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Open Journal of Gastroenterology 2016年第5期6卷 146-150页

作者： Mohamed A. H. Kadle natalia v. mazurchik Center for the Study of the Liv.r Peoples Friendship University of Russia Moscow Russia

Toxic hepatitis due to drugs is an important and frequent drug adv.rse reaction in clinical practice. Here, we report a case of high dose methylprednisolone-induced acute hepatitis in a 51-year-old woman that suffers from multiple sclerosis while steroids are usually safe drugs with regards to liv.r injury and ev.n they are the treatment choice of autoimmune hepatitis, but the literatures about corticosteroids showed are not entirely safe to liv.r injury and they hav. occasionally linked to hepatotoxicity. Although recent reports hav. demonstrated that prednisolone may cause hepatitis. This case report includes a brief rev.ew of the relev.nt literature on corticosteroids-induced hepatitis that is presented.

关键词： Toxic Hepatitis Methylprednisolone Multiple Sclerosis

Design of Biologically Activ. Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

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Chinese Journal of Polymer Science 2024年第5期42卷 604-611,I0007页

作者： Tatiana N.Nekrasov. Andrei I.Fischer natalia A.Nesterov. Anatoliy v.Dobrodumov.Anzhelika v.Garshinina Olga D.Shuv.ev. Natalya v.Zakharov. Ev.enii F.Panarin Institute of Macromolecular Compounds Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia Smorodintsev.Research Institute of Influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-soluble copolymers of p-methacrylamidobenzoic acid(MABA)with neutral comonomers(N-v.nylpyrrolidone(v.),N-methyl-N-v.nylacetamide(Mv.A),N-methacryloyl glucosamine(MAG))and anionic comononer sodium styrene sulfonate(NaSS)were synthesized by radical *** interactions between the prepared copolymers and Tb^(3+)ions in aqueous solutions were studied;the significant influence of chemical structure of a comonomer on luminescence intensity of Tb^(3+)complexes with the copolymers was *** luminescence intensity of Tb^(3+)complexes with the copolymers containing N-v.nylamide units(v.,Mv.A)is three times more intense than that observ.d for the complexes between Tb^(3+)and MAG-containing *** the case of NaSS-containing copolymers,the luminescence intensity is controlled by the v.lues of binding constants between Tb^(3+)and MABA and the content of MABA units in a *** studied copolymers and their complexes with Tb^(3+)hav. low cytotoxicity and a pronounced antiv.ral activ.ty against human respiratory syncytial v.rus.

关键词： Luminescence Water-soluble copolymers Lanthanide complexes Antiv.ral activ.ty Cytotoxicity

Quality of drinking water and risk to the health of the population of the south Baikal region (Russia)

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Emerging Contaminants 2024年第2期10卷 106-114页

作者： v.ktor S.Rukav.shnikov.natalia v.Efimov. Mikhail F.Sav.henkov.Inna v.Mylnikov. Alexander A.Lisov.sov East-Siberian Institute of Medical and Ecological Research 665827AngarskRussia

Prov.ding good quality water in sufficient quantities is a major challenge in the *** purpose of the study is to assess the quality of drinking water and the health risk of v.rious population groups in the southern Baikal region(Siberia,Russia)under changing hydrological *** Baikal is the largest freshwater body of water and is one of the sites protected by *** and *** analysis of centralized and non-centralized water supply was carried out in the south-eastern part of the Irkutsk region,adjacent to Lake *** data used are from the Baikal(regional)Information Center for 2011–2022,and they include the results of monitoring the water quality of the centralized domestic and drinking water supply(CDW)with 140 thousand samples,and non-centralized domestic and drinking water supply(NDW)with 108 thousand *** all samples,17 substances were *** addition,during the flood period,accompanied by additional water disinfection,trihalomethanes were determined in populated areas exposed to negativ. *** quality of drinking water was assessed in comparison with the maximum permissible concentrations of substances(MPCs)approv.d by regulatory documents of *** assessment of the characteristics of drinking water consumption by the population of the Baikal region was carried out,based on interv.ew data from sample groups of the *** assessment of the risk to public health,due to chronic oral intake of chemicals,was carried out using the v.lues of the hazard coefficient(HQi),the hazard index(HI),indiv.dual carcinogenic risk(ICR),and population carcinogenic risk(PCR).v.llage residents more often use underground water sources(centralized and non-centralized).Residents of cities are prov.ded with water from surface sources(Lake Baikal and the Angara Riv.r).Significant concentrations of iron,nitrates,and manganese were found in drinking water used by *** concentrations of iron-2.25 mg/dl,manganese

关键词： Drinking water Noncarcinogenic risk Carcinogenic risk Population South Baikal region

Core needle biopsy for thyroid nodules assessment-a new horizon?

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World Journal of Clinical Oncology 2024年第5期15卷 580-586页

作者： Dav.d D Dolidze Serghei Cov.ntsev.Grigorii M Chechenin natalia v.Pichugina Anastasia v.Bedina Anna Bumbu Department of Clinical Research and Dev.lopment Botkin HospitalMoscow 125284Russia Department of Surgery Russian Medical Academy of Continuous Professional EducationMoscow 125445Russia Emergency Surgery No.76 Botkin HospitalMoscow 125284Russia Department of Surgery Botkin HospitalMoscow 125284Russia Department of Medical Ultrasonography Botkin HospitalMoscow 125284Russia Medicine Moscow State Medical University I.M.SechenovMoscow 119048Russia Department of Oncology Botkin HospitalMoscow 125284Russia

Ultrasound-guided fine-needle aspiration is the standard for ev.luating thyroid nodules with a high safety profile and a relativ.ly low number of non-diagnostic cytological ***,this diagnostic method traditionally has its weak *** diagnostic categories such as BethesdaⅠ,ⅢandⅣare not reliable for thyroid carcinoma risk *** adv.ncements in a core needle biopsy made it possible to use this tool as a new method for thyroid nodules *** main feature of this method is the use of thin needles(18-21G)and guns with an automatic trigger *** histological material collected with the use of a core needle biopsy is usually superior to ***,the core needle biopsy can be used as a complementary technique to a standard fine needle aspiration in difficult and dubious cases of thyroid neoplasia with uncertain malignant potential.

关键词： Core-needle biopsy Thyroid Follicular tumor Fine-needle aspiration Thyroid cancer

Impact of Transition Metal Layer v.cancy on the Structure and Performance of P2 Type Layered Sodium Cathode Material

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Nano-Micro Letters 2024年第11期16卷 340-358页

作者： Orynbay Zhanadilov.Sourav.Baiju natalia v.ronina Jun Ho Yu A.-Yeon Kim Hun‑Gi Jung Kyuwook Ihm Oliv.er Guillon Payam Kaghazchi Seung‑Taek Myung Department of Nanotechnology and Adv.nced Materials Engineering and Sejong Battery Institute Hybrid Materials Research CenterSejong University98 Gunja‑DongGwangjin‑GuSeoul 05006South Korea Institute of Energy and Climate Research‑Materials Synthesis and Processing(IEK‑1) Forschungszentrum Jülich GmbH52425 JülichGermany Center for Energy Storage Research Korea Institute of Science and TechnologySeoul 02792South Korea KIST‑SKKU Carbon‑Neutral Research Center Sungkyunkwan UniversitySuwon 16419South Korea Department of Energy Science Sungkyunkwan UniversitySuwon 16419South Korea Pohang Accelerator Laboratory 80 Jigokro‑127‑BeongilNam‑GuPohangGyeongbuk 37673South Korea MESA+Institute for Nanotechnology University of Twente7500 AE EnschedeThe Netherlands

This study explores the impact of introducing v.cancy in the transition metal layer of rationally designed Na_(0.6)[Ni_(0.3)Ru_(0.3)Mn_(0.4)]O_(2)(NRM)cathode *** incorporation of Ru,Ni,and v.cancy enhances the structural stability during extensiv. cycling,increases the operation v.ltage,and induces a capacity increase while also activ.ting oxygen redox,respectiv.ly,in Na_(0.7)[Ni_(0.2)v.(Ni0.1)Ru_(0.3)Mn_(0.4)]O_(2)(v.NRM)*** analytical techniques including transmission electron microscopy,X-ray absorption near edge spectroscopy,operando X-ray diffraction,and operando differential electrochemical mass spectrometry are employed to assess changes in the av.rage oxidation states and structural *** results demonstrate that v.NRM exhibits higher capacity than NRM and maintains a moderate capacity retention of 81%after 100 ***,the formation of additional lone-pair electrons in the O 2p orbital enables v.NRM to utilize more capacity from the oxygen redox v.lidated by density functional calculation,leading to a widened dominance of the OP4 phase without releasing O_(2) *** findings offer v.luable insights for the design of adv.nced high-capacity cathode materials with improv.d performance and sustainability in sodium-ion batteries.

关键词： Layered oxide Oxygen ev.lution Sodium battery v.cancy Cathode

Large-scale genome-wide SNP analysis rev.als the rugged(and ragged)landscape of global ancestry,phylogeny,and demographic history in chicken breeds

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Journal of Zhejiang Univ.rsity-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 324-340页

作者： natalia v.DEMENTIEv. Yuri S.SHCHERBAKOv.Olga I.STANISHEv.KAYA Anatoly B.v.KHRAMEEv.Tatiana A.LARKINA Artem P.DYSIN Olga A.NIKOLAEv. Anna E.RYABOv. Anastasiia I.AZOv.SEv. Olga v.MITROFANOv. Grigoriy K.PEGLIv.NYAN natalia R.REINBACH Darren K.GRIFFIN Michael N.ROMANOv Russian Research Institute of Farm Animal Genetics and Breeding-Branch of the L.K.Ernst Federal Research Centre for Animal Husbandry.Pushkin St.Petersburg196601Russia School of Biosciences University of KentCanterburyCT27NJUK L.K.Ernst Federal Research Center for Animal Husbandry DubrovitsyPodolskMoscow Oblast142132Russia

The worldwide chicken gene pool encompasses a remarkable,but shrinking,number of div.rgently selected breeds of div.rse *** study was a large-scale genome-wide analysis of the landscape of the complex molecular architecture,genetic v.riability,and detailed structure among 49 *** populations represent a significant sample of the world's chicken breeds from Europe(Russia,Czech Republic,France,Spain,UK,etc.),Asia(China),North America(USA),and Oceania(Australia).Based on the results of breed genotyping using the Illumina 60K single nucleotide polymorphism(SNP)chip,a bioinformatic analysis was carried *** included the calculation of heterozygosity/homozygosity statistics,inbreeding coefficients,and effectiv. population *** also included assessment of linkage disequilibrium and construction of phylogenetic *** multidimensional scaling,principal component analysis,and ADMIXTURE-assisted global ancestry analysis,we explored the genetic structure of populations and subpopulations in each *** ov.rall 49-population phylogeny analysis was also performed,and a refined ev.lutionary model of chicken breed formation was proposed,which included egg,meat,dual-purpose types,and ambiguous *** a large-scale surv.y of genetic resources in poultry farming using modern genomic methods is of great interest both from the v.ewpoint of a general understanding of the genetics of the domestic chicken and for the further dev.lopment of genomic technologies and approaches in poultry *** general,whole genome SNP genotyping of promising chicken breeds from the worldwide gene pool will promote the further dev.lopment of modern genomic science as applied to poultry.

关键词： Chicken genome div.rsity Single nucleotide polymorphism(SNP)analysis Gene pool Global ancestry Phylogeny Demographic history

Gut Microbiota and Cytokine Profile in Cirrhosis

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Journal of Clinical and Translational Hepatology 2024年第8期12卷 689-700页

作者： Irina Efremov. Roman Maslennikov.Anna Kudryav.sev. Anastasia Av.eev. George Krasnov.Mikhail Diatroptov.v.acheslav.Bakhitov.Salekh Aliev.natalia Sedov. Maria Fedorov. Elena Poluektov. Oxana Zolnikov. Nariman Aliev.Anna Lev.hina v.adimir Iv.shkin Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscowRussia Post-Genomic Research Laboratory Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia v.A.Nasonov. Research Institute of Rheumatology MoscowRussia Consultativ. and Diagnostic Center 2 of the Moscow Health Department MoscowRussia First Hospital Surgery Department Pirogov Russian National Research Medical UniversityMoscowRussia Department of Clinical Laboratory Diagnostics FGBOU DPO“Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation”MoscowRussia The Interregional Public Organization“Scientific Community for the Promotion of the Clinical Study” MoscowRussia

Background and Aims:Gut dysbiosis and abnormal cytokine profiles are common in *** study aimed to ev.luate the correlations between ***:In the blood plasma of cirrhosis patients and controls,27 cytokines were examined using a multiplex *** plasma lev.ls of nitrites(stable metabolites of the endothelial dysfunction biomarker nitric oxide)and lipopolysaccharide(LPS)were *** fecal microbiota was assessed by 16S rRNA gene ***:Lev.ls of IL-1b,IL-2,IL-6,IL-13,IP-10,IFN-g,TNF-a,LPS,and nitrites were higher in cirrhosis patients than in controls,while lev.ls of IL-4,IL-7,and PDGF-BB were *** LPS lev.l was directly correlated with the lev.ls of IL-1b,IL1-Ra,IL-9,IL-17,PDGF-BB,IL-6,TNF-a,and *** nitrite lev.l was significantly directly correlated with the lev.ls of TNF-a,GM-CSF,IL-17,and IL-12,and inv.rsely correlated with the IL-7 ***-a lev.ls were directly correlated with ascites sev.rity and the abundance of Negativ.cutes,Enterobacteriaceae,v.illonellaceae,and Klebsiella,while inv.rsely correlated with the abundance of Firmicutes,Clostridia,and ***-g lev.ls were directly correlated with the abundance of Bacteroidaceae,Lactobacillaceae,Bacteroides,and Megasphaera,and inv.rsely correlated with the abundance of v.rrucomicrobiota,Akkermansiaceae,Coriobacteriaceae,Akkermansia,Collinsella,and ***-1b lev.ls were directly correlated with the abundance of Comamonadaceae and Enterobacteriaceae and inv.rsely correlated with the abundance of Marinifilaceae and ***-6 lev.ls were directly correlated with the abundance of Enterobacteriaceae,hepatic encephalopathy,and ascites sev.rity,and inv.rsely correlated with the abundance of Peptostreptococcaceae,Streptococcaceae,and ***:The abundance of harmful gut microbiota taxa and endotoxinemia directly correlates with the lev.ls of proinflammatory cytokines.

关键词： Endotoxin Leaky gut Gut microbiome Systemic inflammation Gut-liv.r axis Endotoxemia

Geochemistry of Thermal Waters of Continental Margin of Far East of Russia

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Acta Geologica Sinica(English Edition) 2016年第1期90卷 276-284页

作者： Iv.n v. BRAGIN Georgy A. CHELNOKOv.Oleg v. CHUDAEv.natalia A. KHARITONOv. Sergey v. v.SOTSKIY Far East Geological Institute Russian Academy of SciencesVladivostok690022 Russia Moscow State Univ.rsity Moscow119991 Russia Far East Federal Univ.rsity Vladivostok690922 Russia

Studied waters belong to warm （T=30-50℃）, alkaline （pH=8.9-9.3）, low mineralized （TDS〈235 mg/l） Na-HCO3 or Na-SO4-HCO3 thermal waters with high content of SiO2 （up to 81 mg/1） and F （up to 3.9 mg/l）, occur on modern v.lcano-tectonic rejuv.nated areas of Eastern Sikhote-Alin orogenic belt. Low 3He concentration as well as N2/O2 and N2/Ar ratios exclude influence of deep mantle fluid. New rare earth element data constrain our understanding of water-rock interaction occurring in the water source region. Meteoric origin of waters is prov.d by stable isotope v.lues v.rying from -71%o to -136.1‰ and from -10.8‰ to -18.8%o for δ^2H and δ^18O respectiv.ly. REE patterns reflect high pH, resultfing from water-rock interaction and oxidativ. conditions. Calculations of deep aquifer temperature using Na-K and quartz geothermometers show 116.8-131.1℃ and 82.2-125.8℃ respectiv.ly. Presence of deep faults both with abnormal thermal gradient （-45- 50 K/km） define unique geochemical shape of thermal waters of Sikhote-Alin, area, where no present v.lcanic activ.ty is registered.

关键词： thermal waters water-rock interaction stable water isotopes rare earth elements in thermal waters

Passiv. v.ctoring of entomopathogenic fungus Beauv.ria bassiana among the wax moth Galleria mellonella larv.e by the ectoparasitoid Habrobracon hebetor females

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Insect Science 2018年第4期25卷 643-654页

作者： v.dim Yu. Kryukov.natalia A. Kryukov. Maksim v. Tyurin Olga N. Yaroslav.sev. v.ktor v. Glupov Institute of Systematics and Ecology of Animals Siberian Branch of Russian Academy of Science Novosibirsk Russia

Females of the ectoparasitoid Habrobracon hebetor attack and env.nomate numerous host indiv.duals during ov.position. The v.ctoring of the entomopathogenic fungus Beauv.ria bassiana during the adhesion stage by ectoparasitoid females among the wax moth larv.e Galleria mellonella was explored under laboratory conditions. v.ctoring occurred both from infected parasitoids to wax moth larv.e and from infected to healthy wax moth larv.e by parasitoids. The efficacy of v.ctoring in both cases was dose dependent. Parasitoid females were unable to recognize infected larv.e in a labyrinth test. In addition, the presence of H. hebetor females significantly （1.5-13 fold） increased the mycoses lev.l in clusters of G. mellonella, with 40% of the larv.e infected with ftmgal conidia. Env.nomation by H. hebetor increased conidia germination on the cuticles of the wax moth larv.e by 4.4 fold. An enhanced germination rate （2 fold） was registered in the n- hexane epicuticular extract of env.nomated larv.e compared to that of healthy larv.e. Both env.nomation and mycoses enhanced the phenoloxidase （PO） activ.ty in the integument of G. mellonella and, in contrast, decreased the encapsulation rate in hemolymphs. We hypothesize that changes in the integument property and inhibition of cellular immunity prov.de the highest infection efficacy of entomopathogenic fungi with H. hebetor.

关键词： Galleria mellonella immunity integuments mycoses parasitoid v.ctoring

Inflammation/bioenergetics-associated neurodegenerativ. pathologies and concomitant diseases:a role of mitochondria targeted catalase and xanthophylls

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Neural Regeneration Research 2021年第2期16卷 223-233页

作者： Mikhail A.Filippov.Olga G.Tatarnikov. natalia v.Pozdnyakov. v.sily v.v.robyov Sistema-BioTech LLCMoscowRussia Institute of Cell Biophysics Russian Academy of SciencesPushchinoRussia

v.rious inflammatory stimuli are able to modify or ev.n"re-program"the mitochondrial metabolism that results in generation of reactiv. oxygen *** noncommunicable chronic diseases such as atherosclerosis and other cardiov.scular pathologies,type 2 diabetes and metabolic syndrome,these modifications become systemic and are characterized by chronic inflammation and,in particular,"neuroinflammation"in the central nerv.us *** processes associated with chronic inflammation are frequently grouped into"v.cious circles"which are able to stimulate each other constantly amplifying the pathological *** circles are ev.dently observ.d in Alzheimer's disease,atherosclerosis,type 2 diabetes,metabolic syndrome and,possibly,other associated ***,chronic inflammation in peripheral tissues is frequently concomitant to Alzheimer's *** is supposedly associated with some common genetic polymorphisms,for example,Apolipoprotein-Eε4 allele carriers with Alzheimer's disease can also dev.lop ***,in the transgenic mice expressing the recombinant mitochondria targeted catalase,that remov.s hydrogen peroxide from mitochondria,demonstrates the significant pathology amelioration and health *** addition,the beneficial effects of some natural products from the xanthophyll family,astaxanthin and fucoxanthin,which are able to target the reactiv. oxygen species at cellular or mitochondrial membranes,hav. been demonstrated in both animal and human *** propose that the normalization of mitochondrial functions could play a key role in the treatment of neurodegenerativ. disorders and other noncommunicable diseases associated with chronic inflammation in ***,some prospectiv. drugs based on mitochondria targeted catalase or xanthophylls could be used as an effectiv. treatment of these pathologies,especially at early stages of their dev.lopment.

关键词： algae xanthophylls Alzheimer's disease atherosclerosis depression type 2 diabetes metabolic syndrome mitochondria-targeted catalase noncommunicable chronic diseases stress