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Neural Regeneration Research 2019年第8期14卷 1364-1366页

作者： Rafael Martinez-Perez natalia Rayo Agustin Montivero Jorge Marcelo Mura Division of Neurosurgery Institute of Clinical Neurosciences Universidad Austral de Chile Valdivia Chile Division of Cerebrovascular and Skull Base Neurosurgery Institute of Neurosurgery Dr Asenjo Santiago Chile Western University London ON Canada

Clipping and coiling are currently the two alternatives in treatment of ruptured cerebral aneurysms. In spite of some meritorious analysis, further discussion is helpful to understand the actual state of art. Retreatment and rebleeding rates clearly favors clipping, although short-term functional outcome seems to be beneficial for clipping, while this different is not such if we perform the comparison at a longer follow up. Longterm follow ups and cost analysis are mandatory to have a clear view of the current picture in treatment of subarachnoid hemorrhage. Treatment strategy should be made by a multi-disciplinary team in accredited centers with proficient experience in both techniques.

关键词： sAH subarachnoid hemorrhage coiling clipping ruptured aneurysm timing intracranial

Fluid Inclusion Evidences for the P-T Conditions of Quartz Veins Formation in the Black Shale-Hosted Gold Deposits, Bodaybo Ore Region, Russia

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Journal of Earth Science 2020年第3期31卷 514-522页

作者： natalia N.Ankusheva Ekaterina E.Palenova Svetlana N.Shanina Institute of Mineralogy South-Urals Federal Research Center of Mineralogy and GeoecologyUrals BranchRussian Academy of SciencesMiass 456317Russia Geological Department South-Urals State UniversityMiass 456300Russia Institute of Geology of the Komi Science Center Urals BranchRussian Academy of SciencesSyktyvkar 167982Russia

The P-T conditions of auriferous and barren quartz veins from Kopylovsky,Kavkaz and Krasnoye gold deposits in Proterozoic black shales of Bodaybo ore region are presented the first time in this *** inclusions trapped in auriferous quartz are aqueous Na±K-Mg chloride with salinity of 6 wt.%-8.8 wt.%*** temperatures vary from 260 to 350℃,and calculated trapping pressures are 1.2-1.6 *** fluids trapped in barren quartz have more complicated compositions with Na,K,Mg and Fe chlorides,salinity up to 13 wt.%NaCleqv,and homogenization temperatures ranging between 140 and 280℃.The volatiles in fluids are dominated by H2O,followed by CO2 with minor amounts of CH4 and *** suppose that auriferous and barren quartz veins have been formed due to the basic metamorphogenic fluid as evidenced by the close slat and gas fluid composition.

关键词： Bodaybo black shales gold deposits gold-bearing quartz barren veins fluid inclusions P-T conditions

A theoretical model for pattern discovery in visual analytics

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Visual Informatics 2021年第1期5卷 23-42页

作者： natalia Andrienko Gennady Andrienko Silvia Miksch Heidrun Schumann Stefan Wrobel Fraunhofer Institute IAIS Sankt-AugustinGermany City University of LondonLondonUK TU Wien ViennaAustria University of Rostock RostockGermany University of Bonn BonnGermany

The word‘pattern’frequently appears in the visualisation and visual analytics literature,but what do we mean when we talk about patterns?We propose a practicable definition of the concept of a pattern in a data distribution as a combination of multiple interrelated elements of two or more data components that can be represented and treated as a unified *** theoretical model describes how patterns are made by relationships existing between data *** the types of these relationships,it is possible to predict what kinds of patterns may *** demonstrate how our model underpins and refines the established fundamental principles of *** model also suggests a range of interactive analytical operations that can support visual analytics workflows where patterns,once discovered,are explicitly involved in further data analysis.

关键词： Visual analytics Data distribution Pattern Abstraction Data organisation Data arrangement Data variation Pattern discovery

Measuring Vertical and Horizontal Intra-Industry Trade:the Case of Mexico and China

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Measuring Vertical and Horizontal Intra-Industry Trade:the C...

作者： natalia Primo Dominguez 南京理工大学

学位级别：硕士

The purpose of this study is *** and analyze the extent of vertical and horizontal intra-industry trade between Mexico and China in seven sectors over a five-year period,from 2012 to 2016,using disaggregated trade data at the SITC three digit level;and to identify in what sectors IIT is rmainly ***,this paper aims to disentangle trade into:inter-industry trade,horizontal intra-industry trade,low quality vertical ITT（low ITTV）and high quality vertical ITT（high-ITTV）.One of the main findings is that there is relatively low bilateral intra-industry trade between Mexico and ***,the results showed that vertical ⅡT took predominance over horizontal IIT in all *** further disentangling vertical IIT,the results demonstrated that it was high-ITTV that prevailed over *** this type of trade,China is mainly exporting low quality goods to Mexico.

关键词：中国对外贸易墨西哥

High-temperature transport properties of BaSn_(1−x)Sc_(x)O_(3−δ) ceramic materials as promising electrolytes for protonic ceramic fuel cells

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Journal of Advanced Ceramics 2022年第7期11卷 1131-1143页

作者： Inna A.ZVONAREVA AlexeyМ.MINEEV natalia A.TARASOVA Xian-Zhu FU Dmitry A.MEDVEDEV Institute of High Temperature Electrochemistry Ural Branch of the Russian Academy of SciencesYekaterinburg 620066Russia Ural Federal University Yekaterinburg 620002Russia Boreskov Institute of Catalysis Novosibirsk 630090Russia College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China

Protonic ceramic fuel cells(PCFCs)offer a convenient means for electrochemical conversion of chemical energy into electricity at intermediate temperatures with very high *** BaCeO_(3)-and BaZrO_(3)-based complex oxides have been positioned as the most promising PCFC electrolytes,the design of new protonic conductors with improved properties is of paramount *** the present work,we studied transport properties of scandium-doped barium stannate(Sc-doped BaSnO_(3)).Our analysis included the fabrication of porous and dense BaSn_(1−x)Sc_(x)O_(3−δ)ceramic materials(0≤x≤0.37),as well as a comprehensive analysis of their total,ionic,and electronic conductivities across all the experimental conditions realized under the PCFC operation:both air and hydrogen atmospheres with various water vapor partial pressures(p(H2O)),and a temperature range of 500–900℃.This work reports on electrolyte domain boundaries of the undoped and doped BaSnO_(3)for the first time,revealing that pure BaSnO_(3)exhibits mixed ionic–electronic conduction behavior under both oxidizing and reducing conditions,while the Sc-doping results in the gradual improvement of ionic(including protonic)conductivity,extending the electrolyte domain boundaries towards reduced *** latter property makes the heavilydoped BaSnO_(3)representatives attractive for PCFC applications.

关键词： BaSnO_(3) protonic ceramic fuel cells(PCFCs) proton transport perovskite hydration electronic conductivity

Aberrant expression of alternative isoforms of transcription factors in hepatocellular carcinoma

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World Journal of Hepatology 2018年第10期10卷 645-661页

作者： Olga Krivtsova Anna Makarova natalia Lazarevich Federal State Budgetary Institution “N.N.Blokhin Medical Research Center of Oncology”of the Ministry of Health of the Russian FederationMoscow 115478Russian M.V.Lomonosov Moscow State University Moscow 119991Russian

Hepatocellular carcinoma(HCC) is one of the most prevalent malignancies worldwide and the second leading cause of death among all cancer types. Deregulation of the networks of tissue-specific transcription factors(TFs) observed in HCC leads to profound changes in the hepatic transcriptional program that facilitates tumor progression. In addition, recent reports suggest that substantial aberrations in the production of TF isoforms occur in HCC. In vitro experiments have identified distinct isoform-specific regulatory functions and related biological effects of liver-specific TFs that are implicated in carcinogenesis, which may be relevant for tumor progression and clinical outcome. This study reviews available data on the expression of isoforms of liver-specific and ubiquitous TFs in the liver and HCC and their effects, including HNF4α, C/EBPs, p73 and TCF7 L2, and indicates that assessment of the ratio of isoforms and targeting specific TF variants may be beneficial for the prognosis and treatment of HCC.

关键词： Alternative isoforms Transcription factors Hepatocellular carcinoma Alternative splicing Hepatic differentiation Personalized treatment

Translational approaches: From fatty liver to non-alcoholic steatohepatitis

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World Journal of Gastroenterology 2014年第27期20卷 9038-9049页

作者： natalia Rosso Norberto C Chavez-Tapia Claudio Tiribelli Stefano Bellentani Fondazione Italiana Fegato 34149 Trieste Italy Obesity and Digestive Diseases Unit Médica Sur Clinic and FoundationMexico 14050 México Department of Medical Sciences University of Trieste Department of Gastroenterology and Endoscopy Azienda USL di ModenaOspedale "Ramazzini" 41012 Carpi (Modena) Italy

Over the past few decades, non-alcoholic fatty liver disease(NAFLD) has become one, if not the most common,cause of chronic liver disease affecting both adults and children. The increasing number of cases at an early age is the most worrying aspect of this pathology, since it provides more time for its evolution. The spectrum of this disease ranges from liver steatosis to steatohepatitis, fibrosis and in some cases, hepatocellular carcinoma. NAFLD may not always be considered a benign disease and hepatologists must be cautious in the presence of fatty liver. This should prompt the use of the available experimental models to understand better the pathogenesis and to develop a rational treatment of a disease that is dangerously increasing. In spite of the growing efforts, the pathogenesis of NAFLD is still poorly understood. In the present article we review the most relevant hypotheses and evidence that account for the progression of NAFLD to non-alcoholic steatohepatitis(NASH) and fibrosis. The available in vitro and in vivo experimental models of NASH are discussed and revised in terms of their validity in translational studies. These studies must be aimed at the discovery of the still unknown triggers or mediators that induce the progression of hepatic inflammation, apoptosis and fibrosis.

关键词： Fatty Liver Obesity Metabolic syndrome Inflammation In vitro Experimental model

Alterations in the polysialylated neural cell adhesion molecule and retinal ganglion cell density in mice with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1608-1615页

作者： natalia Lobanovskaya Monika Jürgenson Anu Aonurm-Helm Alexander Zharkovsky Department of Pharmacology Centre of Excellence for Translational Medicine University of Tartu

AIM：To investigate the impact of polysialylated neural cell adhesion molecule（PSA-NCAM）on the survival of retinal ganglion cells（RGCs）in the experimentally induced diabetes in ***：Diabetes was induced in 2.5 months old Swiss Webster mice by intraperitoneal injection of streptozotocin（STZ,90 mg/kg）once daily for two consecutive *** of the proteins of interest in the retinas from diabetic mice at 2mo after diabetes induction was performed using immunohistochemistry and Western blot *** were counted in the wholemounted retinas,and Brn3a marker was ***：Examination of retinas from diabetic mice at 2mo after diabetes induction revealed a considerable reduction in RGC *** experiments also demonstrated a redistribution of PSA-NCAM in the retina of diabetic ***-NCAM immunoreactivity was diminished in the inner part of the retina where RGCs were *** contrast,an enhanced PSA-NCAM immunoreactivity was detected in the outer layers of the ***-NCAM signal was co-localized with glial fibrillary acidic protein immunoreactivity in the Müller cell *** studies have shown that matrix metalloproteinase-9（MMP-9）is responsible for the reduction in PSA-NCAM levels in neuronal *** reduced levels of PSA-NCAM in inner layers（nerve fiber layer,ganglion cell layer）were accompanied by the increased expression of *** contrast,in the outer retinal layers,the expression of MMP-9 was much less ***：MMP-9 induces PSA-NCAM shedding in the inner part of the retina and the decreased level of PSA-NCAM in the inner part of the retina might be,at least in part,responsible for the loss of RGCs in diabetic mice.

关键词： diabetic retinopathy matrix metalloproteinase-9 polysialylated neural cell adhesion molecule retinal ganglion cells

eIF3 subunit M regulates blood meal digestion in Rhodnius prolixus affecting ecdysis, reproduction, and survival

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Insect Science 2023年第5期30卷 1282-1292页

作者： Pilar Ameijeiras natalia Capriotti Sheila Ons Pedro L.Oliveira Marcos Sterkel Laboratorio de Neurobiología de Insectos(LNI) Centro Regional de Estudios GenómicosFacultad de Ciencias ExactasUniversidad Nacional de La PlataCENEXACONICETLa PlataBuenos AiresArgentina Instituto de Bioquímica Médica Leopoldo de Meis Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular(INCT-EM) Rio de JaneiroBrazil

In triatomines,blood-feeding triggers many physiological processes including post embryonic development and *** feeding habits,such as hematophagy,can shape gene functions to meet the challenges of each type of *** gut of blood-sucking insects faces particular challenges after feeding due to the quantity and the quality of the food ingested.A comparison of transcriptomic and proteomic data indicates that post transcriptional regulation of gene expression is crucial in the triatomine *** was proposed that eukaryotic translation initiation factor 3 subunit m(eIF3m)and eIF3e define 2 different eIF3 complexes with a distinct affinity for the different mRNAs,thus selecting the set of mRNAs to be translated and constituting a post transcriptional mode of regulation of gene *** the eIF3m is mainly expressed in the gut,we evaluated its relevance in Rhodnius prolixus physiology through RNA interference-mediated gene *** knockdown of eIF3m reduced the digestion rate,affecting the processes triggered by a blood *** silencing inhibited molting and caused premature death in nymphs while impaired ovary development,oviposition and increased resistance to starvation in adult *** survival of males after feeding(resistance to starvation)was not affected by eIF3m *** information regarding the eIF3m function in insects is scarce and the phenotypes observed in *** upon eIF3m silencing are different and more severe than those previously described in Drosophila melanogaster,indicating a pleiotropic role of this gene in triatomines.

关键词： egg hatching hematophagous vectors lifespan oviposition post embryonic development starvation resistance

Thermally decarboxylated sodium bicarbonate:Interactions with water vapour,calorimetric study

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Journal of Pharmaceutical Analysis 2013年第3期3卷 193-199页

作者： natalia Volkova Henri Hansson Lennart Ljunggren Department of Biomedical Science Malm UniversitySE-205 06MalmSweden Department of Biotechnology Center for Chemistry and Chemical EngineeringLund UniversityP.O.Box 124SE-221 00 LundSweden Galenica AB Medeon Science ParkSE-205 12MalmSweden

Isothermal titration calorimetry （ITC） was used to study interactions between water vapour and the surface of thermally converted sodium bicarbonate （NaHCO3）. The decarboxyla- tion degree of the samples was varied from 3% to 35% and the humidity range was 54-100%. The obtained enthalpy values were all exothermic and showed a positive linear correlation with decarboxylation degrees for each humidity studied. The critical humidity, 75% （RHo）, was determined as the inflection point on a plot of the mean-AH kJ/mole Na2CO3 against RH. Humidities above the critical humidity lead to complete surface dissolution. The water uptake （m） was determined after each calorimetric experiment, complementing the enthalpy data. A mechanism of water vapour interaction with decarboxylated samples, including the formation of trona and Wegscheider＇s salt on the bicarbonate surface is proposed for humidities below RHo.

关键词： Isothermal titrationcalorimetry Sodium bicarbonate Sodium carbonate Trona salt Wegscheider's salt Enthalpy Relative humidity Pyrolyticdecarboxylation