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Dimensions of hepatocellular carcinoma phenotypic diversity

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World Journal of Gastroenterology 2018年第40期24卷 4536-4547页

作者： Romain Désert natalia Nieto Orlando Musso Institut NuMeCan Université de Rennes 1 Institut national de la recherche agronomique (INRA) Institut national de la santé et de la recherche médicale (INSERM) Department of Pathology Department of Medicine (Gastroenterology and Hepatology) University of Illinois at Chicago

Hepatocellular carcinoma(HCC) is the 3^(rd) leading cause of cancer-related death worldwide. More than 80% of HCCs arise within chronic liver disease resulting from viral hepatitis, alcohol, hemochromatosis, obesity and metabolic syndrome or genotoxins. Projections based on Western lifestyle and its metabolic consequences anticipate a further increase in incidence, despite recent breakthroughs in the management of viral hepatitis. HCCs display high heterogeneity of molecular phenotypes, which challenges clinical management. However, emerging molecular classifications of HCCs have not yet formed a unified corpus translatable to the clinical practice. Thus, patient management is currently based upon tumor number, size, vascular invasion, performance status and functional liver reserve. Nonetheless, an impressive body of molecular evidence emerged within the last 20 years and is becoming increasingly available to medical practitioners and researchers in the form of repositories. Therefore, the aim this work is to review molecular data underlying HCC classifications and to organize this corpus into the major dimensions explaining HCC phenotypic diversity. Major efforts have been recently made worldwide toward a unifying "clinically-friendly" molecular landscape. As a result, a consensus emerges on three major dimensions explaining the HCC heterogeneity. In the first dimension, tumor cell proliferation and differentiation enabled allocation of HCCs to two major classes presenting profoundly different clinical aggressiveness. In the second dimension, HCC microenvironment and tumor immunity underlie recent therapeutic breakthroughs prolonging patients' survival. In the third dimension,metabolic reprogramming, with the recent emergence of subclass-specific metabolic profiles, may lead to adaptive and combined therapeutic approaches. Therefore, here we review recent molecular evidence, their impact on tumor histopathological features and clinical behavior and highlight the r

关键词： Liver metabolism Liver zonation Hepatocellular carcinoma classification Wnt/β-catenin TP53 Tumor microenvironment Inflammation Tumor immunity Hepatocyte proliferation Hepatocyte differentiation

Localized Corrosion Characteristics of Nickel Alloys： A Review

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Acta Metallurgica Sinica(English Letters) 2017年第4期30卷 296-305页

作者： Helmuth Sarmiento Klapper natalia S. Zadorozne Raul B. Rebak Center for Materials Research Baker Hughes 29221 CelleGermany Instituto de Materiales de Misiones (IMAM) UNaMCONICET 3300 Posadas Argentina GE Global Research Schenectady NY 12309 USA

There are a great variety of commercial nickel alloys mainly because nickel is able to dissolve a large amount of alloying elements while maintaining a single ductile austenitic phase. Nickel alloys are generally designed for and used in highly aggressive environments, for example, those where stainless steels may experience pitting corrosion or environmentally assisted cracking. While nickel alloys are generally resistant to pitting corrosion in chloride-containing environments, they may be prone to crevice corrosion attack. Addition of chromium, molybdenum and tungsten increases the localized corrosion resistance of nickel alloys. This review on the resistance to localized corrosion of nickel alloys includes specific environments such as those present in oil and gas upstream operations, in the chemical process industry and in seawater service.

关键词： Nickel alloys Localized corrosion Oil and gas Seawater Chemical process industry

Specific and Selective Bacteriophages in the Fight against Multidrug-resistant Acinetobacter baumannii

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Virologica Sinica 2019年第4期34卷 347-357页

作者： natalia Baginska Anna Pichlak Andrzej Gorski Ewa Jonczyk-Matysiak Bacteriophage Laboratory Hirszfeld Institute of Immunology and Experimental TherapyPolish Academy of Sciences53-114 WroclawPoland Phage Therapy Unit Hirszfeld Institute of Immunology and Experimental TherapyPolish Academy of Sciences53-114 WroclawPoland Department of Clinical Immunology Transplantation InstituteMedical University of Warsaw53-114 WarsawPoland

Acinetobacter baumannii causes serious infections especially in immunocompromised and/or hospitalized *** *** strains are multidrug resistant and infect wounds,bones,and the respiratory *** studies are focused on finding new effective agents against *** therapy is a promising means to fight this bacterium and many studies on procuring and applying new phages against *** are currently being *** shown in animal models,phages against multidrug-resistant *** may control bacterial infections caused by this pathogen and may be a real hope to solve this dangerous health problem.

关键词： Acinetobacter baumannii Bacteriophages Phage therapy Multidrug resistance(MDR)

Histone Acetyltransferase AtGCN5/HAG1 Is a Versatile Regulator of Developmental and Inducible Gene Expression in Arabidopsis

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Molecular Plant 2010年第4期3卷 670-677页

作者： Caroline Servet natalia Conde e Silva Dao-Xiu Zhou Institut de Biologie des Plantes Universite Paris-sud 11 91405 Orsay France

Histone acetylation/deacetylation is a dynamic process and plays an important role in gene regulation. Histone acetylation homeostasis is regulated by antagonist actions of histone acetyltransferases （HAT） and deacetylases （HDAC）. Plant genome encodes multiple HATs and HDACs. The Arabidopsis HAT gene AtGCNS/HAGlplays an essential role in many plant development processes, such as meristem function, cell differentiation, leaf and floral organogenesis, and responses to environmental conditions such as light and cold, indicating an important role of this HAT in the regulation of both long-term developmental switches and short-term inducible gene expression. AtGCN5 targets to a large number of promoters and is required for acetylation of several histone H3 lysine residues. Recruitment of AtGCN5 to target promoters is likely to be mediated by direct or indirect interaction with DNA-binding transcription factors and/or by interaction with acetylated histone lysine residues on the targets. Interplay between AtGCN5 and other HATand HDAC is demonstrated to control specific regulatory pathways. Analysis of the role of AtGCN5 in light-inducible gene expression suggests a function of AtGCN5 in preparing chromatin commitment for priming inducible gene activation in plants.

关键词： Light regulation chromatin structure and remodeling gene regulation leaf/vegetative development meristem development.

ZnO@MOF@PANI core-shell nanoarrays on carbon cloth for high-performance supercapacitor electrodes

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Journal of Energy Chemistry 2019年第8期28卷 124-131,I0005页

作者： Chunmei Zhu Ying He Yijun Liu natalia Kazantseva Petr Saha Qilin Cheng Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and TechnologyShanghai 200237 China Centre of Polymer Systems Tomas Bata University in Zlinnam. T. G. Masaryka 5555 760 01 Zlin Czechia

Hierarchical ZnO@metal-organic framework @polyaniline(ZnO@MOF@PANI) core-shell nanorod arrays on carbon cloth has been fabricated by combining electrodeposition and hydrothermal method. Well-ordered Zn O nanorods not only act as a scaffold for growth of MOF/PANI shell but also as Zn source for the formation of MOF. The morphology of ZnO@MOF@PANI composite is greatly influenced by the number of PANI electrodeposition cycles. Their structural and electrochemical properties were characterized with different techniques. The results indicate that the Zn O@MOF@PANI with 13 CV cycles of PANI deposition demonstrates the maximum specific capacitance of 340.7 F g-1 at 1.0 A g-1, good rate capability with84.3% capacitance retention from 1.0 to 10 A g-1 and excellent cycling life of 82.5% capacitance retention after 5000 cycles at high current density of 2.0 A g-1. This optimized core-shell nanoarchitecture endows the composite electrode with short ion diffusion pathway, rapid ion/electron transfer and high utilization of active materials, which thus result in excellent electrochemical performance of the ternary composite.

关键词： Metal-oragnic framework Polyaniline Core-shell nanoarrays Supercapacitor Electrochemical properties

Improved methodological concepts for processing liquid Mg at high temperature

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Journal of Magnesium and Alloys 2021年第1期9卷 183-191页

作者： Artur Kudyba natalia Sobczak Wojciech Polkowski Grzegorz Bruzda Adelajda Polkowska Donatella Giuranno Lukasiewicz Research Network-Krakow Institute of Technology Zakopianska 73 Str.30-418 KrakowPoland Institute of Metallurgy and Materials Science Polish Academy of Science25 Reymonta St.30-059 KrakówPoland National Research Council of Italy Institute of Condensed Matter Chemistry and Technologies for EnergyVia De Marini 616149GenovaItaly

In this paper,new improvements of methodological concepts upon examining wettability of high vapor pressure liquid metal systems(***-based alloys)in contact with refractory materials,are presented and *** this regard,high-temperature experiments on molten magnesium(Mg)in contact with graphite as a refractory substrate,were performed by utilizing a newly developed testing device and by applying a suitable experimental *** wetting experiments were carried out by the sessile drop method and under identical testing conditions(700℃/10 min under a protective gas atmosphere).Two different procedures were applied:the classical contact heating(CH)or a newly introduced capillary purification(CP)*** contact angle behaviors observed under the same conditions were strongly influenced by the applied ***,in the case of using the CH procedure,a presence of native surface oxide layer on the metal surface hinders the observations of melting process,making not possible to experimentally determine the wetting kinetics curveθ=f(t).Contrarily,during the wetting test performed on the Mg/graphite couple by applying the CP procedure,the native surface oxide layer was mechanically removed during the squeezing of the molten Mg through the hole of a ***,an oxide-free squeezed Mg-drop with regular and spherical shape was successfully obtained and dispensed on the graphite ***,the reliable contact angle value aroundθ=150°for the Mg/graphite system,was measured within the wetting test.

关键词： Mg-alloys Magnesium matrix composites Sessile drop Capillary purification procedure Wettability Contact angle

Bonding effect of liquid magnesium with open-celled carbon foam in interpenetrating phase composite

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Journal of Magnesium and Alloys 2021年第1期9卷 156-165页

作者： Marcin Godzierz Anita Olszowka-Myalska natalia Sobczak Rafal Nowak Patryk Wrze'sniowski Silesian University of Technology Faculty of Materials EngineeringKrasi´nskiego 8 street40-019 KatowicePoland Institute of Metallurgy and Materials Science Polish Academy of SciencesRaymonta 25 streetKrakówPoland Łukasiewicz Foundry Research Institute Zakopia´nska 73 street30-418 KrakówPoland

The issue of bonding formation in liquid metal/open-celled carbon foam(C_(of))systems was examined,taking into account the practical aspects of the synthesis of a new type of Mg-C metal material *** problem is complex due to the strong oxidation and intense evaporation of liquid magnesium,as well as the 3D geometry of the carbon component,where metal transport occurred through the foam cells’*** experiments performed at 700℃ in ceramic crucibles showed that spontaneous carbon foam infiltration by liquid metal is impossible under the applied conditions,either in an air atmosphere coupled with flux protection or under argon *** tests performed in a UHV chamber filled with static pure Ar by a sessile drop method,coupled with non-contact heating and capillary purification at a test temperature of 700℃ directly in the UHV chamber,showed non-wetting behavior of the Mg/C_(of)couple with a correspondingly high contact angle of about 135°.The graphite capillary was then moved down,the liquid drop being slightly pressed into the foam,but these changes did not induce effective foam *** the short contact time for the sessile drop test under an argon atmosphere,SEM+WDS analysis of the solidified Mg/C_(of)couple revealed the formation of an MgO interlayer at the interface,with a thickness of approx.1μ*** experimentally demonstrated presence of oxygen in the carbon foam sample,both before and after its contact with magnesium,points to oxide-type bonding being established between Mg and C_(of).This observation is in a good agreement with previous reports on the interface characterization of magnesium matrix composites reinforced with glassy carbon materials and carbon fibers by stir casting and pressure *** on the findings of this study,a general structural scheme of the bonding process between carbon foam and liquid magnesium,as an important stage in the syntheses of Mg-C composites,was proposed.

关键词： Magnesium matrix composite Open-celled carbon foam Interpenetrating phase composites Wetting Interface

Neuronal activity controls the development of interneurons in the somatosensory cortex

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Frontiers in Biology 2016年第6期11卷 459-470页

作者： Rachel Babij natalia De Marco Garcia Center for Neurogenetics Brain and Mind Research Institute Weill Cornell Medical College New York NY 10065 USA Weill Cornell/Rockefeller/Sloan Kettering Tri-lnstitutional MD-PhD Program New York USA

BACKGROUND： Neuronal activity in cortical areas regulates neurodevelopment by interacting with defined genetic programs to shape the mature central nervous system. Electrical activity is conveyed to sensory cortical areas via intracortical and thalamocortical neurons, and includes oscillatory patterns that have been measured across cortical regions. OBJECTIVE： In this work, we review the most recent findings about how electrical activity shapes the developmental assembly of functional circuitry in the somatosensory cortex, with an emphasis on intemeuron maturation and integration. We include studies on the effect of various neurotransmitters and on the influence of thalamocortical afferent activity on circuit development. We additionally reviewed studies describing network activity patterns. METHODS： We conducted an extensive literature search using both the PubMed and Google Scholar search engines. The following keywords were used in various iterations：＂intemeuron＂, ＂somatosensory＂, ＂development＂, ＂activity＂, ＂network patterns＂, ＂thalamocortical＂, ＂NMDA receptor＂, ＂plasticity＂. We additionally selected papers known to us from past reading, and those recommended to us by reviewers and members of our lab. RESULTS： We reviewed a total of 132 articles that focused on the role of activity in interneuronal migration, maturation, and circuit development, as well as the source of electrical inputs and pattems of cortical activity in the somatosensory cortex. 79 of these papers included in this timely review were written between 2007 and 2016. CONCLUSIONS： Neuronal activity shapes the developmental assembly of functional circuitry in the somatosensory cortical interneurons. This activity impacts nearly every aspect of development and acquisition of mature neuronal characteristics, and may contribute to changing phenotypes, altered transmitter expression, and plasticity in the adult. Progressively changing oscillatory network patterns contribute to this activity in the earl

关键词： interneuron neurodevelopment neuroplasticity thalamocortical NMDA receptors neuronal maturation

The mystery of molten metal

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China Foundry 2010年第4期7卷 425-437页

作者： natalia Sobczak Jerzy Sobczak Rajiv Asthana Robert Purgert Foundry Research Institute Department of Engineering & Technology University of Wisconsin-Stout Energy Industries of Ohio

Recent advances in scientific understanding of high-temperature materials processing using novel experimental methodologies have shed light on the complex role of surface and interface phenomena. New in-situ studies on molten metal/solid ceramic interactions using a unique experimental complex at the Foundry Research Institute, Krakow, have revealed a number of unusual observations in materials processing at high temperatures. We present some such unusual observations and their explanation with reference to liquid metal processing of Al, Ni, and Ti, and their alloys in contact with oxide ceramics. In particular, we focus on the following aspects: primary oxidation of Al from residual water vapor or oxygen, capillary purification to remove surface oxide, substrate protection by CVD carbon, roughening due to spinel whisker formation, inclusions in castings due to mechanical detachment, floatation due to buoyancy forces, and segregation due to directional solidifciation, modification of the solid surface morphology by metal vapor ahead of the liquid, and the complication due to multi-component alloys melted in crucibles made from complex oxide-based ceramics. In the case of Ti, rapid reactions with oxides result in undesirable volumetric changes that create difficulty in casting high-quality Ti parts, particularly by investment casting. Nanoscale (e.g., colloidal) coatings based on Y2O3 protect crucibles and hold ladles against such attack. Practical insights and recommendations for materials processing emerging from the fundamental studies on high-temperature interfacial phenomena have been described.

关键词： molten metal high-temperature phenomena in-situ observation casting defects