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Pancreatic neuroendocrine tumors:Are tumors smaller than 2 cm truly indolent?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1756-1762页

作者： sergio Hoyos Pablo Posada-Moreno natalia Guzman-Arango Romario Chanci-Drago Jaime Chavez Alvaro Andrés-Duarte santiago salazar-Ochoa Hepatobilary and Liver Transplant Unit Hospital Pablo Tobon Uribe and Gastrohepathology Group Universidad de AntioquiaMedellin 050034AntioquiaColombia Department of General surgery Universidad Pontificia BolivarianaMedellín 050034AntioquiaColombia

BACKGROUND Pancreatic neuroendocrine tumors(PNETs)are relatively rare but rank as the second most common pancreatic *** can be functional,causing early metabolic disturbances due to hormone secretion,or non-functional and diagnosed later based on tumor size-related *** diagnoses of PNETs under 2 cm in size have sparked debates about their management;some practitioners advocate for surgical removal and others suggest observation due to the tumors’lower potential for ***,it is unclear whether managing these small tumors expectantly is truly *** To evaluate poor prognostic factors in PNETs based on tumor size(>2 cm orsurgically treated *** This cohort study included 64 patients with PNETs who underwent surgical resection between 2006 and 2019 at a high-complexity reference hospital in Medellín,*** assess patient survival,quarterly follow-ups were conducted during the first year after surgery,followed by semi-annual con-sultations at the hospital's hepatobiliary surgery *** variables were described using absolute and relative frequencies,and quantitative variables were expressed using measures of central tendency and their corresponding measures of *** The presence of lymph node involvement,neural involvement,and lymphovascular invasion were all associated with an increased risk of mortality,with hazard ratios of 5.68(95%CI:1.26–25.61,P=0.024),6.44(95%CI:1.43–28.93,P=0.015),and 24.87(95%CI:2.98–207.19,P=0.003),*** involvement and lymphovascular invasion were present in tumors smaller than 2 cm in diameter and those larger than 2 cm in *** recurrence rates between the two tumor groups were furthermore similar:18.2%for tumors smaller than 2 cm and 21.4%for tumors larger than 2 *** survival was additionally comparable between the two tumor *** Tumor size does not dictate prognosis;lymph node and lymphovascular involvement a

关键词： Neuroendocrine tumor Pancreatic neoplasm Pancreas Pancreatic neuroendocrine neoplasm Pancreatic neuroendocrine tumors

Terrorism Attack Classification Using Machine Learning: The Effectiveness of Using Textual Features Extracted from GTD Dataset

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Computer Modeling in Engineering & sciences 2024年第2期138卷 1427-1467页

作者： Mohammed Abdalsalam Chunlin Li Abdelghani Dahou natalia Kryvinska school of Computer science and Technology Wuhan University of TechnologyWuhan430070China LDDI Laboratory Faculty of Science and TechnologyUniversity of Ahmed DRAIAAdrar01000Algeria Information systems Department Faculty of ManagementComenius UniversityBratislava82005Slovakia

One of the biggest dangers to society today is terrorism, where attacks have become one of the most significantrisks to international peace and national security. Big data, information analysis, and artificial intelligence (AI) havebecome the basis for making strategic decisions in many sensitive areas, such as fraud detection, risk management,medical diagnosis, and counter-terrorism. However, there is still a need to assess how terrorist attacks are related,initiated, and detected. For this purpose, we propose a novel framework for classifying and predicting terroristattacks. The proposed framework posits that neglected text attributes included in the Global Terrorism Database(GTD) can influence the accuracy of the model’s classification of terrorist attacks, where each part of the datacan provide vital information to enrich the ability of classifier learning. Each data point in a multiclass taxonomyhas one or more tags attached to it, referred as “related tags.” We applied machine learning classifiers to classifyterrorist attack incidents obtained from the GTD. A transformer-based technique called DistilBERT extracts andlearns contextual features from text attributes to acquiremore information from text data. The extracted contextualfeatures are combined with the “key features” of the dataset and used to perform the final classification. Thestudy explored different experimental setups with various classifiers to evaluate the model’s performance. Theexperimental results show that the proposed framework outperforms the latest techniques for classifying terroristattacks with an accuracy of 98.7% using a combined feature set and extreme gradient boosting classifier.

关键词： Artificial intelligence machine learning natural language processing data analytic DistilBERT feature extraction terrorism classification GTD dataset

Quality of drinking water and risk to the health of the population of the south Baikal region (Russia)

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Emerging Contaminants 2024年第2期10卷 106-114页

作者： Viktor s.Rukavishnikov natalia V.Efimova Mikhail F.savchenkov Inna V.Mylnikova Alexander A.Lisovtsov East-siberian Institute of Medical and Ecological Research 665827AngarskRussia

Providing good quality water in sufficient quantities is a major challenge in the *** purpose of the study is to assess the quality of drinking water and the health risk of various population groups in the southern Baikal region(siberia,Russia)under changing hydrological *** Baikal is the largest freshwater body of water and is one of the sites protected by *** and *** analysis of centralized and non-centralized water supply was carried out in the south-eastern part of the Irkutsk region,adjacent to Lake *** data used are from the Baikal(regional)Information Center for 2011–2022,and they include the results of monitoring the water quality of the centralized domestic and drinking water supply(CDW)with 140 thousand samples,and non-centralized domestic and drinking water supply(NDW)with 108 thousand *** all samples,17 substances were *** addition,during the flood period,accompanied by additional water disinfection,trihalomethanes were determined in populated areas exposed to negative *** quality of drinking water was assessed in comparison with the maximum permissible concentrations of substances(MPCs)approved by regulatory documents of *** assessment of the characteristics of drinking water consumption by the population of the Baikal region was carried out,based on interview data from sample groups of the *** assessment of the risk to public health,due to chronic oral intake of chemicals,was carried out using the values of the hazard coefficient(HQi),the hazard index(HI),individual carcinogenic risk(ICR),and population carcinogenic risk(PCR).Village residents more often use underground water sources(centralized and non-centralized).Residents of cities are provided with water from surface sources(Lake Baikal and the Angara River).significant concentrations of iron,nitrates,and manganese were found in drinking water used by *** concentrations of iron-2.25 mg/dl,manganese

关键词： Drinking water Noncarcinogenic risk Carcinogenic risk Population south Baikal region

Change in Grain-size Composition of Lignite under Cyclic Freezing-Thawing and Wetting-Drying

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Natural Resources 2024年第1期15卷 17-27页

作者： natalia s. Batugina Vladislav I. Fedorov Chersky Institute of Mining of the North siberian Branch Russian Academy of sciences Yakutsk Russia

The paper presents the change in grain-size composition of lignite under cyclic freezing-thawing (FTC) and wetting-drying (WDC). The article shows that in the spring and autumn periods the lignites can be subjected to repeated freezing-thawing and wetting-drying, which determines the possibility of changing their grain-size composition and structure. Experimental studies in laboratory conditions on the influence of cyclic freezing-thawing (FTC) and wetting-drying (WDC) on the quality indicators of lignites have been carried out, their granulometric (fractional) composition has been studied. Freezing-thawing cycle conditions are as follows (FTC): minimum exposure temperature: -20°C;maximum: +5°C;relative humidity: 30%;number of processing cycles: 3. Wetting-drying cycles are as follows (WDC): drying temperatures are +20, +40, +60, +80°C, drying time 90 minutes, the coals are further subjected to rain (soaking) for a period of water saturation to humidity of 30% - 40% and dry again. The number of wetting-drying cycles is 3 times. The tests have revealed the destructive effects of FTC and WDC on the samples of lower metamorphic grade coal, and the cycles of wet-dry lead to the much higher yield of fine sizes (-6+0;-13+0 mm) than the cycles of freeze-thaw. Furthermore, it is found that the increase in the yield of fines depends on the heating temperature: coal disintegration proceeds more intensively at a higher temperature of drying.

关键词： Lignite Freezing-Thawing Cycle Wetting-Drying Cycle Grain size Composition Dust Coal storage Loss Quality

O'Hare Airport roadway traffic prediction via data fusion and Gaussian process regression

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 721-732页

作者： Damola M.Akinlana Arindam Fadikar stefan M.Wild natalia Zuniga-Garcia Joshua Auld Department of Mathematics and statistics University of South FloridaTampaFL 33620USA Decision and Infrastructure sciences Division Argonne National LaboratoryLemontIL 60439USA Applied Mathematics and Computational Research Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Industrial Engineering and Management sciences Northwestern UniversityEvanstonIL 60208USA Argonne National Laboratory Energy SystemsLemontIL 60439USA

This study proposes an approach of leveraging information gathered from multiple traffic data sources at different resolutions to obtain approximate inference on the traffic distribution of Chicago's O'Hare Airport ***,it proposes the ingestion of traffic datasets at different resolutions to build spatiotemporal models for predicting the distribution of traffic volume on the road *** to its good adaptability and flexibility for spatiotemporal data,the Gaussian process(GP)regression was employed to provide short-term forecasts using data collected by loop detectors(sensors)and supplemented by telematics *** GP regression is used to make predictions of the distribution of the proportion of sensor data traffic volume represented by the telematics data for each location of the ***,the fitted GP model can be used to determine the approximate traffic distribution for a testing location outside of the training *** in the transportation sector can find the results of this work helpful for making informed decisions relating to current and future transportation conditions in the area.

关键词： spatio-temporal Data fusion Gaussian process Multimodal data Airport traffic O'Hare Airport

The sudden ocean warming and its potential influences on earlyfrozen landfast ice in the Prydz Bay, East Antarctica

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Acta Oceanologica sinica 2024年第5期43卷 65-77页

作者： Haihan Hu Jiechen Zhao Jingkai Ma Igor Bashmachnikov natalia Gnatiuk Bo Xu Fengming Hui school of Geospatial Engineering and science Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(sun Yat-sen University) Ministry of EducationZhuhai 519082China Qingdao Innovation and Development Base(Centre)of Harbin Engineering University Qingdao 266500China Key Laboratory for Polar Acoustics and Application of Ministry of Education(Harbin Engineering University) Harbin 150001China Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecasting CentreBeijing 100081China Nansen International Environmental and Remote sensing Centre St.Petersburg 199034Russia saint Petersburg state University St.Petersburg 199034Russia Antarctic Great Wall Ecology National Observation and Research station Polar Research Institute of ChinaShanghai 201209China

The ocean conditions beneath the ice cover play a key role in understanding the sea ice mass balance in the polar *** integrated high-frequency ice-ocean observation system,including Acoustic Doppler Velocimeter,Conductivity-Temperature-Depth sensor,and sea Ice Mass Balance Array(sIMBA),was deployed in the landfast ice region close to the Chinese Zhongshan station in Antarctica.A sudden ocean warming of 0.14℃(ps observed beneath early-frozen landfast ice,from(−1.60±0.03)℃during April 16-19 to(−1.46±0.07)℃during April 20-23,2021,which is the only significant warming event in the nearly 8-month *** sudden ocean warming brought a double rise in oceanic heat flux,from(21.7±11.1)W/m^(2) during April 16-19 to(44.8±21.3)W/m^(2) during April 20-23,2021,which shifted the original growth phase at the ice bottom,leading to a 2 cm melting,as shown from sIMBA and borehole ***,the slowdown of ice bottom freezing decreased salt rejection,and the daily trend of observed ocean salinity changed from+0.02 d^(-1) during April 16-19,2021 to+0.003 d^(-1) during April 20-23,*** potential reasons are increased air temperature due to the transit cyclones and the weakened vertical ocean mixing due to the tide phase transformation from semi-diurnal to *** high-frequency observations within the ice-ocean boundary layer enhance the comprehensive investigation of the ocean’s influence on ice evolution at a daily scale.

关键词： sudden ocean warming oceanic heat flux landfast ice Zhongshan station in-situ observation

systemic juvenile idiopathic arthritis–associated lung disease: A retrospective cohort study

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World Journal of Clinical Pediatrics 2024年第1期13卷 73-83页

作者： Konstantin E Belozerov natalia M solomatina Eugenia A Isupova Alla A Kuznetsova Mikhail M Kostik Department of Pediatric Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia st.Petersburg state Budgetary Institution of Health Care Children's City Polyclinic No.29 of the Kalininsky District of St.PetersburgSt.Petersburg 195274Russia Research Laboratory of Autoimmune and Autoinflammatory Diseases World-Class Research Centre for Personalized MedicineAlmazov National Medical Research CentreSt.Petersburg 197341Russia

BACKGROUND Lung damage in systemic juvenile arthritis(sJIA)is one of the contemporary topics in pediatric *** previous studies showed the severe course and fatal outcomes in some *** information about interstitial lung disease(ILD)in the sJIA is scarce and limited to a total of 100 *** To describe the features of sJIA patients with ILD in *** In the present retrospective cohort study,information about 5 patients less than 18-years-old with sJIA and ILD were *** diagnosis of sJIA was made according to the current 2004 and new provisional International League of Associations for Rheumatology criteria *** was diagnosed with chest computed tomography with the exclusion of other possible reasons for concurrent lung *** activation syndrome(MAs)was diagnosed with HLH-2004 and 2016 EULAR/ACR/PRINTO Classification Criteria and hscores were calculated during the lung *** The onset age of sJIA ranged from 1 year to 10 *** time interval before ILD ranged from 1 mo to 3 *** disease course was characterized by the prevalence of the systemic features above articular involvement,intensive rash(100%),persistent and very active MAs(hscore range:194-220)with transaminitis(100%),and respiratory symptoms(100%).Only 3 patients(60%)developed a clubbing *** patients(100%)had pleural effusion and 4 patients(80%)had pericardial effusion at the disease *** patients(40%)developed pulmonary arterial ***-related reactions to tocilizumab were observed in 3(60%)of the *** patient with trisomy 21 had a fatal disease *** of the remaining patients had sJIA remission and 2 patients had *** disease improved in 3 patients(75%),but 1 of them had initial deterioration of lung *** patient who has not achieved the sJIA remission had the progressed course of *** cases of hyper-eosinophilia were *** patients(80%)received

关键词： systemic juvenile arthritis Interstitial lung disease Canakinumab Tocilizumab Interleukin-6 Interleukin-1

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： natalia Kulesskaya Kira M.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Use of subcutaneous tocilizumab to prepare intravenous solutions for COVID-19 emergency shortage:Comparative analytical study of physicochemical quality attributes

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Journal of Pharmaceutical Analysis 2020年第6期10卷 532-545页

作者： natalia navas.jes.s.hermos.lla Anabel Torrente-Lopez Jose Hernandez-Jimenez Jose Cabeza Raquel Perez-Roblesa Antonio salmeron-García Department of Analytical Chemistry Science Faculty/Biomedical Research Institute ibs.GranadaUniversity of GranadaGranadaE-18071Spain UGC Farmacia Hospitalaria Biomedical Research Institute ibs.Granada.Hospital Universitario San Cecilio de GranadaGranadaE-18012Spain

COVID-19,a disease caused by the novel coronavirus sARs-Co V-2,has produced a serious emergency for global public health,placing enormous stress on national health systems in many *** studies suggest that cytokine storms(interleukins)may play an important role in severe cases of *** key inflammatory factors in cytokine release syndrome(CRs)could therefore be of great value in reducing the mortality ***(TCZ)in its intravenous(IV)form of administration-Ro Actemra?20 mg/m L(Roche)-is indicated for treatment of severe CRs *** investigations have concluded that inhibition of IL-6 with TCZ appears to be efficacious and safe,with several ongoing clinical *** has led to a huge increase in demand for IV TCZ for treating severe COVID-19 patients in hospitals,which has resulted in drug ***,we present a comparability study assessing the main critical physicochemical attributes of TCZ solutions used for infusion,at 6 mg/m L and 4 mg/m L,prepared from Ro Actemra?20 mg/m L(IV form)and from Ro Actemra?162 mg(0.9 m L solution pre-filled syringe,subcutaneous(sC)form),to evaluate the use of the latter for preparing clinical solutions required for IV administration,so that in a situation of shortage of the IV medicine,the sC form could be used to prepare the solutions for IV delivery of *** is important to remember that during the current pandemic all the medicines are used off-label,since none of them has yet been approved for the treatment of COVID-19.

关键词： COVID-19 Tocilizumab Critical quality attributes IV and sC medicines