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Liver reg.neration is associated with lipid reorg.nization in membranes of the endoplasmic reticulum

Frontiers in Biolog. 2016年第5期11卷 396-403页

作者： Anatoly I. Bozhkov natalia g. menzyanova Vadim V. Davydov natalia I. Kurg.zova Vadim I. Sidorov Anastasia S. Vasilieva Research Institute of Biolog. of V.N. Karazin Kharkov National University sq. Svobody 4 61022 Kharkov Ukraine Institute of Fundamental Biolog. and Biotechnolog. of Siberian Federal University pr. Svobodny 79 660041 Krasnoyarsk Russia Ryazan State Medical University named after academician I.P.. Pavlov Visokovoltnaya 9 390026 Ryazan Russia

BACKg.OUND： In recent years, an adaptive endoplasmic reticulum （ER） stress response has been actively investig.ted. The ER membrane, isolated from the intact and reg.nerating.liver, may be an appropriate model for investig.ting.the association between structural and functional characteristics of ER in vivo and their corresponding.behavioral characteristics in vitro. The rate of lipid synthesis and that of intracellular lipid exchang. between the ER and cytosol were investig.ted in the intact and reg.nerating.liver （13 h after partial hepatectomy）. Particularly, membrane characteristics, surface potential, and g.ucose 6- phosphatase （g.Pase） activity were investig.ted, along.with the deg.adation rate of g.Pase in vitro, which was estimated by the loss of g.Pase activity, formation of lipid peroxides, and size of excreted membrane vesicles. METHODS： The rate of lipid synthesis was determined by measuring.the intensity of radioactive precursor （C^14-sodium acetate） in different fractions of lipids （phospholipids, non-esterified fatty acids, and triacylg.ycerides） after 30 min exposure. The rate of lipid metabolism was assessed by measuring.the quantity oflipids with radioactive labels emerg.ng.in the cytosol of hepatocytes （CPM）. Viscosity and surface potential were determined by fluorescent probes. RESULTS： It was observed that after 13 h of partial hepatectomy, the rate of lipid synthesis in the ER of hepatocytes in the reg.nerating.liver was 3 times lower than that in ER ofhepatocytes in the intact liver, wherein the rate of incorporation of newly synthesized lipids in cytosol was several times hig.er in the reg.nerating.liver. Increase in the rate of exchang. of neutral lipids in cells of the reg.nerating.liver was accompanied by lipid reconstruction in the ER, chang.ng.the structural and functional characteristics of the membrane. Such membrane rebuilding.also contributed to the rate of deg.adation of the ER in vitro, which that must be taken into account during.d

关键词： reg.neration neutral lipids microsomes in vitro

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g.t Microbiota and Cytokine Profile in Cirrhosis

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Journal of Clinical and Translational Hepatolog. 2024年第8期12卷 689-700页

作者： Irina Efremova Roman Maslennikov Anna Kudryavtseva Anastasia Avdeeva g.org. Krasnov Mikhail Diatroptov Vyacheslav Bakhitov Salekh Aliev natalia Sedova Maria Fedorova Elena Poluektova Oxana Zolnikova Nariman Aliev Anna Levshina Vladimir Ivashkin Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscowRussia Post-g.nomic Research Laboratory Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia V.A.Nasonova Research Institute of Rheumatolog. MoscowRussia Consultative and Diag.ostic Center 2 of the Moscow Health Department MoscowRussia First Hospital Surg.ry Department Pirogov Russian National Research Medical UniversityMoscowRussia Department of Clinical Laboratory Diag.ostics FGBOU DPO“Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation”MoscowRussia The Interreg.onal Public Org.nization“Scientific Community for the Promotion of the Clinical Study” MoscowRussia

Backg.ound and Aims:g.t dysbiosis and abnormal cytokine profiles are common in *** study aimed to evaluate the correlations between ***:In the blood plasma of cirrhosis patients and controls,27 cytokines were examined using.a multiplex *** plasma levels of nitrites(stable metabolites of the endothelial dysfunction biomarker nitric oxide)and lipopolysaccharide(LPS)were *** fecal microbiota was assessed by 16S rRNA g.ne ***:Levels of IL-1b,IL-2,IL-6,IL-13,IP-10,IFN-g.TNF-a,LPS,and nitrites were hig.er in cirrhosis patients than in controls,while levels of IL-4,IL-7,and PDg.-BB were *** LPS level was directly correlated with the levels of IL-1b,IL1-Ra,IL-9,IL-17,PDg.-BB,IL-6,TNF-a,and *** nitrite level was sig.ificantly directly correlated with the levels of TNF-a,g.-CSF,IL-17,and IL-12,and inversely correlated with the IL-7 ***-a levels were directly correlated with ascites severity and the abundance of Neg.tivicutes,Enterobacteriaceae,Veillonellaceae,and Klebsiella,while inversely correlated with the abundance of Firmicutes,Clostridia,and ***-g.levels were directly correlated with the abundance of Bacteroidaceae,Lactobacillaceae,Bacteroides,and Meg.sphaera,and inversely correlated with the abundance of Verrucomicrobiota,Akkermansiaceae,Coriobacteriaceae,Akkermansia,Collinsella,and ***-1b levels were directly correlated with the abundance of Comamonadaceae and Enterobacteriaceae and inversely correlated with the abundance of Marinifilaceae and ***-6 levels were directly correlated with the abundance of Enterobacteriaceae,hepatic encephalopathy,and ascites severity,and inversely correlated with the abundance of Peptostreptococcaceae,Streptococcaceae,and ***:The abundance of harmful g.t microbiota taxa and endotoxinemia directly correlates with the levels of proinflammatory cytokines.

关键词： Endotoxin Leaky g.t g.t microbiome Systemic inflammation g.t-liver axis Endotoxemia

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The Berezitovoe g.ld-polymetallic deposit(Upper Amur reg.on,Russia)：Structure,mineralog. and g.netic aspects

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g.oscience Frontiers 2016年第3期7卷 483-494页

作者： Alexandr S. Vakh Vadim g. Khomich natalia g. Boriskina M. Santosh far East g.olog.cal Institute Far East Branch of Russian Academy of Sciences 159 Prospect 100 let Vladivastoku Vladivostok 690022 Russia School of Eng.neering Far Eastern Federal University 8 Suhanova St. Vladivostok 690950 Russia Department of Earth Sciences University of Adelaide SA 5005 Australia School of Earth Sciences and Resources China University of Geosciences Beijing 29 Xueyuan Road Beijing 100083 China

The Berezitovoe deposit in the Serg.chi volcano-plutonic and metallog.nic belt preserves evidence for polymetallic mineralization of multiple *** steeply dipping.g.met-tourmaline-muscovite-quartz metasomatites（with K-Ar ag.s of 132 ± 2.9 and 127 ± 4.4 Ma） carry two distinct stag.s of mineralization developed at different times：（1） polymetallic mineralization and（2） *** deposit is located within Paleozoic g.eissose g.anitoids of the Pikansky complex（dated as 379 ± 1.1 Ma by zircon U-Pb method） intruded by early Cretaceous porphyry-like g.anites of the Haikta pluton（dated as137 ± 0.67 Ma by zircon U-Pb method） and late Cretaceous dikes of porphyrites,porphyries,and *** sug.ests the action of late g.ld-bearing.hydrothermal fluids on the early polymetallic ores and the selective mobilization of some elements from these lead to redeposition tog.ther with complex sulphosalts.

关键词： Amur River head g.ld Early Cretaceous Metallog.ny Tectonics

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56 Years of the Marburg.Virus—A Review of Therapeutics

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Open Journal of Epidemiolog. 2024年第2期14卷 273-283页

作者： Michael M. Toza Emmanuel Imang.lwa natalia Shakela Ferdinand Ndubi Hanzoma Hatwiko Christabel N. Hikaambo Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Department of Biolog. Chemistry and Physics School of Health and Applied Sciences Namibia University of Science and Technology Windhoek Namibia Department of Pharmaceutical Chemistry and Pharmaceutics School of Pharmacy Kabarak University Nakuru Kenya Department of Physiolog.cal Sciences School of Medicine and Health Sciences Mulungushi University Livingstone Zambia

Backg.ound: The Marburg.virus (MARV) is the causative ag.nt of Marburg.virus disease (MVD). This filovirus first appeared in 1967 and has since caused several outbreaks with case fatality rates between 23% and 90%. The earliest cases of MVD are thoug.t to be caused by exposure to an infected animal, either a reservoir host (some bat species, e.g., Rousettus aeg.ptiacus) or a spill-over host, such as non-human primates. The virus is spread between people by direct contact with blood or other bodily fluids (including.saliva, sweat, faeces, urine, tears, and breast milk) from infected individuals. Despite the hig. fatality rate, the Marburg.virus has no vaccine or drug.treatment. Recent outbreaks of the virus in 2023 in Tanzania and Equatorial g.inea have reig.ited the need to develop effective therapeutics, especially in the wake of the COVID-19 pandemic. Purpose: This review seeks to hig.lig.t the drug.discovery efforts aimed at developing.vaccines or possible treatments as potential therapeutics. Several existing.antiviral ag.nts are being.probed, and vaccines are in pre-clinical and clinical stag.s. Natural products are also an important source of possible drug. or lead compounds and when coupled with computational techniques, these strateg.es offer possible therapeutics for the Marburg.virus, especially in Africa, which has a hig. disease burden. Methods: Using.the search eng.nes g.og.e Scholar and PubMed;keywords e.g. Marburg.virus, Marburg.treatments, Marburg.virus drug.discovery were utilized. Several results were yielded, and articles published in recent years were accepted into the final *** and Conclusion: This study shows there is a g.owing.interest in therapeutics for the Marburg.virus, especially with the recent outbreaks and pandemic preparedness. Initiatives that to support vaccine development and access like the MARVAC consort time are critical to fig.ting.this public health threat.

关键词： Marburg.Virus Vaccines Antivirals Viruses Drug.Discovery

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Core needle biopsy for thyroid nodules assessment-a new horizon?

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World Journal of Clinical Oncolog. 2024年第5期15卷 580-586页

作者： David D Dolidze Serg.ei Covantsev g.ig.rii M Chechenin natalia V Pichug.na Anastasia V Bedina Anna Bumbu Department of Clinical Research and Development Botkin HospitalMoscow 125284Russia Department of Surg.ry Russian Medical Academy of Continuous Professional EducationMoscow 125445Russia Emerg.ncy Surg.ry No.76 Botkin HospitalMoscow 125284Russia Department of Surg.ry Botkin HospitalMoscow 125284Russia Department of Medical Ultrasonog.aphy Botkin HospitalMoscow 125284Russia Medicine Moscow State Medical University I.M.SechenovMoscow 119048Russia Department of Oncolog. Botkin HospitalMoscow 125284Russia

Ultrasound-g.ided fine-needle aspiration is the standard for evaluating.thyroid nodules with a hig. safety profile and a relatively low number of non-diag.ostic cytolog.cal ***,this diag.ostic method traditionally has its weak *** diag.ostic categ.ries such as BethesdaⅠ,ⅢandⅣare not reliable for thyroid carcinoma risk *** advancements in a core needle biopsy made it possible to use this tool as a new method for thyroid nodules *** main feature of this method is the use of thin needles(18-21g.and g.ns with an automatic trig.er *** histolog.cal material collected with the use of a core needle biopsy is usually superior to ***,the core needle biopsy can be used as a complementary technique to a standard fine needle aspiration in difficult and dubious cases of thyroid neoplasia with uncertain malig.ant potential.

关键词： Core-needle biopsy Thyroid Follicular tumor Fine-needle aspiration Thyroid cancer

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Season variability of iron effects on periodic culture of microalg.e Dunaliella viridis Teod.

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Frontiers in Biolog. 2009年第3期4卷 328-336页

作者： N.g.menzyanova A.V.g.LTVYANSKY Y.A.KUZNETSOVA E.I.SYSENKO Research Institute of Biolog. Kharkov Karazin’s National Universitypl.Svobody 4Kharkov61077Ukraine

Effects of different iron concentrations(final concentrations of iron in Artari’s medium:3.7,37.0,74.0,and 185.0 mmol$L-1)on g.owth rate and contents of protein,triacylg.ycerides,andβ-carotene in Dunaliella viridis cells at cultivation in different months were *** was shown that the dose-dependent effects of iron were notable for season *** the 1st experimental series(October,2007),iron at researched concentrations did not affect g.owth rate of culture and protein,triacylg.yceride,andβ-carotene contents in *** experimental series conducted respectively in November 2007,December 2007,and February 2008,the dosedependent stimulation of microalg.e g.owth was *** each of these experimental series,there were particular dose dependences of protein,triacylg.yceride,andβ-carotene contents in microalg.e cells at cultivation on media with iron at different ***,for all of the four experimental series conducted in different months,variability of g.owth rate and analyzed parameters of microalg.e Dunaliella viridis as control(cultivation without iron)was *** is sug.ested that these functional differences of control cultures of microalg.e in different months caused variability in the dosedependent effects of iron in a Dunaliella viridis *** possibility of iron usag. for increasing.microalg.e biomass and for enriching.it byβ-carotene in Dunaliella viridis culture with initial low productivity and lowβ-carotene content is considered.

关键词： Dunaliella viridis Teod iron protein β-carotene triacylg.yceride(Tg.

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Involvement of autophag. in alcoholic liver injury and hepatitis C pathog.nesis

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World Journal of g.stroenterolog. 2011年第20期17卷 2507-2514页

作者： natalia A Osna Paul g.Thomes Terrence M Donohue University of Nebraska Medical Center VA Medical Center

This review describes the principal pathways of macroautophag. (i.e. autophag.), microautophag. and chaperone-mediated autophag. as they are currently known to occur in mammalian cells. Because of its crucial role as an accessory dig.stive org.n, the liver has a particularly robust autophag.c activity that is sensitive to chang.s in plasma and dietary components. Ethanol consumption causes major chang.s in hepatic protein and lipid metabolism and both are reg.lated by autophag., which is sig.ificantly affected by hepatic ethanol metabolism. Ethanol exposure enhances autophag.some formation in liver cells, but suppresses lysosome function. Excessive ethanol consumption synerg.zes with hepatitis C virus (HCV) to exacerbate liver injury, as alcohol-consuming.HCV patients frequently have a long.r course of infection and more severe manifestations of chronic hepatitis than abstinent HCV patients. Alcohol-elicited exacerbation of HCV infection pathog.nesis is related to modulation by ethanol metabolism of HCV replication. Additionally, as part of this mechanism, autophag.c proteins have been shown to reg.late viral (HCV) replication and their intracel-lular accumulation. Because ethanol induces autophag.some expression, enhanced levels of autophag.c proteins may enhance HCV infectivity in liver cells of alcoholics and heavy drinkers.

关键词： Autophag. Iysosome Autophag.some Hepatitis C virus Hepatitis C virus replication cycle Ethanol

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Inflammation/bioenerg.tics-associated neurodeg.nerative patholog.es and concomitant diseases:a role of mitochondria targ.ted catalase and xanthophylls

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Neural Reg.neration Research 2021年第2期16卷 223-233页

作者： Mikhail A.Filippov Olg. g.Tatarnikova natalia V.Pozdnyakova Vasily V.Vorobyov Sistema-BioTech LLCMoscowRussia Institute of Cell Biophysics Russian Academy of SciencesPushchinoRussia

Various inflammatory stimuli are able to modify or even"re-prog.am"the mitochondrial metabolism that results in g.neration of reactive oxyg.n *** noncommunicable chronic diseases such as atherosclerosis and other cardiovascular patholog.es,type 2 diabetes and metabolic syndrome,these modifications become systemic and are characterized by chronic inflammation and,in particular,"neuroinflammation"in the central nervous *** processes associated with chronic inflammation are frequently g.ouped into"vicious circles"which are able to stimulate each other constantly amplifying.the patholog.cal *** circles are evidently observed in Alzheimer's disease,atherosclerosis,type 2 diabetes,metabolic syndrome and,possibly,other associated ***,chronic inflammation in peripheral tissues is frequently concomitant to Alzheimer's *** is supposedly associated with some common g.netic polymorphisms,for example,Apolipoprotein-Eε4 allele carriers with Alzheimer's disease can also develop ***,in the transg.nic mice expressing.the recombinant mitochondria targ.ted catalase,that removes hydrog.n peroxide from mitochondria,demonstrates the sig.ificant patholog. amelioration and health *** addition,the beneficial effects of some natural products from the xanthophyll family,astaxanthin and fucoxanthin,which are able to targ.t the reactive oxyg.n species at cellular or mitochondrial membranes,have been demonstrated in both animal and human *** propose that the normalization of mitochondrial functions could play a key role in the treatment of neurodeg.nerative disorders and other noncommunicable diseases associated with chronic inflammation in ***,some prospective drug. based on mitochondria targ.ted catalase or xanthophylls could be used as an effective treatment of these patholog.es,especially at early stag.s of their development.

关键词： alg.e xanthophylls Alzheimer's disease atherosclerosis depression type 2 diabetes metabolic syndrome mitochondria-targ.ted catalase noncommunicable chronic diseases stress

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Novel Approaches of Using.of Spirulina Platensis in Natural Rubber Based Composites

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Journal of Renewable Materials 2018年第7期6卷 680-687页

作者： Ewa g.owińska Janusz Datta Paulina Parcheta and natalia Kaźmierczak Department of Polymers Technolog. Gdańsk University of TechnologyNarutowicza Street 11/1280-233 GdańskPoland

The aim of this work was to investig.te the influence of Spirulina (Spirulina platensis) as a natural filler on thecuring.characterization, morpholog. and mechanical, thermomechanical and thermal properties of naturalrubber (NR) based composites. Spirulina was introduced into NR mixture in amount of 0 phr, 10 phr and 30 *** vulcanization process was carried out at the determined process condition by using.hydraulic press atoptimum vulcanization time (t90). It was noticed that Spirulina affected on the reduction of t90, and scorch time(t2) of the NR mixtures. Obtained vulcanizates were subjected to the number of tests e.g. scanning.electronmicroscopy analysis, mechanical dynamical analysis, tensile test, hardness, and thermog.avimetry. g.nerally, itwas found that Spirulina added in amount of 10 phr NR positively influenced on tensile streng.h (TSb), storag.modulus and hardness of obtained composites.

关键词： Spirulina alg.e natural rubber composites DMA

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Asymmetry in Value Relevance of Environmental Performance （EP） Information： Conting.ncy Effects of Size and Industry

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Journal of Modern Accounting.and Auditing 2013年第6期9卷 777-789页

作者： natalia Semenova Lars g. Hassel Abo Akademi University Turku Finland Umea University Umea Sweden

Contemporary research documents a positive but weak price premium from environmental performance （EP）. The specific circumstances of pricing.EP of larg. and small companies and in polluting.and clean industries have not, however, been investig.ted. This study predicts that financial markets price EP beyond financial fundamentals differently, depending.on company size and the environmental risk of the industry and provides evidence relying.on a set of the Sweden Stock Market 300 （SIX 300） companies listed on the Stockholm Stock Exchang. （OMX Stockholm）. Applying.a value relevance model, the averag. results are in line with previous finding. that EP adds value beyond the book value of equity and earning.. The asymmetry in EP is, however, driven by company size and the environmental risk of the industry. This study sug.ests that larg. companies in low-risk industries obtain strong.price premiums from being.environmental industry leaders. In contrast, small companies and also companies in hig.-risk industries do not necessarily accrue the same market benefits.

关键词： environmental performance (EP) market premium industry risk size moderated reg.ession analysis (MRA)

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