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The Role of Eumelanin in Generating Reactive Oxygen and Reactive Nitrogen in s.lution: Pos.ible Relevance to Keloid Formation

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Open Journal of Phys.cal Chemis.ry 2013年第4期3卷 157-162页

作者： Julian M. Menter Comnuan Nokkaew Danita Eatman Aquilla s.rewell natalia s.lves.rov Abrienne M. Patta s.ndra Harris.Hooker Analytical Laboratory Department of Pharmacology and Toxicology Morehouse School of Medicine Atlanta USA Department of Microbiology Biochemistry and Immunology Morehouse School of Medicine Atlanta USA Office of s.ons.red Res.arch Department of Pathology Morehouse School of Medicine Atlanta USA

Recently, nitric oxide (NO) has.been implicated as.an epigenetic factor in keloids. a s.arring dis.as. occurring primarily in dark s.inned people who have relatively high amounts.of pigment melanin. In this.work, we tes.ed whether a melanin-mediated redox reaction involving ads.rbed NO and O2 can couple NO oxidation with O2 reduction to form reactive oxygen s.ecies.(ROs. or reactive nitrogen s.ecies.(RNs. in vitro at pH 7.4. We meas.red the formation of reactive s.ecies.that oxidize dihydrorhodamine123 (DHR) to fluores.ent rhodamine123 in the pres.nce and abs.nce of s.pia melanin. In s.parate experiments. we monitored NO concentration with 4,5-diaminofluores.ein (DAF) by meas.ring the highly fluores.ent NO-adduct, DAF-2T. We attempted to detect peroxynitrite with 5 μM 3-methyl-1,2-cyclopentanedione (MCP), a s.lective s.avenger of peroxynitrite (IC50 = 3.6 μM for ONOO- vs. 63.8 μM and >> 100 μM for NO and O2- res.ectively). However, MCP its.lf oxidized DHR. We found that in the abs.nce of NO, melanin its.lf oxidizes.DHR, with no los. of DAF-fluores.ence (i.e. no net cons.mption of NO). In the pres.nce of NO, there was.a ~ 57% los. of DAF fluores.ence, indicating that NOx is.formed at the expens. of NO. The data provided good fit (r2 = 0.94) to a Langmuir ads.rption is.therm, with ps.udo firs. order rate k' = 8.2 × 107) s.1 and ads.rption coefficient Kad = 4.04 M-1. Both of thes. parameters.are cons.s.ent with a facile chemis.rption reaction between NO and O2 on the melanin s.rface. Pos.ible reactions.are a) NO and O2- → ONOO- and/or b) 2NO + O2 → 2NO2. The latter reaction is.dis.avored in s.lution but is.s.gnificantly accelerated on the melanin s.rface via an entropy effect.

关键词： Melanin Nitric Oxide NOx Redox

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Environmental Is.ues.of a Marine Protected Area in a Tectonic Es.uary in the Tropical Eas.ern Pacific:Uramba(Malaga Bay Colombia):Context,Biodivers.ty,Threats.and Challenges

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Journal of Water Res.urce and Protection 2013年第11期5卷 1037-1047页

作者： Jaime Ricardo Cantera Kintz Edgardo Londono-Cruz Luz Marina Mejia-Ladino Leonardo Herrera-Orozco Carlos.Andres.s.tizabal natalia Uribe-Cas.aneda Res.arch Group in Es.uaries.and Mangroves.of Colombian Pacific Departamento de BiologiaUniversidad del ValleCaliColombia Res.arch Group in Taxonomy Systematic and Marine EcologyInstituto de Investigaciones Marinas y Costeras“Jose Benito Vives de Andreis”Santa MartaColombia

The environmental protection of tropical marine and coas.al areas.faces.different challenges.due to the divers.ty of as.ects.related to thes. areas. which include natural, s.cial and economical is.ues. Des.ite thes. challenges. efforts.for the protection of thes. areas.are urgent nowadays.becaus. of the dramatical increas. of human related threats.like habitat des.ruction and population growth. Malaga Bay (MB) is.a tectonic es.uarine s.s.em located in Panama Bight (central region of the Colombian Pacific coas.), which due to its.origin s.ows.important environmental characteris.ics.of few s.tes.in the Tropical Eas.ern Pacific (TEP) match. For thes. reas.ns. the government of Colombia declared in 2010, the bay’s.marine area as.a Marine National Natural Park in order to pres.rve its.unique es.uarine marine biodivers.ty. Des.ite this.meas.re, MB pres.nts.s.veral conditions.that make environmental protection a very difficult tas.. In this.paper, we pres.nt the geographical context, biodivers.ty and natural res.urces. environmental threats. the complexity of economic and s.cial context, and the ins.itutional and legal context of MB, to exemplify the difficulty that the protection of marine areas.face in the TEP.

关键词： Protected Marine Areas Res.urces.Cons.rvation Es.uaries Tropical Eas.ern Pacific

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“Quito municipal s.hools. cohort s.udy: Bas.line res.lts

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Open Journal of Epidemiology 2012年第3期2卷 70-74页

作者： natalia Romero-s.ndoval Virginia Ruiz Juan Quizanga Ricardo Recalde Efrén Anchali Jaime Falconí Os.ar Flores.Miguel Martín Ins.ituto s.perior de Pos.grado Facultad de Ciencias Médicas Universidad Central del Ecuador Quito Ecuador Grupos.de Inves.igación de América y Africa Latinas.(GRAAL) Barcelona Espana and Quito Ecuador Cons.ltora de UNICEF Quito Ecuador Municipio del Dis.rito Metropolitano de Quito Quito Ecuador Unidad de Bioes.adís.ica Facultad de Medicina Universidad Autónoma de Barcelona Cerdanyola del Vallès Spain

The lack of population-level data on growth and development of children and adoles.ents.in Ecuador, and the exis.ence of previous.data s.gges.ing an alarming increas. in the numbers.of children pres.nting overweight or obes.ty jus.ifies.the pres.nt cohort s.udy which includes.all pupils.of municipal s.hools.of Quito aged 9 to 17 years. Follow-up will continue for a minimum of 7 years. This.will allow determining the evolution of prevalence of thes. phenomena and their trends.as.well as.other indices. both phys.ological and family-related cus.oms. in order to plan appropriate preventive interventions. The pres.nt cros.-s.ctional s.udy includes.21 municipal s.hools. grouped into four health zones. each of which depends.on a health centre, als. municipal, and which are res.ons.ble for the health of pupils.in thes. s.hools. Of the 6964 pupils.s.udied, 18.7% s.ffer overweight and 7.9% obes.ty: 19.3% and 9.7% res.ectively in boys. compared to 18.2% and 5.4% in girls. The s.udy als. as.es.es.family characteris.ics. degree of s.dentaris. and nutritional habits. 62.3% declared living in a nuclear family, and 60.5% declared their families.to be in the “adoles.ent” life-cycle s.age;91.9% of pupils.were s.dentary while 5.4% (CI95% 4.87 - 5.94) reported not eating breakfas. every day.

关键词： Overweight and Obes.ty Equatorian s.hool Children s.dentaris. Type of Family

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Functional Orai1 Dimers.As.emble to Form Hexameric Channels

Functional Orai1 Dimers Assemble to Form Hexameric Channels

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第十一届全国钙信号和细胞功能研讨会

作者： Xiangyu Cai Yandong Zhou Xianming Wang Robert M.Nwokonko natalia A Loktionova Donald L.Gill Department of Cellular and Molecular Phys.ology Pennsylvania State University College of Medicine The Milton S.Hershey Medical Center

The multimeric as.embly of the CRAC channel has.remained a contentious.is.ue des.ite s.rong crys.allographic evidence of a hexameric s.ructure for both Dros.phila and human Orai1. Recent s.udies.s.gges.ed concatemeric tetramers.of Orai1 mediate authentic CRAC current whereas.equivalent hexameric concatemers.form only non-s.lective cation channels. We expres.ed concatenated human Orai1 cons.ructs.with intervening 36-aa linkers. We compared expres.ion and function of C-terminally td Tomato-tagged monomeric, dimeric, trimeric, tetrameric, pentameric and hexameric concatemers.of human Orai1 in HEK cells.in which Orai1 was.knocked out us.ng CRs.R technology and cells.s.ably expres.ed s.IM1-YFP. All cons.ructs.were obs.rved to be exclus.vely PM-localized. The Orai1 monomer, dimer, trimer, tetramer, pentamer and hexamer cons.ructs.all gave ris. to the s.me level of s.ore-operated Ca2+ entry, and exhibited authentic CRAC channel activity with s.milar inward rectification and revers.l potential. In experiments.s.bs.ituting wt-Orai1 s.bunits.with pore-inactive E106 A mutant s.bunits. we obs.rved that the initial two N-terminal units.of tetrameric Orai1 concatemers.are crucial for channel activity. The remaining two C-terminal res.dues.in tetramers.were incons.quential for function. In hexamers. the pos.tion of inactive mutants.in the concatemer are not s.ecific. s.bs.itution with a s.ngle E106 A mutant monomer in the hexamer had s.milar effect in reducing channel function at each pos.tion. s.bs.itution with two E106 A res.dues.at the firs. N-terminal pos.tions.in the hexamer res.lted in no channel function. s.bs.itution with two E106 A res.dues.els.where in the hexamer, res.lted in approximately 50% of channel the wildtype hexamer. We interpret thes. res.lts.to reveal that hexamers. not tetramers. are likely the true functional Orai1 channel unit. Tetrameric concatemers.appear to feed dimers.into a hexameric s.ructure, with the two remaining Cterminal res.dues.outs.de the hex

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The Children’s.Faecal Matter s.ructure Is.Built by Their Parents

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Open Journal of Epidemiology 2019年第1期9卷 64-74页

作者： Eduard Cueto Rua Ricardo Wright Cecilia Zubiri Luciana Guzmán Claudia Los.da M. Inés.Urrutia María T. Gonzalez Ricardo Drut Mariela Es.ós.to Norberto Recalde Jorge Fiad Ignacio Goni natalia Belén María Cris.ina Arregui Facultad de Ciencias.Médicas Universidad Nacional de La Plata La Plata Argentina Comis.ón de Inves.igación Científica de la Provincia de Buenos.Aires Buenos Aires Argentina Pediatric Hos.ital “s.r María Ludovica” La Plata Argentina Univers.dad Nacional de La Plata La Plata Argentina Cons.ltant in Pediatrics Mar del Plata City Argentina Dolores.City Argentina

Introduction: Humans.have gone through phys.cal changes.over the las. 4 million years. The mouth, however, has.not changed teeth quantity or quality. Eight incis.rs.for fruits. vegetables.and tubers.four little canines.for little animals.eight premolars.and twelve flat molars.are us.d for crus.ing thes. foods. es.ecially whole grains.and legumes. The teeth crus.ing foods.are the firs. s.ep in the building of faecal matter. Foods.are s.lected mos.ly according to cultural guidelines.than to biological needs. The patterns.of cons.mption are induced by the publicity of indus.rialized or proces.ed foods. Material and Methods. This.s.udy des.gn was.obs.rvational, analytical, correlational, trans.ers.l and pros.ective. One thous.nd children (0 - 12 years.old) were ques.ioned in order to learn about the relations.ip between Weekly Eating Frequency (WEF) and Faecal Matter (FM) characteris.ics. The FM was.clas.ified as.s.ft, normal or hard and the outcome was.expres.ed as.Dry Faecal Res.due (DFR). The WEF and Weekly Bowel Movement Frequency (WBMF) were determined and tabulated according to times.per week. Environmental factors. parents. education level and children’s.birth order were examined. Res.lts. There was.a s.rong as.ociation between DFR, WBMF and WEF. Environment and education level did not play a key role although birth order did matter. Conclus.ons. Fibre-free foods.(dairies. meats. flours.and s.eeties.or s.das. increas.d DFR. Foods.containing fibre from vegetables.decreas.d DFR, which in turn contributed to the WBMF. Lowes. DFR was.obs.rved in children under Exclus.ve Breas.feeding (EB). Dis.ant las.-born children had higher DFR. Comments. Daily examples.s.pport thes. res.lts.and it is.clear that children’s.FM is.built by their parents. We encourage parents.to follow the “mouth nature” rather than the “advertis.ments.nature”.

关键词： Bowel Movement Frequency Cons.ipation Culture Faecal Matter Foods

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“s.形根管的处理技术附病例报告

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中国口腔医学继续教育杂志 2012年第4期15卷 246-252页

作者： natalia Lopez-Ampudia James.L Gutmann 王娜(译) 岳林(审) 北京大学口腔医学院牙体牙髓科北京市中关村南大街22号 100081

对“s.形弯根管进行预备时．要达到适当成形和彻底清理较为困难。鲜有文献专门报道这类不规则解剖形态根管的临床处理技巧。本文的目的在于详细说明如何安全有效地对“s.形根管进行根管治疗．并通过一例病例报告和治疗效果进行阐述。

关键词：不规则解剖结构清创根管成形 “s.形根管

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Implementation of a virtual multicenter gas.rointes.inal tumor board to reduce cancer dis.arities.in Argentina

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World Journal of Clinical Oncology 2022年第6期13卷 423-428页

作者： Federico Es.es. natalia s.ledad Tis.era Juan Manuel O'Connor Romina Luca Eduardo Huertas.Fernando s.nchez Loria Ivana Pedraza Alejandro Pairola Fernando Brancato Lis.ndro Paganini Mariana Kucharczyk Mora Amat Maria Teres. Pombo Mariana Galli Luis.na Bruno Luis.Caro Andrés.Rodriguez Diego Enrico Federico Wais.erg Matías.Chacón Department of Gas.rointes.inal Medical Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of s.rgery Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Radiology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Pathology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Radiation Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Gas.roenterology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Medical Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina

Given the increas.ng complexity of cancer care,multidis.iplinary tumor boards.have become es.ential in daily clinical oncology *** Project Extens.on for Community Healthcare Outcomes.ECHO)initiative developed an innovative telementoring model us.ng a"hub and s.oke"des.gn cons.s.ing of a team of experts.hub)that offers.a full s.rvice to multiple participants.the s.okes.during regularly s.heduled s.s.ions.dis.us.ing patients.clinical *** Alexander Fleming Cancer Ins.itute in Buenos.Aires.was.the firs. hub in Latin America to implement Project ECHO for gas.rointes.inal *** our 3-year experience,80 patients.from 37 centers.were evaluated within Project ECHO and a range of three to five cas.s.were dis.us.ed in each *** our pers.ective,the impact of this.novel approach was.a remarkable s.rategy to reduce care dis.arities.by equalizing acces. to high-quality medical knowledge in a multidis.iplinary environment for medical ***,it was.s.own to have a cos.-effective impact directly on the patients.and the local health s.s.em,s.nce relevant cos.s.were s.ved after unneces.ary treatments.s.udies.and travel expens.s.were avoided.

关键词： Tumor board Virtual Gas.rointes.inal Cancer dis.arities Oncology Extens.on for Community Healthcare Outcomes.project

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多层月球模型的自转动力学与着陆探测

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深空探测学报 2014年第3期1卷 175-180页

作者： Alexander GUs.V 孟治国平劲松 natalia PETROVA Hideo HANADA 李文潇中国科学院国家天文台月球与深空探测重点实验室北京100012 俄罗斯喀山联邦大学天文系喀山420008 吉林大学地质探索科学技术学院长春130012 日本国立天文台北京师范大学天文系

着重于寻找月核证据并将月核模型引入月球天平动理论中,探讨如何将多种空间探测技术应用于毫角秒精度的月球天平动观测,进而测定液态和固态月核参量。通过讨论多层月球的月球物理参数、流体核的几何与动力学椭率、松散黏滞的月幔,可获... 详细信息

着重于寻找月核证据并将月核模型引入月球天平动理论中,探讨如何将多种空间探测技术应用于毫角秒精度的月球天平动观测,进而测定液态和固态月核参量。通过讨论多层月球的月球物理参数、流体核的几何与动力学椭率、松散黏滞的月幔,可获得月球相关详细信息与参量,这些参量对评估多层结构的月球自由天平动很重要。物理天平动的解析理论还可应用于未来多种月球工作中,期望在近代月球科学研究基础上能有进一步发展。

关键词：月球内部结构动力学物理天平动月球任务

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急性呼吸道感染患儿前期病毒或支原体感染与鼻咽部定植菌之间的时间相关性

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中华实用儿科临床杂志 2014年第10期29卷 728-731页

作者： natalia Tana Gres.na 陈正荣王宇清严永东邵雪君张学兰陶云珍朱宏季伟苏州大学附属儿童医院呼吸科 215003

目的探讨急性呼吸道感染患儿前期病毒或肺炎支原体（MP）感染与鼻咽部定植菌之间的时间相关性.方法选取2006年1月至2010年12月因急性呼吸道感染（ARI）在苏州大学附属儿章医院住院治疗的忠儿作为研究对象,共8 322例.同时采集忠儿鼻咽... 详细信息

目的探讨急性呼吸道感染患儿前期病毒或肺炎支原体（MP）感染与鼻咽部定植菌之间的时间相关性.方法选取2006年1月至2010年12月因急性呼吸道感染（ARI）在苏州大学附属儿章医院住院治疗的忠儿作为研究对象,共8 322例.同时采集忠儿鼻咽部分泌物及血清标本进行多病原检测.应用直接免疫荧光法检测鼻咽分泌物中呼吸道合胞病毒（Rs.）、流感病毒A（Ⅳ-A）和流感病毒B（Ⅳ-B）、副流感病毒1～3型、腺病毒（ADV）;荧光定量聚合酶链反应检测鼻咽分泌物中MP;反转录-聚合酶链反应检测人类偏肺病毒（hMPV）;痰培养检测定植菌;定量酶联免疫吸附法检测MP特异性抗体.分析常见呼吸道病原与定植菌之间的时间相关性以及滞后效应.结果同期（滞后0个月）,仅Rs.与卡他莫拉菌之间存在显著相关性（rs.0.270,P=0.035）,且滞后1个月时二者仍存在显著相关性（rs.0.290,P=0.024）.滞后1个月时,Rs.（rs.0.370,P=0.004）和hMPV（rs.0.350,P=0.006）与流感嗜血杆菌存在相关性,且Rs.的此种相关性在滞后2个月时增强.Ⅳ-A与肺炎链球菌在滞后1个月时存在显著负相关性（rs.-0.339,P=0.009）;滞后1个月,ADV与肺炎链球菌也存在显著负相关性（rs.-0.269,P=0.040）;同时ADV与卡他莫拉菌也存在显著负相关（rs.-0.300,P=0.021）,且此种相关性在滞后2个月时显著增强（r=-0.380,P=0.003）.结论住院儿童病毒或MP流行活性与鼻咽部定植菌之间存在一定的时间相关性,而且Rs.、hMPV、Ⅳ-A、ADV、MP与定植菌存在滞后效应.

关键词：急性呼吸道感染呼吸道病毒肺炎支原体定植菌儿童

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TNFα和IL-6体外对颗粒物的反应：随颗粒物大小、季节、多环芳烃和土壤含量的变化

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环境与职业医学 2016年第12期33卷 1202-1208页

作者： natalia Manzano-León Jes.s.s.rrano-Lomelin Bris. N.s.nchez Raúl Quintana-Belmares.Elizabeth Vega Inés.Vázquez-López Leonora Rojas.Bracho Maria Tania López-Villegas.Felipe Vadillo-Ortega Andrea De Vizcaya-Ruiz Irma Ros.s.Perez Marie s.O’Neill Alvaro R.Os.rnio-Vargas.季麟(翻译) 金泰廙(审校) Departamento de Inves.igacion Bas.ca Instituto Nacional de CancerologiaMexicoDFMexico s.hool of Public Health University of AlbertaEdmontonAlbertaCanada Department of Environmental Health s.iences Department of Epidemiology School of Public HealthUniversity of MichiganAnn ArborMichiganUSA Direccion de Inves.igacion y Pos.rado Instituto Mexicano del PetroleoMexicoDFMexico Gerencia de Ciencias.Ambientales Instituto Nacional de Investigaciones NuclearesLa MarquesaOcoyoacacEstado de MexieoMexico Ins.ituto Nacional de Ecologta y Cambio Climatico MexicoDFMexico National Autonomous.Univers.ty of Mexico(UNAM)at the National Ins.itute of Genomic Medicine MexicoDFMexico Departamento de Toxicologla CinvestavMexicoDFMexico Centro de Ciencias.de la Atmos.era UNAMMexicoDFMexico Department of Paediatrics University of AlbertaEdmontonAlbertaCanada 不详

[背景]颗粒物(PM)与人类健康之间的关联随着季节变化而不同,这种现象可能与颗粒物的成分以及毒性相关的季节性交互作用有关。[目的]检测PM成分的季节性变化,并使用多个PM样本评估PM的体外促炎症可能性。[方法]以5个污染源不同的城市地... 详细信息

[背景]颗粒物(PM)与人类健康之间的关联随着季节变化而不同,这种现象可能与颗粒物的成分以及毒性相关的季节性交互作用有关。[目的]检测PM成分的季节性变化,并使用多个PM样本评估PM的体外促炎症可能性。[方法]以5个污染源不同的城市地区为采集地点,每周采集样本,在多雨温暖季节和干燥寒冷季节累积采集90份PM_(10)和PM_(2.5)样本。对其中检测到的元素、多环芳烃(PAHs.和内毒素进行主成分分析(PCA)。在人单核细胞(THP-1)中检测PM诱导肿瘤坏死因子α(TNFα)和白介素6(IL-6)分泌的可能性,并用组分评分建立促炎症反应的模型。[结果]PM的成分随其大小和季节而变化。PCA确定了PM中两种随季节变化的主要组分。燃烧相关的成分(如钒、苯并(a)芘、苯并(a)蒽)组成组分1(C_1),土壤相关的成分(如内毒素、硅、铝)组成组分2(C_2)。多雨温暖季节采集的PM中C_2含量较高,而干燥寒冷季节采集的PM(尤其是PM_(2.5))中C_1含量较高。细胞因子生成水平与PM_(10)和C_2(多雨温暖季节)正相关,但与PM_(2.5)和C_1(干燥寒冷季节)负相关。C_2含量较高的PM暴露水平越高,TNFα分泌越多;样本含有≥0.1%的C_1相关PAHs.,无论样本中C_2含量高低,暴露于该样本后TNFα对PM的反应性分泌都会降低。IL-6检测结果提示PM成分和颗粒大小之间存在复杂的交互作用。[结论]TNFα分泌具有季节性并与PM大小相关,PM中的土壤含量及PAH含量的变化是其根本原因。这些结果提示,流行病学研究中一些健康结局与PM之间关联的季节性差异能用PM组分的混合物来解释。

关键词：多环芳烃主成分分析内毒素检测采集样流行病学研究细胞因子城市地区肿瘤坏死因子α 变异系数苯并

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