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Systemic juvenile idiopathic arthritis–associated lung disease: A retrospective cohort study

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World Journal of Clinical Pediatrics 2024年第1期13卷 73-83页

作者： Konstantin e Belozerov natalia M Solomatina eugenia A Isupova Alla A Kuznetsova Mikhail M Kostik Department of Pediatric Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia St.Petersburg State Budgetary Institution of Health Care Children's City Polyclinic No.29 of the Kalininsky District of St.PetersburgSt.Petersburg 195274Russia Research Laboratory of Autoimmune and Autoinflammatory Diseases World-Class Research Centre for Personalized MedicineAlmazov National Medical Research CentreSt.Petersburg 197341Russia

BACKGROUND Lung damage in systemic juvenile arthritis(sJIA)is one of the contemporary topics in pediatric *** previous studies showed the severe course and fatal outcomes in some *** information about interstitial lung disease(ILD)in the sJIA is scarce and limited to a total of 100 *** To describe the features of sJIA patients with ILD in *** In the present retrospective cohort study,information about 5 patients less than 18-years-old with sJIA and ILD were *** diagnosis of sJIA was made according to the current 2004 and new provisional International League of Associations for Rheumatology criteria *** was diagnosed with chest computed tomography with the exclusion of other possible reasons for concurrent lung *** activation syndrome(MAS)was diagnosed with HLH-2004 and 2016 eULAR/ACR/PRINTO Classification Criteria and hScores were calculated during the lung *** The onset age of sJIA ranged from 1 year to 10 *** time interval before ILD ranged from 1 mo to 3 *** disease course was characterized by the prevalence of the systemic features above articular involvement,intensive rash(100%),persistent and very active MAS(hScore range:194-220)with transaminitis(100%),and respiratory symptoms(100%).Only 3 patients(60%)developed a clubbing *** patients(100%)had pleural effusion and 4 patients(80%)had pericardial effusion at the disease *** patients(40%)developed pulmonary arterial ***-related reactions to tocilizumab were observed in 3(60%)of the *** patient with trisomy 21 had a fatal disease *** of the remaining patients had sJIA remission and 2 patients had *** disease improved in 3 patients(75%),but 1 of them had initial deterioration of lung *** patient who has not achieved the sJIA remission had the progressed course of *** cases of hyper-eosinophilia were *** patients(80%)received

关键词： Systemic juvenile arthritis Interstitial lung disease Canakinumab Tocilizumab Interleukin-6 Interleukin-1

Large-scale genome-wide SNP analysis reveals the rugged(and ragged)landscape of global ancestry,phylogeny,and demographic history in chicken breeds

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 324-340页

作者： natalia V.DeMeNTIeVA Yuri S.SHCHeRBAKOV Olga I.STANISHeVSKAYA Anatoly B.VAKHRAMeeV Tatiana A.LARKINA Artem P.DYSIN Olga A.NIKOLAeVA Anna e.RYABOVA Anastasiia I.AZOVTSeVA Olga V.MITROFANOVA Grigoriy K.PeGLIVANYAN natalia R.ReINBACH Darren K.GRIFFIN Michael N.ROMANOV Russian Research Institute of Farm Animal Genetics and Breeding-Branch of the L.K.ernst Federal Research Centre for Animal Husbandry.Pushkin St.Petersburg196601Russia School of Biosciences University of KentCanterburyCT27NJUK L.K.ernst Federal Research Center for Animal Husbandry DubrovitsyPodolskMoscow Oblast142132Russia

The worldwide chicken gene pool encompasses a remarkable,but shrinking,number of divergently selected breeds of diverse *** study was a large-scale genome-wide analysis of the landscape of the complex molecular architecture,genetic variability,and detailed structure among 49 *** populations represent a significant sample of the world's chicken breeds from europe(Russia,Czech Republic,France,Spain,UK,etc.),Asia(China),North America(USA),and Oceania(Australia).Based on the results of breed genotyping using the Illumina 60K single nucleotide polymorphism(SNP)chip,a bioinformatic analysis was carried *** included the calculation of heterozygosity/homozygosity statistics,inbreeding coefficients,and effective population *** also included assessment of linkage disequilibrium and construction of phylogenetic *** multidimensional scaling,principal component analysis,and ADMIXTURe-assisted global ancestry analysis,we explored the genetic structure of populations and subpopulations in each *** overall 49-population phylogeny analysis was also performed,and a refined evolutionary model of chicken breed formation was proposed,which included egg,meat,dual-purpose types,and ambiguous *** a large-scale survey of genetic resources in poultry farming using modern genomic methods is of great interest both from the viewpoint of a general understanding of the genetics of the domestic chicken and for the further development of genomic technologies and approaches in poultry *** general,whole genome SNP genotyping of promising chicken breeds from the worldwide gene pool will promote the further development of modern genomic science as applied to poultry.

关键词： Chicken genome diversity Single nucleotide polymorphism(SNP)analysis Gene pool Global ancestry Phylogeny Demographic history

Antioxidants enzymes Activities and NO Levels in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis—A Comparative Study

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Journal of Biosciences and Medicines 2024年第2期12卷 50-59页

作者： natalia Cristina Aparecida Ribeiro e Ribeiro Anderson Martins Tavares Jaslana Hainfellner da Silva João Paulo Lima Daher Salim Kanaan Luciene de Carvalho Cardoso-Weide Laboratory of Neuroplasticity Neurobiology Department Biology Institute Federal Fluminense University Rio de Janeiro Brazil Postgraduate Program in Medical Sciences School of Medicine Federal Fluminense University Rio de Janeiro Brazil School of Biology UNIVERSO—Salgado de Oliveira University Rio de Janeiro Brazil Department of Pathology Faculty of Medicine Federal Fluminense University Rio de Janeiro Brazil

It consists of a retrospective study with twenty-two individuals diagnosed with DRC: fourteen HD and eight CAPD, followed up in the dialysis center of Antonio Pedro University Hospital (HUAP) of Fluminense Federal University (UFF), between 2015 and 2017. Fifteen healthy control (HC) subjects were included, without diagnosed CKD. Patients with HIV positive, hepatitis A, B, and C, pregnant, cancer, smokers, alcoholics and those exposed to X-rays in the last 3 months, were excluded. Objectives: As oxidative stress and endothelial dysfunction may be linked to the higher prevalence of CVD in CKD patients, we measured the activities of the antioxidants enzymes: SOD and GPx and total NO levels in the plasma and serum of end-stage CKD patients undergoing dialysis therapy, comparing with the HC group. Methods: Quantification of NO levels was performed by fluorometric kit, while activities of SOD and GPx were determined using kinetic methods. Results: We found higher plasma SOD activity in HD (8.58 U/ml) and CAPD (10.14 U/ml), compared to C (3.73 U/ml) group, while GPx activity was decreased in HD (115.38 nmol/h/ml) and CAPD (122.76 nmol/h/ml) groups compared to HC group (275.83 nmol/h/ml). Total serum NO concentration was decreased in HD (14.09 pmol/μl) and CAPD (10.26 pmol/μl), compared to non-CKD patients (49.65 pmol/μl). Conclusion: Decreased total serum NO and GPx activities may lead to endothelial dysfunction and consequently a higher prevalence of CVD in CKD patients.

关键词： Hemodialysis CAPD SOD GPx NO

efficacy of Mometasone Furoate Nasal Spray in Delayed Antibiotic Prescriptions for Acute Rhinosinusitis: A Multicenter, Randomized, Open-Label, Comparative, Prospective, Parallel Group Study

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第5期13卷 321-343页

作者： Vasyl Popovych Ivanna Koshel Vitalii Leshak Oleksandr Malofiichuk Liubov Piletska natalia Kapustina Oksana Martynnyk Volodimir Kuderskyi Head Department of Surgery No. 1 Lviv Medical University Lviv Ukraine e.N.T. Department Ivano-Frankivsk National Medical University Ivano-Frankivsk Ukraine e.N.T. Department Uzhhorod National University Uzhhorod Ukraine Municipal Non-Profit Institution Regional Clinical Hospital n. a. O. F.Herbachevskyi Zhytomyr Region Ukraine

While their clinical presentation is similar, post-viral rhinosinusitis does not indicate the possible development of bacterial rhinosinusitis which occurs in only 0.5% to 5% of all cases of ARS. However, unreasonable antibacterial therapy is prescribed in 54% to 77% of cases. The perspective is to use delayed antibacterial therapy management. The purpose of the study was to investigate the efficacy of mometasone furoate nasal spray within the delayed prescription approach. Methods: A multicenter, randomized, open-label, comparative, prospective, parallel group study enrolled a total of 156 patients with ARS aged 18 to 60 years, of them 155 patients completed the study. The patients were randomized into the main group of Mometasone Furoate (Flix) Nasal Spray or into the control group of amoxicillin clavulanate tablets while both groups were administered a standard ARS therapy. Findings: The use of MF nasal spray within the delayed antibiotics prescription approach has a significantly higher efficacy compared to the immediate antibiotics prescription in the first days of treatment (p erial therapy was prescribed to 42.3% of patients in the main group compared to 100.0% of patients in the control group (p ere were statistically significant differences in the dynamics of changes in the total symptom score between the patients administered antibiotics and the antibiotic-naive patients. Conclusion: The use of MF within the delayed antibiotics prescription approach reliably improves the pattern of symptoms over time at the disease onset and significantly reduces the need for NSAIDs administration and antibiotics prescription frequency.

关键词： Rhinosinusitis Mometasone Furoate Delayed Antibiotic

56 Years of the Marburg Virus—A Review of Therapeutics

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Open Journal of epidemiology 2024年第2期14卷 273-283页

作者： Michael M. Toza emmanuel Imangolwa natalia Shakela Ferdinand Ndubi Hanzoma Hatwiko Christabel N. Hikaambo Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Department of Biology Chemistry and Physics School of Health and Applied Sciences Namibia University of Science and Technology Windhoek Namibia Department of Pharmaceutical Chemistry and Pharmaceutics School of Pharmacy Kabarak University Nakuru Kenya Department of Physiological Sciences School of Medicine and Health Sciences Mulungushi University Livingstone Zambia

Background: The Marburg virus (MARV) is the causative agent of Marburg virus disease (MVD). This filovirus first appeared in 1967 and has since caused several outbreaks with case fatality rates between 23% and 90%. The earliest cases of MVD are thought to be caused by exposure to an infected animal, either a reservoir host (some bat species, e.g., Rousettus aegyptiacus) or a spill-over host, such as non-human primates. The virus is spread between people by direct contact with blood or other bodily fluids (including saliva, sweat, faeces, urine, tears, and breast milk) from infected individuals. Despite the high fatality rate, the Marburg virus has no vaccine or drug treatment. Recent outbreaks of the virus in 2023 in Tanzania and equatorial Guinea have reignited the need to develop effective therapeutics, especially in the wake of the COVID-19 pandemic. Purpose: This review seeks to highlight the drug discovery efforts aimed at developing vaccines or possible treatments as potential therapeutics. Several existing antiviral agents are being probed, and vaccines are in pre-clinical and clinical stages. Natural products are also an important source of possible drugs or lead compounds and when coupled with computational techniques, these strategies offer possible therapeutics for the Marburg virus, especially in Africa, which has a high disease burden. Methods: Using the search engines Google Scholar and PubMed;keywords e.g. Marburg virus, Marburg treatments, Marburg virus drug discovery were utilized. Several results were yielded, and articles published in recent years were accepted into the final *** and Conclusion: This study shows there is a growing interest in therapeutics for the Marburg virus, especially with the recent outbreaks and pandemic preparedness. Initiatives that to support vaccine development and access like the MARVAC consort time are critical to fighting this public health threat.

关键词： Marburg Virus Vaccines Antivirals Viruses Drug Discovery

Histone Acetyltransferase AtGCN5/HAG1 Is a Versatile Regulator of Developmental and Inducible Gene expression in Arabidopsis

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Molecular Plant 2010年第4期3卷 670-677页

作者： Caroline Servet natalia Conde e Silva Dao-Xiu Zhou Institut de Biologie des Plantes Universite Paris-sud 11 91405 Orsay France

Histone acetylation/deacetylation is a dynamic process and plays an important role in gene regulation. Histone acetylation homeostasis is regulated by antagonist actions of histone acetyltransferases （HAT） and deacetylases （HDAC）. Plant genome encodes multiple HATs and HDACs. The Arabidopsis HAT gene AtGCNS/HAGlplays an essential role in many plant development processes, such as meristem function, cell differentiation, leaf and floral organogenesis, and responses to environmental conditions such as light and cold, indicating an important role of this HAT in the regulation of both long-term developmental switches and short-term inducible gene expression. AtGCN5 targets to a large number of promoters and is required for acetylation of several histone H3 lysine residues. Recruitment of AtGCN5 to target promoters is likely to be mediated by direct or indirect interaction with DNA-binding transcription factors and/or by interaction with acetylated histone lysine residues on the targets. Interplay between AtGCN5 and other HATand HDAC is demonstrated to control specific regulatory pathways. Analysis of the role of AtGCN5 in light-inducible gene expression suggests a function of AtGCN5 in preparing chromatin commitment for priming inducible gene activation in plants.

关键词： Light regulation chromatin structure and remodeling gene regulation leaf/vegetative development meristem development.

Fluid Inclusion evidences for the P-T Conditions of Quartz Veins Formation in the Black Shale-Hosted Gold Deposits, Bodaybo Ore Region, Russia

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Journal of earth Science 2020年第3期31卷 514-522页

作者： natalia N.Ankusheva ekaterina e.Palenova Svetlana N.Shanina Institute of Mineralogy South-Urals Federal Research Center of Mineralogy and GeoecologyUrals BranchRussian Academy of SciencesMiass 456317Russia Geological Department South-Urals State UniversityMiass 456300Russia Institute of Geology of the Komi Science Center Urals BranchRussian Academy of SciencesSyktyvkar 167982Russia

The P-T conditions of auriferous and barren quartz veins from Kopylovsky,Kavkaz and Krasnoye gold deposits in Proterozoic black shales of Bodaybo ore region are presented the first time in this *** inclusions trapped in auriferous quartz are aqueous Na±K-Mg chloride with salinity of 6 wt.%-8.8 wt.%*** temperatures vary from 260 to 350℃,and calculated trapping pressures are 1.2-1.6 *** fluids trapped in barren quartz have more complicated compositions with Na,K,Mg and Fe chlorides,salinity up to 13 wt.%NaCleqv,and homogenization temperatures ranging between 140 and 280℃.The volatiles in fluids are dominated by H2O,followed by CO2 with minor amounts of CH4 and *** suppose that auriferous and barren quartz veins have been formed due to the basic metamorphogenic fluid as evidenced by the close slat and gas fluid composition.

关键词： Bodaybo black shales gold deposits gold-bearing quartz barren veins fluid inclusions P-T conditions

effect of flow rates of gases flowing through a coal bed during coal heating and cooling on concentrations of gases emitted and fire hazard assessment

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International Journal of Coal Science & Technology 2020年第1期7卷 107-121页

作者： Marek Wieckowski natalia Howaniec Adam Smolinski Department of Mining Aerology Central Mining InstitutePlac Gwarkow 140-166 KatowicePoland Department of energy Saving and Air Protection Central Mining InstitutePlac Gwarkow 140-166 Katowice.Poland Central Mining Institute Plac Gwarkow 1.40-166 KatowicePoland

The flow velocity of gases in gobs directly influences the kinetics and intensity of gaseous components release during heating and cooling of *** assessment of fire hazard is performed on the basis of concentrations of particular gases in a mine *** concentrations differ in coal heating and cooling phase which was proven in the *** paper presented the results of the experimental study on temperature distribution in a simulated coal bed in heating(50–250°C)and cooling(250–35°C)phases as well as its correlation to variations in concentration of gases released in these phases and flow rates of gases flowing through the coal *** research was performed on twenty-two samples of bituminous coals acquired from various coal beds of Polish coal *** differences were observed between heating and cooling phases in terms of the concentrations of gases taken into account in calculations of self-combustion *** the heating phase temperature increase resulted in the decrease of concentrations ratios of ethane,ethylene,propane,propylene and acetylene,while in the cooling phase these ratios increased *** effect of air(in heating phase)and nitrogen(in cooling phase)flow rate on the self-ignition index CO/CO2 was also determined.

关键词： Coal Self-heating Fire hazard Flow rate

The present and the future in the diagnosis and management of celiac disease

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Gastroenterology Report 2015年第1期3卷 3-11页

作者： natalia e.Castillo Thimmaiah G.Theethira Daniel A.Leffler Division of Gastroenterology Beth Israel Deaconess Medical CenterBostonMAUSA

Celiac disease is an autoimmune enteropathy caused by gluten in genetically predisposed *** celiac disease,adaptive and innate immune activation results in intestinal damage and a wide range of clinical *** the past,celiac disease was thought to result in signs and symptoms solely related to the gastrointestinal ***,more than half of the adult population presents with extra-intestinal manifestations that can also be expected to improve on a gluten-free *** this reason,it is recommended that physicians have a low threshold of suspicion for celiac *** knowledge of the immune pathogenesis of this autoimmune disease has served as a catalyst for the development of novel diagnostic tools and *** the years,highly sensitive and speciﬁc serological assays,in addition to genetic markers,have been found to target speciﬁc steps in the cascade pathway of celiac *** the advent of the gluten challenge has enabled experts to design diagnostic algorithms and monitor clinical responses in clinical *** gluten challenge has provided substantial beneﬁt in the advance of novel therapeutics as an adjuvant treatment to the gluten free ***,a strict gluten-free diet is highly burdensome to patients and can be limited in its efﬁ*** therapies-including gluten modiﬁcation,modulation of intestinal permeability and immune response--could be central to the future treatment of celiac disease.

关键词： celiac disease gluten-free diet autoimmune diseases