞学一直受到科学的贬斥。研究表明,对科学文本中使用修辞元素的消极态度有着深厚的历史根源,可以追溯到古代哲学思想,即苏格拉底对演说术和论辩术的批评。对科学话语中形象性的功能展开分析可以发现,形象性是专业交际和知识理论模型构建都不可或缺的机制。

关键词：科学修辞学科学逻辑学非形式逻辑逻辑学形象论证逻辑科学话语话语行为形象性交际

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Evaluating chromosomal segregation in a family where both spouses carry an autosomal translocation

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Reproductive and Developmental Medicine 2023年第3期7卷 189-192页

作者： Irina L.Puppo Ziravard N.Tonyan Alsu F.Saifitdinova Julia A.Loginova Anna A.Kinunen Alisa N.Panina Julia R.Pastuhova Olga A.Leonteva Olga G.Chiryaeva Olga V.Malysheva Oleg S.Glotov Irina V.Poliakova Andrey V.Tikhonove Tatyana V.Vavilova Irina L.Menshikova Elvira V.Isakova Andrey S.Glotov natalya K.Bichevaya International Centre for Reproductive Medicine Saint-Petersburg 197350Russia Department of Laboratory Medicine and Genetics Almazov National Medical Research CentreSaint-Petersburg197341Russia Department of Genomic Medicine D.O.Ott's Institute of ObstetricsGynecologyand ReproductologySaint-Petersburg 199034Russia Department of Biology.Herzen State Pedagogical University of Russia Saint-Petersburg 191186Russia DiaCarta Inc.2600 Hilltop DriveRichmondCA 94806 St.Petersburg Centre for Medical Genetics Saint Petersburg194044Russia Department of ExperimentalMedical Virology MolecularGenetics and Biobankingof Pediatric Researchand Clinical Center for Infectious DiseasesSaint-Petersburg 197022Russia Medical institute of Surgut State University Surgut 628403 Russia CerbaLab Ltd. Saint-Petersburg 199106Russia

Autosomal reciprocal translocations represent exchanges of chromatin fragments between non-homologous *** are facilitated by the creation of quadrivalent structures during the first meiotic division,which are characterized by the length of the translocated and centric segments,asymmetry,and the presence of terminal breakpoints,all of which may impact segregation ***,we report a rare case of multiple reciprocal translocations within a single *** includes the evaluation of the translocations in each of the spouses and an analysis of their chromosome segregation patterns as determined by the constellation of universal characteristics in each of their *** obtained results will be of interest to fundamental biology,as they will expand the understanding of the factors affecting chromosome segregation during meiosis.

关键词： Embryo viability Genetic counseling Pre-implantation genetic testing Quadrivalent characteristics

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