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Electroacupuncture alleviates stress-induced visceral hypersensitivity through an opioid system in rats

World journal of Gastroenterology 2012年第48期18卷 7201-7211页

作者： Yuan-Yuan Zhou natalie j wanner Ying Xiao Xuan-Zheng Shi Xing-Hong jiang jian-Guo Gu Guang-Yin Xu Institute of Neuroscience and Department of Neurobiology Key Laboratory of Pain Research and Therapy Soochow Uni-versity Suzhou 215123 Jiangsu Province China Divisionof Gastroenterology Department of Internal Medicine University of Texas Medical Branch Galveston TX 77555-0655United States Department of Anesthesiology and the GraduateProgram in Neuroscience University of Cincinnati College ofMedicine Cincinnati OH 45267-0531 United States

AIM:To investigate whether stress-induced visceral hypersensitivity could be alleviated by electroacupuncture(EA) and whether EA effect was mediated by endogenous ***:Six to nine week-old male SpragueDawley rats were used in this *** hypersensitivity was induced by a 9-d heterotypic intermittent stress(HIS) protocol composed of 3 randomly stressors,which included cold restraint stress at 4?℃ for 45 min,water avoidance stress for 60 min,and forced swimming stress for 20 min,in adult male *** extent of visceral hypersensitivity was quantified by electromyography or by abdominal withdrawal reflex(AWR) scores of colorectal distension at different distention pressures(20 mmHg,40 mmHg,60 mmHg and 80 mmHg).AWR scores either 0,1,2,3 or 4 were obtained by a blinded *** or sham EA was performed at classical acupoint ST-36(Zu-San-Li) or BL-43(Gao-Huang) in both hindlimbs of rats for 30 ***(NLX) or NLX methiodide(m-NLX) was administered intraperitoneally to HIS rats in some ***:HIS rats displayed an increased sensitivity to colorectal distention,which started from 6 h(the first measurement),maintained for 24 h,and AWR scores returned to basal levels at 48 h and 7 d after HIS compared to pre-HIS baseline at different distention *** AWR scores before HIS were 0.6 ± 0.2,1.3 ± 0.2,1.9 ± 0.2 and 2.3 ± 0.2 for 20 mmHg,40 mmHg,60 mmHg and 80 mmHg distention pressures,*** hours after termination of the last stressor,the AWR scores were 2.0 ± 0.1,2.5 ± 0.1,2.8 ± 0.2 and 3.5 ± 0.2 for 20 mmHg,40 mmHg,60 mmHg and 80 mmHg distention pressures,*** given at classical acupoint ST-36 in both hindlimbs for 30 min significantly attenuated the hypersensitive responses to colorectal distention in HIS rats compared with sham EA treatment [AWRs at 20 mmHg:2.0 ± 0.2 vs 0.7 ± 0.1,P = 4.23 711 E-4;AWRs at 40 mmHg:2.6 ± 0.2 vs 1.5 ± 0.2,P = 0.00 163;AWRs at 60 mmHg:3.1 ± 0.2 vs 1.9 ± 0.1,P = 0.003;AWRs at 80

关键词： Irritable bowel syndrome Visceral pain Electroacupuncture Opioid pathway Stress

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Extracellular vesicles and angiotensin-converting enzyme 2 in COVID-19 disease

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BIOCELL 2024年第1期48卷 1-8页

作者： YU LIU ROBERT j.KASPER natalie j.S.CHOI Department of Family and Community Medicine Northwestern University Feinberg School of MedicineChicagoIllinois

Extracellular vesicles(EVs)are membranous vesicular structures released from almost all eukaryotic cell types under different physiological or pathological *** evidence demonstrates that EVs can serve as mediators of intercellular communication between donor and recipient cells or microorganism-infected and noninfected *** disease 2019(COVID-19)disease is caused by infection of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)of host cells in the respiratory system and various extra-pulmonary tissue/organs,resulting in complications of multiple organ *** the cell surface receptor,angiotensin-converting enzyme 2(ACE2)mediates cellular entry of SARS-CoV-2 into the host cells in patients with *** studies have found that ACE2 can be released with EVs,which have been shown to interfere with the entry of the virus into host cells and thus may be involved in COVID-19 *** addition,ACE2,neprilysin(NEP),and thimet oligopeptidase(TOP)are the key enzymes that regulate angiotensin metabolism by converting angiotensin II or angiotensin I to angiotensin 1-7,the latter of which has protective effects in counterbalancing the harmful effects of angiotensin II in COVID-19 *** review summarizes the recent research progress regarding EV-associated ACE2,NEP,and TOP and the perspectives of their potential involvement in the pathophysiology of COVID-19 disease.

关键词： Extracellular vesicles COVID-19 Angiotensin converting enzyme 2 Thimet oligopeptidase

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Association between Mental Disorders and Subsequent Medical Conditions

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四川生理科学杂志 2024年第4期46卷 217-217页

作者： natalie C Momen From the National Center for Register-based Research (N.C.M. O.P.-R. E.A. M.K.C. S.D. J.-C.P.G.D. T.M.L. P.B.M. K.L.M. C.B.P. L.V.P. B.V. N.W. J.J.M.) Center for Integrated Register-based Research (E.A. P.B.M. C.B.P.) the Departments of Biomedicine-Human Genetics (A.D.B.) and Public Health (M.K.C. M.F.-G. K.M.I. M.V. A.P.) the Center for Integrative Sequencing (A.D.B.) and the Big Data Center for Environment and Health (C.B.P.) Aarhus University the Lundbeck Foundation Initiative for Integrative Psychiatric Research (E.A. A.D.B. S.D. O.M. P.B.M. K.L.M. M.N. C.B.P. L.V.P. A.J.S. B.V. T.W.) the Center for Genomics and Personalized Medicine (A.D.B.) the Department of Neurology (J.-C.P.G.D.) and the Research Unit Department of Psychosis (O.M.) Aarhus University Hospital and the Research Unit for General Practice (M.F.-G. A.R.R. M.V. A.P.) Aarhus the Copenhagen Research Center for Mental Health Mental Health Center Copenhagen Copenhagen University Hospital (M.E.B. M.N. H.J.S.) Psychiatric Center Copenhagen (L.V.K.) Faculty of Health and Medical Sciences (L.V.K.) the Department of Clinical Medicine (T.W.) and the Lundbeck Foundation GeoGenetics Center GLOBE Institute (T.W.) University of Copenhagen Copenhagen and the Institute of Biological Psychiatry Mental Health Center Sankt Hans Mental Health Services Capital Region Roskilde (A.J.S. T.W.) - all in Denmark the National Drug and Alcohol Research Centre University of New South Wales Sydney (L.D.) the Department of General Practice Melbourne Medical School University of Melbourne Melbourne VIC (J.M.G.) and the Queensland Brain Institute (C.C.W.L. S.S. J.J.M.) Queensland Centre for Mental Health Research the Park Centre for Mental Health (C.C.W.L. S.S. T.J.S. H.A.W. J.J.M.) and the School of Public Health Faculty of Medicine (H.A.W.) University of Queensland Brisbane - all in Australia the Departments of Psychology (P.J.) and Developmental Psychology (A.M.R.) Heymans Institute and the I

Background:Persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical ***:We used a population-based cohort from Danish national registries that included data on more than 5.9 million persons born in Denmark from 1900 through 2015 and followed them from 2000 through 2016,for a total of 83.9 million person-years.

关键词： conditions milli population

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Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi jawaun j.Harris Kaitlyn Storm Edwin j.Yoo Ariel Isser Vivek P.jani natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng jonathan P.Schneck jordan j.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

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Overcoming EGFR-TKI resistance by targeting the tumor microenvironment

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Chinese Medical journal Pulmonary and Critical Care Medicine 2024年第3期2卷 151-161页

作者： jinsong Zhang natalie Vokes Man Li jiachen Xu Hua Bai jie Wang Zhijie Wang jianjun Zhang State Key Laboratory of Molecular Oncology CAMS Key Laboratory of Translational Research on Lung CancerDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17PanjiayuannanliChaoyang DistrictBeijing 100021China Department of Thoracic/Head and Neck Medical Oncology Department of Genomic MedicineThe Lung Cancer Interception ProgramThe Lung Cancer Genomics ProgramThe University of TexasMD Anderson Cancer CenterHoustonTX 77030USA Shanxi Cancer Hospital(Shanxi Cancer Institute) Cancer Hospital of Chinese Academy of Medical Sciences Shanxi HospitalShanxi Medical University Affiliated HospitalTaiyuanShanxi 030013China

Targeted therapy has ushered in a new era of precision medicine for non-small cell lung cancer(NSCLC).Currently,epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKIs)stand as the recommended first-line therapy for advanced NSCLC harboring sensitive EGFR ***,most patients inevitably confront the challenge of drug *** phenomenon arises not solely from intrinsic alterations within cancer cells but also from the intricate dynamics of the tumor microenvironment and the complex interactions that occur between cancer cells and their immediate *** review consolidates the current knowledge regarding EGFR-TKI resistance mechanisms,with a specific emphasis on unraveling the role played by the tumor *** addition,the review delineates strategic approaches to surmount TKI resistance,thereby enriching the understanding of the interplay between therapeutic agents and the intricate milieu surrounding cancer cells.

关键词： Non-small cell lung cancer Epidermal growth factor receptor Tumor microenvironment Epidermal growth factor receptor-tyrosine kinase inhibitor Drug resistance

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The impact of vitamin D deficiency on neurogenesis in the adult brain

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Neural Regeneration Research 2017年第3期12卷 393-394页

作者： natalie j.Groves Thomas H.j.Burne Queensland Brain Institute The University of QueenslandSt.LuciaAustralia Queensland Centre for Mental Health Research The Park Centrefor Mental HealthWacolAustralia

There is increasing evidence from epidemiological studies indicating that vitamin D deficiency during adulthood is associated with adverse brain outcomes in humans（Ginde et al.,2009）and rodents（Groves et al.,2014）... 详细信息

关键词： The impact of vitamin D deficiency on neurogenesis in the adult brain GAD

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Associations of self-reported and device-assessed physical activity with fatigue,quality of life,and sleep quality in adults living with and beyond cancer

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journal of Sport and Health Science 2023年第6期12卷 664-673,F0003页

作者： Phillippa Lally natalie Ella Miller Claire Lawrence Rebecca j Beeken Abigail Fisher Department of Behavioural Science and Health University College LondonLondon WC1E 6BTUK Department of Psychology University of SurreyGuildford GU27XHUK Leeds Institute of Health Sciences Leeds LS29NLUK

Background Greater physical activity is associated with improved outcomes in people living with and beyond ***,most studies in exercise oncology use self-reported measures of physical *** have explored agreement between self-reported and device-based measures of physical activity in people living with and beyond *** study aimed to describe physical activity in adults affected by cancer across self-reported and device-assessed activity,to explore levels of agreement between these measures in terms of their utility for categorizing participants as meeting/not meeting physical activity guidelines,and to explore whether meeting guidelines is associated with fatigue,quality of life,and sleep *** A total of 1348 adults living with and beyond cancer from the Advancing Survivorship Cancer Outcomes Trial completed a survey assessing fatigue,quality of life,sleep quality,and physical *** Godin-Shephard Leisure-Time Physical Activity Questionnaire was used to calculate a Leisure Score Index(LSI)and an estimate of moderate-to-vigorous physical activity(MVPA).Average daily steps and weekly aerobic steps were derived from pedometers worn by *** The percentage of individuals meeting physical activity guidelines was 44.3%using LSI,49.5%using MVPA,10.8%using average daily steps,and 28.5%using weekly aerobic ***(Cohen'sκ)between self-reported and pedometer measures ranged from 0.13(LSI *** daily steps)to 0.60(LSI ***).After adjusting for sociodemographic and health-related covariates,meeting activity guidelines using all measures was associated with not experiencing severe fatigue(odds ratios(ORs):1.43–1.97).Meeting guidelines using MVPA was associated with no quality-of-life issues(OR=1.53).Meeting guidelines using both self-reported measures were associated with good sleep quality(ORs:1.33–1.40).Conclusion Less than half of all adults affected by cancer are meeting physical activity guidelines,

关键词： Cancer survivorship Fatigue Physical activity Quality of life SleepTagedAPTARAEnd

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Galvanically induced potentials to enable minimal tribochemical wear of stainless steel lubricated with sodium chloride and ionic liquid aqueous solution

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Friction 2018年第2期6卷 230-242页

作者： Tobias AMANN Felix GATTI natalie OBERLE Andreas KAILER jürgen RüHE Fraunhofer Institute for Mechanics of Materials IWM Institute for Macromolecular Chemistry University of Freiburg IMTEK-Department of Microsystems Engineering University of Freiburg

The effect of galvanically induced potentials on the friction and wear behavior of a 1 RK91 stainless steel regarding to tribocorrosion was investigated using an oscillating ball-on-disk tribometer equipped with an electrochemical cell. The aim of this investigation is to develop a water-based lubricant. Therefore 1 molar sodium chloride(NaCl) and 1% 1-ethyl-3-methylimidazolium chloride [C_2 mim][Cl] water solutions were used. Tribological performance at two galvanically induced potentials was compared with the non-polarized state: cathodic potential-coupling with pure aluminum- and anodic potential-coupling with pure copper. Frictional and electrochemical response was recorded during the tests. In addition, wear morphology and chemical composition of the steel were analyzed using scanning electron microscopy(SEM) and X-ray photoelectron spectroscopy(XPS), respectively. The galvanically induced cathodic polarization of the stainless steel surface results in electrochemical corrosion protection and the formation of a tribolayer. Cations from the electrolyte(sodium Na^+ and 1-ethyl- 3-methylimidazolium [C_2 mim]^+) interact and adhere on the surface. These chemical interactions lead to considerably reduced wear using 1 NaC l(86%) and 1% 1-ethyl-3-methylimidazolium chloride [C_2 mim][Cl](74%) compared to the nonpolarized system. In addition, mechanical and corrosive part of wear was identified using this electrochemical technique. Therefore this method describes a promising method to develop water-based lubricants for technical applications.

关键词： sliding wear tribochemistry potential controlled friction and wear galvanic coupling ionic liquids tribolayer formation

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Ubiquitin homeostasis disruption, a common cause of proteostasis collapse in amyotrophic lateral sclerosis?

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Neural Regeneration Research 2022年第10期17卷 2218-2220页

作者： Christen G.Chisholm jeremy S.Lum natalie E.Farrawell justin j.Yerbury Illawarra Health and Medical Research Institute/Molecular Horizons and School of Chemistry and Molecular Bioscience Science Medicine and Health FacultyUniversity of WollongongNorthfields AveWollongongNSWAustralia

Amyotrophic lateral sclerosis(ALS)is associated with proteostasis collapse:ALS is an unrelenting neurodegenerative disease that is characterized by the loss of motor neurons in the brain and spinal cord,resulting in the progressive atrophy,and eventual paralysis,of skeletal *** due to respiratory failure usually occurs within 2-5 years from symptom *** 90%of ALS cases are of unknown etiology and are termed sporadic ALS(sALS).The remaining 10%of ALS cases present with a family history(familial ALS;fALS)and are associated with genetic mutations in a range of over 20 functionally heterogeneous *** of disease origin,the pathological hallmark of ALS is the accumulation of ubiquitylated protein inclusions in motor neurons and surrounding glial *** presence of these inclusions,compromised largely of misfolded and aggregated proteins,implies a collapse in *** refers to the maintenance of the proteome in a state of balance or equilibrium so that a cell can perform its proper function.

关键词： stasis homeostasis collapse

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Ultraviolet light exposure and its penetrance through the eye in a porcine model

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International journal of Ophthalmology(English edition) 2023年第2期16卷 172-177页

作者： Hideki Fukuoka Helena E.Gali jennifer j.Bu Ruti Sella natalie A.Afshari Shiley Eye Institute Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCA 92093USA

AIM:To determine the amount of ultraviolet(UV)light irradiance that various layers of the eye receive as sunlight passes through the eye,and to investigate the protective benefits of UV light-blocking contact ***:Twenty-four porcine eyes were prepared in one of three ways:isolated cornea,cornea and lens together,or whole eye *** light irradiance was measured with a UV-A/B light meter before and after the eye preparations were placed over the meter to measure UV light penetration in each eye *** the whole eye preparation,a hole was placed in the fovea to measure light as it passed through the ***,UVprotective contact lenses were placed over the structures,and UV light penetrance was *** of UV light exposure were taken outdoors at various locations and ***:Cornea absorbed 63.56%of UV light that reached the *** and lens absorbed 99.34%of UV *** eye absorbed 99.77%of UV *** UV-protective contact lenses were placed,absorption was 98.90%,99.55%,and 99.87%,*** light exposure was dependent on directionality and time of day,and was greatest in areas of high albedo that reflect significant amounts of light,such as a ***:Cornea absorbs the majority of UV light that reaches the eye in this ***-protective contact lenses reduce UV exposure to the *** with high albedo expose the eye to higher levels of UV light.

关键词： ultraviolet light penetrance contact lens cornea lens

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