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Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi Jawaun J.Harris Kaitlyn Storm Edwin J.Yoo Ariel Isser Vivek P.Jani natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng Jonathan P.Schneck Jordan J.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

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CO2 activation on bimetallic CuNi nanoparticles

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Progress in Natural Science:Materials International 2016年第5期26卷 487-492页

作者： natalie Austin Brandon Butina Giannis Mpourmpakis Department of Chemical Engineering University of Pittsburgh

Density functional theory calculations have been performed to investigate the structural, electronic, and CO2adsorption properties of 55-atom bimetallic Cu Ni nanoparticles（NPs） in core-shell and decorated architectures,as well as of their monometallic counterparts. Our results revealed that with respect to the monometallic Cu55and Ni55parents, the formation of decorated Cu12Ni43and core-shell Cu42Ni13are energetically favorable. We found that CO2chemisorbs on monometallic Ni55, core-shell Cu13Ni42, and decorated Cu12Ni43and Cu43Ni12,whereas, it physisorbs on monometallic Cu55and core-shell Cu42Ni13. The presence of surface Ni on the NPs is key in strongly adsorbing and activating the CO2molecule（linear to bent transition and elongation of C=O bonds）. This activation occurs through a charge transfer from the NPs to the CO2molecule, where the local metal d-orbital density localization on surface Ni plays a pivotal role. This work identifies insightful structureproperty relationships for CO2activation and highlights the importance of keeping a balance between NP stability and CO2adsorption behavior in designing catalytic bimetallic NPs that activate CO2.

关键词： Density functional theory Alloys CO2adsorption Catalysis Stability

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Sexual selection and environmental change:what do we know and what comes next?

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Current Zoology 2021年第3期67卷 293-298页

作者： natalie Pilakouta Murielle Aluimd School of Biological Sciences University of AberdeenAberdeen AB243FXUK Department of Ecology and Genetics Animal EcologyEvolutionary Biology Centre(EBC)Uppsala UniversityNorbyvagen 18D 75236 UppsalaSweden

Anthropogenic environmental change is the most significant threat to biodiversity in the 21st *** populations are experiencing rapid changes in their biotic and abiotic environment,which impose novel selection pressures on organisms and increase the risk of population *** is thus a pressing need to understand what affects the capacity of populations to respond and adapt to environmental *** behavioral traits are very labile,they provide a means of rapidly responding to environmental change(Sih et al.2011;Tuomainen and Candolin 2011).

关键词： al. selection threat

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LVMH路威酪轩集团董事会主席兼CEO 伯纳德·阿尔诺:我们的每项计划都着眼于未来

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商业周刊（中文版） 2024年第12期 42-49页

作者： BRAD STONE ANGELINA RASCOUET RUVEN AFANADOR(摄影) Jeannette Neumann natalie Wong Daniela Wei Shirley Zhao 杨飞(译) 不详

LVMH路威酪轩集团已将全球众多奢侈品牌收入囊中,如今又成为2024年巴黎奥运会的最大赞助商。阿尔诺认为,该集团作为法国文化旗手,有责任让奥运会取得成功每周六早上,伯纳德·阿尔诺(BernardArnault)都会在副手、保镖和子女轮流担当的随... 详细信息

LVMH路威酪轩集团已将全球众多奢侈品牌收入囊中,如今又成为2024年巴黎奥运会的最大赞助商。阿尔诺认为,该集团作为法国文化旗手,有责任让奥运会取得成功每周六早上,伯纳德·阿尔诺(BernardArnault)都会在副手、保镖和子女轮流担当的随从陪同下,花几个小时的时间巡查他供奉着手袋、时装、珠宝和昂贵手表的时尚神殿。

关键词：集团董事会奢侈品牌阿尔诺奥运会伯纳德 CEO 赞助商

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Role of serotonin in modulating the development and function of adult-born neurons in the olfactory bulb

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Neural Regeneration Research 2022年第6期17卷 1253-1254页

作者： natalie Fomin-Thunemann Olga Garaschuk Department of Biomedical Engineering Boston UniversityBostonMAUSA Institute of Physiology Department NeurophysiologyEberhard Karls University of TübingenTübingenGermany

The neuromodulatory transmitter serotonin(5-hydroxytryptamine,5-HT)is synthesized by neurons located in the brainstem,which project more or less densely to the entire central nervous system(Charnay and Leger,2010).Serotonin regulates a variety of physiological functions,including food intake,reward,reproduction,sleep-wake cycle,memory,cognition,emotion,and mood(Charnay and Leger,2010).

关键词： serotonin intake modulator

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Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben Susan Varghese Carmen Behrens Tina McDowell Luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning Le natalie I Vokes Chao Cheng John V.Heymach Don L.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

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Responses to threat in a freshwater invader： longitudinal data reveal personality, habituation, and robustness to changing water temperatures in the ＂killer shrimp＂ Dikerogammarus villosus （Crustacea： Amphipoda）

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Current Zoology 2016年第1期62卷 45-51页

作者： Mark BRIFFA natalie JONES Calum MACNEIL Marine Biology and Ecology Research Centre School of Marine Science & Engineering Plymouth University Plymouth PL4 8AA UK Department of Environment Food and Agriculture The Isle of Man GovernmentSt Johns IM4 3AS Isle of Man

Freshwater biodiversity and ecosystem integrity are under threat from biological invasions. The ＂killer shrimp＂ Dikerogammarus villosus is a highly predatory amphipod that has spread readily across Central Europe and recently the UK and its arrival has been associated with the significant loss of resident species. Despite this, studies of its behavioral ecology are sparse, even though its be- havior may contribute to its invasion success. For the first time, we investigated antipredator ＂fleeing＂ behavior in D. villosus and how this changed with water temperature. Three key patterns emerged from our analysis. First, within a particular temperature condition there are moderate but consistent among-individual differences in behavior. These are driven by a combination of mean level among-individual differences and within-individual relative consistency in behavior, and pro- vide the key marker for animal personalities. Second, the fleeing responses were not influenced by temperature and third, regardless of temperature, all individuals appeared to habituate to a repeated nondangerous stimulus, indicating a capacity for individual learning. We suggest that the antipreda- tor behavior of D. villosus contributes to its rapid spread and that consistent among-individual differ- ences in behavior may promote biological invasions across heterogeneous conditions. Robustness to changing water temperatures may also be potentially advantageous, particularly in an era of glo- bal climate change, where average temperatures could be elevated and less predictable.

关键词： invasions Dikerogammarus villosus animal personalities habituation temperature.

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No evidence of contagious yawning in the red-footed tortoise Geochelone carbonaria

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Current Zoology 2011年第4期57卷 477-484页

作者： Anna WILKINSON natalie SEBANZ Isabella MANDL Ludwig HUBER Department of Cognitive Biology University of Vienna Althanstrasse 14 Vienna 1090 Austria Department of Biological Sciences University of Lincoln Lincoln LN2 2LG UK Donders Institute for Brain Cognition and Behavior Centre for Cognition Radboud University Nijmegen P.O. Box 9104 6500 HE Nijmegen The Netherlands

Three hypotheses have attempted to explain the phenomenon of contagious yawning. It has been hypothesized that it is a fixed action pattern for which the releasing stimulus is the observation of another yawn, that it is the result of non-conscious mimicry emerging through close links between perception and action or that it is the result of empathy, involving the ability to engage in mental state attribution. This set of experiments sought to distinguish between these hypotheses by examining contagious yawning in a species that is unlikely to show nonconscious mimicry and empathy but does respond to social stimuli： the red-footed tortoise Geochelone carbonaria. A demonstrator tortoise was conditioned to yawn when presented with a red square-shaped stimulus. Observer tortoises were exposed to three conditions： observation of conditioned yawn, non demonstration control, and stimulus only control. We measured the number of yawns for each observer animal in each condition. There was no difference between conditions. Experiment 2 therefore increased the number of conditioned yawns presented. Again, there was no significant difference between conditions. It seemed plausible that the tortoises did not view the conditioned yawn as a real yawn and therefore a final experiment was run using video recorded stimuli. The observer tortoises were presented with three conditions： real yawn, conditioned yawns and empty background. Again there was no significant difference between conditions. We therefore conclude that the red-footed tortoise does not yawn in response to observing a conspecific yawn. This suggests that contagious yawning is not the result of a fixed action pattern but may involve more complex social processes [Current Zoology 57 （4）： 477-484, 2011].

关键词： Reptile Contagious yawn Empathy Nonconscious mimicry Fixed action pattern

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可持续未来:不让任何一个人掉队——跨越政治、经济和美学的界限,在国际建筑师协会世界建筑师大会上团结起来

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世界建筑 2024年第1期 4-7页

作者：娜塔莉·莫辛孙斯坦(译) 国际建筑师协会世界建筑师大会丹麦皇家建筑艺术学院建筑与技术研究所不详

当全球建筑师社群于2029年齐聚北京时,将迎来国际建筑师协会(Union International des Architectes,简称UIA)第30届世界建筑师大会。这一旅程始于1948年在瑞士洛桑召开的创始大会(图1),横跨了各大洲,并于2023年在丹麦哥本哈根以“可持... 详细信息

当全球建筑师社群于2029年齐聚北京时,将迎来国际建筑师协会(Union International des Architectes,简称UIA)第30届世界建筑师大会。这一旅程始于1948年在瑞士洛桑召开的创始大会(图1),横跨了各大洲,并于2023年在丹麦哥本哈根以“可持续未来——不让任何一个人掉队”为主题拉开帷幕(图2)。这一全球交流之旅的初衷源于许多人在二战后对和平以及跨越国界的合作的深切需求。对于丹麦建筑师而言,二战结束的那一刻是充满压力的,但同时也是为社会和更美好的未来做贡献的时刻。

关键词：国际建筑师协会世界建筑师大会丹麦哥本哈根瑞士洛桑建筑师

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A case of gas gangrene in an immunosuppressed Crohn's patient

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World Journal of Gastroenterology 2011年第33期17卷 3856-3858页

作者： natalie Kiel Vincent Ho Andrew Pascoe Department of Gastroenterology Princess Alexandra HospitalBrisbane4102 QueenslandAustralia

Clostridium septicum(***)gas gangrene is well documented in the literature,typically in the setting of trauma or *** this paper,we report a unique case of spontaneous clostridial myonecrosis in a patient with Crohn's disease and sulfasalazineinduced *** patient presented with left thigh pain,vomiting and *** tests demonstrated a profound neutropenia,and magnetic resonance imaging of the thigh confirmed extensive *** patient underwent emergency hip disarticulation,followed by *** was cultured from the *** completion of antibiotic therapy,the patient developed myonecrosis of the right pectoral muscle necessitating further debridement,and remains on lifelong prophylactic antibiotic therapy.

关键词： Crohn's disease Inflammatory bowel disease Sulfasalazine Neutropenia Clostridium septicum

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